{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:24:55Z","timestamp":1780395895057,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1014313","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000}}],"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-030046"],"award-info":[{"award-number":["INV-030046"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P026400\/1"],"award-info":[{"award-number":["MR\/P026400\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P026400\/1"],"award-info":[{"award-number":["MR\/P026400\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P026400\/1"],"award-info":[{"award-number":["MR\/P026400\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Trachoma is estimated to be the leading infectious cause of blindness globally, predominantly affecting low-income populations with poor sanitation and hygiene. Over a decade of mass drug administration with antibiotics has led to substantial progress in control and elimination, but hotspots remain where infection persists or rebounds following mass drug administration for reasons that remain unclear. Transmission modelling is a key component of understanding these dynamics, but the complex dynamics of infection and reinfection with\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    are challenging to infer from cross\u2013sectional surveys. Here, we analyze longitudinal data collected over six months in 1991 using multiple diagnostics from two villages in The Gambia by developing and fitting a Bayesian epidemiological model that classifies individuals into disease states at each time point using a forward-filtering backward-sampling algorithm. We find that infection risk is clustered within households and the weekly probability of transmission within a shared room is 40\u2013fold higher than in a shared village. Infected children are estimated to contribute disproportionately to transmission, accounting for 70\u201390% of the force of infection within the observed period. We estimate the basic reproduction number,\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    , to be 2.2 by simulation and find that the distribution of secondary cases per individual is less aggregated than for other directly-transmitted pathogens. We further quantify heterogeneity in predisposition to becoming infected and estimate the sensitivity and specificity for PCR, antigen detection tests, and clinical examinations. Our study uncovers the natural history of trachoma infection, with implications for simulating pathogen dynamics and designing interventions to halt transmission and prevent avoidable cases of blindness.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1014313","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:46:37Z","timestamp":1779299197000},"page":"e1014313","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamics of trachoma infection in West Africa revealed by a hidden state model"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-0971","authenticated-orcid":true,"given":"Jake","family":"Carson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Crellen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Borlase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin M.","family":"Prada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. D\u00e9irdre","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon E. F.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"pcbi.1014313.ref001","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/bmb\/ldp046","article-title":"Neglected tropical diseases","volume":"93","author":"N Feasey","year":"2010","journal-title":"Br Med Bull"},{"key":"pcbi.1014313.ref002","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bmb\/ldm034","article-title":"Trachoma: an overview","volume":"84","author":"MJ Burton","year":"2007","journal-title":"Br Med Bull"},{"issue":"1","key":"pcbi.1014313.ref003","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41572-022-00359-5","article-title":"Trachoma","volume":"8","author":"AW Solomon","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"pcbi.1014313.ref004","unstructured":"World Health Organization. Trachoma. Accessed: 27-03-2026. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/trachoma"},{"key":"pcbi.1014313.ref005","volume-title":"Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021\u20132030","author":"World Health Organization","year":"2021"},{"issue":"8869","key":"pcbi.1014313.ref006","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0140-6736(93)91591-9","article-title":"Randomised controlled trial of single-dose azithromycin in treatment of trachoma","volume":"342","author":"RL Bailey","year":"1993","journal-title":"Lancet"},{"key":"pcbi.1014313.ref007","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiaa082","article-title":"Trachoma Prevalence After Discontinuation of Mass Azithromycin Distribution","volume":"221","author":"W Godwin","year":"2020","journal-title":"J Infect 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