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The basic unit of neurostimulation, a single electrical pulse, can travel through white matter to influence connected neuronal populations. However, the mechanisms by which it influences connected populations is not well understood: stimulation may excite, inhibit, or add noise to neuronal population activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this study, we investigated how single pulses modulate the neuronal processing of images in a well-controlled visual paradigm. In two human subjects implanted with iEEG electrodes for clinical purposes, single pulses were delivered to electrodes in white matter tracts connected to measurement electrodes in visual cortex. Images appeared on-screen at 0, 100, or 200 ms after each pulse. Using finite impulse response modeling, we decomposed the broadband and evoked potential responses into separate components induced by electrical stimulation and by visual processing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Single pulses induced transient broadband increases followed by suppression, but they did not modulate the visual broadband responses (i.e., stimulation response was additive to visual response). In contrast, single pulses elicited prominent brain stimulation evoked potentials\n                      <jats:italic>and<\/jats:italic>\n                      they modulated the visual evoked potentials. Specifically, visual evoked potentials were larger when stimulation occurred closer to visual onset. This indicates that a single electrical pulse can increase the strength or synchrony of visual inputs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, these findings suggest that the effects of electrical stimulation in the visual system are two-fold: stimulation induces additive effects on broadband power, possibly by adding noise, and it interacts with synchronous visual inputs to amplify them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pcbi.1014563","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:45:45Z","timestamp":1784915145000},"page":"e1014563","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single pulse electrical stimulation in white matter modulates iEEG visual responses 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mechanism for perceptual decision-making in the human brain","volume":"431","author":"HR Heekeren","year":"2004","journal-title":"Nature"},{"issue":"2","key":"pcbi.1014563.ref028","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jneumeth.2009.10.005","article-title":"Automated electrocorticographic electrode localization on individually rendered brain surfaces","volume":"185","author":"D Hermes","year":"2010","journal-title":"J Neurosci Methods"},{"key":"pcbi.1014563.ref029","first-page":"6175","article-title":"A canonical visualization tool for SEEG electrodes","volume":"2021","author":"H Huang","year":"2021","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"2","key":"pcbi.1014563.ref030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"AM Dale","year":"1999","journal-title":"Neuroimage"},{"issue":"13","key":"pcbi.1014563.ref031","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/18.13.23","article-title":"The human connectome project 7 tesla retinotopy dataset: description and population receptive field analysis","volume":"18","author":"NC Benson","year":"2018","journal-title":"J Vis"},{"issue":"10","key":"pcbi.1014563.ref032","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1093\/cercor\/bhu277","article-title":"Probabilistic maps of visual topography in human cortex","volume":"25","author":"L Wang","year":"2014","journal-title":"Cereb Cortex"},{"issue":"1","key":"pcbi.1014563.ref033","article-title":"Evaluating the reliability of human brain white matter tractometry","volume":"1","author":"J Kruper","year":"2021","journal-title":"Apert Neuro"},{"key":"pcbi.1014563.ref034","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuroimage.2017.07.015","article-title":"Recognition of white matter bundles using local and global streamline-based registration and clustering","volume":"170","author":"E Garyfallidis","year":"2018","journal-title":"Neuroimage"},{"key":"pcbi.1014563.ref035","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroimage.2018.05.027","article-title":"Population-averaged atlas of the macroscale human structural connectome and its network topology","volume":"178","author":"F-C Yeh","year":"2018","journal-title":"Neuroimage"},{"key":"pcbi.1014563.ref036","doi-asserted-by":"crossref","first-page":"110153","DOI":"10.1016\/j.jneumeth.2024.110153","article-title":"CARLA: adjusted common average referencing for cortico-cortical evoked potential data","volume":"407","author":"H Huang","year":"2024","journal-title":"J Neurosci Methods"},{"key":"pcbi.1014563.ref037","doi-asserted-by":"crossref","unstructured":"Mewett DT, Nazeran H, Reynolds KJ. Removing power line noise from recorded EMG. 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Physiol"},{"issue":"6705","key":"pcbi.1014563.ref040","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/27674","article-title":"Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons","volume":"395","author":"NV Marrion","year":"1998","journal-title":"Nature"},{"issue":"6","key":"pcbi.1014563.ref041","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0896-6273(93)90066-Z","article-title":"Desensitization of AMPA receptors upon multiquantal neurotransmitter release","volume":"10","author":"LO Trussell","year":"1993","journal-title":"Neuron"},{"issue":"4","key":"pcbi.1014563.ref042","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0166-2236(96)01001-6","article-title":"Multiple overlapping processes underlying short-term synaptic enhancement","volume":"20","author":"SA Fisher","year":"1997","journal-title":"Trends 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Uematsu","year":"1992","journal-title":"Neurosurgery"},{"issue":"5","key":"pcbi.1014563.ref052","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.brs.2020.05.009","article-title":"The effects of direct brain stimulation in humans depend on frequency, amplitude, and white-matter proximity","volume":"13","author":"UR Mohan","year":"2020","journal-title":"Brain Stimul"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1014563","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000}}],"container-title":["PLOS Computational 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