{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:26:32Z","timestamp":1787682392433,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1014702","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000}}],"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["NIAID AI160664"],"award-info":[{"award-number":["NIAID AI160664"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Primary immune responses induce CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses characterized by activation via antigen presenting cells, expansion, differentiation into effector and memory phenotypes, and contraction resulting in long-term memory populations. In this study a mathematical stochastic agent-based model is developed to simulate all phases of the CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell response following vaccination. Importantly, the model successfully captures the stochastic nature of T cell dynamics throughout the response. It predicts T cell population with high accuracy while addressing mouse-to-mouse variability, highlighting its robust predictive power. This predictive model aims to improve T cell vaccination strategies by both informing the biology of the T cell response and streamlining vaccine development.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1014702","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:39:40Z","timestamp":1787074780000},"page":"e1014702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The SATvac model of CD8+ T cell expansion and contraction phases considering memory and effector cell differentiation"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9938-8370","authenticated-orcid":true,"given":"Seyedeh Fatemeh","family":"Seyyedizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-9851","authenticated-orcid":true,"given":"Thomas A.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"8","key":"pcbi.1014702.ref001","article-title":"Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans","author":"JE Mold","year":"2021","journal-title":"Cell Rep"},{"issue":"6055","key":"pcbi.1014702.ref002","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1126\/science.1211548","article-title":"Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8 T Cell Immunity","volume":"334","author":"JE Epstein","year":"2011","journal-title":"Science"},{"issue":"4","key":"pcbi.1014702.ref003","article-title":"A critical role for CD8 T cells in a nonhuman primate model of tuberculosis","volume":"5","author":"CY Chen","year":"2009","journal-title":"PLoS Pathog"},{"issue":"6","key":"pcbi.1014702.ref004","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41591-020-0858-8","article-title":"T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers","volume":"26","author":"PS Arunachalam","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"pcbi.1014702.ref005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12967-025-06291-y","article-title":"New insights on anti-tumor immunity of CD8 T cells: cancer stem cells, tumor immune microenvironment and immunotherapy","volume":"23","author":"Y Lin","year":"2025","journal-title":"J Transl Med"},{"issue":"2","key":"pcbi.1014702.ref006","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","article-title":"Cytotoxic CD8 T cells in cancer and cancer immunotherapy","volume":"124","author":"H Raskov","year":"2021","journal-title":"Br J Cancer"},{"key":"pcbi.1014702.ref007","doi-asserted-by":"crossref","first-page":"101435","DOI":"10.1016\/j.smim.2020.101435","article-title":"Memory CD8+ T cell responses to cancer","volume":"49","author":"J Han","year":"2020","journal-title":"Semin Immunol"},{"key":"pcbi.1014702.ref008","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3389\/fimmu.2019.01833","article-title":"Memory CD8 T cell protection from viral reinfection depends on interleukin-33 alarmin signals","volume":"10","author":"C Baumann","year":"2019","journal-title":"Front Immunol"},{"issue":"3","key":"pcbi.1014702.ref009","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/v15030648","article-title":"Role of T Cells in Vaccine-Mediated Immunity against Marek\u2019s Disease","volume":"15","author":"M Heidari","year":"2023","journal-title":"Viruses"},{"issue":"8","key":"pcbi.1014702.ref010","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3390\/vaccines10081367","article-title":"Current Vaccine Platforms in Enhancing T-Cell Response","volume":"10","author":"T Ura","year":"2022","journal-title":"Vaccines (Basel)"},{"issue":"9","key":"pcbi.1014702.ref011","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.4049\/jimmunol.1600965","article-title":"Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy","volume":"198","author":"R Billeskov","year":"2017","journal-title":"J Immunol"},{"key":"pcbi.1014702.ref012","doi-asserted-by":"crossref","unstructured":"Banerjee S, Majumder K, Gutierrez GJ, Gupta D, Mittal B. 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