{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:54:51Z","timestamp":1790794491161,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1014809","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000}}],"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["221786\/Z\/20\/Z"],"award-info":[{"award-number":["221786\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Many eukaryotic cells produce attractant molecules to which they themselves are also attracted. For example, neutrophils produce leukotriene B4 while swarming. These autoattractants create a secondary signalling layer that coordinates collective cell behaviour. The principles by which autoattractants shape migration, however, remain poorly understood. Here we use a hybrid agent-based computational model to dissect the effects of autoattractants on the collective chemotaxis of immune cells. We find that autoattractant signals strongly enhance cells\u2019 responses to primary attractant, but only if the autoattractant is sufficiently short-lived: at longer lifetimes, accumulation degrades the directional information cells can extract. The overall effect of autoattractants therefore depends crucially on the balance between production and efficient removal \u2014 whether through cellular uptake, enzymatic breakdown, or inherent chemical instability. Optimal lifetimes exist, determined by cell speed and autoattractant diffusion, yet remarkably independent of cell density and primary attractant concentration. Autoattractants whose removal is governed by inherent instability rather than direct cellular breakdown coordinate migration less efficiently, but work more robustly across different environments. In the absence of cell-mediated breakdown, the model further reveals a characteristic optimal cell\u2013cell distance: too little communication leaves cells uncoordinated, while excessive signalling drives them into slow-moving aggregates. Strikingly, the conditions that produce the most efficient chemotaxis lie close to those that trigger aggregation, suggesting that many autoattractant systems operate near a critical boundary that can be tuned by evolution either to disperse cells or to bring them together.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1014809","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:38:17Z","timestamp":1790098697000},"page":"e1014809","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Communication through autoattractants can enhance and limit collective migration of immune cells"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-6907","authenticated-orcid":true,"given":"David M.","family":"Versluis","sequence":"first","affiliation":[{"name":"University College London","place":["London, United Kingdom"],"department":["Department of Cell 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