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To describe the effect of deformation injury on the physiological electrical signals of neurons, several axonal electrophysiological damage models based on the Hodgkin-Huxley equations have been proposed. However, none of these models can fully characterize the results of white matter nerve stretching experiments under different rates and amplitudes. Building on previous work by peers, we propose a novel axonal deformation damage model that comprehensively considers the coupled effects of sodium and potassium channel damage on gating variable rate constants, as well as the differences in mechanical properties and injury among individual axons during deformation\u2014with these differences continuously modeled by a statistical distribution. The proposed model can not only reasonably describe the sodium left-shift phenomenon (a key post-injury feature) but also accurately reproduce the neuro-electrophysiological responses of nerve fascicles under various stretching conditions. This new neuro-electrophysiological model for nerve fascicle injury exhibits good universality and provides a mechanical mechanism-based reference for future clinical treatment strategies of nerve injury.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1014837","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:37:35Z","timestamp":1791567455000},"page":"e1014837","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A statistical damage model for coupled mechano-electrophysiological axonal injury"],"prefix":"10.1371","volume":"22","author":[{"given":"Zexuan","family":"Chen","sequence":"first","affiliation":[{"name":"South China University of Technology","place":["Guangzhou, Guangdong, China"],"department":["Department of Engineering Mechanics, School of Civil Engineering and 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Civil Engineering and Transportation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"South China University of Technology","place":["Guangzhou, Guangdong, China"],"department":["Department of Engineering Mechanics, School of Civil Engineering and Transportation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"South China University of Technology","place":["Guangzhou, Guangdong, China"],"department":["Department of Engineering Mechanics, School of Civil Engineering and Transportation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejia","family":"Liu","sequence":"additional","affiliation":[{"name":"South China University of Technology","place":["Guangzhou, Guangdong, China"],"department":["Department of Engineering Mechanics, School of Civil Engineering and 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