{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:47:41Z","timestamp":1792086461855,"version":"4.4.0"},"reference-count":10,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Developing sustainable genomics capacity in the Global South requires more than technology transfer; it depends on human-centered approaches based on the workflows and existing expertise of laboratory personnel, institutional collaboration, and long-term integration into health systems. Drawing on lessons learned from regional capacity-building initiatives, this article proposes ten simple rules for implementing and sustaining genomics capacity within public health and clinical laboratory settings. These rules emphasize local context, strategic planning, continuous learning, and equitable collaboration. Together, they provide a roadmap for laboratories aiming to transform genomic technologies from research tools for diagnosis, surveillance and decision-making, into routine instruments for public health in low- and middle-income countries.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1014863","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:26:24Z","timestamp":1792085184000},"page":"e1014863","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ten simple rules to build genomics capacity for routine laboratory practice in the Global South"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-6620","authenticated-orcid":true,"given":"Emilyn Costa","family":"Concei\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Stellenbosch University","place":["Cape Town, South Africa"],"department":["South African Medical Research Council Centre for Tuberculosis Research (SAMRC), Division of Molecular Biology and Human Genetics (MBHG), Biomedical Research Institute (BMRI), Faculty of Medicine and Health Sciences (FMHS)"]},{"name":"Stellenbosch University","place":["Stellenbosch, South Africa"],"department":["Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking"]},{"name":"Rede Brasileira de Pesquisas em Tuberculose (REDE-TB)","place":["Rio de Janeiro, Rio de Janeiro, Brazil"]},{"name":"Universidade do Estado do Par\u00e1 (UEPA)","place":["Bel\u00e9m, Par\u00e1, Brazil"],"department":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Biologia Parasit\u00e1ria na Amaz\u00f4nia (PPG-BPA)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-6993","authenticated-orcid":true,"given":"Abhinav","family":"Sharma","sequence":"additional","affiliation":[{"name":"Stellenbosch University","place":["Cape Town, South Africa"],"department":["South African Medical Research Council Centre for Tuberculosis Research (SAMRC), Division of Molecular Biology and Human Genetics (MBHG), Biomedical Research Institute (BMRI), Faculty of Medicine and Health Sciences (FMHS)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davi Josu\u00e9","family":"Marcon","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Par\u00e1 (UEPA)","place":["Bel\u00e9m, Par\u00e1, Brazil"],"department":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Biologia Parasit\u00e1ria na Amaz\u00f4nia (PPG-BPA)"]},{"name":"Instituto Evandro Chagas (IEC)","place":["Ananindeua, Par\u00e1, Brazil"],"department":["Se\u00e7\u00e3o de Bacteriologia e Micologia (SABMI)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layana Rufino","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Instituto Evandro Chagas (IEC)","place":["Ananindeua, Par\u00e1, Brazil"],"department":["Se\u00e7\u00e3o de Bacteriologia e Micologia (SABMI)"]},{"name":"Instituto Evandro Chagas (IEC)","place":["Ananindeua, Par\u00e1, Brazil"],"department":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Epidemiologia e Vigil\u00e2ncia em Sa\u00fade (PPGEVS)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-2755","authenticated-orcid":true,"given":"Danna Karen Corr\u00eaa","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Par\u00e1 (UEPA)","place":["Bel\u00e9m, Par\u00e1, Brazil"],"department":["Programa de P\u00f3s-gradua\u00e7\u00e3o em Biologia Parasit\u00e1ria na Amaz\u00f4nia (PPG-BPA)"]},{"name":"Instituto Evandro Chagas (IEC)","place":["Ananindeua, Par\u00e1, Brazil"],"department":["Se\u00e7\u00e3o de Bacteriologia e Micologia (SABMI)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Eduarda de Oliveira","family":"Freitas","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Vigil\u00e2ncia em Sa\u00fade do Amazonas Dra. 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