{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:54:18Z","timestamp":1782345258137,"version":"3.54.5"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACYT-FORDECYT-PRONACES","award":["11311"],"award-info":[{"award-number":["11311"]}]},{"name":"CONACYT-FORDECYT-PRONACES","award":["6390"],"award-info":[{"award-number":["6390"]}]},{"name":"PROGRAMA DE APOYO A PROYECTOS DE INVESTIGACI\u00d3N E INNOVACI\u00d3N TECNOL\u00d3GICA-UNIVERSIDAD NACIONAL AUT\u00d3NOMA DE M\u00c9XICO","award":["IA203021"],"award-info":[{"award-number":["IA203021"]}]},{"name":"PROGRAMA DE APOYO A PROYECTOS DE INVESTIGACI\u00d3N E INNOVACI\u00d3N TECNOL\u00d3GICA-UNIVERSIDAD NACIONAL AUT\u00d3NOMA DE M\u00c9XICO","award":["IN218023"],"award-info":[{"award-number":["IN218023"]}]},{"name":"Consejo Nacional de Humanidades Ciencia y Tecnolog\u00eda","award":["CVU\/BECARIO 711015\/790972"],"award-info":[{"award-number":["CVU\/BECARIO 711015\/790972"]}]},{"name":"Consejo Nacional de Humanidades Ciencia y Tecnolog\u00eda","award":["CVU 371892"],"award-info":[{"award-number":["CVU 371892"]}]},{"name":"Rebecca L Cooper Medical Research Foundation through an Al & Val Rosenstrauss Fellowship","award":["F20231230"],"award-info":[{"award-number":["F20231230"]}]}],"content-domain":{"domain":["www.plosdigitalhealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Digit Health"],"abstract":"<jats:p>Higher prevalence and worst outcome have been reported among people with systemic lupus erythematosus with non-European ancestries, with both genetic and socioeconomic variables as contributing factors. In Mexico, studies assessing the inequities related to quality of life for Systemic Lupus Erythematosus patients remain sparse. This study aims to assess the inequities related to quality of life in a cohort of Mexican people with SLE. This study included 942 individuals with SLE from the Mexican Lupus Registry (LupusRGMX) and two healthy control groups. Self-answered surveys were collected via the Research Electronic Data Capture platform between May 2021 and January 2023. Data was analyzed as a cross-sectional study. A random forest model was implemented to assess potential predictive variables. Permutation tests were performed to analyze the effect health providers had on diagnosis lag and quality of life\u2019s differences among socioeconomic levels. Partial correlation analysis between the number of patients and rheumatologists registered was also performed. Systemic Lupus Erythematosus participants had significantly lower quality of life than healthy people (p-values &lt; 0.0001). Socioeconomic status, delay in diagnosis, and corticosteroid consumption were the factors that influenced QoL the most (RMSE = 9.53 with the importance variable validated); lower quality of life was associated with lower socioeconomic status (p-value &lt; 0.0001). Disparities in health services were reflected in longer diagnosis time among people with public health providers (p-value = 0.0419). A significant association between diagnosed patients and available rheumatologists by geographical state was observed (\u03c1 = 0.4, p-value = 0.0259), which can be translated into restricted access to specialists. Since most of our cohort exhibited low socioeconomic status, it is important to consider them as a vulnerable population; this study settles the necessity to deepen the effects of the socioeconomic disparities, allowing to design public policies and strategies aimed to reduce Systemic Lupus Erythematosus disparities, therefore improving quality of life of Mexican people with Systemic Lupus Erythematosus.<\/jats:p>","DOI":"10.1371\/journal.pdig.0000706","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T18:32:51Z","timestamp":1737657171000},"page":"e0000706","update-policy":"https:\/\/doi.org\/10.1371\/journal.pdig.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quality of life disparities among Mexican people with systemic lupus erythematosus"],"prefix":"10.1371","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-7471","authenticated-orcid":true,"given":"Ana 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Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donaj\u00ed","family":"Dom\u00ednguez-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbet","family":"Tinajero-Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Pe\u00f1a-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Torres-Valdez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Frontana-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Guti\u00e9rrez-Arcelus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Rosetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarael","family":"Alcauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel 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The impact of patient-physician interactions on lupus patients\u2019 psychological well-being, cognition and health-care-seeking behaviour.","author":"M Sloan","year":"2020","journal-title":"Rheumatol Adv Pract."},{"issue":"4","key":"pdig.0000706.ref038","doi-asserted-by":"crossref","DOI":"10.4081\/reumatismo.2021.1447","article-title":"Quality of life measures in Systemic Lupus Erythematosus: A systematic review.","volume":"73","author":"M Radin","year":"2022","journal-title":"Reumatismo"},{"issue":"22","key":"pdig.0000706.ref039","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.3390\/ijerph182212022","article-title":"Anxiety, Depression and Quality of Life-A Systematic Review of Evidence from Longitudinal Observational Studies.","volume":"18","author":"JK Hohls","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"9","key":"pdig.0000706.ref040","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00296-018-4017-1","article-title":"Living with systemic lupus erythematosus in the developing world","volume":"38","author":"A Phuti","year":"2018","journal-title":"Rheumatol Int"},{"issue":"7","key":"pdig.0000706.ref041","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s00421-022-04948-w","article-title":"Maximal strength training in patients with inflammatory rheumatic disease: implications for physical function and quality of life","volume":"122","author":"H Haglo","year":"2022","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"pdig.0000706.ref042","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/annrheumdis-2020-218272","article-title":"Update \u03bfn the diagnosis and management of systemic lupus erythematosus","volume":"80","author":"A Fanouriakis","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"pdig.0000706.ref043","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40258-014-0085-x","article-title":"Impact of early versus late systemic lupus erythematosus diagnosis on clinical and economic outcomes","volume":"12","author":"A Oglesby","year":"2014","journal-title":"Appl Health Econ Health Policy"},{"issue":"1","key":"pdig.0000706.ref044","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13075-021-02466-2","article-title":"Association of glucocorticoid doses and emotional health in lupus low disease activity state (LLDAS): a cross-sectional study.","volume":"23","author":"Y Miyawaki","year":"2021","journal-title":"Arthritis Res Ther."},{"issue":"9","key":"pdig.0000706.ref045","article-title":"Glucocorticoids in Systemic Lupus Erythematosus.","volume":"9","author":"S Porta","year":"2020","journal-title":"Ten Questions and Some Issues. 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