{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:32:09Z","timestamp":1785367929631,"version":"3.55.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009595","name":"Public Service of Wallonia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009595","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009595","name":"Public Service of Wallonia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009595","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009595","name":"Public Service of Wallonia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009595","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosdigitalhealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Digit Health"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Children with cerebral palsy (CP) and adults with chronic stroke (CS) usually have disabilities in voluntary motor control. Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), an evidence-based therapy, has always been provided during day camps. This pilot study investigates if HABIT-ILE@home, a remote neurorehabilitation, is feasible for children with CP and adults with CS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Four children with CP (5-18y) and three adults with CS were recruited. They received 15h (5x3h) of HABIT-ILE@home provided by a caregiver with a remote supervision of 30min at the beginning and end of each session. A large touch screen, the REAtouch Lite, was used as a support for the therapy. An interview based on a questionnaire (n\u2009=\u200973 items for CP\/ n\u2009=\u200974 items for stroke patients; scored from 0 \u201cdisagree\u201d to 3 \u201cagree\u201d, a higher rating meaning a more positive aspect of the therapy) was conducted with patients and their caregivers after 15h of supervised home-therapy to assess their adherence to the treatment and the feasibility of HABIT-ILE@home. Performance and satisfaction in achieving functional goals were assessed before and after the intervention using the Canadian Occupational Performance Measure (COPM).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Caregivers felt sufficiently supported by the supervision team (medians\u2009=\u20093) to carry out HABIT-ILE@home sessions thanks to an adequate clinical supervision (CP median\u2009=\u20092.6; CS median\u2009=\u20092.9). HABIT-ILE principles were transferable at patients\u2019 home (CP median\u2009=\u20092.6; CS median\u2009=\u20092.8). The impact of the therapy on daily organization was more problematic for children\u2019s caregivers (median\u2009=\u20091.5) than for adults\u2019 caregivers (median\u2009=\u20093). Children with CP enjoyed the therapy (median\u2009=\u20092) but felt that it was too long (median\u2009=\u20091) and significant fatigue was present (median\u2009=\u20091.3). CS adults did not find the therapy fun (median\u2009=\u20091) but considered it as extremely useful (median\u2009=\u20093). Although the motivational source differed between children and adults, this did not seem to strongly affect adherence to treatment. Performance and satisfaction in achieving functional goals improved over the MCID (2 points) for all CS participants and for 3 out 4 CP children.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>HABIT-ILE@home seems to be feasible for children with CP and adults with CS. It may allow more patients to benefit from an efficient neurorehabilitation, whatever sanitary conditions or patients\u2019 home geographical locations.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pdig.0000850","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T17:37:26Z","timestamp":1746725846000},"page":"e0000850","update-policy":"https:\/\/doi.org\/10.1371\/journal.pdig.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Feasibility of HABIT-ILE@home in children with cerebral palsy and adults with chronic stroke: A pilot study"],"prefix":"10.1371","volume":"4","author":[{"given":"Edouard","family":"Ducoffre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlyne","family":"Arnould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin","family":"Somville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00e9lie","family":"Rosselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3226-6834","authenticated-orcid":true,"given":"Geoffroy","family":"Saussez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-932X","authenticated-orcid":true,"given":"Yannick","family":"Bleyenheuft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"pdig.0000850.ref001","doi-asserted-by":"crossref","first-page":"15082","DOI":"10.1038\/nrdp.2015.82","article-title":"Cerebral palsy","volume":"2","author":"HK Graham","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"8","key":"pdig.0000850.ref002","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1017\/S001216220500112X","article-title":"Proposed definition and classification of cerebral palsy, April 2005","volume":"47","author":"M Bax","year":"2005","journal-title":"Dev Med Child Neurol"},{"issue":"2","key":"pdig.0000850.ref003","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000506396","article-title":"Global, Regional and Country-Specific Burden of Ischaemic Stroke, Intracerebral Haemorrhage and Subarachnoid Haemorrhage: A Systematic Analysis of the Global Burden of Disease Study 2017","volume":"54","author":"RV Krishnamurthi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"pdig.0000850.ref004","doi-asserted-by":"crossref","first-page":"7949","DOI":"10.1038\/ncomms8949","article-title":"Clinically relevant copy number variations detected in cerebral palsy","volume":"6","author":"M Oskoui","year":"2015","journal-title":"Nat Commun"},{"key":"pdig.0000850.ref005","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions","volume":"97","author":"V Saini","year":"2021","journal-title":"Neurology"},{"issue":"2","key":"pdig.0000850.ref006","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/0103-5150.028.002.AR02","article-title":"Disability after stroke: a systematic review","volume":"28","author":"do Carmo JF","year":"2015","journal-title":"Fisioter mov"},{"issue":"6","key":"pdig.0000850.ref007","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-055061","article-title":"Neurodevelopmental Therapy for Cerebral Palsy: A Meta-analysis","volume":"149","author":"A Te Velde","year":"2022","journal-title":"Pediatrics"},{"key":"pdig.0000850.ref008","doi-asserted-by":"crossref","DOI":"10.12968\/ijtr.2016.23.Sup11.S549","article-title":"An observational study on usual physiotherapy care in a stroke rehabilitation unit","volume":"23","author":"G Hendrey","year":"2016","journal-title":"Int J Therapy Rehabilitation"},{"issue":"2","key":"pdig.0000850.ref009","doi-asserted-by":"crossref","first-page":"78","DOI":"10.12968\/ijtr.2009.16.2.38893","article-title":"How much physical activity do people recovering from stroke do during physiotherapy sessions?","volume":"16","author":"T Elson","year":"2009","journal-title":"Int J Therapy Rehabilitation"},{"issue":"2","key":"pdig.0000850.ref010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11910-020-1022-z","article-title":"State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy","volume":"20","author":"I Novak","year":"2020","journal-title":"Curr Neurol Neurosci Rep"},{"key":"pdig.0000850.ref011","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fnhum.2016.00442","article-title":"Rehabilitation of Motor Function after Stroke: A Multiple Systematic Review Focused on Techniques to Stimulate Upper Extremity Recovery","volume":"10","author":"SM Hatem","year":"2016","journal-title":"Front Hum Neurosci"},{"issue":"5","key":"pdig.0000850.ref012","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1161\/STROKEAHA.111.000559","article-title":"Method for enhancing real-world use of a more affected arm in chronic stroke: transfer package of constraint-induced movement therapy","volume":"44","author":"E Taub","year":"2013","journal-title":"Stroke"},{"issue":"4","key":"pdig.0000850.ref013","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.apmr.2004.10.008","article-title":"Methods of constraint-induced movement therapy for children with hemiplegic cerebral palsy: development of a child-friendly intervention for improving upper-extremity function","volume":"86","author":"AM Gordon","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"issue":"10","key":"pdig.0000850.ref014","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/dmcn.12246","article-title":"A systematic review of interventions for children with cerebral palsy: state of the evidence","volume":"55","author":"I Novak","year":"2013","journal-title":"Dev Med Child Neurol"},{"issue":"9778","key":"pdig.0000850.ref015","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(11)60325-5","article-title":"Stroke rehabilitation","volume":"377","author":"P Langhorne","year":"2011","journal-title":"Lancet"},{"issue":"11","key":"pdig.0000850.ref016","first-page":"931","article-title":"Development of hand-arm bimanual intensive training (HABIT) for improving bimanual coordination in children with hemiplegic cerebral palsy","volume":"48","author":"J Charles","year":"2006","journal-title":"Dev Med Child Neurol"},{"issue":"4","key":"pdig.0000850.ref017","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3109\/01942638.2014.932884","article-title":"Hand-arm bimanual intensive therapy including lower extremities (HABIT-ILE) for children with cerebral palsy","volume":"34","author":"Y Bleyenheuft","year":"2014","journal-title":"Phys Occup Ther Pediatr"},{"issue":"8","key":"pdig.0000850.ref018","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/0883073814535503","article-title":"Evidence-based diagnosis, health care, and rehabilitation for children with cerebral palsy","volume":"29","author":"I Novak","year":"2014","journal-title":"J Child Neurol"},{"issue":"7","key":"pdig.0000850.ref019","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1177\/1545968314562109","article-title":"Hand and Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) in Children With Unilateral Spastic Cerebral Palsy: A Randomized Trial","volume":"29","author":"Y Bleyenheuft","year":"2015","journal-title":"Neurorehabil Neural Repair"},{"issue":"6","key":"pdig.0000850.ref020","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/dmcn.13379","article-title":"Intensive upper- and lower-extremity training for children with bilateral cerebral palsy: a quasi-randomized trial","volume":"59","author":"Y Bleyenheuft","year":"2017","journal-title":"Dev Med Child Neurol"},{"issue":"8","key":"pdig.0000850.ref021","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/dmcn.14141","article-title":"Interventions to improve upper limb function for children with bilateral cerebral palsy: a systematic review","volume":"61","author":"VFP Plasschaert","year":"2019","journal-title":"Dev Med Child Neurol"},{"issue":"4","key":"pdig.0000850.ref022","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-070642","article-title":"Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) in adults with chronic stroke: protocol of a randomised controlled trial","volume":"13","author":"D Ebner-Karestinos","year":"2023","journal-title":"BMJ Open"},{"issue":"2","key":"pdig.0000850.ref023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087987","article-title":"What is the evidence for physical therapy poststroke? A systematic review and meta-analysis","volume":"9","author":"JM Veerbeek","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"pdig.0000850.ref024","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/NPT.0b013e3182a3d353","article-title":"Motor skill learning is associated with diffusion characteristics of white matter in individuals with chronic stroke","volume":"38","author":"MR Borich","year":"2014","journal-title":"J Neurol Phys Ther"},{"key":"pdig.0000850.ref025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bandl.2014.03.011","article-title":"Intensive therapy induces contralateral white matter changes in chronic stroke patients with Broca\u2019s aphasia","volume":"136","author":"CY Wan","year":"2014","journal-title":"Brain Lang"},{"key":"pdig.0000850.ref026","first-page":"1150","article-title":"The impact of an anti-gravity treadmill (AlterG) training on walking capacity and corticospinal tract structure in children with cerebral palsy","volume":"2017","author":"S Azizi","year":"2017","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"pdig.0000850.ref027","doi-asserted-by":"crossref","first-page":"798481","DOI":"10.1155\/2015\/798481","article-title":"Brain Plasticity following Intensive Bimanual Therapy in Children with Hemiparesis: Preliminary Evidence","volume":"2015","author":"M Weinstein","year":"2015","journal-title":"Neural Plast"},{"issue":"4","key":"pdig.0000850.ref028","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1542\/peds.113.4.846","article-title":"Early experience alters brain function and structure","volume":"113","author":"H Als","year":"2004","journal-title":"Pediatrics"},{"key":"pdig.0000850.ref029","unstructured":"Stroke FoundationNational Stroke Audit \u2013 Acute Services Report 2021Melbourne, AustraliaStroke Foundation2021"},{"issue":"3","key":"pdig.0000850.ref030","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1748-0361.2011.00397.x","article-title":"Postacute stroke rehabilitation utilization: are there differences between rural-urban patients and taxonomies?","volume":"28","author":"H Jia","year":"2012","journal-title":"J Rural Health"},{"issue":"6","key":"pdig.0000850.ref031","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1161\/STROKEAHA.107.501643","article-title":"Stroke in rural areas and small communities","volume":"39","author":"J Joubert","year":"2008","journal-title":"Stroke"},{"issue":"1","key":"pdig.0000850.ref032","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1017\/cjn.2015.324","article-title":"Community Stroke Rehabilitation: How Do Rural Residents Fare Compared With Their Urban Counterparts?","volume":"43","author":"L Allen","year":"2016","journal-title":"Can J Neurol Sci"},{"issue":"6","key":"pdig.0000850.ref033","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.3390\/ijerph18062980","article-title":"Access to Healthcare during COVID-19","volume":"18","author":"A N\u00fa\u00f1ez","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"pdig.0000850.ref034","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/17474930211055878","article-title":"Maintaining stroke care during the COVID-19 pandemic in lower- and middle-income countries: World Stroke Organization Position Statement endorsed by American Stroke Association and American Heart Association","volume":"17","author":"JD Pandian","year":"2022","journal-title":"Int J Stroke"},{"issue":"5","key":"pdig.0000850.ref035","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/dmcn.15055","article-title":"Interventions to improve physical function for children and young people with cerebral palsy: international clinical practice guideline","volume":"64","author":"M Jackman","year":"2022","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"pdig.0000850.ref036","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0003-9993(02)04896-7","article-title":"Rasch analysis of the Gross Motor Function Measure: validating the assumptions of the Rasch model to create an interval-level measure","volume":"84","author":"LM Avery","year":"2003","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"pdig.0000850.ref037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2340\/1650197771331","article-title":"The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance","volume":"7","author":"AR Fugl-Meyer","year":"1975","journal-title":"Scand J Rehabil Med"},{"issue":"1","key":"pdig.0000850.ref038","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12984-023-01218-4","article-title":"Efficacy of integrating a semi-immersive virtual device in the HABIT-ILE intervention for children with unilateral cerebral palsy: a non-inferiority randomized controlled trial","volume":"20","author":"G Saussez","year":"2023","journal-title":"J Neuroeng Rehabil"},{"issue":"194","key":"pdig.0000850.ref039","first-page":"4","article-title":"SUS-A quick and dirty usability scale","volume":"189","author":"J Brooke","year":"1996","journal-title":"Usability evaluation in industry"},{"key":"pdig.0000850.ref040","article-title":"Construction and evaluation of a user experience questionnaire. Symposium of the Austrian HCI and usability engineering group;","author":"B Laugwitz","year":"2008"},{"key":"pdig.0000850.ref041","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-322-80058-9_19","article-title":"AttrakDiff: Ein Fragebogen zur Messung wahrgenommener hedonischer und pragmatischer Qualit\u00e4t.","volume-title":"Mensch & Computer 2003: Interaktion in Bewegung","author":"M Hassenzahl","year":"2003"},{"issue":"5","key":"pdig.0000850.ref042","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.erap.2015.08.002","article-title":"Cr\u00e9ation et validation d\u2019une version fran\u00e7aise du questionnaire AttrakDiff pour l\u2019\u00e9valuation de l\u2019exp\u00e9rience utilisateur des syst\u00e8mes interactifs","volume":"65","author":"C Lallemand","year":"2015","journal-title":"European Review of Applied Psychology"},{"key":"pdig.0000850.ref043","author":"GA Morgan","year":"2015","journal-title":"The revised dimensions of mastery questionnaire (DMQ 18)"},{"issue":"1","key":"pdig.0000850.ref044","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/02701367.1989.10607413","article-title":"Psychometric properties of the Intrinsic Motivation Inventory in a competitive sport setting: a confirmatory factor analysis","volume":"60","author":"E McAuley","year":"1989","journal-title":"Res Q Exerc Sport"},{"issue":"2","key":"pdig.0000850.ref045","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.physio.2016.11.001","article-title":"The development and initial psychometric evaluation of a measure assessing adherence to prescribed exercise: the Exercise Adherence Rating Scale (EARS)","volume":"103","author":"NA Newman-Beinart","year":"2017","journal-title":"Physiotherapy"},{"issue":"11","key":"pdig.0000850.ref046","doi-asserted-by":"crossref","DOI":"10.1016\/j.apmr.2017.03.015","article-title":"Development and Preliminary Psychometrics of the Exercise Therapy Burden Questionnaire for Patients With Chronic Conditions","volume":"98","author":"W Martin","year":"2017","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"pdig.0000850.ref047","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/000841749005700207","article-title":"The Canadian occupational performance measure: an outcome measure for occupational therapy","volume":"57","author":"M Law","year":"1990","journal-title":"Can J Occup Ther"},{"issue":"4","key":"pdig.0000850.ref048","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/000841740407100406","article-title":"The Canadian Occupational Performance Measure: a research and clinical literature review","volume":"71","author":"A Carswell","year":"2004","journal-title":"Can J Occup Ther"},{"issue":"10","key":"pdig.0000850.ref049","article-title":"Feasibility and effectiveness of home-based therapy programmes for children with cerebral palsy: a systematic review","volume":"10","author":"LWME Beckers","year":"2020","journal-title":"BMJ Open"},{"issue":"1","key":"pdig.0000850.ref050","article-title":"Telerehabilitation services for stroke","volume":"1","author":"KE Laver","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"pdig.0000850.ref051","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/17518423.2014.948641","article-title":"Feasibility of caregiver-directed home-based hand-arm bimanual intensive training: a brief report","volume":"18","author":"CL Ferre","year":"2015","journal-title":"Dev Neurorehabil"},{"issue":"4","key":"pdig.0000850.ref052","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1207\/S15327965PLI1104_01","article-title":"The \u201cWhat\u201d and \u201cWhy\u201d of Goal Pursuits: Human Needs and the Self-Determination of Behavior","volume":"11","author":"EL Deci","year":"2000","journal-title":"Psychological Inquiry"},{"issue":"11","key":"pdig.0000850.ref053","article-title":"Barriers, Facilitators and Interventions to Support Virtual Reality Implementation in Rehabilitation: A Scoping Review","volume":"10","author":"SMN Glegg","year":"2018","journal-title":"PMR"},{"key":"pdig.0000850.ref054","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4135\/9781446249215.n21","article-title":"Self-determination theory","volume-title":"Handbook of theories of social psychology","author":"E Deci","year":"2012"},{"issue":"6","key":"pdig.0000850.ref055","first-page":"371","article-title":"Motivation in pediatric motor rehabilitation: A systematic search of the literature using the self-determination theory as a conceptual framework","volume":"21","author":"P Meyns","year":"2018","journal-title":"Dev Neurorehabil"},{"issue":"9","key":"pdig.0000850.ref056","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/jamaneurol.2019.1604","article-title":"Efficacy of Home-Based Telerehabilitation vs In-Clinic Therapy for Adults After Stroke: A Randomized Clinical Trial","volume":"76","author":"SC Cramer","year":"2019","journal-title":"JAMA Neurol"},{"key":"pdig.0000850.ref057","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12883-015-0334-0","article-title":"Twenty weeks of home-based interactive training of children with cerebral palsy improves functional abilities","volume":"15","author":"J Lorentzen","year":"2015","journal-title":"BMC Neurol"},{"issue":"1","key":"pdig.0000850.ref058","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/09638288.2019.1618400","article-title":"Feasibility of a randomised controlled trial to evaluate home-based virtual reality therapy in children with cerebral palsy","volume":"43","author":"WJ Farr","year":"2021","journal-title":"Disabil Rehabil"},{"issue":"3","key":"pdig.0000850.ref059","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/1440-1630.12666","article-title":"What is the threshold dose of upper limb training for children with cerebral palsy to improve function? A systematic review","volume":"67","author":"M Jackman","year":"2020","journal-title":"Aust Occup Ther J"}],"container-title":["PLOS Digital Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pdig.0000850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T17:37:38Z","timestamp":1746725858000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pdig.0000850"}},"subtitle":[],"editor":[{"given":"Haleh","family":"Ayatollahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":59,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pdig.0000850","relation":{},"ISSN":["2767-3170"],"issn-type":[{"value":"2767-3170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}