{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:13:16Z","timestamp":1791313996911,"version":"4.3.1"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosdigitalhealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Digit Health"],"abstract":"<jats:p>Heart failure with reduced ejection fraction is a chronic, progressive medical condition affecting millions of individuals worldwide. It is associated with high morbidity and mortality. The use of \u201cfoundational quadruple therapy\u201d titrated to the maximum tolerated doses improves survival, quality of life, and reduces heart failure-related hospitalisation. Despite this evidence, there is a consistent trend of suboptimal dose up-titration, prolonged optimisation periods, and early therapy discontinuation. Virtual wards offer a potential innovative solution in transforming heart failure management by combining rapid medication optimisation with remote monitoring to improve patient outcomes. This retrospective study employed a single-group pre-post design to evaluate the effectiveness of a prescribing pharmacist in the rapid uptitration of Guidelines Directed Medical Therapy (GDMT) in patients with heart failure with reduced ejection fraction within a virtual ward setting. The study assessed clinical outcomes of 86 patients at baseline, following discharge from the virtual ward (typically after 4 weeks), and at 3\u20136 months post-discharge. Improvements were seen in NYHA scores, cardiac systolic function, and Optimal Medical Therapy (OMT) scores. The median Left Ventricular Ejection Fraction increased from 29% at baseline to 39% post-optimisation, signifying improved myocardial performance and a reduction in the severity of left ventricular dysfunction. Post-optimisation, 37% of patients attained an optimal OMT score of 8, 52% attained an acceptable score (5\u20137), and only 5% remained in the suboptimal range (0\u20134). Additionally, 84% of patients were prescribed all four foundational therapies. There was no notable increase in adverse events such as hypotension, bradycardia, or hyperkalaemia. Remote up-titration of heart failure medications within a virtual ward environment is a promising approach, offering a fast, feasible, safe, and efficient treatment solution for patients who are otherwise undertreated.<\/jats:p>","DOI":"10.1371\/journal.pdig.0000868","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T17:39:22Z","timestamp":1749145162000},"page":"e0000868","update-policy":"https:\/\/doi.org\/10.1371\/journal.pdig.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacist-led rapid uptitration clinic in heart failure patients with reduced ejection fraction: Our experience within a virtual 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