{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:08:48Z","timestamp":1789495728176,"version":"build-2803163510"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Garvey Institute for Brain Health Solutions","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066509"],"award-info":[{"award-number":["P30AG066509"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosdigitalhealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Digit Health"],"abstract":"<jats:p>\n                    With the rising prevalence of age-related memory impairments, efficiently detecting and monitoring decline is increasingly urgent. Unfortunately, traditional assessment methods fall short of these needs, as they typically require in-person administration and cannot be repeated frequently. Here, we demonstrate that remote identification and monitoring of abnormal memory function is possible by combining an online assessment platform with computational phenotyping, allowing repeatable, unsupervised remote observations from patients. Fifty-one well-characterized older individuals, including 24 patients with amnestic mild cognitive impairment and 27 age- and education-matched healthy controls, completed a series of longitudinal, unsupervised, remote weekly 8-minute online memory assessments for up to one year. Weekly test data were fit to a formal model of memory consolidation and forgetting, yielding an individualized index of memory function, the Seattle-Groningen Memory Assessment (SGMA) score. The SGMA score was found to be reliable, with a mean correlation of\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.70 across assessments. The score was also found to be stable across different study materials, and only barely affected by practice effects, which averaged to a 0.2% increase per assessment. Finally, the SGMA score was found to be diagnostic, being capable of detecting mild cognitive impairment with up to 87% accuracy. These findings show that model-based, adaptive assessments can support high-frequency, remote detection and scalable longitudinal monitoring of early memory decline, providing a new way to assess memory decline trajectories in healthy aging and dementia.\n                  <\/jats:p>","DOI":"10.1371\/journal.pdig.0001686","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:46:13Z","timestamp":1789494373000},"page":"e0001686","update-policy":"https:\/\/doi.org\/10.1371\/journal.pdig.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reliable detection and continuous monitoring of memory dysfunction in mild cognitive impairment and healthy aging through adaptive computational phenotyping"],"prefix":"10.1371","volume":"5","author":[{"given":"Holly S.","family":"Hake","sequence":"first","affiliation":[{"name":"University of Washington","place":["Seattle, Washington, United States of America"],"department":["Department of Psychology"]},{"name":"University of Washington","place":["Seattle, Washington, United States of America"],"department":["Graduate Program in Neuroscience"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"van der Velde","sequence":"additional","affiliation":[{"name":"Precision Cognition Labs","place":["Groningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Grabowski","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, Washington, United States of America"],"department":["Departments of Radiology and Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedderik","family":"van Rijn","sequence":"additional","affiliation":[{"name":"Precision Cognition Labs","place":["Groningen, The Netherlands"]},{"name":"University of Groningen","place":["Groningen, The Netherlands"],"department":["Department of Experimental Psychology"]},{"name":"University of Groningen","place":["Groningen, The Netherlands"],"department":["Behavioral and Cognitive Neurosciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8919-3934","authenticated-orcid":true,"given":"Andrea","family":"Stocco","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, Washington, United States of America"],"department":["Department of Psychology"]},{"name":"University of Washington","place":["Seattle, Washington, United States of America"],"department":["Graduate Program in Neuroscience"]},{"name":"Precision Cognition Labs","place":["Groningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"9984","key":"pdig.0001686.ref001","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial","volume":"385","author":"T Ngandu","year":"2015","journal-title":"Lancet"},{"issue":"7","key":"pdig.0001686.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219569","article-title":"Validity of screening instruments for the detection of dementia and mild cognitive impairment in hospital inpatients: a systematic review of diagnostic accuracy studies","volume":"14","author":"AB Hwang","year":"2019","journal-title":"PLoS One"},{"issue":"6","key":"pdig.0001686.ref003","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1080\/13854046.2015.1087596","article-title":"Longitudinal change in performance on the Montreal Cognitive Assessment in older adults","volume":"29","author":"SA Cooley","year":"2015","journal-title":"Clin Neuropsychol"},{"issue":"1","key":"pdig.0001686.ref004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14283\/jpad.2023.131","article-title":"Detection rates of mild cognitive impairment in primary care for the United States Medicare population","volume":"11","author":"Y Liu","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"issue":"12","key":"pdig.0001686.ref005","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1007\/s11606-021-07169-7","article-title":"Observational study of patient characteristics associated with a timely diagnosis of dementia and mild cognitive impairment without dementia","volume":"37","author":"L White","year":"2022","journal-title":"J Gen Intern Med"},{"issue":"4","key":"pdig.0001686.ref006","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/ageing\/afv020","article-title":"Who has undiagnosed dementia? 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