{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:51:44Z","timestamp":1792788704053,"version":"4.5.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Data Sciences Institute, University of Toronto","award":["DSI-PDFY3R1P13"],"award-info":[{"award-number":["DSI-PDFY3R1P13"]}],"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["432856"],"award-info":[{"award-number":["432856"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosdigitalhealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Digit Health"],"abstract":"\n Drug-induced parkinsonism is a potentially reversible movement disorder that may be subtle and difficult to monitor in residential dementia care. Vision-based machine learning analysis of gait may provide unobtrusive longitudinal monitoring around medication changes. We conducted a two-center cohort study of 61 residents with dementia receiving psychotropic medication. Hallway gait sequences were recorded using ceiling-mounted cameras and converted to three-dimensional body pose. A TabPFN classifier estimated UPDRS-III item 29 gait severity for each walk. We evaluated associations between acute antipsychotic (AP) and antidepressant (AD) dose reduction\/cessation (\n \n \n \n \n \n \u2265<\/mml:mo>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n 50% dose reduction or cessation, 0\u201321 days after change) and daily mean predicted gait severity using linear mixed-effects models in ever-exposed participants, with complementary equal-weight paired analyses among participants observed in both medication states. In mixed-effects models, acute AP dose reduction\/cessation was associated with lower predicted gait severity (\n \n \n \n \n \n \u03b2<\/mml:mi>\n =<\/mml:mo>\n \u2212<\/mml:mo>\n 0.127<\/mml:mn>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n ,\n p<\/jats:italic>\n \u2009=\u20090.022), whereas AD dose reduction\/cessation was not (\n \n \n \n \n \n \u03b2<\/mml:mi>\n =<\/mml:mo>\n \u2212<\/mml:mo>\n 0.060<\/mml:mn>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n ,\n p<\/jats:italic>\n \u2009=\u20090.210). Equal-weight paired analyses found no statistically significant participant-average within-person change among paired participants (AP mean change\u2009=\u20090.031, 95% CI [\n \n \n \n \n \n \u2212<\/mml:mo>\n 0.114<\/mml:mn>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n , 0.176],\n p<\/jats:italic>\n \u2009=\u20090.653; AD mean change\n \n \n \n \n \n =<\/mml:mo>\n \u2212<\/mml:mo>\n 0.021<\/mml:mn>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n , 95% CI [\n \n \n \n \n \n \u2212<\/mml:mo>\n 0.098<\/mml:mn>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n , 0.056],\n p<\/jats:italic>\n \u2009=\u20090.575), consistent with heterogeneous individual responses. Vision-based monitoring captured within-participant gait variation around psychotropic dose-reduction periods, but findings are associative. Larger prospective studies with documented reasons for medication changes are needed before using such monitoring to guide medication decisions.\n <\/jats:p>","DOI":"10.1371\/journal.pdig.0001780","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:45:41Z","timestamp":1792086341000},"page":"e0001780","update-policy":"https:\/\/doi.org\/10.1371\/journal.pdig.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of change in drug-induced parkinsonism in daily-life gait using vision-based machine learning"],"prefix":"10.1371","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-6883","authenticated-orcid":true,"given":"Benjamin","family":"Filtjens","sequence":"first","affiliation":[{"name":"Delft University of Technology","place":["Delft, the Netherlands"],"department":["Department of Engineering Systems and Services"]},{"name":"Institute for Health Systems Science, Delft University of Technology","place":["Delft, the Netherlands"]},{"name":"KITE Research Institute, University Health Network","place":["Toronto, Ontario, Canada"]},{"name":"Vector Institute","place":["Toronto, Ontario, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Adeli","sequence":"additional","affiliation":[{"name":"KITE Research Institute, University Health Network","place":["Toronto, Ontario, Canada"]},{"name":"Vector Institute","place":["Toronto, Ontario, Canada"]},{"name":"University of Toronto","place":["Toronto, Ontario, Canada"],"department":["Department of Computer Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Mehraban","sequence":"additional","affiliation":[{"name":"KITE Research Institute, University Health Network","place":["Toronto, Ontario, Canada"]},{"name":"Vector Institute","place":["Toronto, Ontario, Canada"]},{"name":"University of Toronto","place":["Toronto, Ontario, Canada"],"department":["Institute of Biomedical Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sabo","sequence":"additional","affiliation":[{"name":"KITE Research Institute, University Health Network","place":["Toronto, Ontario, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Taati","sequence":"additional","affiliation":[{"name":"KITE Research Institute, University Health Network","place":["Toronto, Ontario, Canada"]},{"name":"Vector Institute","place":["Toronto, Ontario, Canada"]},{"name":"University of Toronto","place":["Toronto, Ontario, Canada"],"department":["Department of Computer Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-6832","authenticated-orcid":true,"given":"Andrea","family":"Iaboni","sequence":"additional","affiliation":[{"name":"KITE Research Institute, University Health Network","place":["Toronto, Ontario, Canada"]},{"name":"University of Toronto","place":["Toronto, Ontario, Canada"],"department":["Department of Psychiatry"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"1","key":"pdig.0001780.ref001","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3988\/jcn.2012.8.1.15","article-title":"Drug-induced parkinsonism","volume":"8","author":"HW Shin","year":"2012","journal-title":"J Clin Neurol"},{"issue":"3","key":"pdig.0001780.ref002","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/mds.21854","article-title":"Failure of recognition of drug-induced parkinsonism in the elderly: recognition of dip in the elderly","volume":"23","author":"CD Esper","year":"2008","journal-title":"Mov Disord"},{"issue":"1","key":"pdig.0001780.ref003","doi-asserted-by":"crossref","DOI":"10.1136\/bmjno-2019-000034","article-title":"Parkinsonism in the psychiatric setting: an update on clinical 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