{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:57:54Z","timestamp":1791338274637,"version":"4.3.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.0030237","type":"journal-article","created":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T22:16:48Z","timestamp":1197929808000},"page":"e237","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":205,"title":["Human Subtelomeric WASH Genes Encode a New Subclass of the WASP Family"],"prefix":"10.1371","volume":"3","author":[{"given":"Elena V","family":"Linardopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean S","family":"Parghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E","family":"Osborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Parkhurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J","family":"Trask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,12,21]]},"reference":[{"key":"pgen-0030237-b001","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00412-005-0005-9","article-title":"The mechanism of telomere protection: a comparison between Drosophila and humans.","volume":"114","year":"2005","journal-title":"Chromosoma"},{"key":"pgen-0030237-b002","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/embo-reports\/kvf215","article-title":"Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity.","volume":"3","year":"2002","journal-title":"EMBO Rep"},{"key":"pgen-0030237-b003","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1128\/MCB.26.5.1865-1878.2006","article-title":"Telomere position effect and silencing of transgenes near telomeres in the mouse.","volume":"26","year":"2006","journal-title":"Mol Cell Biol"},{"key":"pgen-0030237-b004","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature04029","article-title":"Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication.","volume":"437","year":"2005","journal-title":"Nature"},{"key":"pgen-0030237-b005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1086\/377137","article-title":"A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set.","volume":"73","year":"2003","journal-title":"Am J Hum Genet"},{"key":"pgen-0030237-b006","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence.","volume":"426","year":"2003","journal-title":"Nature"},{"key":"pgen-0030237-b007","article-title":"Elevated rates of sister chromatid exchange at chromosome ends.","volume":"3","year":"2007","journal-title":"PLoS Genet"},{"key":"pgen-0030237-b008","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0020-7519(02)00247-3","article-title":"Why are parasite contingency genes often associated with telomeres?","volume":"33","year":"2003","journal-title":"Int J Parasitol"},{"key":"pgen-0030237-b009","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/molbev\/msi070","article-title":"Comparative genomics in hemiascomycete yeasts: evolution of sex, silencing, and subtelomeres.","volume":"22","year":"2005","journal-title":"Mol Biol Evol"},{"key":"pgen-0030237-b010","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/jmg.2005.036350","article-title":"Subtelomere FISH analysis of 11 688 cases: an evaluation of the frequency and pattern of subtelomere rearrangements in individuals with developmental disabilities.","volume":"43","year":"2006","journal-title":"J Med Genet"},{"key":"pgen-0030237-b011","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/hmg\/9.3.395","article-title":"Differentially regulated and evolved genes in the fully sequenced Xq\/Yq pseudoautosomal region.","volume":"9","year":"2000","journal-title":"Hum Mol Genet"},{"key":"pgen-0030237-b012","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000048796","article-title":"Characterization of the murine orthologue of a novel human subtelomeric multigene family.","volume":"94","year":"2001","journal-title":"Cytogenet Cell Genet"},{"key":"pgen-0030237-b013","article-title":"New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.","volume":"1","year":"2005","journal-title":"PLoS Genet"},{"key":"pgen-0030237-b014","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/35050590","article-title":"Interaction of WASP\/Scar proteins with actin and vertebrate Arp2\/3 complex.","volume":"3","year":"2001","journal-title":"Nat Cell Biol"},{"key":"pgen-0030237-b015","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1083\/jcb.200403127","article-title":"Regulation of WASP\/WAVE proteins: making a long story short.","volume":"166","year":"2004","journal-title":"J Cell Biol"},{"key":"pgen-0030237-b016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20040176","article-title":"Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2\/3 complex.","volume":"380","year":"2004","journal-title":"Biochem J"},{"key":"pgen-0030237-b017","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbamcr.2006.07.001","article-title":"Regulation of the actin cytoskeleton in cancer cell migration and invasion.","volume":"1773","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"pgen-0030237-b018","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrm2069","article-title":"The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.","volume":"8","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"pgen-0030237-b019","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes.","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pgen-0030237-b020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0014-5793(01)03242-2","article-title":"WH2 domain: a small, versatile adapter for actin monomers.","volume":"513","year":"2002","journal-title":"FEBS Lett"},{"key":"pgen-0030237-b021","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nsb952","article-title":"A conserved amphipathic helix in WASP\/Scar proteins is essential for activation of Arp2\/3 complex.","volume":"10","year":"2003","journal-title":"Nat Struct Biol"},{"key":"pgen-0030237-b022","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S1534-5807(03)00166-7","article-title":"Regulation by phosphorylation. Yet another twist in the WASP story.","volume":"4","year":"2003","journal-title":"Dev Cell"},{"key":"pgen-0030237-b023","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","article-title":"Cellular motility driven by assembly and disassembly of actin filaments.","volume":"112","year":"2003","journal-title":"Cell"},{"key":"pgen-0030237-b024","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0960-9822(01)00603-0","article-title":"Different WASP family proteins stimulate different Arp2\/3 complex-dependent actin-nucleating activities.","volume":"11","year":"2001","journal-title":"Curr Biol"},{"key":"pgen-0030237-b025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.152.1.1","article-title":"Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling.","volume":"152","year":"2001","journal-title":"J Cell Biol"},{"key":"pgen-0030237-b026","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1083\/jcb.200109057","article-title":"SCAR is a primary regulator of Arp2\/3-dependent morphological events in Drosophila.","volume":"156","year":"2002","journal-title":"J Cell Biol"},{"key":"pgen-0030237-b027","first-page":"RESEARCH0088","article-title":"Systematic determination of patterns of gene expression during Drosophila embryogenesis.","volume":"3","year":"2002","journal-title":"Genome Biol"},{"key":"pgen-0030237-b028","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/genetics\/153.1.135","article-title":"The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes.","volume":"153","year":"1999","journal-title":"Genetics"},{"key":"pgen-0030237-b029","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ceb.2004.02.004","article-title":"The WASP-Arp2\/3 pathway: genetic insights.","volume":"16","year":"2004","journal-title":"Curr Opin Cell Biol"},{"key":"pgen-0030237-b030","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1083\/jcb.136.3.649","article-title":"Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton.","volume":"136","year":"1997","journal-title":"J Cell Biol"},{"key":"pgen-0030237-b031","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.devcel.2007.02.019","article-title":"A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion.","volume":"12","year":"2007","journal-title":"Dev Cell"},{"key":"pgen-0030237-b032","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.devcel.2007.01.016","article-title":"WIP\/WASp-based actin-polymerization machinery is essential for myoblast fusion in Drosophila.","volume":"12","year":"2007","journal-title":"Dev Cell"},{"key":"pgen-0030237-b033","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ydbio.2007.01.015","article-title":"The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila.","volume":"304","year":"2007","journal-title":"Dev Biol"},{"key":"pgen-0030237-b034","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature01167","article-title":"TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila.","volume":"420","year":"2002","journal-title":"Nature"},{"key":"pgen-0030237-b035","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0955-0674(03)00050-4","article-title":"The nucleoskeleton: lamins and actin are major players in essential nuclear functions.","volume":"15","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"pgen-0030237-b036","doi-asserted-by":"crossref","first-page":"42515","DOI":"10.1074\/jbc.M302177200","article-title":"Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90.","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"pgen-0030237-b037","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/ncb1433","article-title":"Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.","volume":"8","year":"2006","journal-title":"Nat Cell Biol"},{"key":"pgen-0030237-b038","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ncb1001-897","article-title":"N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.","volume":"3","year":"2001","journal-title":"Nat Cell Biol"},{"key":"pgen-0030237-b039","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1093\/emboj\/cdg350","article-title":"WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.","volume":"22","year":"2003","journal-title":"EMBO J"},{"key":"pgen-0030237-b040","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1073\/pnas.0438033100","article-title":"Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.","volume":"100","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pgen-0030237-b041","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1182\/blood.V90.7.2680","article-title":"Wiskott-Aldrich syndrome\/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype.","volume":"90","year":"1997","journal-title":"Blood"},{"key":"pgen-0030237-b042","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2006.02.005","article-title":"The Wiskott-Aldrich syndrome.","volume":"117","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"pgen-0030237-b043","first-page":"217","article-title":"Identification of genes differentially expressed in breast cancer cell line SKBR3: potential identification of new prognostic biomarkers.","volume":"14","year":"2004","journal-title":"Int J Mol Med"},{"key":"pgen-0030237-b044","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1534\/genetics.105.048058","article-title":"Stability of large segmental duplications in the yeast genome.","volume":"172","year":"2006","journal-title":"Genetics"},{"key":"pgen-0030237-b045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1462-5822.1999.00021.x","article-title":"New insights into the role of the cytoskeleton in phagocytosis of Entamoeba histolytica.","volume":"1","year":"1999","journal-title":"Cell Microbiol"},{"key":"pgen-0030237-b046","first-page":"re5","article-title":"Signaling during pathogen infection.","volume":"2006","year":"2006","journal-title":"Sci STKE"},{"key":"pgen-0030237-b047","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/cm.20105","article-title":"Rho signaling in Entamoeba histolytica modulates actomyosin-dependent activities stimulated during invasive behavior.","volume":"63","year":"2006","journal-title":"Cell Motil Cytoskeleton"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.0030237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T19:38:45Z","timestamp":1630352325000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.0030237"}},"subtitle":[],"editor":[{"given":"Greg","family":"Barsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,12,21]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2007,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.0030237","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,21]]}}}