{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:15:56Z","timestamp":1791062156845,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T00:00:00Z","timestamp":1234483200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1000380","type":"journal-article","created":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T00:17:42Z","timestamp":1234484262000},"page":"e1000380","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["ERCC1\/XPF Protects Short Telomeres from Homologous Recombination in Arabidopsis thaliana"],"prefix":"10.1371","volume":"5","author":[{"given":"Jean-Baptiste","family":"Vannier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Depeiges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Gallego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/35040500","article-title":"Telomere states and cell fates.","volume":"408","author":"EH Blackburn","year":"2000","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.febslet.2004.11.036","article-title":"Telomeres and telomerase: their mechanisms of action and the effects of altering their functions.","volume":"579","author":"EH Blackburn","year":"2005","journal-title":"FEBS Lett"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/sj.emboj.7600598","article-title":"Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.","volume":"24","author":"MA Blasco","year":"2005","journal-title":"Embo J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0092-8674(04)00038-8","article-title":"Beginning to understand the end of the chromosome.","volume":"116","author":"TR Cech","year":"2004","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1101\/gad.1214504","article-title":"Functional links between telomeres and proteins of the DNA-damage response.","volume":"18","author":"F d'Adda di Fagagna","year":"2004","journal-title":"Genes Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1097-2765(03)00531-8","article-title":"Indecent exposure: when telomeres become uncapped.","volume":"13","author":"MG Ferreira","year":"2004","journal-title":"Mol Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.gde.2003.12.007","article-title":"Those dam-aged telomeres!","volume":"14","author":"L Harrington","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0022-2836(92)90096-3","article-title":"Telomere end-replication problem and cell aging.","volume":"225","author":"MZ Levy","year":"1992","journal-title":"J Mol Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1101\/gad.1346005","article-title":"Shelterin: the protein complex that shapes and safeguards human telomeres.","volume":"19","author":"T de Lange","year":"2005","journal-title":"Genes Dev"},{"key":"ref10","article-title":"How Shelterin Protects Mammalian Telomeres.","author":"W Palm","year":"2008","journal-title":"Annu Rev Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.molcel.2008.06.013","article-title":"How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.","volume":"31","author":"A Bianchi","year":"2008","journal-title":"Mol Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrm1961","article-title":"The biogenesis and regulation of telomerase holoenzymes.","volume":"7","author":"K Collins","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10577-005-0995-4","article-title":"DNA repair and recombination functions in Arabidopsis telomere maintenance.","volume":"13","author":"ME Gallego","year":"2005","journal-title":"Chromosome Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.genet.39.110304.095755","article-title":"The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology.","volume":"40","author":"K Riha","year":"2006","journal-title":"Annu Rev Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S1097-2765(03)00478-7","article-title":"ERCC1\/XPF removes the 3\u2032 overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.","volume":"12","author":"XD Zhu","year":"2003","journal-title":"Mol Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"24638","DOI":"10.1074\/jbc.270.42.24638","article-title":"Role of the Rad1 and Rad10 proteins in nucleotide excision repair and recombination.","volume":"270","author":"AA Davies","year":"1995","journal-title":"Journal of Biological Chemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/embo-reports\/kvf211","article-title":"Role of the AtRad1p endonuclease in homologous recombination in plants.","volume":"3","author":"S Dubest","year":"2002","journal-title":"EMBO Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-313X.2004.02136.x","article-title":"Roles of the AtErcc1 protein in recombination.","volume":"39","author":"S Dubest","year":"2004","journal-title":"Plant J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1104\/pp.124.2.579","article-title":"The Arabidopsis UVH1 gene is a homolog of the yeast repair endonuclease RAD1.","volume":"124","author":"AL Fidantsef","year":"2000","journal-title":"Plant Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.1365-313x.2000.00694.x","article-title":"AtRAD1, a plant homologue of human and yeast nucleotide excision repair endonucleases, is involved in dark repair of UV damages and recombination.","volume":"21","author":"F Gallego","year":"2000","journal-title":"Plant J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/jxb\/erg069","article-title":"Arabidopsis mutants sensitive to gamma radiation include the homologue of the human repair gene ERCC1.","volume":"54","author":"E Hefner","year":"2003","journal-title":"J Exp Bot"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-313X.2001.01031.x","article-title":"Arabidopsis UVH3 gene is a homolog of the Saccharomyces cerevisiae RAD2 and human XPG DNA repair genes.","volume":"26","author":"Z Liu","year":"2001","journal-title":"Plant J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1128\/MCB.14.3.2029","article-title":"The rad16 gene of Schizosaccharomyces pombe: a homolog of the RAD1 gene of Saccharomyces cerevisiae.","volume":"14","author":"AM Carr","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/nar\/25.14.2823","article-title":"Complementation of the DNA repair-deficient swi10 mutant of fission yeast by the human ERCC1 gene.","volume":"25","author":"C Rodel","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/genetics\/90.3.531","article-title":"The Utilization during Mitotic Cell Division of Loci Controlling Meiotic Recombination and Disjunction in DROSOPHILA MELANOGASTER.","volume":"90","author":"BS Baker","year":"1978","journal-title":"Genetics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/genetics\/141.2.619","article-title":"The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1.","volume":"141","author":"JJ Sekelsky","year":"1995","journal-title":"Genetics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1126\/science.8091230","article-title":"Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease.","volume":"265","author":"AJ Bardwell","year":"1994","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.biochem.77.070306.102408","article-title":"Structural and functional relationships of the XPF\/MUS81 family of proteins.","volume":"77","author":"A Ciccia","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1074\/jbc.273.14.7835","article-title":"DNA structural elements required for ERCC1-XPF endonuclease activity.","volume":"273","author":"WL de Laat","year":"1998","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/362860a0","article-title":"Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonuclease.","volume":"362","author":"AE Tomkinson","year":"1993","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0092-8674(88)90494-1","article-title":"Isolation of a higher eukaryotic telomere from Arabidopsis thaliana.","volume":"53","author":"EJ Richards","year":"1988","journal-title":"Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1365-313x.2000.00831.x","article-title":"Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures.","volume":"23","author":"K Riha","year":"2000","journal-title":"Plant J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-313X.2003.01882.x","article-title":"Telomere looping in P. sativum (common garden pea).","volume":"36","author":"AJ Cesare","year":"2003","journal-title":"Plant J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbaexp.2007.02.001","article-title":"Composition of plant telomeres.","volume":"1769","author":"B Zellinger","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1126\/science.1057110","article-title":"Living with genome instability: plant responses to telomere dysfunction.","volume":"291","author":"K Riha","year":"2001","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1038\/sj.emboj.7601345","article-title":"Two roles for Rad50 in telomere maintenance.","volume":"25","author":"JB Vannier","year":"2006","journal-title":"Embo J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European Molecular Biology Open Software Suite.","volume":"16","author":"P Rice","year":"2000","journal-title":"Trends Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ng1193-217","article-title":"Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning.","volume":"5","author":"J McWhir","year":"1993","journal-title":"Nat Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/377165a0","article-title":"High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene.","volume":"377","author":"H Nakane","year":"1995","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1093\/nar\/29.22.4541","article-title":"Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene.","volume":"29","author":"J Selfridge","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1128\/MCB.24.3.1200-1205.2004","article-title":"Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF.","volume":"24","author":"M Tian","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-9822(06)00190-4","article-title":"Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.","volume":"7","author":"G Weeda","year":"1997","journal-title":"Curr Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.molcel.2008.05.028","article-title":"Chromosome fusions following telomere loss are mediated by single-strand annealing.","volume":"31","author":"X Wang","year":"2008","journal-title":"Mol Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"14813","DOI":"10.1073\/pnas.96.26.14813","article-title":"Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA.","volume":"96","author":"MS Fitzgerald","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1105\/tpc.6.2.227","article-title":"Isolation of Uvh1, an Arabidopsis Mutant Hypersensitive to Ultraviolet Light and Ionizing Radiation.","volume":"6(2)","author":"GR Harlow","year":"1994","journal-title":"Plant Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1073\/pnas.98.4.1711","article-title":"RAD50 function is essential for telomere maintenance in Arabidopsis.","volume":"98","author":"ME Gallego","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s11103-006-9061-7","article-title":"Telomere-length regulation in inter-ecotype crosses of Arabidopsis.","volume":"62","author":"G Maillet","year":"2006","journal-title":"Plant Mol Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s004120050413","article-title":"A homologue of the yeast HOP1 gene is inactivated in the Arabidopsis meiotic mutant asy1.","volume":"109","author":"AP Caryl","year":"2000","journal-title":"Chromosoma"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00412-004-0316-2","article-title":"Chromosome territory arrangement and homologous pairing in nuclei of Arabidopsis thaliana are predominantly random except for NOR-bearing chromosomes.","volume":"113","author":"A Pecinka","year":"2004","journal-title":"Chromosoma"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1023\/A:1013137415093","article-title":"Chromosome painting in plants.","volume":"23","author":"I Schubert","year":"2001","journal-title":"Methods Cell Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1139\/G06-082","article-title":"Identification of chromosomal fusion sites in Arabidopsis mutants using sequential bicolour BAC-FISH.","volume":"49","author":"P Mokros","year":"2006","journal-title":"Genome"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1000380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T18:08:46Z","timestamp":1633111726000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1000380"}},"subtitle":[],"editor":[{"given":"Mathilde","family":"Grelon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,2,13]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1000380","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,13]]}}}