{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:24:01Z","timestamp":1778628241915,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T00:00:00Z","timestamp":1237507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1000432","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T22:14:09Z","timestamp":1237500849000},"page":"e1000432","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["Capturing the Spectrum of Interaction Effects in Genetic Association Studies by Simulated Evaporative Cooling Network Analysis"],"prefix":"10.1371","volume":"5","author":[{"given":"Brett A.","family":"McKinney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00125817-200203000-00002","article-title":"A comprehensive review of genetic association studies.","volume":"4","author":"JN Hirschhorn","year":"2002","journal-title":"Genet Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1086\/324069","article-title":"Genomewide scans of complex human diseases: true linkage is hard to find.","volume":"69","author":"J Altmuller","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1093\/hmg\/11.20.2463","article-title":"Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans.","volume":"11","author":"HJ Cordell","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1086\/338759","article-title":"A perspective on epistasis: limits of models displaying no main effect.","volume":"70","author":"R Culverhouse","year":"2002","journal-title":"Am J Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2165\/00822942-200605020-00002","article-title":"Machine learning for detecting gene-gene interactions: a review.","volume":"5","author":"BA McKinney","year":"2006","journal-title":"Appl Bioinformatics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nrg1407","article-title":"Epistasis: too often neglected in complex trait studies?","volume":"5","author":"O Carlborg","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2156-7-23","article-title":"The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases.","volume":"7","author":"AG Heidema","year":"2006","journal-title":"BMC Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrg1155","article-title":"Mathematical multi-locus approaches to localizing complex human trait genes.","volume":"4","author":"J Hoh","year":"2003","journal-title":"Nat Rev Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000099179","article-title":"Detection of gene x gene interactions in genome-wide association studies of human population data.","volume":"63","author":"SK Musani","year":"2007","journal-title":"Hum Hered"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/genetics\/139.3.1455","article-title":"Epistasis and its contribution to genetic variance components.","volume":"139","author":"JM Cheverud","year":"1995","journal-title":"Genetics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/geno.2001.6569","article-title":"Genetic analysis of a new mouse model for non-insulin-dependent diabetes.","volume":"74","author":"JH Kim","year":"2001","journal-title":"Genomics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.genet.35.102401.090633","article-title":"The genetic architecture of quantitative traits.","volume":"35","author":"TF Mackay","year":"2001","journal-title":"Annu Rev Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng1489","article-title":"Modular epistasis in yeast metabolism.","volume":"37","author":"D Segre","year":"2005","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1101\/gr.171601","article-title":"Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice.","volume":"11","author":"K Shimomura","year":"2001","journal-title":"Genome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/bies.10401","article-title":"The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?","volume":"26","author":"SM Williams","year":"2004","journal-title":"Bioessays"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2007.05.022","article-title":"GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.","volume":"54","author":"EM Reiman","year":"2007","journal-title":"Neuron"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.1146554","article-title":"Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.","volume":"317","author":"G Thorleifsson","year":"2007","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature06007","article-title":"Variants conferring risk of atrial fibrillation on chromosome 4q25.","volume":"448","author":"DF Gudbjartsson","year":"2007","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ng998","article-title":"Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease.","volume":"32","author":"MM Carrasquillo","year":"2002","journal-title":"Nat Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random Forests.","volume":"45","author":"L Breiman","year":"2001","journal-title":"Machine Learning"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/gepi.20041","article-title":"Identifying SNPs predictive of phenotype using random forests.","volume":"28","author":"A Bureau","year":"2005","journal-title":"Genet Epidemiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2156-5-32","article-title":"Screening large-scale association study data: exploiting interactions using random forests.","volume":"5","author":"KL Lunetta","year":"2004","journal-title":"BMC Genet"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1109\/CVPRW.2003.10065","article-title":"Iterative Relief","author":"B Draper","year":"2003"},{"key":"ref24","first-page":"166","article-title":"Tuning ReliefF for Genome-Wide Genetic Analysis. Lecture Notes in Computer Science: Evolutionary Computation, Machine Learning, and Data Mining in Bioinformatics","author":"JH Moore","year":"2007"},{"key":"ref25","first-page":"359","article-title":"Improving Random Forests.","author":"M Robnik-Sikonja"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/bioinformatics\/btm317","article-title":"Evaporative cooling feature selection for genotypic data involving interactions.","volume":"23","author":"BA McKinney","year":"2007","journal-title":"Bioinformatics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1086\/588670","article-title":"Genetic basis for adverse events following smallpox vaccination.","volume":"198","author":"DM Reif","year":"2008","journal-title":"Journal of Infectious Diseases"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF02289159","article-title":"Multivariate information transmission.","volume":"19","author":"WJ McGill","year":"1954","journal-title":"Psychometrika"},{"key":"ref29","first-page":"229","article-title":"Analyzing attribute interactions.","volume":"2838","author":"A Jakulin","year":"2003","journal-title":"Lecture Notes in Artificial Intelligence"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jtbi.2005.11.036","article-title":"A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility.","volume":"241","author":"JH Moore","year":"2006","journal-title":"J Theor Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/biostatistics\/kxm010","article-title":"Penalized logistic regression for detecting gene interactions.","volume":"9","author":"MY Park","year":"2008","journal-title":"Biostatistics"},{"key":"ref32","first-page":"499","article-title":"Data simulation software for whole-genome association and other studies in human genetics.","author":"SM Dudek","year":"2006","journal-title":"Pac Symp Biocomput"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa073493","article-title":"Risk alleles for multiple sclerosis identified by a genomewide study.","volume":"357","author":"DA Hafler","year":"2007","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ng2075","article-title":"A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.","volume":"39","author":"DJ Hunter","year":"2007","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.tig.2004.09.007","article-title":"Genetics, statistics and human disease: analytical retooling for complexity.","volume":"20","author":"TA Thornton-Wells","year":"2004","journal-title":"Trends Genet"},{"key":"ref36","article-title":"PARF parallel RF algorithm","author":"G Topic","year":"2004"},{"key":"ref37","first-page":"171","article-title":"Analysis and extensions of Relief; European Conference on Machine Learning","author":"I Kononenko","year":"1994"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1103\/PhysRevB.34.3476","article-title":"Evaporative cooling of a magnetically trapped and compressed spin-polarized hydrogen gas.","volume":"34","author":"H Hess","year":"1986","journal-title":"Physical Review B"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1515\/9781400874668","article-title":"Adaptive Control Processes","author":"R Bellman","year":"1961"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks.","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1000432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T12:31:24Z","timestamp":1633264284000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1000432"}},"subtitle":[],"editor":[{"given":"Emmanouil T.","family":"Dermitzakis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,3,20]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1000432","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,20]]}}}