{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:12:23Z","timestamp":1789204343178,"version":"build-2803163510"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T00:00:00Z","timestamp":1267747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1000871","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T17:29:34Z","timestamp":1267723774000},"page":"e1000871","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Mislocalization of XPF-ERCC1 Nuclease Contributes to Reduced DNA Repair in XP-F Patients"],"prefix":"10.1371","volume":"6","author":[{"given":"Anwaar","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline H.","family":"Enzlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil R.","family":"Bhagwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Wijgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Raams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Appledoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan F.","family":"Theil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"J. Hoeijmakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas G.","family":"J. Jaspers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando D.","family":"Sch\u00e4rer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Niedernhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archderm.1987.01660260111026","article-title":"Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases.","volume":"123","author":"KH Kraemer","year":"1987","journal-title":"Arch Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.dnarep.2008.03.015","article-title":"Nucleotide excision repair and neurological diseases.","volume":"7","author":"T Nouspikel","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/brain\/114.3.1335","article-title":"Neurological disease in xeroderma pigmentosum. Documentation of a late onset type of the juvenile onset form.","volume":"114 ( Pt 3)","author":"JH Robbins","year":"1991","journal-title":"Brain"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cr040483f","article-title":"Molecular mechanisms of mammalian global genome nucleotide excision repair.","volume":"106","author":"LC Gillet","year":"2006","journal-title":"Chem Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1097-2765(00)80132-X","article-title":"Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.","volume":"2","author":"K Sugasawa","year":"1998","journal-title":"Mol Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1097-2765(01)00281-7","article-title":"Sequential assembly of the nucleotide excision repair factors in vivo.","volume":"8","author":"M Volker","year":"2001","journal-title":"Mol Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10735-006-9044-7","article-title":"UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair.","volume":"37","author":"K Sugasawa","year":"2006","journal-title":"J Mol Histol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tig.2006.06.006","article-title":"When transcription and repair meet: a complex system.","volume":"22","author":"JP Laine","year":"2006","journal-title":"Trends Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nrm2549","article-title":"Transcription-coupled DNA repair: two decades of progress and surprises.","volume":"9","author":"PC Hanawalt","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0092-8674(92)90390-X","article-title":"ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.","volume":"71","author":"C Troelstra","year":"1992","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(95)90028-4","article-title":"The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.","volume":"82","author":"KA Henning","year":"1995","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"34931","DOI":"10.1074\/jbc.M004936200","article-title":"XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription.","volume":"275","author":"Y Nakatsu","year":"2000","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1093\/emboj\/16.21.6559","article-title":"Mechanism of open complex and dual incision formation by human nucleotide excision repair factors.","volume":"16","author":"E Evans","year":"1997","journal-title":"Embo J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/371432a0","article-title":"XPG endonuclease makes the 3\u2032 incision in human DNA nucleotide excision repair.","volume":"371","author":"A O'Donovan","year":"1994","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1126\/science.8091230","article-title":"Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease.","volume":"265","author":"AJ Bardwell","year":"1994","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(00)80155-5","article-title":"Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease.","volume":"86","author":"AM Sijbers","year":"1996","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/emboj.2009.49","article-title":"Coordination of dual incision and repair synthesis in human nucleotide excision repair.","volume":"28","author":"L Staresincic","year":"2009","journal-title":"EMBO J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1021\/bi00015a012","article-title":"Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA.","volume":"34","author":"MK Shivji","year":"1995","journal-title":"Biochemistry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.molcel.2007.06.014","article-title":"Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner.","volume":"27","author":"J Moser","year":"2007","journal-title":"Mol Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/ncb1417","article-title":"The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair.","volume":"8","author":"T Ogi","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1074\/jbc.273.14.7835","article-title":"DNA structural elements required for ERCC1-XPF endonuclease activity.","volume":"273","author":"WL de Laat","year":"1998","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1128\/MCB.24.13.5776-5787.2004","article-title":"The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.","volume":"24","author":"LJ Niedernhofer","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1128\/MCB.00293-08","article-title":"ERCC1-XPF endonuclease facilitates DNA double-strand break repair.","volume":"28","author":"A Ahmad","year":"2008","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/nar\/29.4.872","article-title":"Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair.","volume":"29","author":"PH Gaillard","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1093\/nar\/26.18.4146","article-title":"Mapping of interaction domains between human repair proteins ERCC1 and XPF.","volume":"26","author":"WL de Laat","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1002\/j.1460-2075.1993.tb06043.x","article-title":"Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro.","volume":"12","author":"M Biggerstaff","year":"1993","journal-title":"EMBO J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/emboj\/21.8.2045","article-title":"The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif.","volume":"21","author":"JH Enzlin","year":"2002","journal-title":"Embo J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1038\/sj.emboj.7601894","article-title":"Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.","volume":"26","author":"OV Tsodikov","year":"2007","journal-title":"EMBO J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1073\/pnas.91.11.5012","article-title":"Specific association between the human DNA repair proteins XPA and ERCC1.","volume":"91","author":"L Li","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","first-page":"1077","article-title":"Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C.","volume":"4","author":"L Zeng","year":"1997"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1034\/j.1600-0781.2001.017002047.x","article-title":"Xeroderma pigmentosum\u2013bridging a gap between clinic and laboratory.","volume":"17","author":"S Moriwaki","year":"2001","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/nature05456","article-title":"A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.","volume":"444","author":"LJ Niedernhofer","year":"2006","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1046\/j.1523-1747.1998.00171.x","article-title":"Homozygous R788W point mutation in the XPF gene of a patient with xeroderma pigmentosum and late-onset neurologic disease.","volume":"110","author":"AM Sijbers","year":"1998","journal-title":"J Invest Dermatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/81603","article-title":"Sublimiting concentration of TFIIH transcription\/DNA repair factor causes TTD-A trichothiodystrophy disorder.","volume":"26","author":"W Vermeulen","year":"2000","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0921-8777(90)90007-R","article-title":"Use of in vivo and in vitro assays for the characterization of mammalian excision repair and isolation of repair proteins.","volume":"236","author":"JH Hoeijmakers","year":"1990","journal-title":"Mutat Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"8658","DOI":"10.1073\/pnas.94.16.8658","article-title":"Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair\/transcription gene.","volume":"94","author":"EM Taylor","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","first-page":"191","article-title":"Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3.","volume":"54","author":"W Vermeulen","year":"1994","journal-title":"Am J Hum Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1073\/pnas.94.7.3116","article-title":"A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function.","volume":"94","author":"T Nouspikel","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.molcel.2007.03.013","article-title":"XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G\/CS patients.","volume":"26","author":"S Ito","year":"2007","journal-title":"Mol Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.neuroscience.2006.12.020","article-title":"Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.","volume":"145","author":"KH Kraemer","year":"2007","journal-title":"Neuroscience"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.1070174","article-title":"Premature aging in mice deficient in DNA repair and transcription.","volume":"296","author":"J de Boer","year":"2002","journal-title":"Science"},{"key":"ref42","first-page":"263","article-title":"Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy.","volume":"58","author":"K Takayama","year":"1996","journal-title":"Am J Hum Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1093\/emboj\/16.19.5955","article-title":"The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.","volume":"16","author":"AJ van Gool","year":"1997","journal-title":"Embo J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.biochi.2003.10.014","article-title":"The XPG story.","volume":"85","author":"SG Clarkson","year":"2003","journal-title":"Biochimie"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/S1097-2765(03)00182-5","article-title":"Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients.","volume":"11","author":"S Dubaele","year":"2003","journal-title":"Mol Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/hmg\/7.6.969","article-title":"Characterization of molecular defects in xeroderma pigmentosum group F in relation to its clinically mild symptoms.","volume":"7","author":"Y Matsumura","year":"1998","journal-title":"Hum Mol Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0027-5107(80)90144-X","article-title":"Repair of damage by ultraviolet radiation in xeroderma pigmentosum cell strains of complementation groups E and F.","volume":"73","author":"B Zelle","year":"1980","journal-title":"Mutat Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1086\/512486","article-title":"First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.","volume":"80","author":"NG Jaspers","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1073\/pnas.89.15.7262","article-title":"Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.","volume":"89","author":"UM Moll","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrc1274","article-title":"Nuclear transport and cancer: from mechanism to intervention.","volume":"4","author":"TR Kau","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1158\/0008-5472.CAN-04-0174","article-title":"Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia.","volume":"64","author":"YH Min","year":"2004","journal-title":"Cancer Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/emboj\/cdg105","article-title":"Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription.","volume":"22","author":"R Rosin-Arbesfeld","year":"2003","journal-title":"Embo J"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc780","article-title":"NF-kappaB in cancer: from innocent bystander to major culprit.","volume":"2","author":"M Karin","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"21315","DOI":"10.1074\/jbc.M200769200","article-title":"BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export.","volume":"277","author":"M Fabbro","year":"2002","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0165-6147(00)01513-3","article-title":"Localization of G-protein-coupled receptors in health and disease.","volume":"21","author":"SW Edwards","year":"2000","journal-title":"Trends Pharmacol Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0092-8674(93)90353-R","article-title":"Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis.","volume":"73","author":"MJ Welsh","year":"1993","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-9822(06)00190-4","article-title":"Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.","volume":"7","author":"G Weeda","year":"1997","journal-title":"Curr Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrfmmm.2005.11.008","article-title":"Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.","volume":"596","author":"ME Dolle","year":"2006","journal-title":"Mutat Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1432-1033.1987.tb10598.x","article-title":"Influence of cumene hydroperoxide and 4-hydroxynonenal on the glutathione metabolism during in vitro ageing of human skin fibroblasts.","volume":"162","author":"M Poot","year":"1987","journal-title":"Eur J Biochem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0027-5107(79)90202-1","article-title":"A sixth complementation group in xeroderma pigmentosum.","volume":"59","author":"S Arase","year":"1979","journal-title":"Mutat Res"},{"key":"ref61","first-page":"431","article-title":"The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect.","volume":"60","author":"M Berneburg","year":"2000","journal-title":"Cancer Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1093\/nar\/gkp023","article-title":"A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU).","volume":"37","author":"S Limsirichaikul","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0921-8777(95)00009-9","article-title":"Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities.","volume":"337","author":"AJ van Vuuren","year":"1995","journal-title":"Mutat Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1073\/pnas.0511160103","article-title":"The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.","volume":"103","author":"MG Kapetanaki","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/j.1460-2075.1983.tb01477.x","article-title":"Microinjection of human cell extracts corrects xeroderma pigmentosum defect.","volume":"2","author":"AJ de Jonge","year":"1983","journal-title":"Embo J"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(90)90122-U","article-title":"A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.","volume":"62","author":"G Weeda","year":"1990","journal-title":"Cell"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1000871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T12:52:46Z","timestamp":1558875166000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1000871"}},"subtitle":[],"editor":[{"given":"Nancy","family":"Maizels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,3,5]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1000871","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,5]]}}}