{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:29:40Z","timestamp":1791462580213,"version":"4.3.4"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T00:00:00Z","timestamp":1288828800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1001190","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T19:48:06Z","timestamp":1288900086000},"page":"e1001190","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":252,"title":["Hormad1 Mutation Disrupts Synaptonemal Complex Formation, Recombination, and Chromosome Segregation in Mammalian Meiosis"],"prefix":"10.1371","volume":"6","author":[{"given":"Yong-Hyun","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil Uckac","family":"Erdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A.","family":"Yatsenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Kloc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Jeremy","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin L.","family":"Meistrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Rajkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev.cellbio.19.111301.155141","article-title":"The genetics and molecular biology of the synaptonemal complex.","volume":"20","author":"SL Page","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1101\/gad.12.22.3551","article-title":"Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein.","volume":"12","author":"JM Bailis","year":"1998","journal-title":"Genes Dev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0092-8674(00)80609-1","article-title":"A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis.","volume":"98","author":"F Klein","year":"1999","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1083\/jcb.125.6.1191","article-title":"Homologous pairing is reduced but not abolished in asynaptic mutants of yeast.","volume":"125","author":"J Loidl","year":"1994","journal-title":"J Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0968-0004(98)01257-2","article-title":"The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair.","volume":"23","author":"L Aravind","year":"1998","journal-title":"Trends Biochem Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35053094","article-title":"MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells.","volume":"409","author":"LS Michel","year":"2001","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0092-8674(00)80875-2","article-title":"Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2.","volume":"101","author":"M Dobles","year":"2000","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0092-8674(90)90216-2","article-title":"The HOP1 gene encodes a meiosis-specific component of yeast chromosomes.","volume":"61","author":"NM Hollingsworth","year":"1990","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1083\/jcb.136.5.957","article-title":"The yeast Red1 protein localizes to the cores of meiotic chromosomes.","volume":"136","author":"AV Smith","year":"1997","journal-title":"J Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1101\/gad.13.17.2258","article-title":"Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation.","volume":"13","author":"MC Zetka","year":"1999","journal-title":"Genes Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1242\/jcs.00048","article-title":"Asy1, a protein required for meiotic chromosome synapsis, localizes to axis-associated chromatin in Arabidopsis and Brassica.","volume":"115","author":"SJ Armstrong","year":"2002","journal-title":"J Cell Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(03)00232-6","article-title":"Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination.","volume":"5","author":"MP Colaiacovo","year":"2003","journal-title":"Dev Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cub.2004.03.033","article-title":"A component of C. elegans meiotic chromosome axes at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination.","volume":"14","author":"F Couteau","year":"2004","journal-title":"Curr Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1023\/A:1018497804129","article-title":"Cytological characterization of four meiotic mutants of Arabidopsis isolated from T-DNA-transformed lines.","volume":"5","author":"KJ Ross","year":"1997","journal-title":"Chromosome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s004120050413","article-title":"A homologue of the yeast HOP1 gene is inactivated in the Arabidopsis meiotic mutant asy1.","volume":"109","author":"AP Caryl","year":"2000","journal-title":"Chromosoma"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.modgep.2004.07.008","article-title":"Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein.","volume":"5","author":"SA Pangas","year":"2004","journal-title":"Gene Expr Patterns"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1000702","DOI":"10.1371\/journal.pgen.1000702","article-title":"Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.","volume":"5","author":"L Wojtasz","year":"2009","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.yexcr.2009.08.007","article-title":"A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes.","volume":"316","author":"T Fukuda","year":"2010","journal-title":"Exp Cell Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/MCB.18.3.1424","article-title":"DNA-binding activities of Hop1 protein, a synaptonemal complex component from Saccharomyces cerevisiae.","volume":"18","author":"KM Kironmai","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/144.1.71","article-title":"Analysis of meiotic recombination pathways in the yeast Saccharomyces cerevisiae.","volume":"144","author":"Y Mao-Draayer","year":"1996","journal-title":"Genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cell.2008.01.035","article-title":"Phosphorylation of the axial element protein Hop1 by Mec1\/Tel1 ensures meiotic interhomolog recombination.","volume":"132","author":"JA Carballo","year":"2008","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1128\/MCB.20.13.4838-4848.2000","article-title":"Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins.","volume":"20","author":"JM Bailis","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1002\/j.1460-2075.1992.tb05616.x","article-title":"A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes.","volume":"11","author":"RL Meuwissen","year":"1992","journal-title":"EMBO J"},{"issue":"Pt 10","key":"ref24","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1242\/jcs.107.10.2749","article-title":"Synaptonemal complex proteins: occurrence, epitope mapping and chromosome disjunction.","volume":"107","author":"MJ Dobson","year":"1994","journal-title":"J Cell Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1128\/MCB.14.2.1137","article-title":"The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes.","volume":"14","author":"JH Lammers","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1093\/nar\/26.11.2572","article-title":"SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat.","volume":"26","author":"HH Offenberg","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1097-2765(00)80404-9","article-title":"The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.","volume":"5","author":"L Yuan","year":"2000","journal-title":"Mol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00285884","article-title":"Centromeric proteins recognized by CREST sera and meiotic chromosome segregation.","volume":"96","author":"J del Mazo","year":"1987","journal-title":"Chromosoma"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1070594","article-title":"Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3.","volume":"296","author":"L Yuan","year":"2002","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1097-2765(00)80069-6","article-title":"Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog.","volume":"1","author":"DL Pittman","year":"1998","journal-title":"Mol Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1101\/gad.329705","article-title":"Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation.","volume":"19","author":"FA de Vries","year":"2005","journal-title":"Genes Dev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1101\/gad.12.14.2208","article-title":"Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes.","volume":"12","author":"SL Gasior","year":"1998","journal-title":"Genes Dev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0092-8674(00)81312-4","article-title":"Meiotic pachytene arrest in MLH1-deficient mice.","volume":"85","author":"W Edelmann","year":"1996","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00412-005-0334-8","article-title":"Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility.","volume":"114","author":"NK Kolas","year":"2005","journal-title":"Chromosoma"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1128\/MCB.20.18.6646-6658.2000","article-title":"Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p.","volume":"20","author":"D Woltering","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"47759","DOI":"10.1074\/jbc.C100569200","article-title":"Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.","volume":"276","author":"IM Ward","year":"2001","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1101\/gad.321105","article-title":"The control of Spo11&apos;s interaction with meiotic recombination hotspots.","volume":"19","author":"S Prieler","year":"2005","journal-title":"Genes Dev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.1128\/MCB.24.14.6215-6230.2004","article-title":"Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.","volume":"24","author":"TM Nakamura","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1534-5807(03)00093-5","article-title":"H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.","volume":"4","author":"O Fernandez-Capetillo","year":"2003","journal-title":"Dev Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cub.2004.11.032","article-title":"BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.","volume":"14","author":"JM Turner","year":"2004","journal-title":"Curr Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1038\/sj.emboj.7601231","article-title":"Involvement of novel autophosphorylation sites in ATM activation.","volume":"25","author":"SV Kozlov","year":"2006","journal-title":"EMBO J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1097-2765(00)80070-2","article-title":"The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis.","volume":"1","author":"K Yoshida","year":"1998","journal-title":"Mol Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/5075","article-title":"Mammalian MutS homologue 5 is required for chromosome pairing in meiosis.","volume":"21","author":"W Edelmann","year":"1999","journal-title":"Nat Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1242\/dev.125.20.4007","article-title":"Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I.","volume":"125","author":"C Barlow","year":"1998","journal-title":"Development"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1073\/pnas.0601083103","article-title":"Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.","volume":"103","author":"SA Pangas","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","first-page":"9","article-title":"Methodologies to study implantation in mice.","volume":"121","author":"K Deb","year":"2006","journal-title":"Methods Mol Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncb1135","article-title":"Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination.","volume":"6","author":"E Revenkova","year":"2004","journal-title":"Nat Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1083\/jcb.200603063","article-title":"Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.","volume":"173","author":"F Yang","year":"2006","journal-title":"J Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1101\/gad.10.19.2411","article-title":"Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.","volume":"10","author":"Y Xu","year":"1996","journal-title":"Genes Dev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S1097-2765(00)00097-6","article-title":"The mouse Spo11 gene is required for meiotic chromosome synapsis.","volume":"6","author":"PJ Romanienko","year":"2000","journal-title":"Mol Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1074\/jbc.274.3.1783","article-title":"Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.","volume":"274","author":"T de los Santos","year":"1999","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.200512077","article-title":"Structural damage to meiotic chromosomes impairs DNA recombination and checkpoint control in mammalian oocytes.","volume":"173","author":"H Wang","year":"2006","journal-title":"J Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1073\/pnas.0406212102","article-title":"Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.","volume":"102","author":"M Di Giacomo","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/genetics\/147.1.33","article-title":"Genetic interactions between HOP1, RED1 and MEK1 suggest that MEK1 regulates assembly of axial element components during meiosis in the yeast Saccharomyces cerevisiae.","volume":"147","author":"NM Hollingsworth","year":"1997","journal-title":"Genetics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy.","volume":"2","author":"T Hassold","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/ng1672","article-title":"SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction.","volume":"37","author":"CA Hodges","year":"2005","journal-title":"Nat Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nrg2723","article-title":"Genetics of mammalian meiosis: regulation, dynamics and impact on fertility.","volume":"11","author":"MA Handel","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.1128\/MCB.21.20.6984-6998.2001","article-title":"Novel meiosis-specific isoform of mammalian SMC1.","volume":"21","author":"E Revenkova","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer&apos;s disease.","volume":"349","author":"A Goate","year":"1991","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/gni035","article-title":"Simple and highly efficient BAC recombineering using galK selection.","volume":"33","author":"S Warming","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1099755","article-title":"NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.","volume":"305","author":"A Rajkovic","year":"2004","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/ng1919","article-title":"In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication.","volume":"38","author":"AE Baltus","year":"2006","journal-title":"Nat Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1095\/biolreprod.108.069393","article-title":"Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival.","volume":"79","author":"Y Choi","year":"2008","journal-title":"Biol Reprod"},{"key":"ref64","article-title":"The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory.","author":"M Li","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0015-0282(01)01966-5","article-title":"Discovery of germ cell-specific transcripts by expressed sequence tag database analysis.","volume":"76","author":"A Rajkovic","year":"2001","journal-title":"Fertil Steril"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/86927","article-title":"An abundance of X-linked genes expressed in spermatogonia.","volume":"27","author":"PJ Wang","year":"2001","journal-title":"Nat Genet"},{"key":"ref67","article-title":"MiR-205 silences MED1 in hypoxic primary human trophoblasts.","author":"JF Mouillet","year":"2010","journal-title":"FASEB J"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments.","volume":"3","author":"GK Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1073\/pnas.0408378102","article-title":"An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.","volume":"102","author":"E Seli","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"updated-by":[{"DOI":"10.1371\/annotation\/8aa656b6-55f7-4795-a441-cf243ea62175","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T00:00:00Z","timestamp":1297209600000}}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1001190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T02:39:08Z","timestamp":1636771148000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1001190"}},"subtitle":[],"editor":[{"given":"R. Scott","family":"Hawley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,11,4]]},"references-count":69,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,11,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1001190","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/8aa656b6-55f7-4795-a441-cf243ea62175","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,4]]}}}