{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:10:41Z","timestamp":1774671041780,"version":"3.50.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T00:00:00Z","timestamp":1296691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1001293","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T16:38:21Z","timestamp":1296751101000},"page":"e1001293","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Mapping a New Spontaneous Preterm Birth Susceptibility Gene, IGF1R, Using Linkage, Haplotype Sharing, and Association Analysis"],"prefix":"10.1371","volume":"7","author":[{"given":"Ritva","family":"Haataja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna K.","family":"Karjalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aino","family":"Luukkonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Teramo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilkka","family":"Puttonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja","family":"Ojaniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppo","family":"Varilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bimal P.","family":"Chaudhari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jevon","family":"Plunkett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A.","family":"McCarroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J.","family":"Muglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarno","family":"Palotie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Hallman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/GCO.0b013e3283186964","article-title":"Prevention of preterm birth: A renewed national priority.","volume":"20","author":"K Damus","year":"2008","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"9606","key":"ref2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth.","volume":"371","author":"RL Goldenberg","year":"2008","journal-title":"Lancet"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/AOG.0b013e318184181a","article-title":"Estimating recurrence of spontaneous preterm delivery.","volume":"112","author":"MS Esplin","year":"2008","journal-title":"Obstet Gynecol"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/0002-9378(79)90742-7","article-title":"The tendency to repeat gestational age and birth weight in successive births.","volume":"135","author":"LS Bakketeig","year":"1979","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra0904308","article-title":"The enigma of spontaneous preterm birth.","volume":"362","author":"LJ Muglia","year":"2010","journal-title":"N Engl J Med"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0029-7844(97)00215-9","article-title":"The risk of preterm birth across generations.","volume":"90","author":"TF Porter","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/ije\/27.2.248","article-title":"Familial patterns in birth characteristics: Impact on individual and population risks.","volume":"27","author":"A Winkvist","year":"1998","journal-title":"Int J Epidemiol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"43.e1","DOI":"10.1016\/j.ajog.2007.12.014","article-title":"Heritability of parturition timing: An extended twin design analysis.","volume":"199","author":"ZA Kistka","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1471-0528.2000.tb13234.x","article-title":"Genetic influence on birthweight and gestational length determined by studies in offspring of twins.","volume":"107","author":"B Clausson","year":"2000","journal-title":"BJOG"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1375\/136905200320565526","article-title":"Genetic influences on premature parturition in an Australian twin sample.","volume":"3","author":"SA Treloar","year":"2000","journal-title":"Twin Res"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/07853890701806181","article-title":"Genetic contributions to preterm birth: Implications from epidemiological and genetic association studies.","volume":"40","author":"J Plunkett","year":"2008","journal-title":"Ann Med"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/gepi.1029","article-title":"Tumor necrosis factor-alpha promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort project IX.","volume":"21","author":"M Aidoo","year":"2001","journal-title":"Genet Epidemiol"},{"issue":"4","key":"ref13","first-page":"377","article-title":"Tumor necrosis factor-alpha gene G308A polymorphism is associated with the risk of preterm delivery.","volume":"35","author":"D Chen","year":"2003","journal-title":"Beijing Da Xue Xue Bao"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.ajog.2004.05.067","article-title":"Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairs.","volume":"191","author":"JH Amory","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1067\/S0002-9378(03)00843-3","article-title":"Interleukin-6 promoter -174 polymorphism and spontaneous preterm birth.","volume":"189","author":"HN Simhan","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.ajog.2004.04.021","article-title":"Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth.","volume":"191","author":"MF Annells","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/molehr\/gah120","article-title":"Polymorphisms of genes involved in innate immunity: Association with preterm delivery.","volume":"10","author":"C Hartel","year":"2004","journal-title":"Mol Hum Reprod"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.ajog.2003.09.066","article-title":"Interleukin-4 and -10 gene polymorphisms and spontaneous preterm birth in multifetal gestations.","volume":"190","author":"RB Kalish","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.ajog.2004.01.001","article-title":"A polymorphism in the promoter region of TNF and bacterial vaginosis: Preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth.","volume":"190","author":"GA Macones","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1471-0528.2003.00024.x-i1","article-title":"An investigation into the association among preterm birth, cytokine gene polymorphisms and periodontal disease.","volume":"111","author":"S Moore","year":"2004","journal-title":"BJOG"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/01.ede.0000164539.09250.31","article-title":"Risk of spontaneous preterm birth is associated with common proinflammatory cytokine polymorphisms.","volume":"16","author":"SA Engel","year":"2005","journal-title":"Epidemiology"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ajhg.2008.11.005","article-title":"The genome-wide patterns of variation expose significant substructure in a founder population.","volume":"83","author":"E Jakkula","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/1479-7364-2-5-336","article-title":"A survey of data mining methods for linkage disequilibrium mapping.","volume":"2","author":"P Onkamo","year":"2006","journal-title":"Hum Genomics"},{"issue":"5829","key":"ref24","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","article-title":"Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.","volume":"316","author":"R Saxena","year":"2007","journal-title":"Science"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ng1294-380","article-title":"Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis.","volume":"8","author":"RH Houwen","year":"1994","journal-title":"Nat Genet"},{"issue":"15","key":"ref26","doi-asserted-by":"crossref","first-page":"10759","DOI":"10.1016\/S0021-9258(19)50083-7","article-title":"Insulin-like growth factor I receptor gene structure.","volume":"267","author":"AM Abbott","year":"1992","journal-title":"J Biol Chem"},{"issue":"5","key":"ref27","first-page":"1249","article-title":"Differential expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor in human neuroendocrine tumors.","volume":"15","author":"L Vitale","year":"2006","journal-title":"Oncol Rep"},{"issue":"23","key":"ref28","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa010107","article-title":"IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation.","volume":"349","author":"MJ Abuzzahab","year":"2003","journal-title":"N Engl J Med"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1210\/jc.2004-1947","article-title":"Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.","volume":"90","author":"Y Kawashima","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1210\/jc.2005-1597","article-title":"A variable degree of intrauterine and postnatal growth retardation in a family with a missense mutation in the insulin-like growth factor I receptor.","volume":"91","author":"MJ Walenkamp","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1210\/jc.2006-2354","article-title":"A familial insulin-like growth factor-I receptor mutant leads to short stature: Clinical and biochemical characterization.","volume":"92","author":"K Inagaki","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.beem.2008.03.001","article-title":"Polymorphisms in the IGF1 and IGF1R genes and children born small for gestational age: Results of large population studies.","volume":"22","author":"WA Ester","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrd2359","article-title":"Modifying IGF1 activity: An approach to treat endocrine disorders, atherosclerosis and cancer.","volume":"6","author":"DR Clemmons","year":"2007","journal-title":"Nat Rev Drug Discov"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2174\/138161207780249146","article-title":"The IGF-I signaling pathway.","volume":"13","author":"L Laviola","year":"2007","journal-title":"Curr Pharm Des"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/biof.20","article-title":"Insulin-like growth factor-I receptor signal transduction and the janus Kinase\/Signal transducer and activator of transcription (JAK-STAT) pathway.","volume":"35","author":"E Himpe","year":"2009","journal-title":"Biofactors"},{"issue":"7\u20138","key":"ref36","first-page":"604","article-title":"Relation of cord serum levels of growth hormone, insulin-like growth factors, insulin-like growth factor binding proteins, leptin, and interleukin-6 with birth weight, birth length, and head circumference in term and preterm neonates.","volume":"18","author":"HC Lo","year":"2002","journal-title":"Nutrition"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1515\/jpm.2010.019","article-title":"The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.","volume":"38","author":"SM Cooley","year":"2010","journal-title":"J Perinat Med"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1471-0528.2010.02551.x","article-title":"Elevated levels of decidual insulin-like growth factor binding protein-1 in cervical fluid in early and mid-pregnancy are associated with an increased risk of spontaneous preterm delivery.","volume":"117","author":"L Rahkonen","year":"2010","journal-title":"BJOG"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1101\/gr.108597.110","article-title":"Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15.","volume":"20","author":"AJ Sharp","year":"2010","journal-title":"Genome Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e12391","DOI":"10.1371\/journal.pone.0012391","article-title":"Racial differences in genetic and environmental risk to preterm birth.","volume":"5","author":"TP York","year":"2010","journal-title":"PLoS ONE"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000224641","article-title":"Mother&apos;s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth.","volume":"68","author":"J Plunkett","year":"2009","journal-title":"Hum Hered"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/aje\/kwp324","article-title":"Maternal contributions to preterm delivery.","volume":"170","author":"HA Boyd","year":"2009","journal-title":"Am J Epidemiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e5472","DOI":"10.1371\/journal.pone.0005472","article-title":"Genetic structure of Europeans: A view from the North-East.","volume":"4","author":"M Nelis","year":"2009","journal-title":"PLoS ONE"},{"key":"ref44","article-title":"The age of the mutations in the Finnish disease heritage; a genealogical and linkage disequilibrium study.","author":"T Varilo","year":"1999"},{"issue":"8","key":"ref45","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/07853890903186176","article-title":"Genetic association of SP-C with duration of preterm premature rupture of fetal membranes and expression in gestational tissues.","volume":"41","author":"A Salminen","year":"2009","journal-title":"Ann Med"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/1471-2156-6-S1-S13","article-title":"Comparing single-nucleotide polymorphism marker-based and microsatellite marker-based linkage analyses.","volume":"6","author":"A Ulgen","year":"2005","journal-title":"BMC Genet"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/301904","article-title":"PedCheck: A program for identification of genotype incompatibilities in linkage analysis.","volume":"63","author":"JR O'Connell","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1375\/twin.8.1.16","article-title":"AUTOGSCAN: Powerful tools for automated genome-wide linkage and linkage disequilibrium analysis.","volume":"8","author":"T Hiekkalinna","year":"2005","journal-title":"Twin Res Hum Genet"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1086\/302845","article-title":"Linkage analysis in the presence of errors IV: Joint pseudomarker analysis of linkage and\/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.","volume":"66","author":"HH Goring","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000073204","article-title":"How to model a complex trait. 1. general considerations and suggestions.","volume":"55","author":"K Strauch","year":"2003","journal-title":"Hum Hered"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1002\/gepi.20112","article-title":"Assessment and implications of linkage disequilibrium in genome-wide single-nucleotide polymorphism and microsatellite panels.","volume":"29","author":"EL Goode","year":"2005","journal-title":"Genet Epidemiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1186\/1471-2156-6-S1-S28","article-title":"Whole-genome linkage analysis in mapping alcoholism genes using single-nucleotide polymorphisms and microsatellites.","volume":"6","author":"S Wang","year":"2005","journal-title":"BMC Genet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1186\/1471-2156-6-S1-S83","article-title":"Examining the effect of linkage disequilibrium on multipoint linkage analysis.","volume":"6","author":"Q Huang","year":"2005","journal-title":"BMC Genet"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1089\/cmb.2005.12.719","article-title":"Computing the minimum recombinant haplotype configuration from incomplete genotype data on a pedigree by integer linear programming.","volume":"12","author":"J Li","year":"2005","journal-title":"J Comput Biol"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/521987","article-title":"Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.","volume":"81","author":"SR Browning","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: Analysis and visualization of LD and haplotype maps.","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"7","key":"ref58","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1210\/jc.2002-021810","article-title":"Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: Cues for an evolutionarily conserved mechanism of life span control.","volume":"88","author":"M Bonafe","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits.","volume":"19","author":"S Purcell","year":"2003","journal-title":"Bioinformatics"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1001293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T08:42:53Z","timestamp":1637224973000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1001293"}},"subtitle":[],"editor":[{"given":"Takashi","family":"Gojobori","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,2,3]]},"references-count":59,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1001293","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.8747956.9265054","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,3]]}}}