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APOE and Alzheimer Disease Meta Analysis Consortium.","volume":"278","author":"LA Farrer","year":"1997","journal-title":"JAMA"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies.","volume":"55","author":"B Devlin","year":"1999","journal-title":"Biometrics"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000073729","article-title":"Detecting disease associations due to linkage disequilibrium using haplotype tags: A class of tests and the determinants of statistical power.","volume":"56","author":"JM Chapman","year":"2003","journal-title":"Hum Hered"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ygeno.2007.02.002","article-title":"Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer&apos;s disease: Patterns of linkage disequilibrium and disease\/marker association.","volume":"89","author":"CE Yu","year":"2007","journal-title":"Genomics"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e1001101","DOI":"10.1371\/journal.pgen.1001101","article-title":"SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer&apos;s Disease.","volume":"6","author":"C Cruchaga","year":"2010","journal-title":"PLoS Genet"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/jama.279.10.751","article-title":"The APOE-epsilon 4 allele and the risk of Alzheimer disease among African Americans, Whites, and Hispanics.","volume":"279","author":"MX Tang","year":"1998","journal-title":"JAMA"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1001\/archneur.59.1.87","article-title":"Familial Alzheimer disease among Caribbean Hispanics - A reexamination of its association with APOE.","volume":"59","author":"SN Romas","year":"2002","journal-title":"Arch Neurol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/gepi.20400","article-title":"Replication of Genetic Associations as Pseudoreplication due to Shared Genealogy.","volume":"33","author":"NA Rosenberg","year":"2009","journal-title":"Genet Epidemiol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ejhg.2008.210","article-title":"Investigation of the fine structure of European populations with applications to disease association studies.","volume":"16","author":"SC Heath","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"ref82","first-page":"253","article-title":"Pattern of gradient of apolipoprotein E allele *4 frequencies in Western Europe.","volume":"69","author":"G Lucotte","year":"1997","journal-title":"Hum Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1469-1809.1999.6340301.x","article-title":"Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a \u2018thrifty\u2019 allele?","volume":"63","author":"RM Corbo","year":"1999","journal-title":"Ann Hum Genet"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/03014460600594513","article-title":"APOE distribution in world populations with new data from India and the UK.","volume":"33","author":"PP Singh","year":"2006","journal-title":"Ann Hum Biol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0304-3940(03)00049-1","article-title":"An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer&apos;s disease.","volume":"340","author":"H Rosenmann","year":"2003","journal-title":"Neurosci Lett"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1089\/gtmb.2008.0129","article-title":"Estrogen Receptor Beta Gene Variant Is Associated with Vascular Dementia in Elderly Women.","volume":"13","author":"R Dresner-Pollak","year":"2009","journal-title":"Genet Test Mol Biomarkers"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00439-008-0592-7","article-title":"Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement.","volume":"125","author":"J Little","year":"2009","journal-title":"Hum Genet"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"e5472","DOI":"10.1371\/journal.pone.0005472","article-title":"Genetic Structure of Europeans: A View from the North-East.","volume":"4","author":"M Nelis","year":"2009","journal-title":"PLoS ONE"},{"key":"ref89","first-page":"575","article-title":"High frequency of the apolipoprotein E *4 allele in African pygmies and most of the African populations in sub-Saharan Africa.","volume":"69","author":"L Zekraoui","year":"1997","journal-title":"Hum Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1371\/journal.pgen.0010032","article-title":"Confounding from cryptic relatedness in case-control association studies.","volume":"1","author":"BF Voight","year":"2005","journal-title":"PLoS Genet"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ajhg.2010.01.026","article-title":"Using Principal Components of Genetic Variation for Robust and Powerful Detection of Gene-Gene Interactions in Case-Control and Case-Only Studies.","volume":"86","author":"S Bhattacharjee","year":"2010","journal-title":"Am J Hum Genet"},{"key":"ref92","first-page":"498","article-title":"Results of a high resolution genome screen in 443 Alzheimer&apos;s disease families: the NIMH Genetics Initiative.","volume":"69","author":"D Blacker","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1001\/archneur.65.11.1518","article-title":"Analyses of the National Institute on Aging Late-Onset Alzheimer&apos;s Disease Family Study Implication of Additional Loci.","volume":"65","author":"JH Lee","year":"2008","journal-title":"Arch Neurol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ana.10636","article-title":"Apolipoprotein E \u03b54 modifies Alzheimer&apos;s disease onset in an E280A PS1 Kindred.","volume":"54","author":"P Pastor","year":"2003","journal-title":"Ann Neurol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/ajmg.b.30087","article-title":"APOE and other loci affect age-at-onset in Alzheimer&apos;s disease families with PS2 mutation.","volume":"132B","author":"EM Wijsman","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/ajmg.b.31072","article-title":"Evidence for three loci modifying age-at-onset of Alzheimer&apos;s disease in early-onset PSEN2 families.","volume":"153B","author":"EE Marchani","year":"2010","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molbrainres.2005.07.006","article-title":"NAPOR-3 RNA binding protein is required for apoptosis in hippocampus.","volume":"140","author":"A Pacini","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"29096","DOI":"10.1074\/jbc.M602532200","article-title":"Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP.","volume":"281","author":"A Falkevall","year":"2006","journal-title":"J Biol Chem"},{"key":"ref99","doi-asserted-by":"crossref","DOI":"10.1001\/archneurol.2010.201","article-title":"Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes.","author":"G Jun","year":"2010"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/archneurol.2010.147","article-title":"Replication of CLU, CR1, and PICALM Associations With 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