{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:12:42Z","timestamp":1793916762118,"version":"4.8.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1001353","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T20:48:30Z","timestamp":1302209310000},"page":"e1001353","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":65,"title":["Incorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies"],"prefix":"10.1371","volume":"7","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1086\/522374","article-title":"Pathway-based approaches for analysis of genomewide association studies.","volume":"81","author":"K Wang","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ejhg.2009.115","article-title":"Gene and pathway-based second-wave analysis of genome-wide association studies.","volume":"18","author":"G Peng","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/gepi.20448","article-title":"Comparisons of multi-marker association methods to detect association between a candidate region and disease.","volume":"34","author":"DH Ballard","year":"2010","journal-title":"Genet Epidemiol"},{"key":"ref4","article-title":"Identification of association between disease and multiple markers within a candidate region via sparse partial least squares regression.","author":"H Chun","year":"2011"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1086\/504300","article-title":"Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes.","volume":"78","author":"L Franke","year":"2006","journal-title":"Am J Hum Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nbt1203","article-title":"Gene prioritization through genomic data fusion.","volume":"24","author":"S Aerts","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/bioinformatics\/btl569","article-title":"CGI: a new approach for prioritizing genes by combining gene expression and protein-protein interaction data.","volume":"23","author":"X Ma","year":"2007","journal-title":"Bioinformatics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/gepi.20346","article-title":"Candid: a flexible method for prioritizing candidate genes for complex human traits.","volume":"32","author":"JE Hutz","year":"2008","journal-title":"Genet Epidemiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ajhg.2008.02.013","article-title":"Walking the interactome for prioritization of candidate disease genes.","volume":"82","author":"S K\u00f6hler","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/msb.2008.27","article-title":"Network-based global inference of human disease genes.","volume":"4","author":"X Wu","year":"2008","journal-title":"Mol Syst Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/bioinformatics\/btn315","article-title":"Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.","volume":"24","author":"SF Saccone","year":"2008","journal-title":"Bioinformatics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/bioinformatics\/btm612","article-title":"Incorporating gene networks into statistical tests for genomic data via a spatially correlated mixture model.","volume":"24","author":"P Wei","year":"2008","journal-title":"Bioinformatics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/bioinformatics\/btm129","article-title":"A Markov random field model for network-based analysis of genomic data.","volume":"23","author":"Z Wei","year":"2007","journal-title":"Bioinformatics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/biostatistics\/kxp043","article-title":"A hidden markov random field model for genome-wide association studies.","volume":"11","author":"H Li","year":"2010","journal-title":"Biostatistics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease genes.","volume":"314","author":"RH Duerr","year":"2006","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1471-2105-8-217","article-title":"Genmapp 2: new features and resources for pathway analysis.","volume":"8","author":"N Salomonis","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"Kegg: kyoto encyclopedia of genes and genomes.","volume":"28","author":"M Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1090\/conm\/001","article-title":"Markov random fields and their applications.","author":"R Kindermann","year":"1980"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.2517-6161.1986.tb01412.x","article-title":"On the statistical analysis of dirty pictures.","volume":"48","author":"J Besag","year":"1986","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1198\/016214504000001646","article-title":"Optimal sample size for multiple testing: the case of gene expression microarrays.","volume":"99","author":"P M\u00fcller","year":"2004","journal-title":"Journal of the American Statistical Association"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing.","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng.175","article-title":"Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.","volume":"40","author":"JC Barrett","year":"2008","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.2517-6161.1972.tb00889.x","article-title":"Nearest-neighbour systems and the auto-logistic model for binary data.","volume":"34","author":"J Besag","year":"1972","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.2517-6161.1974.tb00999.x","article-title":"Spatial interaction and the statistical analysis of lattice systems.","volume":"36","author":"J Besag","year":"1974","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.","volume":"3","author":"RB Sartor","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/gast.1996.v111.pm8780562","article-title":"Familial aggregation in Crohn's disease: increased age-adjusted risk and concordance in clinical characteristics.","volume":"111","author":"M Peeters","year":"1996","journal-title":"Gastroenterology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/gepi.20219","article-title":"Testing association between disease and multiple SNPs in a candidate gene.","volume":"31","author":"WJ Gauderman","year":"2007","journal-title":"Genet Epidemiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/gepi.20266","article-title":"A principal components regression approach to multilocus genetic association studies.","volume":"32","author":"K Wang","year":"2008","journal-title":"Genet Epidemiol"},{"key":"ref29","article-title":"Integration of Genomic Data to Identify Genes and Pathways Associated with Disease.","author":"DH Ballard","year":"2009"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1001353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T01:36:56Z","timestamp":1592444216000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1001353"}},"subtitle":[],"editor":[{"given":"David B.","family":"Allison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,4,7]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1001353","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,7]]}}}