{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:42:26Z","timestamp":1789177346851,"version":"build-2803163510"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2011,5,19]],"date-time":"2011-05-19T00:00:00Z","timestamp":1305763200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1002066","type":"journal-article","created":{"date-parts":[[2011,5,19]],"date-time":"2011-05-19T20:47:09Z","timestamp":1305838029000},"page":"e1002066","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["A \u2212436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria"],"prefix":"10.1371","volume":"7","author":[{"given":"Kathrin","family":"Schuldt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima C.","family":"Kretz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Timmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Sievertsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Ehmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Esser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wibke","family":"Loag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ansong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Dering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsiri","family":"Agbenyega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf D.","family":"Horstmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,5,19]]},"reference":[{"key":"ref1","first-page":"S1","article-title":"Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster.","volume":"94","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1056\/NEJM199505253322102","article-title":"Indicators of life-threatening malaria in African children.","volume":"332","author":"K Marsh","year":"1995","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1086\/432519","article-title":"How malaria has affected the human genome and what human genetics can teach us about malaria.","volume":"77","author":"DP Kwiatkowski","year":"2005","journal-title":"Am J Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1002\/eji.1830241221","article-title":"Structure of the human APO-1 gene.","volume":"24","author":"I Behrmann","year":"1994","journal-title":"Eur J Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0888-7543(05)80302-7","article-title":"The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19.","volume":"14","author":"P Lichter","year":"1992","journal-title":"Genomics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/35037728","article-title":"CD95's deadly mission in the immune system.","volume":"407","author":"PH Krammer","year":"2000","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0092-8674(93)90326-L","article-title":"Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.","volume":"75","author":"T Suda","year":"1993","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/j.1460-2075.1995.tb07096.x","article-title":"Expression of the functional soluble form of human fas ligand in activated lymphocytes.","volume":"14","author":"M Tanaka","year":"1995","journal-title":"EMBO J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.immunol.24.021605.090513","article-title":"Genetic disorders of programmed cell death in the immune system.","volume":"24","author":"N Bidere","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1062416","article-title":"T cell death and memory.","volume":"293","author":"J Sprent","year":"2001","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.immuni.2009.01.001","article-title":"The many roles of FAS receptor signaling in the immune system.","volume":"30","author":"A Strasser","year":"2009","journal-title":"Immunity"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2249.2002.01714.x","article-title":"Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria.","volume":"127","author":"K Kemp","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1128\/IAI.68.5.3061-3063.2000","article-title":"Increased levels of soluble Fas ligand in serum in Plasmodium falciparum malaria.","volume":"68","author":"P Kern","year":"2000","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1365-3024.2000.00307.x","article-title":"Apoptosis modulation in mononuclear cells recovered from individuals exposed to Plasmodium falciparum infection.","volume":"22","author":"AT Balde","year":"2000","journal-title":"Parasite Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1086\/429297","article-title":"Genomewide analysis of the host response to malaria in Kenyan children.","volume":"191","author":"MJ Griffiths","year":"2005","journal-title":"J Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1128\/IAI.00408-06","article-title":"Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria.","volume":"74","author":"CF Ockenhouse","year":"2006","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0161-5890(97)00081-3","article-title":"Identification and characterization of polymorphisms in the promoter region of the human Apo-1\/Fas (CD95) gene.","volume":"34","author":"QR Huang","year":"1997","journal-title":"Mol Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1086\/302333","article-title":"Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance.","volume":"64","author":"CE Jackson","year":"1999","journal-title":"Am J Hum Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1371\/journal.pgen.0030048","article-title":"Genome-wide linkage analysis of malaria infection intensity and mild disease.","volume":"3","author":"C Timmann","year":"2007","journal-title":"PLoS Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/eji.1830230737","article-title":"Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens.","volume":"23","author":"SF Ziegler","year":"1993","journal-title":"Eur J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.4049\/jimmunol.175.11.7466","article-title":"Heterogeneous human NK cell responses to Plasmodium falciparum-infected erythrocytes.","volume":"175","author":"DS Korbel","year":"2005","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-3024.2006.00775.x","article-title":"Regulating immunity to malaria.","volume":"28","author":"EM Riley","year":"2006","journal-title":"Parasite Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri1686","article-title":"Immunological processes in malaria pathogenesis.","volume":"5","author":"L Schofield","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref24","first-page":"97","article-title":"The anemia of malaria infection: role of inflammatory cytokines.","volume":"3","author":"MA McDevitt","year":"2004","journal-title":"Curr Hematol Rep"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tig.2009.12.010","article-title":"The role of protozoa-driven selection in shaping human genetic variability.","volume":"26","author":"U Pozzoli","year":"2010","journal-title":"Trends Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1182\/blood.V83.10.3101a.3101a","article-title":"High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children.","volume":"83","author":"KM Debatin","year":"1994","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/375497a0","article-title":"Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.","volume":"375","author":"MO Westendorp","year":"1995","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1001\/jama.297.20.2220","article-title":"Hemoglobin variants and disease manifestations in severe falciparum malaria.","volume":"297","author":"J May","year":"2007","journal-title":"JAMA"},{"key":"ref29","first-page":"S1","article-title":"Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster.","volume":"94","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.trstmh.2005.09.021","article-title":"Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network.","volume":"100","author":"T Taylor","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref31","first-page":"i","article-title":"WHO Expert Committee on Malaria.","volume":"892","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"ref32","doi-asserted-by":"crossref","DOI":"10.1002\/9783527633654","article-title":"A statistical approach to genetic epidemiology","author":"A Ziegler","year":"2010"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/429864","article-title":"A note on exact tests of Hardy-Weinberg equilibrium.","volume":"76","author":"JE Wigginton","year":"2005","journal-title":"Am J Hum Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"Article17","DOI":"10.2202\/1544-6115.1281","article-title":"A method for meta-analysis of case-control genetic association studies using logistic regression.","volume":"6","author":"PG Bagos","year":"2007","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps.","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1086\/338688","article-title":"Score tests for association between traits and haplotypes when linkage phase is ambiguous.","volume":"70","author":"DJ Schaid","year":"2002","journal-title":"Am J Hum Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/302698","article-title":"A general test of association for quantitative traits in nuclear families.","volume":"66","author":"GR Abecasis","year":"2000","journal-title":"Am J Hum Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1086\/381563","article-title":"PBAT: tools for family-based association studies.","volume":"74","author":"C Lange","year":"2004","journal-title":"Am J Hum Genet"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1002066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T09:24:11Z","timestamp":1592558651000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1002066"}},"subtitle":[],"editor":[{"given":"Daniel C.","family":"Jeffares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,5,19]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1002066","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,19]]}}}