{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:03:37Z","timestamp":1793156617059,"version":"4.5.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1002228","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T19:16:38Z","timestamp":1313090198000},"page":"e1002228","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":270,"title":["Analysis of DNA Methylation in a Three-Generation Family Reveals Widespread Genetic Influence on Epigenetic Regulation"],"prefix":"10.1371","volume":"7","author":[{"given":"Jason","family":"Gertz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Varley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Bowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina S.","family":"Kucera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huntington F.","family":"Willard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.","volume":"99","author":"M Okano","year":"1999","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrc1279","article-title":"The history of cancer epigenetics.","volume":"4","author":"AP Feinberg","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1038\/sj.onc.1205597","article-title":"DNA methylation and cancer.","volume":"21","author":"PA Jones","year":"2002","journal-title":"Oncogene"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ajhg.2008.01.008","article-title":"Epigenomic profiling reveals DNA-methylation changes associated with major psychosis.","volume":"82","author":"J Mill","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1521-6616(03)00206-7","article-title":"DNA methylation and autoimmune disease.","volume":"109","author":"B Richardson","year":"2003","journal-title":"Clin Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2337\/db09-1003","article-title":"Epigenetics: a molecular link between environmental factors and type 2 diabetes.","volume":"58","author":"C Ling","year":"2009","journal-title":"Diabetes"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic imprinting: parental influence on the genome.","volume":"2","author":"W Reik","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.tig.2005.04.005","article-title":"Genomic imprinting and methylation: epigenetic canalization and conflict.","volume":"21","author":"JF Wilkins","year":"2005","journal-title":"Trends Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ng1158","article-title":"The role of DNA methylation in setting up chromatin structure during development.","volume":"34","author":"T Hashimshony","year":"2003","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/BF02443782","article-title":"Methylation status of CpG-rich islands on active and inactive mouse X chromosomes.","volume":"1","author":"DP Norris","year":"1991","journal-title":"Mamm Genome"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0092-8674(87)90329-1","article-title":"Allele-specific methylation of the human c-Ha-ras-1 gene.","volume":"50","author":"LA Chandler","year":"1987","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0092-8674(88)90546-6","article-title":"Inheritance of allelic blueprints for methylation patterns.","volume":"54","author":"AJ Silva","year":"1988","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng.174","article-title":"Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.","volume":"40","author":"K Kerkel","year":"2008","journal-title":"Nat Genet"},{"key":"ref14","article-title":"Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome.","author":"R Shoemaker","year":"2010","journal-title":"Genome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"R138","DOI":"10.1186\/gb-2009-10-12-r138","article-title":"Non-imprinted allele-specific DNA methylation on human autosomes.","volume":"10","author":"Y Zhang","year":"2009","journal-title":"Genome Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/nature08990","article-title":"Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis.","volume":"464","author":"SE Baranzini","year":"2010","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng.286","article-title":"DNA methylation profiles in monozygotic and dizygotic twins.","volume":"41","author":"ZA Kaminsky","year":"2009","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1045","article-title":"The power and the promise of DNA methylation markers.","volume":"3","author":"PW Laird","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature07107","article-title":"Genome-scale DNA methylation maps of pluripotent and differentiated cells.","volume":"454","author":"A Meissner","year":"2008","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e8888","DOI":"10.1371\/journal.pone.0008888","article-title":"The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing.","volume":"5","author":"Y Huang","year":"2010","journal-title":"PLoS ONE"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts.","volume":"282","author":"JA Thomson","year":"1998","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females.","volume":"434","author":"L Carrel","year":"2005","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1096\/fj.09-150490","article-title":"Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology.","volume":"24","author":"RP Talens","year":"2010","journal-title":"FASEB J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"29233","DOI":"10.1074\/jbc.M501670200","article-title":"NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.","volume":"280","author":"WH Hu","year":"2005","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1186\/1753-6561-3-s7-s19","article-title":"Genome-wide discovery of maternal effect variants.","volume":"3","author":"JW Kent Jr","year":"2009","journal-title":"BMC Proc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1101\/gr.6584707","article-title":"Computational and experimental identification of novel human imprinted genes.","volume":"17","author":"PP Luedi","year":"2007","journal-title":"Genome Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2174\/1566524024605789","article-title":"Acid alpha-glucosidase deficiency (glycogenosis type II, Pompe disease).","volume":"2","author":"N Raben","year":"2002","journal-title":"Curr Mol Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1073\/pnas.0906183107","article-title":"Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease.","volume":"107","author":"AP Feinberg","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory.","volume":"16","author":"A Bird","year":"2002","journal-title":"Genes Dev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nature10008","article-title":"Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.","volume":"473","author":"G Ficz","year":"2011","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature10102","article-title":"Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.","volume":"473","author":"WA Pastor","year":"2011","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature10066","article-title":"TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.","volume":"473","author":"K Williams","year":"2011","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"D620","DOI":"10.1093\/nar\/gkp961","article-title":"ENCODE whole-genome data in the UCSC Genome Browser.","volume":"38","author":"KR Rosenbloom","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1126\/science.1184655","article-title":"Heritable individual-specific and allele-specific chromatin signatures in humans.","volume":"328","author":"R McDaniell","year":"2010","journal-title":"Science"},{"key":"ref35","article-title":"Myers Lab RRBS Protocol."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.","volume":"10","author":"B Langmead","year":"2009","journal-title":"Genome Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies.","volume":"100","author":"JD Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1093\/nar\/gkp457","article-title":"Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing.","volume":"37","author":"KE Varley","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0022-2836(87)90689-9","article-title":"CpG islands in vertebrate genomes.","volume":"196","author":"M Gardiner-Garden","year":"1987","journal-title":"J Mol Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1101\/gr.097857.109","article-title":"Detection of nonneutral substitution rates on mammalian phylogenies.","volume":"20","author":"KS Pollard","year":"2010","journal-title":"Genome Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"D61","DOI":"10.1093\/nar\/gkl842","article-title":"NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins.","volume":"35","author":"KD Pruitt","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"D613","DOI":"10.1093\/nar\/gkp939","article-title":"The UCSC Genome Browser database: update 2010.","volume":"38","author":"B Rhead","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software.","volume":"20","author":"MJ de Hoon","year":"2004","journal-title":"Bioinformatics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns.","volume":"95","author":"MB Eisen","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq.","volume":"5","author":"A Mortazavi","year":"2008","journal-title":"Nat Methods"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing.","volume":"467","author":"RM Durbin","year":"2010","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research.","volume":"125","author":"Y Benjamini","year":"2001","journal-title":"Behav Brain Res"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1002228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T20:50:31Z","timestamp":1560459031000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1002228"}},"subtitle":[],"editor":[{"given":"Wendy A.","family":"Bickmore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,8,11]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,8,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1002228","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,11]]}}}