{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:52:37Z","timestamp":1791215557310,"version":"4.1.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1002580","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T17:50:30Z","timestamp":1331833830000},"page":"e1002580","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Variation in MSRA Modifies Risk of Neonatal Intestinal Obstruction in Cystic Fibrosis"],"prefix":"10.1371","volume":"8","author":[{"given":"Lindsay B.","family":"Henderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal K.","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Blackman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda G.","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackob","family":"Moskovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Durie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell L.","family":"Drumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry R.","family":"Cutting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"ref1","first-page":"5121","article-title":"Cystic Fibrosis.","author":"MJ Welsh","year":"2001"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/adc.43.228.178","article-title":"Protein in meconium from meconium ileus.","volume":"43","author":"WH Schutt","year":"1968","journal-title":"Arch Dis Child"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/pd.1970060409","article-title":"Biochemical analysis of meconium in fetuses presumed to have cystic fibrosis.","volume":"6","author":"DJ Brock","year":"1986","journal-title":"Prenat Diagn"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF01535750","article-title":"Protease inhibitor and defective proteolysis in cystic fibrosis.","volume":"33","author":"MC Hsieh","year":"1988","journal-title":"Dig Dis Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1183\/09031936.01.00053701","article-title":"The impact of meconium ileus on the clinical course of children with cystic fibrosis.","volume":"18","author":"AK Evans","year":"2001","journal-title":"Eur Respir J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/aje\/kwh083","article-title":"Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosis.","volume":"159","author":"HJ Lai","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/ppul.21119","article-title":"Long-term pulmonary outcome after meconium ileus in cystic fibrosis.","volume":"44","author":"M Kappler","year":"2009","journal-title":"Pediatr Pulmonol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1542\/peds.37.5.833","article-title":"A review of 164 children with meconium ileus seen at the Children&apos;s Hospital Medical Center, Boston.","volume":"37","author":"AB Donnison","year":"1966","journal-title":"Pediatrics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00442105","article-title":"Familial occurence of meconium ileus.","volume":"135","author":"JR Allan","year":"1981","journal-title":"Eur J Ped"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0022-3476(89)80134-9","article-title":"Clinical and genetic comparisons of patients with cystic fibrosis, with or without meconium ileus.","volume":"114","author":"E Kerem","year":"1989","journal-title":"J Pediatr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ppul.20111","article-title":"Familial concordance of phenotype and microbial variation among siblings with CF.","volume":"38","author":"E Picard","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1053\/j.gastro.2006.07.016","article-title":"Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis.","volume":"131","author":"SM Blackman","year":"2006","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.2570460","article-title":"Identification of the cystic fibrosis gene: genetic analysis.","volume":"245","author":"B Kerem","year":"1989","journal-title":"Science"},{"key":"ref14","first-page":"1178","article-title":"Genetic determination of exocrine pancreatic function in cystic fibrosis.","volume":"50","author":"P Kristidis","year":"1992","journal-title":"Am J Hum Genet"},{"key":"ref15","first-page":"245","article-title":"Cystic fibrosis patients bearing the common missense mutation Gly-&gt;Asp at codon 551 and the deltaF508 are indistinguishable from deltaF508 homozygotes except for decreased risk of meconium ileus.","volume":"51","author":"A Hamosh","year":"1992","journal-title":"Am J Hum Genet"},{"key":"ref16","first-page":"147","article-title":"Genetic comparisons of patients with cystic fibrosis with or without meconium ileus. Clinical Centers of the French CF Registry.","volume":"42","author":"J Feingold","year":"1999","journal-title":"Ann Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.257.5073.1083","article-title":"An animal model for cystic fibrosis made by gene targeting.","volume":"257","author":"JN Snouwaert","year":"1992","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/ng0593-35","article-title":"Production of a severe cystic fibrosis mutation in mice by gene targeting.","volume":"4","author":"R Ratcliff","year":"1993","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng0396-280","article-title":"Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor.","volume":"12","author":"R Rozmahel","year":"1996","journal-title":"Nature Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MPG.0b013e3181a6e01d","article-title":"Defining DIOS and constipation in cystic fibrosis with a multicentre study on the incidence, characteristics, and treatment of DIOS.","volume":"50","author":"RH Houwen","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/S1569-1993(11)60005-2","article-title":"Guidelines for the diagnosis and management of distal intestinal obstruction syndrome in cystic fibrosis patients.","volume":"10","author":"C Colombo","year":"2011","journal-title":"J Cyst Fibros"},{"key":"ref22","first-page":"S193","article-title":"Pathophysiology of gene-targeted mouse models for cystic fibrosis.","volume":"79","author":"BR Grubb","year":"1999","journal-title":"APS Conf"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/359211a0","article-title":"Cystic fibrosis in the mouse by targeted insertional mutagenesis.","volume":"359","author":"JR Dorin","year":"1992","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/ng0895-445","article-title":"Generation and characterization of a deltaF508 cystic fibrosis mouse model.","volume":"10","author":"WH Colledge","year":"1995","journal-title":"Nature Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF00369314","article-title":"Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type CFTR gene expression.","volume":"5","author":"JR Dorin","year":"1994","journal-title":"Mamm Genome"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1002\/j.1460-2075.1995.tb00119.x","article-title":"A mouse model for the cystic fibrosis deltaF508 mutation.","volume":"14","author":"JH van Doorninck","year":"1995","journal-title":"EMBO J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/j.1460-2075.1996.tb00432.x","article-title":"Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.","volume":"15","author":"SJ Delaney","year":"1996","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1008915026660","article-title":"Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting.","volume":"9","author":"P Dickinson","year":"2000","journal-title":"Transgenic Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"G886","DOI":"10.1152\/ajpgi.90520.2008","article-title":"Reduced NHE3-mediated Na+ absorption increases survival and decreases the incidence of intestinal obstructions in cystic fibrosis mice.","volume":"296","author":"EM Bradford","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1172\/JCI3820","article-title":"Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus.","volume":"102","author":"RR Parmley","year":"1998","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1053\/j.gastro.2007.10.007","article-title":"Amelioration of cystic fibrosis intestinal mucous disease in mice by restoration of mCLCA3.","volume":"133","author":"FD Young","year":"2007","journal-title":"Gastroenterology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1172\/JCI43052","article-title":"Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.","volume":"120","author":"X Sun","year":"2010","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2353\/ajpath.2010.090849","article-title":"Pathology of gastrointestinal organs in a porcine model of cystic fibrosis.","volume":"176","author":"DK Meyerholz","year":"2010","journal-title":"Am J Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/ng.838","article-title":"Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.","volume":"43","author":"FA Wright","year":"2011","journal-title":"Nature Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/gepi.209","article-title":"On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations.","volume":"23","author":"C Lange","year":"2002","journal-title":"Genet Epidemiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1093\/hmg\/ddn123","article-title":"Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis.","volume":"17","author":"LA Bremer","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e5639","DOI":"10.1371\/journal.pone.0005639","article-title":"Failure to replicate a genetic association may provide important clues about genetic architecture.","volume":"4","author":"CS Greene","year":"2009","journal-title":"PLoS ONE"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ng.707","article-title":"Fine-mapping at three loci known to affect fetal hemoglobin levels explains addtional genetic variation.","volume":"42","author":"G Galarneau","year":"2010","journal-title":"Nature Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1093\/hmg\/ddr328","article-title":"Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.","volume":"20","author":"AR Wood","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00439-009-0724-8","article-title":"Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results.","volume":"126","author":"R Dorfman","year":"2009","journal-title":"Hum Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/01.GIM.0000139506.11694.7C","article-title":"Cystic fibrosis population carrier screening: 2004 revision of American College of Medical Genetics mutation panel.","volume":"6","author":"MS Watson","year":"2004","journal-title":"Genet Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/sim.1040","article-title":"Advanced methods in meta-analysis: multivariate approach and meta-regression.","volume":"21","author":"HC van Houwelingen","year":"2002","journal-title":"Stat Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1016\/S1569-1993(11)60020-9","article-title":"Mouse models of cystic fibrosis: Phenotypic analysis and research applications.","volume":"10","author":"M Wilke","year":"2011","journal-title":"Journal of Cystic Fibrosis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"L944","DOI":"10.1152\/ajplung.00387.2003","article-title":"Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice.","volume":"287","author":"AM Van Heeckeren","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/362160a0","article-title":"Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties.","volume":"362","author":"DN Sheppard","year":"1993","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000154705","article-title":"Transmembrane mutations alter the channels characteristics of the cystic fibrosis transmembrane conductance regulator expressed in <italic>Xenopus<\/italic> oocytes.","volume":"4","author":"TP Carroll","year":"1994","journal-title":"Cell Physiol Biochem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1056\/NEJM199310283291804","article-title":"Correlation between Genotype and Phenotype in Patients with Cystic Fibrosis.","volume":"329","year":"1993","journal-title":"N Engl J Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/dvg.20433","article-title":"Generation of a conditional null allele for Cftr in mice.","volume":"46","author":"CA Hodges","year":"2008","journal-title":"Genesis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/9635","article-title":"Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13.","volume":"22","author":"J Zielenski","year":"1999","journal-title":"Nature Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2156-6-29","article-title":"Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.","volume":"6","author":"O Norkina","year":"2005","journal-title":"BMC Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"12920","DOI":"10.1073\/pnas.231472998","article-title":"Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.","volume":"98","author":"J Moskovitz","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MPG.0b013e3181afce6c","article-title":"Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.","volume":"50","author":"HP van der Doef","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1096\/fasebj.2.10.2838365","article-title":"Altered intestinal chloride transport in cystic fibrosis.","volume":"2","author":"HM Berschneider","year":"1988","journal-title":"FASEB J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/gut.29.7.957","article-title":"Failure to induce secretion in jejunal biopsies from children with cystic fibrosis.","volume":"29","author":"CJ Taylor","year":"1988","journal-title":"Gut"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1542\/peds.21.4.635","article-title":"Studies in cystic fibrosis of the pancreas; protein pattern in meconium ileus.","volume":"21","author":"MN Green","year":"1958","journal-title":"Pediatrics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/hmg\/2.10.1561","article-title":"A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus.","volume":"2","author":"WK O'Neal","year":"1993","journal-title":"Hum Mol Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0070-2153(07)80003-2","article-title":"Substrates of the methionine sulfoxide reductase system and their physiological relevance.","volume":"80","author":"DB Oien","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0014-5793(99)00917-5","article-title":"Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA).","volume":"456","author":"L Kuschel","year":"1999","journal-title":"FEBS Lett"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1073\/pnas.93.5.2095","article-title":"Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.","volume":"93","author":"J Moskovitz","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1073\/pnas.93.8.3205","article-title":"Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.","volume":"93","author":"J Moskovitz","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbapap.2004.10.004","article-title":"Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.","volume":"1703","author":"H Weissbach","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-3476(98)70344-0","article-title":"The diagnosis of cystic fibrosis: A consensus statement.","volume":"132","author":"BJ Rosenstein","year":"1998","journal-title":"J Pediatr"},{"key":"ref63","first-page":"307","article-title":"Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American Black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene.","volume":"44","author":"GR Cutting","year":"1989","journal-title":"Am J Med Genet"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/clinchem\/48.7.1121","article-title":"Development and Evaluation of a PCR-based, Line Probe Assay for the Detection of 58 Alleles in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene.","volume":"48","author":"X Wang","year":"2002","journal-title":"Clin Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1056\/NEJMoa011899","article-title":"Variant cystic fibrosis phenotypes in the absence of CFTR mutations.","volume":"347","author":"JD Groman","year":"2002","journal-title":"N Engl J Med"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps.","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1086\/381563","article-title":"PBAT: tools for family-based association studies.","volume":"74","author":"C Lange","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.0006-341X.2000.00645.x","article-title":"A note on robust variance estimation for cluster-correlated data.","volume":"56","author":"RL Williams","year":"2000","journal-title":"Biometrics"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1002580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T12:30:38Z","timestamp":1641213038000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1002580"}},"subtitle":[],"editor":[{"given":"Marshall S.","family":"Horwitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,15]]},"references-count":68,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1002580","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717598020.793052934","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,15]]}}}