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J"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.toxlet.2010.04.013","article-title":"Mitochondria, reactive oxygen species and cadmium toxicity in the kidney.","volume":"198","author":"G Gobe","year":"2010","journal-title":"Toxicol Lett"},{"issue":"23","key":"ref15","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1242\/dev.125.23.4655","article-title":"Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function.","volume":"125","author":"IA Drummond","year":"1998","journal-title":"Development"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ydbio.2005.06.038","article-title":"Organization of the pronephric filtration apparatus in zebrafish requires nephrin, podocin and the FERM domain protein mosaic eyes.","volume":"285","author":"AG Kramer-Zucker","year":"2005","journal-title":"Dev Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1371\/journal.pgen.0030189","article-title":"The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros.","volume":"3","author":"RA Wingert","year":"2007","journal-title":"PLoS Genet"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1074\/jbc.M805996200","article-title":"Characterization of an evolutionarily conserved metallophosphoesterase that is expressed in the fetal brain and associated with the WAGR syndrome.","volume":"284","author":"R Tyagi","year":"2009","journal-title":"J Biol Chem"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1006\/geno.1995.9973","article-title":"cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.","volume":"29","author":"F Schwartz","year":"1995","journal-title":"Genomics"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1681\/ASN.2010060598","article-title":"CUBN is a gene locus for albuminuria.","volume":"22","author":"CA Boger","year":"2011","journal-title":"J Am Soc Nephrol"},{"issue":"7367","key":"ref21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10405","article-title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","volume":"478","author":"GB Ehret","year":"2011","journal-title":"Nature"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng.784","article-title":"Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","volume":"43","author":"H Schunkert","year":"2011","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2350-11-41","article-title":"A meta-analysis of genome-wide data from five european isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.","volume":"11","author":"C Pattaro","year":"2010","journal-title":"BMC Med Genet"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.291.7.844","article-title":"Predictors of new-onset kidney disease in a community-based population.","volume":"291","author":"CS Fox","year":"2004","journal-title":"JAMA"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1053\/ajkd.2002.32765","article-title":"Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate.","volume":"39","author":"J Coresh","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. modification of diet in renal disease study group.","volume":"130","author":"AS Levey","year":"1999","journal-title":"Ann Intern Med"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/j.ajkd.2007.11.018","article-title":"Estimating GFR using serum cystatin C alone and in combination with serum creatinine: A pooled analysis of 3,418 individuals with CKD.","volume":"51","author":"LA Stevens","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"ref28","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification.","volume":"39","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"ref29","article-title":"GWAtoolbox: An R package for fast quality control and handling of GWAS meta-analysis data.","author":"C Fuchsberger","year":"2011","journal-title":"Bioinformatics"},{"issue":"17","key":"ref30","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: Fast and efficient meta-analysis of genomewide association scans.","volume":"26","author":"CJ Willer","year":"2010","journal-title":"Bioinformatics"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies.","volume":"55","author":"B Devlin","year":"1999","journal-title":"Biometrics"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/gepi.20303","article-title":"Estimation of the multiple testing burden for genomewide association studies of nearly all common variants.","volume":"32","author":"I Pe'er","year":"2008","journal-title":"Genet Epidemiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/0049124183012001003","article-title":"Comparing regression coefficients across subsamples.","volume":"12","author":"A Cohen","year":"1983","journal-title":"Sociol Methods Res"},{"issue":"16","key":"ref34","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies.","volume":"100","author":"JD Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7414","key":"ref35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses.","volume":"327","author":"JP Higgins","year":"2003","journal-title":"BMJ"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ng2119","article-title":"Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes.","volume":"39","author":"HH Goring","year":"2007","journal-title":"Nat Genet"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng.495","article-title":"Geographical genomics of human leukocyte gene expression variation in southern morocco.","volume":"42","author":"Y Idaghdour","year":"2010","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-8794-2-1","article-title":"Complex nature of SNP genotype effects on gene expression in primary human leucocytes.","volume":"2","author":"GA Heap","year":"2009","journal-title":"BMC Med Genomics"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ng2109","article-title":"A genome-wide association study of global gene expression.","volume":"39","author":"AL Dixon","year":"2007","journal-title":"Nat Genet"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng2142","article-title":"Population genomics of human gene expression.","volume":"39","author":"BE Stranger","year":"2007","journal-title":"Nat Genet"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ng.2007.57","article-title":"Genome-wide analysis of transcript isoform variation in humans.","volume":"40","author":"T Kwan","year":"2008","journal-title":"Nat Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1371\/journal.pbio.1000001","article-title":"Tissue-specific genetic control of splicing: Implications for the study of complex traits.","volume":"6","author":"EL Heinzen","year":"2008","journal-title":"PLoS Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e10693","DOI":"10.1371\/journal.pone.0010693","article-title":"Genetics and beyond\u2014the transcriptome of human monocytes and disease susceptibility.","volume":"5","author":"T Zeller","year":"2010","journal-title":"PLoS ONE"},{"issue":"7186","key":"ref44","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature06758","article-title":"Genetics of gene expression and its effect on disease.","volume":"452","author":"V Emilsson","year":"2008","journal-title":"Nature"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1101\/gr.112821.110","article-title":"A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort.","volume":"21","author":"DM Greenawalt","year":"2011","journal-title":"Genome Res"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2009.03.011","article-title":"Genetic control of human brain transcript expression in alzheimer disease.","volume":"84","author":"JA Webster","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.pbio.0060107","article-title":"Mapping the genetic architecture of gene expression in human liver.","volume":"6","author":"EE Schadt","year":"2008","journal-title":"PLoS Biol"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1101\/gr.095224.109","article-title":"Population genomics in a disease targeted primary cell model.","volume":"19","author":"E Grundberg","year":"2009","journal-title":"Genome Res"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ajhg.2010.10.024","article-title":"Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals.","volume":"87","author":"J Ding","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"5945","key":"ref50","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1174148","article-title":"Common regulatory variation impacts gene expression in a cell type-dependent manner.","volume":"325","author":"AS Dimas","year":"2009","journal-title":"Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.1371\/journal.pbio.0020427","article-title":"A transcriptional profile of aging in the human kidney.","volume":"2","author":"GE Rodwell","year":"2004","journal-title":"PLoS Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e1000685","DOI":"10.1371\/journal.pgen.1000685","article-title":"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.","volume":"5","author":"HE Wheeler","year":"2009","journal-title":"PLoS 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