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Doniach","year":"1984","journal-title":"Dev Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/genetics\/114.1.15","article-title":"Sex determination in the nematode <italic>C. elegans<\/italic>: analysis of <italic>tra-3<\/italic> suppressors and characterization of <italic>fem<\/italic> genes.","volume":"114","author":"J Hodgkin","year":"1986","journal-title":"Genetics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ydbio.2009.06.044","article-title":"Regulation of sperm gene expression by the GATA factor ELT-1.","volume":"333","author":"A del Castillo-Olivares","year":"2009","journal-title":"Dev Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1101\/gad.11.13.1651","article-title":"ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in <italic>Caenorhabditis elegans<\/italic>.","volume":"11","author":"BD Page","year":"1997","journal-title":"Genes 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Miller","year":"2001","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1107\/S0907444904017846","article-title":"Structure of sperm-specific protein SSP-19 from <italic>Caenorhabditis elegans<\/italic>.","volume":"60","author":"N Schormann","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1091\/mbc.E09-03-0240","article-title":"Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of <italic>Ascaris<\/italic> sperm.","volume":"20","author":"K Yi","year":"2009","journal-title":"Mol Biol Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/genetics\/88.2.285","article-title":"Characterization of temperature-sensitive, fertilization-defective mutants of the nematode <italic>Caenorhabditis 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phosphorylation.","volume":"2","author":"R Visintin","year":"1998","journal-title":"Mol Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1210\/mend.14.7.0494","article-title":"Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins.","volume":"14","author":"S Kaul","year":"2000","journal-title":"Mol Endocrinol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2009.12.030","article-title":"Aire&apos;s partners in the molecular control of immunological tolerance.","volume":"140","author":"J Abramson","year":"2010","journal-title":"Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1073\/pnas.95.13.7322","article-title":"Chromatin components as part of a putative transcriptional repressing complex.","volume":"95","author":"N Lehming","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1073\/pnas.95.13.7316","article-title":"Interaction of SP100 with PH1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.","volume":"95","author":"JS Seeler","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1101\/gad.1812609","article-title":"The SAND domain protein ULTRAPETALA1 acts as a trithorax group factor to regulate cell fate in plants.","volume":"23","author":"CC Carles","year":"2009","journal-title":"Genes Dev"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1101\/gr.2639304","article-title":"A phylogeny of <italic>Caenorhabditis<\/italic> reveals frequent loss of introns during nematode evolution.","volume":"14","author":"S Cho","year":"2004","journal-title":"Genome Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1073\/pnas.0403094101","article-title":"<italic>Caenorhabditis<\/italic> phylogeny predicts convergence of hermaphroditism and extensive intron loss.","volume":"101","author":"K Kiontke","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1371\/journal.pbio.0030006","article-title":"<italic>fog-2<\/italic> and the evolution of self-fertile hermaphroditism in <italic>Caenorhabditis<\/italic>.","volume":"3","author":"S Nayak","year":"2005","journal-title":"PLoS Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.cub.2009.09.042","article-title":"Independent recruitment of F box genes to regulate hermaphrodite development during nematode evolution.","volume":"19","author":"Y Guo","year":"2009","journal-title":"Curr 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Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in <italic>C. elegans<\/italic>: extrachromosomal maintenance and integration of transforming sequences.","volume":"10","author":"CC Mello","year":"1991","journal-title":"EMBO J"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/genetics\/146.1.227","article-title":"Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis <italic>elegans<\/italic> gene.","volume":"146","author":"WG Kelly","year":"1997","journal-title":"Genetics"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(93)90498-F","article-title":"Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.","volume":"75","author":"J Gyuris","year":"1993","journal-title":"Cell"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1083\/jcb.119.1.55","article-title":"Mutation of a putative sperm membrane protein in <italic>Caenorhabditis elegans<\/italic> prevents sperm differentiation but not its associated meiotic divisions.","volume":"119","author":"SW L'Hernault","year":"1992","journal-title":"J Cell Biol"},{"key":"ref79","article-title":"Methods in Yeast Genetics: A Laboratory Course Manual","author":"MD Rose","year":"1990"},{"key":"ref80","article-title":"RNA <italic>in situ<\/italic> hybridization of dissected gonads.","author":"MH Lee","year":"2006"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0.","volume":"23","author":"MA Larkin","year":"2007","journal-title":"Bioinformatics"}],"container-title":["PLoS 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