{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:18:52Z","timestamp":1791105532750,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1003109","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T22:04:21Z","timestamp":1359065061000},"page":"e1003109","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left\u2013Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry"],"prefix":"10.1371","volume":"9","author":[{"given":"Kari F.","family":"Lenhart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia G.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D.","family":"Burdine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1101\/gad.14.7.763","article-title":"Conserved and divergent mechanisms in left-right axis formation","volume":"14","author":"RD Burdine","year":"2000","journal-title":"Genes Dev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1242\/dev.000166","article-title":"Nodal signaling: developmental roles and regulation","volume":"134","author":"MM Shen","year":"2007","journal-title":"Development"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.07.038","article-title":"Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination","volume":"288","author":"AF Ramsdell","year":"2005","journal-title":"Dev Biol"},{"key":"ref4","article-title":"Human Heterotaxy Syndrome","author":"I Shiraishi","year":"2012","journal-title":"Circ J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"H2102","DOI":"10.1152\/ajpheart.01118.2011","article-title":"Congenital heart disease and the specification of left-right asymmetry","volume":"302","author":"RJ Francis","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.genom.4.070802.110428","article-title":"Genetics of human laterality disorders: insights from vertebrate model systems","volume":"4","author":"BW Bisgrove","year":"2003","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/bdra.20785","article-title":"BMP signaling in congenital heart disease: New developments and future directions","volume":"91","author":"J Wang","year":"2011","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1084952102001040","article-title":"Cardiac development in zebrafish: coordination of form and function","volume":"13","author":"NS Glickman","year":"2002","journal-title":"Semin Cell Dev Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"13924","DOI":"10.1073\/pnas.0802159105","article-title":"Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart","volume":"105","author":"K Baker","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1002\/dvdy.21777","article-title":"Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish","volume":"237","author":"MI de Campos-Baptista","year":"2008","journal-title":"Dev Dyn"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1161\/CIRCRESAHA.107.165241","article-title":"Asymmetric involution of the myocardial field drives heart tube formation in zebrafish","volume":"102","author":"S Rohr","year":"2008","journal-title":"Circ Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.devcel.2007.11.015","article-title":"Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells","volume":"14","author":"KA Smith","year":"2008","journal-title":"Dev Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1242\/dev.124.21.4373","article-title":"Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish","volume":"124","author":"JN Chen","year":"1997","journal-title":"Development"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ydbio.2007.03.001","article-title":"Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points","volume":"305","author":"S Chocron","year":"2007","journal-title":"Dev Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cub.2004.04.002","article-title":"The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry","volume":"14","author":"JD Amack","year":"2004","journal-title":"Curr Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1124\/mol.65.3.744","article-title":"SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7","volume":"65","author":"S DaCosta Byfield","year":"2004","journal-title":"Mol Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ydbio.2007.07.010","article-title":"The role of maternal Activin-like signals in zebrafish embryos","volume":"309","author":"EG Hagos","year":"2007","journal-title":"Dev Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1101\/gad.13.19.2527","article-title":"Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation","volume":"13","author":"YT Yan","year":"1999","journal-title":"Genes Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/dbio.1999.9214","article-title":"Regulation of left-right asymmetries in the zebrafish by Shh and BMP4","volume":"210","author":"TF Schilling","year":"1999","journal-title":"Dev Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1242\/dev.071092","article-title":"Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish","volume":"138","author":"KF Lenhart","year":"2011","journal-title":"Development"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1101\/gad.1682108","article-title":"BMP\/SMAD1 signaling sets a threshold for the left\/right pathway in lateral plate mesoderm and limits availability of SMAD4","volume":"22","author":"MB Furtado","year":"2008","journal-title":"Genes Dev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1242\/dev.02087","article-title":"Cellular and molecular analyses of vascular tube and lumen formation in zebrafish","volume":"132","author":"SW Jin","year":"2005","journal-title":"Development"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1242\/dev.126.14.3253","article-title":"Regulation of midline development by antagonism of lefty and nodal signaling","volume":"126","author":"BW Bisgrove","year":"1999","journal-title":"Development"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1242\/dev.127.16.3567","article-title":"Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry","volume":"127","author":"BW Bisgrove","year":"2000","journal-title":"Development"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1242\/dev.126.2.229","article-title":"Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction","volume":"126","author":"C Thisse","year":"1999","journal-title":"Development"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1242\/dev.02857","article-title":"Endocardium is necessary for cardiomyocyte movement during heart tube assembly","volume":"134","author":"NG Holtzman","year":"2007","journal-title":"Development"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1242\/dev.064261","article-title":"The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis","volume":"138","author":"R Totong","year":"2011","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1002072","DOI":"10.1371\/journal.pgen.1002072","article-title":"Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin","volume":"7","author":"CE Slagle","year":"2011","journal-title":"PLoS Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ydbio.2007.01.023","article-title":"FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish","volume":"304","author":"J Choi","year":"2007","journal-title":"Dev Biol"},{"key":"ref30","article-title":"Retinoic acid signaling sequentially controls visceral and heart laterality in Zebrafish","author":"S Huang","year":"2011","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.devcel.2008.01.004","article-title":"Genome-wide identification of Smad\/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development","volume":"14","author":"C Silvestri","year":"2008","journal-title":"Dev Cell"},{"key":"ref32","first-page":"141","article-title":"Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts","volume":"8","author":"S Pittlik","year":"2008","journal-title":"Gene Expr\/Patterns"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/dvdy.10356","article-title":"Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish","volume":"228","author":"CJ Huang","year":"2003","journal-title":"Dev Dyn"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1242\/dev.00436","article-title":"The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry","volume":"130","author":"S Long","year":"2003","journal-title":"Development"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/79951","article-title":"Effective targeted gene \u2018knockdown\u2019 in zebrafish","volume":"26","author":"A Nasevicius","year":"2000","journal-title":"Nat Genet"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1003109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T19:23:45Z","timestamp":1644175425000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1003109"}},"subtitle":[],"editor":[{"given":"Mary C.","family":"Mullins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1003109","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,24]]}}}