{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:05:56Z","timestamp":1787241956899,"version":"build-2736575974"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T00:00:00Z","timestamp":1360195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1003248","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T17:34:50Z","timestamp":1360258490000},"page":"e1003248","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["Complex Inheritance of Melanoma and Pigmentation of Coat and Skin in Grey Horses"],"prefix":"10.1371","volume":"9","author":[{"given":"Ino","family":"Curik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Druml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Seltenhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerli Rosengren","family":"Pielberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"S\u00f6lkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrg2554","article-title":"Human genetic variation and its contribution to complex traits","volume":"10","author":"KA Frazer","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrg2612","article-title":"The genetics of quantitative traits: challenges and prospects","volume":"10","author":"TFC Mackay","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrg2575","article-title":"Mapping genes for complex traits in domestic animals and their use in breeding programs","volume":"10","author":"ME Goddard","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1101\/gr.086660.108","article-title":"Genetic architecture of quantitative traits in mice, flies, and humans","volume":"19","author":"J Flint","year":"2009","journal-title":"Genome Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng.608","article-title":"Common SNPs explain a large proportion of the heritability for human height","volume":"42","author":"J Yang","year":"2010","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/gb-2012-13-4-244","article-title":"Genetic architecture of body size in mammals","volume":"13","author":"KE Kemper","year":"2012","journal-title":"Genome Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1093\/hmg\/dds332","article-title":"Understanding and predicting complex traits: knowledge from cattle","volume":"21","author":"KE Kemper","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ng.185","article-title":"A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse","volume":"40","author":"RG Pielberg","year":"2008","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1755-148X.2011.00902.x","article-title":"Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses","volume":"25","author":"E Sundstr\u00f6m","year":"2012","journal-title":"Pigm Cell Mel Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/1471-2164-13-365","article-title":"Copy number expansion of the STX17 duplication in melanoma tissue from Grey horses","volume":"13","author":"E Sundstr\u00f6m","year":"2012","journal-title":"BMC Genomics"},{"key":"ref11","unstructured":"Sponenberg DP (2003) Equine Color Genetics. Ames and London: Iowa State University Press\/Blackwell. 215 p."},{"key":"ref12","unstructured":"Curik I, Seltenhammer M, S\u00f6lkner J (2002) Quantitative genetic analysis of melanoma and grey level in Lipizzan horses. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, CD-ROM: Communication No. 05-09, August 19\u201323, Monpellier, France."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.2527\/jas.2005-704","article-title":"Quantitative genetic aspects of coat color in horses","volume":"84","author":"Z Toth","year":"2006","journal-title":"J Anim Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/030098589102800503","article-title":"Congenital and acquired melanocytomas (benign melanomas) in Eighteen Young Horses","volume":"28","author":"GL Foley","year":"1991","journal-title":"Vet Pathol"},{"key":"ref15","unstructured":"Pulley LT, Stannard AA (1990) Tumors of the skin and soft tissues. In: Moulton JE, editor. Tumors in domestic animals. Berkeley: University California Press. pp. 75\u201382."},{"key":"ref16","first-page":"446","article-title":"Melanoma in the grey horse: The darker side of equine aging","volume":"81","author":"S Gorham","year":"1986","journal-title":"Vet Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1439-0442.1980.tb01667.x","article-title":"Polyamin- und Hisatmingehalt im Blut von pigmentierten, depigmentierten und melanomtragenden Lipizzanerpferden","volume":"27","author":"H Desser","year":"1980","journal-title":"Zbl Vet Med, Reihe A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1034\/j.1600-0749.2000.130109.x","article-title":"The study of cutaneous melanomas in Camargue-type gray-skinned horses (2): Epidemiological survey","volume":"13","author":"C Fleury","year":"2000","journal-title":"Pigment Cell Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1939-1676.1995.tb01087.x","article-title":"Equine melanotic tumors: A retrospective study of 53 Horses (1988\u20131991)","volume":"9","author":"BA Valentine","year":"1995","journal-title":"J Vet Int Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1439-0388.2000x.00245.x","article-title":"A comparative genetic approach for the investigation of aging grey horse melanoma","volume":"117","author":"S Rieder","year":"2000","journal-title":"J Anim Breed Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2746\/042516403776114234","article-title":"Equine melanoma in a population of 296 grey Lipizzan horses","volume":"35","author":"MH Seltenhammer","year":"2003","journal-title":"Equine Vet J"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Hann SK, Nordlund JJ (2000) Vitiligo. Oxford: Blackwell Science. 320 p.","DOI":"10.1002\/9780470760116"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2005.10.001","article-title":"Physiopathology and genetics of vitiligo","volume":"25","author":"T Passeron","year":"2005","journal-title":"J Autoimm"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jdermsci.2005.06.004","article-title":"The concept of vitiligo","volume":"39","author":"XJ Zhang","year":"2005","journal-title":"J Dermatol Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/jid.2009.273","article-title":"Fine-mapping of vitiligo susceptibility loci on chromosome 7 and 9 and interactions with NLRP1 (NALP1)","volume":"130","author":"Y Jin","year":"2010","journal-title":"J Invest Dermatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1470-2045(10)70137-6","article-title":"Vitiligo and melanoma-two sides of the same coin?","volume":"11","author":"A Pirisi","year":"2010","journal-title":"Lancet Oncol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/5938","article-title":"A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the <italic>IGF2<\/italic> locus","volume":"21","author":"J-T Jeon","year":"1999","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nature02064","article-title":"A regulatory mutation in <italic>IGF2<\/italic> causes a major QTL effect on muscle growth in the pig","volume":"425","author":"AS Van Laere","year":"2003","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1101\/gr.224202","article-title":"Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition","volume":"12","author":"B Grisart","year":"2002","journal-title":"Genome Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2052.2011.02293.x","article-title":"Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus","volume":"43","author":"M Littlejohn","year":"2012","journal-title":"Anim Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.meatsci.2009.04.010","article-title":"The effects of a mutation in the myostatin gene on meat and carcass quality","volume":"83","author":"P Wiener","year":"2009","journal-title":"Meat Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1001139","DOI":"10.1371\/journal.pgen.1001139","article-title":"Genetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traits","volume":"6","author":"BJ Hayes","year":"2010","journal-title":"PLoS Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000934","DOI":"10.1371\/journal.pgen.1000934","article-title":"Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci","volume":"6","author":"F Liu","year":"2010","journal-title":"PLoS Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.cellbio.24.110707.175302","article-title":"Evolution of coloration patterns","volume":"24","author":"ME Protas","year":"2008","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e1000341","DOI":"10.1371\/journal.pgen.1000341","article-title":"Contrasting mode of evolution at a coat color locus in wild and domestic pigs","volume":"5","author":"M Fang","year":"2009","journal-title":"PLoS Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s003350020017","article-title":"Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)","volume":"12","author":"S Rieder","year":"2001","journal-title":"Mammal Genome"},{"key":"ref37","unstructured":"Gilmour AR, Gogel BJ, Cullis BR, Thompson R (2009) ASReml User Guide Release 3.0, Hemel Hempstead, UK: VSN International Ltd."},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Mrode RA (2005) Linear Models for the Prediction of Animal Breeding Values. Cambridge: CABI Publishing. 344 p.","DOI":"10.1079\/9780851990002.0000"},{"key":"ref39","unstructured":"Falconer DS, Mackay TFC (1996) Introduction to quantitative genetics. Harlow, Essex, UK: Longman Group. 464 p."}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1003248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T17:24:11Z","timestamp":1540315451000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1003248"}},"subtitle":[],"editor":[{"given":"Mike E.","family":"Goddard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1003248","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,7]]}}}