{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:06:12Z","timestamp":1775279172838,"version":"3.50.1"},"reference-count":106,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1003353","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T23:33:28Z","timestamp":1363304008000},"page":"e1003353","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans"],"prefix":"10.1371","volume":"9","author":[{"given":"Shaun E.","family":"Hunter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily F.","family":"Finnegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios G.","family":"Zisoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Lovci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya V.","family":"Melnik-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene W.","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Pasquinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ceb.2012.03.006","article-title":"Small non-coding RNAs mount a silent revolution in gene expression","volume":"24","author":"AP Aalto","year":"2012","journal-title":"Curr Opin in Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"VN Kim","year":"2009","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"J Winter","year":"2009","journal-title":"Nature cell biology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrg2936","article-title":"Gene silencing by microRNAs: contributions of translational repression and mRNA decay","volume":"12","author":"E Huntzinger","year":"2011","journal-title":"Nature reviews Genetics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrg3162","article-title":"MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship","volume":"13","author":"AE Pasquinelli","year":"2012","journal-title":"Nature reviews Genetics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"BJ Reinhart","year":"2000","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1097-2765(00)80245-2","article-title":"The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor","volume":"5","author":"FJ Slack","year":"2000","journal-title":"Molecular cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.6494891","article-title":"Heterochronic mutants of the nematode Caenorhabditis elegans","volume":"226","author":"V Ambros","year":"1984","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1534-5807(03)00127-8","article-title":"The Caenorhabditis elegans hunchback-like gene lin-57\/hbl-1 controls developmental time and is regulated by microRNAs","volume":"4","author":"JE Abrahante","year":"2003","journal-title":"Developmental cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1534-5807(03)00124-2","article-title":"The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target","volume":"4","author":"SY Lin","year":"2003","journal-title":"Developmental cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.devcel.2004.12.019","article-title":"The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans","volume":"8","author":"H Grosshans","year":"2005","journal-title":"Developmental cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"AE Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387038-4.00001-X","article-title":"Let&apos;s make it happen: the role of let-7 microRNA in development","volume":"99","author":"V Mondol","year":"2012","journal-title":"Current topics in developmental biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1677\/ERC-09-0184","article-title":"The role of let-7 in cell differentiation and cancer","volume":"17","author":"B Boyerinas","year":"2010","journal-title":"Endocrine-related cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.tcb.2012.06.001","article-title":"How does Lin28 let-7 control development and disease?","author":"JE Thornton","year":"2012","journal-title":"Trends Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.molcel.2008.09.014","article-title":"Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA","volume":"32","author":"I Heo","year":"2008","journal-title":"Molecular cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1261\/rna.1155108","article-title":"Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing","volume":"14","author":"MA Newman","year":"2008","journal-title":"RNA"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ncb1759","article-title":"A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment","volume":"10","author":"A Rybak","year":"2008","journal-title":"Nature cell biology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1154040","article-title":"Selective blockade of microRNA processing by Lin28","volume":"320","author":"SR Viswanathan","year":"2008","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.cell.2009.08.002","article-title":"TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation","volume":"138","author":"I Heo","year":"2009","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nsmb.1675","article-title":"LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans","volume":"16","author":"NJ Lehrbach","year":"2009","journal-title":"Nature structural & molecular biology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2011.10.039","article-title":"Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms","volume":"147","author":"E Piskounova","year":"2011","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nsmb.1986","article-title":"LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans","volume":"18","author":"PM Van Wynsberghe","year":"2011","journal-title":"Nature structural & molecular biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ng.392","article-title":"Lin28 promotes transformation and is associated with advanced human malignancies","volume":"41","author":"SR Viswanathan","year":"2009","journal-title":"Nature genetics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2011.08.033","article-title":"The Lin28\/let-7 axis regulates glucose metabolism","volume":"147","author":"H Zhu","year":"2011","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"21075","DOI":"10.1073\/pnas.1118922109","article-title":"Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs","volume":"108","author":"RJ Frost","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2005.01.014","article-title":"RAS is regulated by the let-7 microRNA family","volume":"120","author":"SM Johnson","year":"2005","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1158\/0008-5472.CAN-07-1083","article-title":"The let-7 microRNA represses cell proliferation pathways in human cells","volume":"67","author":"CD Johnson","year":"2007","journal-title":"Cancer research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1158\/0008-5472.CAN-08-0264","article-title":"Identification of let-7-regulated oncofetal genes","volume":"68","author":"B Boyerinas","year":"2008","journal-title":"Cancer research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"11400","DOI":"10.1073\/pnas.0704372104","article-title":"Let-7 expression defines two differentiation stages of cancer","volume":"104","author":"S Shell","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2007.10.054","article-title":"let-7 regulates self renewal and tumorigenicity of breast cancer cells","volume":"131","author":"F Yu","year":"2007","journal-title":"Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1101\/gad.1540407","article-title":"The tumor suppressor microRNA let-7 represses the HMGA2 oncogene","volume":"21","author":"YS Lee","year":"2007","journal-title":"Genes & development"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","article-title":"Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation","volume":"315","author":"C Mayr","year":"2007","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"759","DOI":"10.4161\/cc.7.6.5834","article-title":"The let-7 microRNA reduces tumor growth in mouse models of lung cancer","volume":"7","author":"A Esquela-Kerscher","year":"2008","journal-title":"Cell cycle"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0712321105","article-title":"Suppression of non-small cell lung tumor development by the let-7 microRNA family","volume":"105","author":"MS Kumar","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","article-title":"MicroRNA targets in Drosophila","volume":"5","author":"AJ Enright","year":"2003","journal-title":"Genome biology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"BP Lewis","year":"2003","journal-title":"Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cub.2006.01.050","article-title":"A genome-wide map of conserved microRNA targets in C. elegans","volume":"16","author":"S Lall","year":"2006","journal-title":"Current biology : CB"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes","volume":"126","author":"KC Miranda","year":"2006","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"M Kertesz","year":"2007","journal-title":"Nature genetics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nmeth.1247","article-title":"mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts","volume":"5","author":"M Hammell","year":"2008","journal-title":"Nature methods"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"DP Bartel","year":"2009","journal-title":"Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2010.06.005","article-title":"Expanding the microRNA targeting code: functional sites with centered pairing","volume":"38","author":"C Shin","year":"2010","journal-title":"Molecular cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1158\/0008-5472.CAN-09-0352","article-title":"New tricks for animal microRNAS: targeting of amino acid coding regions at conserved and nonconserved sites","volume":"69","author":"I Rigoutsos","year":"2009","journal-title":"Cancer research"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"B Wightman","year":"1993","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"RC Lee","year":"1993","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1093\/nar\/gkr330","article-title":"Experimental strategies for microRNA target identification","volume":"39","author":"DW Thomson","year":"2011","journal-title":"Nucleic acids research"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/nmeth1130","article-title":"Using expression profiling data to identify human microRNA targets","volume":"4","author":"JC Huang","year":"2007","journal-title":"Nature methods"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","article-title":"Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs","volume":"433","author":"LP Lim","year":"2005","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1093\/nar\/gkl646","article-title":"Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells","volume":"34","author":"D Schmitter","year":"2006","journal-title":"Nucleic acids research"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1073\/pnas.0511045103","article-title":"Cell-type-specific signatures of microRNAs on target mRNA expression","volume":"103","author":"P Sood","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"D Baek","year":"2008","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"M Selbach","year":"2008","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nmeth.1504","article-title":"A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans","volume":"7","author":"M Jovanovic","year":"2010","journal-title":"Nature methods"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"H Guo","year":"2010","journal-title":"Nature"},{"issue":"12","key":"ref56","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1101\/gr.136515.111","article-title":"Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets","volume":"22","author":"M Stadler","year":"2012","journal-title":"Genome Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4161\/rna.4.2.4640","article-title":"Identification of human microRNA targets from isolated argonaute protein complexes","volume":"4","author":"M Beitzinger","year":"2007","journal-title":"RNA biology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1261\/rna.563707","article-title":"Isolation of microRNA targets by miRNP immunopurification","volume":"13","author":"G Easow","year":"2007","journal-title":"RNA"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e2126","DOI":"10.1371\/journal.pone.0002126","article-title":"Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance","volume":"3","author":"DG Hendrickson","year":"2008","journal-title":"PLoS ONE"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"19291","DOI":"10.1073\/pnas.0709971104","article-title":"A biochemical approach to identifying microRNA targets","volume":"104","author":"FV Karginov","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1261\/rna.1351608","article-title":"Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs","volume":"14","author":"M Landthaler","year":"2008","journal-title":"RNA"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.molcel.2007.09.014","article-title":"Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2","volume":"28","author":"L Zhang","year":"2007","journal-title":"Molecular cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature08170","article-title":"Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps","volume":"460","author":"SW Chi","year":"2009","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2010.03.009","article-title":"Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP","volume":"141","author":"M Hafner","year":"2010","journal-title":"Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nsmb.1991","article-title":"Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs","volume":"18","author":"AK Leung","year":"2011","journal-title":"Nature structural & molecular biology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nsmb.1745","article-title":"Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans","volume":"17","author":"DG Zisoulis","year":"2010","journal-title":"Nature structural & molecular biology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","article-title":"Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation","volume":"122","author":"S Bagga","year":"2005","journal-title":"Cell"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/emboj.2008.275","article-title":"Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins","volume":"28","author":"XC Ding","year":"2009","journal-title":"The EMBO journal"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"BP Lewis","year":"2005","journal-title":"Cell"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1101\/gad.1165404","article-title":"The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3\u2032UTR","volume":"18","author":"MC Vella","year":"2004","journal-title":"Genes & development"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00412-009-0210-z","article-title":"An elegant miRror: microRNAs in stem cells, developmental timing and cancer","volume":"118","author":"RA Nimmo","year":"2009","journal-title":"Chromosoma"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1242\/dev.122.8.2517","article-title":"Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development","volume":"122","author":"JC Bettinger","year":"1996","journal-title":"Development"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1242\/dev.121.8.2491","article-title":"The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans","volume":"121","author":"AE Rougvie","year":"1995","journal-title":"Development"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.4161\/cc.7.19.6778","article-title":"The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation","volume":"7","author":"XC Ding","year":"2008","journal-title":"Cell cycle"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"RS Kamath","year":"2003","journal-title":"Nature"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1101\/gr.2505604","article-title":"Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library","volume":"14","author":"JF Rual","year":"2004","journal-title":"Genome research"},{"key":"ref77","first-page":"1","article-title":"Vulval development","author":"PW Sternberg","year":"2005","journal-title":"WormBook : the online review of C elegans biology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.cell.2005.03.031","article-title":"FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans","volume":"121","author":"DR Sherwood","year":"2005","journal-title":"Cell"},{"key":"ref79","first-page":"125","article-title":"Induced pluripotent cells mimicking human embryonic stem cells","volume":"11","author":"M Mohamadnejad","year":"2008","journal-title":"Archives of Iranian medicine"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"J Yu","year":"2007","journal-title":"Science"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nature07299","article-title":"MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation","volume":"455","author":"Y Tay","year":"2008","journal-title":"Nature"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1242\/dev.02655","article-title":"The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25","volume":"133","author":"GD Hayes","year":"2006","journal-title":"Development"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, Caenorhabditis elegans","volume":"56","author":"JE Sulston","year":"1977","journal-title":"Developmental biology"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1242\/jcs.02678","article-title":"The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion","volume":"118","author":"JA Smith","year":"2005","journal-title":"Journal of cell science"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.devcel.2005.07.009","article-title":"The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans","volume":"9","author":"AL Abbott","year":"2005","journal-title":"Developmental cell"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.1164899","article-title":"Nuclear hormone receptor regulation of microRNAs controls developmental progression","volume":"324","author":"A Bethke","year":"2009","journal-title":"Science"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"18668","DOI":"10.1073\/pnas.0908131106","article-title":"A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans","volume":"106","author":"CM Hammell","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature11134","article-title":"Autoregulation of microRNA biogenesis by let-7 and Argonaute","volume":"486","author":"DG Zisoulis","year":"2012","journal-title":"Nature"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.molmed.2008.07.001","article-title":"let-7 microRNAs in development, stem cells and cancer","volume":"14","author":"I Bussing","year":"2008","journal-title":"Trends in molecular medicine"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ydbio.2009.07.012","article-title":"Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1","volume":"334","author":"SF Roush","year":"2009","journal-title":"Developmental biology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"36739","DOI":"10.1074\/jbc.M403415200","article-title":"Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans","volume":"279","author":"B Meissner","year":"2004","journal-title":"The Journal of biological chemistry"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1074\/jbc.M309528200","article-title":"Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters","volume":"279","author":"E Veljkovic","year":"2004","journal-title":"The Journal of biological chemistry"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.molcel.2008.09.013","article-title":"Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt","volume":"32","author":"K Yamagata","year":"2008","journal-title":"Molecular cell"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"44657","DOI":"10.1074\/jbc.M307351200","article-title":"A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+\/H+ exchanger NHX-2 increases life span","volume":"278","author":"K Nehrke","year":"2003","journal-title":"The Journal of biological chemistry"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"e6279","DOI":"10.1371\/journal.pone.0006279","article-title":"How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans","volume":"4","author":"B Spanier","year":"2009","journal-title":"PLoS ONE"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/dvdy.20572","article-title":"Post-embryonic expression of C. elegans microRNAs belonging to the lin-4 and let-7 families in the hypodermis and the reproductive system","volume":"234","author":"A Esquela-Kerscher","year":"2005","journal-title":"Developmental dynamics : an official publication of the American Association of Anatomists"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0012-1606(03)00202-1","article-title":"The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter","volume":"259","author":"SM Johnson","year":"2003","journal-title":"Developmental biology"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1101\/gr.083055.108","article-title":"Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity","volume":"18","author":"NJ Martinez","year":"2008","journal-title":"Genome research"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0960-9822(01)00294-9","article-title":"Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1","volume":"11","author":"BD Strahl","year":"2001","journal-title":"Current biology : CB"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1060781","article-title":"Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor","volume":"293","author":"H Wang","year":"2001","journal-title":"Science"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cmet.2011.03.017","article-title":"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16","volume":"13","author":"Y Takahashi","year":"2011","journal-title":"Cell metabolism"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"RA Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nature protocols"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"W Huang da","year":"2009","journal-title":"Nucleic acids research"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1371\/journal.pgen.0030085","article-title":"Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements","volume":"3","author":"GW Yeo","year":"2007","journal-title":"PLoS Genet"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1003353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T13:54:23Z","timestamp":1644587663000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1003353"}},"subtitle":[],"editor":[{"given":"Kaveh","family":"Ashrafi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,14]]},"references-count":106,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1003353","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,14]]}}}