{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:11:02Z","timestamp":1781194262287,"version":"3.54.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1003362","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T23:34:24Z","timestamp":1363304064000},"page":"e1003362","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression"],"prefix":"10.1371","volume":"9","author":[{"given":"Marcela","family":"Preininger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Arafat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artika P.","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Idaghdour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Brigham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1371\/journal.pmed.0030374","article-title":"Combining information from common type 2 diabetes risk polymorphisms improves disease prediction","volume":"3","author":"MN Weedon","year":"2006","journal-title":"PLoS Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1056\/NEJMp1006304","article-title":"The path to personalized medicine","volume":"363","author":"MA Hamburg","year":"2010","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1104635","article-title":"Systems biology and new technologies enable predictive and preventative medicine","volume":"306","author":"L Hood","year":"2004","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrg2815","article-title":"Genome-wide allele-specific analysis: insights into regulatory variation","volume":"11","author":"T Pastinen","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-genom-082908-150121","article-title":"Inherited variation in gene expression","volume":"10","author":"DA Skelly","year":"2009","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/1471-2105-9-244","article-title":"Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis","volume":"9","author":"S Biswas","year":"2008","journal-title":"BMC Bioinf"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/bioinformatics\/btl550","article-title":"Inferential, robust non-negative matrix factorization analysis of microarray data","volume":"23","author":"P Fogel","year":"2007","journal-title":"Bioinformatics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"P Langfelder","year":"2008","journal-title":"BMC Bioinf"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1000479","DOI":"10.1371\/journal.pgen.1000479","article-title":"Modulated modularity clustering as an exploratory tool for functional genomic inference","volume":"5","author":"EA Stone","year":"2009","journal-title":"PLoS Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature10110","article-title":"Transcriptomic analysis of autistic brain reveals convergent molecular pathology","volume":"474","author":"I Voineagu","year":"2011","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng.332","article-title":"Systems genetics of complex traits in <italic>Drosophila melanogaster<\/italic>","volume":"41","author":"JF Ayroles","year":"2009","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.immuni.2008.05.012","article-title":"A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus","volume":"29","author":"D Chaussabel","year":"2008","journal-title":"Immunity"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng.495","article-title":"Geographical genomics of human leukocyte gene expression variation in southern Morocco","volume":"42","author":"Y Idaghdour","year":"2010","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e14479","DOI":"10.1371\/journal.pone.0014479","article-title":"Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia","volume":"5","author":"E Mason","year":"2010","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"MP Berry","year":"2010","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-8794-2-1","article-title":"Complex nature of SNP genotype effects on gene expression in primary human leucocytes","volume":"2","author":"GA Heap","year":"2009","journal-title":"BMC Med Genom"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1001113","DOI":"10.1371\/journal.pgen.1001113","article-title":"An immune response network associated with blood lipid levels","volume":"6","author":"M Inouye","year":"2010","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1101\/gr.126540.111","article-title":"Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent","volume":"22","author":"JE Powell","year":"2012","journal-title":"Genome Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene Suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"J Chen","year":"2009","journal-title":"Nucl Acids Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cell.2012.02.009","article-title":"Personal omics profiling reveals dynamic molecular and medical phenotypes","volume":"148","author":"R Chen","year":"2012","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/106652701753307520","article-title":"Assessing gene significance from cDNA microarray expression data via mixed models","volume":"8","author":"RD Wolfinger","year":"2001","journal-title":"J Comput Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1002207","DOI":"10.1371\/journal.pgen.1002207","article-title":"Variance of gene expression identifies altered network constraints in neurological disease","volume":"7","author":"JC Mar","year":"2011","journal-title":"PLoS Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e12262","DOI":"10.1371\/journal.pone.0012262","article-title":"Cancer biomarker discovery: the entropic hallmark","volume":"5","author":"R Berretta","year":"2010","journal-title":"PLoS ONE"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1086\/426461","article-title":"Genetic inheritance of gene expression in human cell lines","volume":"75","author":"SA Monks","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nature02797","article-title":"Genetic analysis of genome-wide variation in human gene expression","volume":"430","author":"M Morley","year":"2004","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1093\/bioinformatics\/btq118","article-title":"Supervised normalization of microarrays","volume":"26","author":"BH Mecham","year":"2010","journal-title":"Bioinformatics"},{"key":"ref27","first-page":"160","article-title":"Effect of normalization on statistical and biological interpretation of gene fxpression profiles","volume":"3","author":"SP Qin","year":"2012","journal-title":"Front Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fgene.2012.00243","article-title":"Using blood informative transcripts in geographical genomics: impact of lifestyle on gene expression in Fijians","volume":"3","author":"A Nath","year":"2012","journal-title":"Front Genet"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1003362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T21:24:25Z","timestamp":1540329865000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1003362"}},"subtitle":[],"editor":[{"given":"Anna","family":"Di Rienzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,14]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1003362","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,14]]}}}