{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:10:45Z","timestamp":1791223845925,"version":"4.1.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1003544","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T22:29:42Z","timestamp":1371767382000},"page":"e1003544","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["The NADPH Metabolic Network Regulates Human \u03b1B-crystallin Cardiomyopathy and Reductive Stress in Drosophila melanogaster"],"prefix":"10.1371","volume":"9","author":[{"given":"Heng B.","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Cammarato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namakkal S.","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Suggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford I.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivor J.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent G.","family":"Golic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/B978-0-08-045031-5.00011-6","article-title":"Myofibrillar myopathies","volume":"101","author":"D Selcen","year":"2011","journal-title":"Handbook of clinical neurology\/edited by PJ Vinken and GW Bruyn"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/1765","article-title":"A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy","volume":"20","author":"P Vicart","year":"1998","journal-title":"Nat Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1172\/JCI38027","article-title":"Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease","volume":"119","author":"LG Goldfarb","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1073\/pnas.96.11.6137","article-title":"Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function","volume":"96","author":"MP Bova","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"33235","DOI":"10.1074\/jbc.274.47.33235","article-title":"The cardiomyopathy and lens cataract mutation in alphaB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro","volume":"274","author":"MD Perng","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/hh1301.092688","article-title":"Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice","volume":"89","author":"X Wang","year":"2001","journal-title":"Circ Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2007.06.044","article-title":"Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice","volume":"130","author":"NS Rajasekaran","year":"2007","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/sj.emboj.7601930","article-title":"The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases","volume":"27","author":"KF Winklhofer","year":"2008","journal-title":"The EMBO Journal"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nchembio.283","article-title":"A causative link between the structure of aberrant protein oligomers and their toxicity","volume":"6","author":"S Campioni","year":"2010","journal-title":"Nature Chemical Biology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention","volume":"319","author":"WE Balch","year":"2008","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1021\/cb1001203","article-title":"ANS binding reveals common features of cytotoxic amyloid species","volume":"5","author":"B Bolognesi","year":"2010","journal-title":"ACS Chemical Biology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/S0033583506004422","article-title":"Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?","volume":"39","author":"HA Lashuel","year":"2006","journal-title":"Quarterly Reviews of Biophysics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis","volume":"300","author":"R Kayed","year":"2003","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10132","DOI":"10.1073\/pnas.0401900101","article-title":"Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis","volume":"101","author":"A Sanbe","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1126\/science.287.5461.2204","article-title":"Comparative genomics of the eukaryotes","volume":"287","author":"GM Rubin","year":"2000","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","article-title":"Gene regulatory networks in the evolution and development of the heart","volume":"313","author":"EN Olson","year":"2006","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e18497","DOI":"10.1371\/journal.pone.0018497","article-title":"A Mighty Small Heart: The Cardiac Proteome of Adult Drosophila melanogaster","volume":"6","author":"A Cammarato","year":"2011","journal-title":"PLoS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cell.2010.02.023","article-title":"A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function","volume":"141","author":"GG Neely","year":"2010","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/hh1001.090857","article-title":"Age-associated cardiac dysfunction in Drosophila melanogaster","volume":"88","author":"G Paternostro","year":"2001","journal-title":"Circ Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1471-4892(02)00206-0","article-title":"Drosophila melanogaster as a model system for drug discovery and pathway screening","volume":"2","author":"S Tickoo","year":"2002","journal-title":"Curr Opin Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2004.07.018","article-title":"Drosophila, an emerging model for cardiac disease","volume":"342","author":"E Bier","year":"2004","journal-title":"Gene"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrg2563","article-title":"Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants","volume":"10","author":"D Lessing","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1161\/CIRCULATIONAHA.105.593541","article-title":"Images in cardiovascular medicine: in vivo imaging of the adult Drosophila melanogaster heart with real-time optical coherence tomography","volume":"114","author":"MA Choma","year":"2006","journal-title":"Circulation"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1073\/pnas.0609278104","article-title":"KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging","volume":"104","author":"K Ocorr","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.mad.2006.11.023","article-title":"Age-related cardiac disease model of Drosophila","volume":"128","author":"K Ocorr","year":"2007","journal-title":"Mech Ageing Dev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"11999","DOI":"10.1073\/pnas.0603098103","article-title":"The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman","volume":"103","author":"T Akasaka","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1073\/pnas.0507359103","article-title":"Drosophila as a model for the identification of genes causing adult human heart disease","volume":"103","author":"MJ Wolf","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1474-9726.2008.00367.x","article-title":"Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype","volume":"7","author":"O Taghli-Lamallem","year":"2008","journal-title":"Aging Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/332853a0","article-title":"GAL4 activates transcription in Drosophila","volume":"332","author":"JA Fischer","year":"1988","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"AH Brand","year":"1993","journal-title":"Development"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"H1220","DOI":"10.1152\/ajpheart.00601.2011","article-title":"Desmin-Related Cardiomyopathy: An Unfolding Story","volume":"301","author":"PM McLendon","year":"2011","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"key":"ref32","first-page":"1435","article-title":"Semi-automated Optical Heartbeat Analysis of Small Hearts","volume":"31","author":"K Ocorr","year":"2009","journal-title":"Journal of Visualized Experiments"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1242\/dev.125.6.1049","article-title":"Systematic gain-of-function genetics in Drosophila","volume":"125","author":"P R\u00f8rth","year":"1998","journal-title":"Development"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.genet.39.110304.095804","article-title":"Drosophila as a model for human neurodegenerative disease","volume":"39","author":"J Bilen","year":"2005","journal-title":"Annu Rev Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.pathol.3.121806.151529","article-title":"Drosophila models of neurodegenerative diseases","volume":"4","author":"B Lu","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0006-291X(80)91150-X","article-title":"Heat shock proteins and thermal resistance in yeast","volume":"93","author":"L McAlister","year":"1980","journal-title":"Biochem Biophys Res Commun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1128\/JB.162.3.1083-1091.1985","article-title":"Heat shock response of Neurospora crassa: protein synthesis and induced thermotolerance","volume":"162","author":"N Plesofsky-Vig","year":"1985","journal-title":"J Bacteriol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"32492","DOI":"10.1074\/jbc.M805832200","article-title":"Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span of Drosophila melanogaster","volume":"283","author":"SK Legan","year":"2008","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/excr.1998.4347","article-title":"Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery","volume":"247","author":"X Preville","year":"1999","journal-title":"Exp Cell Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s10545-008-0704-5","article-title":"Glucose-6-phosphate dehydrogenase deficiency protects against coronary heart disease","volume":"31","author":"L Meloni","year":"2008","journal-title":"J Inherit Metab Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1182\/blood.V91.2.706","article-title":"Mortality in a cohort of men expressing the glucose-6-phosphate dehydrogenase deficiency","volume":"91","author":"P Cocco","year":"1998","journal-title":"Blood"},{"key":"ref42","first-page":"35","article-title":"Associations between red cell glucose-6-phosphate dehydrogenase variants and vascular diseases","volume":"19","author":"WK Long","year":"1967","journal-title":"Am J Hum Genet"},{"key":"ref43","first-page":"252049","article-title":"Effect of alphaB-crystallin on protein aggregation in Drosophila","volume":"2012","author":"NT Tue","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00019052-199710000-00012","article-title":"Desmin-related myopathies","volume":"10","author":"HH Goebel","year":"1997","journal-title":"Curr Opin Neurol"},{"key":"ref45","first-page":"1282","article-title":"Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching","volume":"14","author":"S Song","year":"2008","journal-title":"Mol Vis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","article-title":"The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells","volume":"31","author":"R Moll","year":"1982","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/ars.2007.1672","article-title":"NAD+\/NADH and NADP+\/NADPH in cellular functions and cell death: regulation and biological consequences","volume":"10","author":"W Ying","year":"2008","journal-title":"Antioxidants & redox signaling"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/BF00504310","article-title":"Relationship of the oxidative pentose shunt pathway to lipid synthesis in Drosophila melanogaster","volume":"17","author":"BW Geer","year":"1979","journal-title":"Biochem Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/BF00504309","article-title":"Ontogeny, cell distribution, and the physiological role of NADP-malic enzyme in Drosophila melanogaster","volume":"17","author":"BW Geer","year":"1979","journal-title":"Biochem Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1534\/genetics.109.100677","article-title":"Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster","volume":"182","author":"TJ Merritt","year":"2009","journal-title":"Genetics"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.yjmcc.2010.09.004","article-title":"Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways","volume":"49","author":"H Zhang","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0925-4773(98)00157-9","article-title":"Gal4 in the Drosophila female germline","volume":"78","author":"P Rorth","year":"1998","journal-title":"Mech Dev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.6289436","article-title":"Genetic transformation of Drosophila with transposable element vectors","volume":"218","author":"GM Rubin","year":"1982","journal-title":"Science"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1126\/science.6289435","article-title":"Transposition of cloned P elements into Drosophila germ line chromosomes","volume":"218","author":"AC Spradling","year":"1982","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1073\/pnas.0611511104","article-title":"An optimized transgenesis system for Drosophila using germ-line-specific \u03c6C31 integrases","volume":"104","author":"J Bischof","year":"2006","journal-title":"PNAS"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e10168","DOI":"10.1371\/journal.pone.0010168","article-title":"Splinkerette PCR for Mapping Transposable Elements in Drosophila","volume":"5","author":"CJ Potter","year":"2010","journal-title":"PLoS ONE"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0092-8674(00)81385-9","article-title":"Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye","volume":"87","author":"M Freeman","year":"1996","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nature05954","article-title":"A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila","volume":"448","author":"G Dietzl","year":"2007","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e4216","DOI":"10.1371\/journal.pone.0004216","article-title":"Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for Glaucoma","volume":"4","author":"MA Carbone","year":"2009","journal-title":"PLoS ONE"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1242\/dev.01899","article-title":"Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis","volume":"132","author":"Z Han","year":"2005","journal-title":"Development"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e601","DOI":"10.1371\/journal.pone.0000601","article-title":"Genetic Variation for Cardiac Dysfunction in Drosophila","volume":"2","author":"KA Ocorr","year":"2007","journal-title":"PLoS ONE"},{"key":"ref62","first-page":"1425","article-title":"Visualizing the Beating Heart in Drosophila","volume":"31: pii","author":"G Vogler","year":"2009","journal-title":"J Vis Exp"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2144\/000113078","article-title":"A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts","volume":"46","author":"M Fink","year":"2009","journal-title":"BioTechniques"},{"key":"ref64","first-page":"e1423","article-title":"Fluorescent Labeling of Drosophila Heart Structures","author":"NN Alayari","year":"2009","journal-title":"J Vis Exp"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.freeradbiomed.2011.10.493","article-title":"Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress","volume":"52","author":"PM Scarbrough","year":"2012","journal-title":"Free Radical Biol Med"},{"key":"ref66","unstructured":"Miller A (1950) The Internal Anatomy and Histology of the Imago of Drosophila melanogaster. In: Demerec M, editor. Biology of Drosophila. New York: John Wiley and Sons, Inc. pp. 420\u2013534."}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1003544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T23:41:49Z","timestamp":1645832509000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1003544"}},"subtitle":[],"editor":[{"given":"Bingwei","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":66,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1003544","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]}}}