{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:56:14Z","timestamp":1787021774185,"version":"build-2736575974"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1003785","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T21:34:25Z","timestamp":1379626465000},"page":"e1003785","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["MicroRNA-17-92, a Direct Ap-2\u03b1 Transcriptional Target, Modulates T-Box Factor Activity in Orofacial Clefting"],"prefix":"10.1371","volume":"9","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie B.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Klysik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/ajmg.a.33608","article-title":"Recurrence risk for offspring of twins discordant for oral cleft: a population-based cohort study of the Danish 1936\u20132004 cleft twin cohort","volume":"152A","author":"D Grosen","year":"2010","journal-title":"Am J Med Genet A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/jmg.2009.069385","article-title":"A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance","volume":"47","author":"D Grosen","year":"2010","journal-title":"J Med Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng.580","article-title":"A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4","volume":"42","author":"TH Beaty","year":"2010","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"MJ Dixon","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/ajmg.a.32814","article-title":"Phenotype and 244k array-CGH characterization of chromosome 13q deletions: an update of the phenotypic map of 13q21.1-qter","volume":"149A","author":"M Kirchhoff","year":"2009","journal-title":"Am J Med Genet A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ng.915","article-title":"Germline deletion of the miR-17- 92 cluster causes skeletal and growth defects in humans","volume":"43","author":"L de Pontual","year":"2011","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2008.04.001","article-title":"miRiad roles for the miR-17-92 cluster in development and disease","volume":"133","author":"JT Mendell","year":"2008","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","article-title":"Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters","volume":"132","author":"A Ventura","year":"2008","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.devcel.2010.10.022","article-title":"Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism","volume":"19","author":"J Wang","year":"2010","journal-title":"Dev Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ni1575","article-title":"Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes","volume":"9","author":"C Xiao","year":"2008","journal-title":"Nat Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1242\/dev.01676","article-title":"Distinct functions for Bmp signaling in lip and palate fusion in mice","volume":"132","author":"W Liu","year":"2005","journal-title":"Development"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ajhg.2009.02.002","article-title":"Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip","volume":"84","author":"S Suzuki","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e6049","DOI":"10.1371\/journal.pone.0006049","article-title":"Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner","volume":"4","author":"FG Fulcoli","year":"2009","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1242\/dev.00850","article-title":"Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development","volume":"130","author":"TL Macatee","year":"2003","journal-title":"Development"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Y Chai","year":"2000","journal-title":"Development"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.stem.2012.07.006","article-title":"Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest","volume":"11","author":"A Rada-Iglesias","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1093\/hmg\/dds071","article-title":"Tbx1 regulates oral epithelial adhesion and palatal development","volume":"21","author":"N Funato","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijporl.2012.10.009","article-title":"A candidate gene approach to identify modifiers of the palatal phenotype in 22q11.2 deletion syndrome patients","volume":"77","author":"JC Widdershoven","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejmg.2009.02.008","article-title":"Microduplication 22q11.2: a new chromosomal syndrome","volume":"52","author":"MF Portnoi","year":"2009","journal-title":"Eur J Med Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ddrr.4","article-title":"Genetic modifiers of the physical malformations in velo-cardio-facial syndrome\/DiGeorge syndrome","volume":"14","author":"VS Aggarwal","year":"2008","journal-title":"Dev Disabil Res Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ydbio.2009.09.020","article-title":"Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse","volume":"336","author":"S Zirzow","year":"2009","journal-title":"Dev Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ejmg.2010.12.010","article-title":"The face of Ulnar Mammary syndrome?","volume":"54","author":"S Joss","year":"2011","journal-title":"Eur J Med Genet"},{"key":"ref23","first-page":"285","article-title":"Modulation of cell proliferation during palatogenesis by the interplay between Tbx3 and Bmp4","volume":"327","author":"JM Lee","year":"2007","journal-title":"Cell Tissue Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e398","DOI":"10.1371\/journal.pone.0000398","article-title":"Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling","volume":"2","author":"I Ribeiro","year":"2007","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ydbio.2004.09.010","article-title":"The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice","volume":"277","author":"SR Alappat","year":"2005","journal-title":"Dev Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1172\/JCI20384","article-title":"Disruption of Fgf10\/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate","volume":"113","author":"R Rice","year":"2004","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/ng1757","article-title":"Mutations in different components of FGF signaling in LADD syndrome","volume":"38","author":"E Rohmann","year":"2006","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/dvdy.20833","article-title":"Recent advances in craniofacial morphogenesis","volume":"235","author":"Y Chai","year":"2006","journal-title":"Dev Dyn"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"18603","DOI":"10.1073\/pnas.0609157103","article-title":"Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis","volume":"103","author":"VP Eswarakumar","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/ng.82","article-title":"MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis","volume":"40","author":"JK Eberhart","year":"2008","journal-title":"Nat Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/ng.333","article-title":"Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24","volume":"41","author":"S Birnbaum","year":"2009","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature03677","article-title":"c-Myc-regulated microRNAs modulate E2F1 expression","volume":"435","author":"KA O'Donnell","year":"2005","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/ng1855","article-title":"Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster","volume":"38","author":"M Dews","year":"2006","journal-title":"Nat Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1095\/biolreprod.106.052407","article-title":"Analysis of transcription factor AP-2 expression and function during mouse preimplantation development","volume":"75","author":"Q Winger","year":"2006","journal-title":"Biol Reprod"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/75578","article-title":"Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus","volume":"25","author":"M Satoda","year":"2000","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ydbio.2006.12.042","article-title":"Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos","volume":"304","author":"W Li","year":"2007","journal-title":"Dev Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.242","article-title":"Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip","volume":"40","author":"F Rahimov","year":"2008","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1242\/dev.097360","article-title":"Bmp signaling represses Vegfa to promote outflow tract cushion development","volume":"140","author":"Y Bai","year":"2013","journal-title":"Development"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/dvdy.20441","article-title":"Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform","volume":"234","author":"MB Yaylaoglu","year":"2005","journal-title":"Dev Dyn"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/45797","article-title":"Function of Rieger syndrome gene in left-right asymmetry and craniofacial development","volume":"401","author":"MF Lu","year":"1999","journal-title":"Nature"},{"key":"ref41","first-page":"5466","article-title":"Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways","volume":"58","author":"BC Turner","year":"1998","journal-title":"Cancer Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nature09692","article-title":"A unique chromatin signature uncovers early developmental enhancers in humans","volume":"470","author":"A Rada-Iglesias","year":"2011","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"B Langmead","year":"2009","journal-title":"Genome Biol"}],"updated-by":[{"DOI":"10.1371\/annotation\/90602bc3-5052-49ac-a7fb-33210d7c8b4d","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000}}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1003785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T09:14:39Z","timestamp":1646558079000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1003785"}},"subtitle":[],"editor":[{"given":"Loydie Anne","family":"Jerome-Majewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,19]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1003785","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,19]]}}}