{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:33:32Z","timestamp":1792640012146,"version":"4.5.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004024","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T17:11:30Z","timestamp":1387473090000},"page":"e1004024","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":81,"title":["Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart"],"prefix":"10.1371","volume":"9","author":[{"given":"Girish C.","family":"Melkani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S.","family":"Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Bodmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford I.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ocorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJMra023144","article-title":"Molecular mechanisms of amyloidosis","volume":"349","author":"G Merlini","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-6273(02)00761-4","article-title":"Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?","volume":"35","author":"PJ Muchowski","year":"2002","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.genom.7.080505.115758","article-title":"Of flies and man: <italic>Drosophila<\/italic> as a model for human complex traits","volume":"7","author":"TF Mackay","year":"2006","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399403006549","article-title":"Huntington&apos;s disease: molecular basis of neurodegeneration","volume":"5","author":"DC Rubinsztein","year":"2003","journal-title":"Expert Rev Mol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1534\/genetics.109.112516","article-title":"A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in <italic>Drosophila<\/italic>","volume":"184","author":"S Zhang","year":"2010","journal-title":"Genetics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e23841","DOI":"10.1371\/journal.pone.0023841","article-title":"High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington&apos;s disease model","volume":"6","author":"J Schulte","year":"2011","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"La Spada AR, Weydt P, Pineda VV (2011) Huntington&apos;s Disease Pathogenesis: Mechanisms and Pathways. In: Lo DC, Hughes RE, editors. Neurobiology of Huntington&apos;s Disease: Applications to Drug Discovery. Boca Raton (FL): CRC Press, Chapter 2. Frontiers in Neuroscience.","DOI":"10.1201\/EBK0849390005-c2"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1212\/WNL.38.5.769","article-title":"Huntington&apos;s disease mortality in the United States","volume":"38","author":"DJ Lanska","year":"1988","journal-title":"Neurology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/jmg.29.12.911","article-title":"Causes of death in patients with Huntington&apos;s disease and in unaffected first degree relatives","volume":"29","author":"SA Sorensen","year":"1992","journal-title":"J Med Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.nbd.2006.09.016","article-title":"Cardiac dysfunction in the R6\/2 mouse model of Huntington&apos;s disease","volume":"25","author":"MJ Mihm","year":"2007","journal-title":"Neurobiol Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the brain: widespread pathology in Huntington&apos;s disease","volume":"8","author":"JM van der Burg","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1000772","DOI":"10.1371\/journal.pcbi.1000772","article-title":"Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences","volume":"6","author":"VV Lakhani","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.013","article-title":"Protein aggregates in Huntington&apos;s disease","volume":"238","author":"M Arrasate","year":"2012","journal-title":"Exp Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9982","DOI":"10.1074\/jbc.M111.305417","article-title":"Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay","volume":"287","author":"S Gupta","year":"2012","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/iub.111","article-title":"Protein misfolding inside cells: the case of huntingtin and Huntington&apos;s disease","volume":"60","author":"DM Hatters","year":"2008","journal-title":"IUBMB Life"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/8.5.813","article-title":"Formation of polyglutamine inclusions in non-CNS tissue","volume":"8","author":"K Sathasivam","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e8025","DOI":"10.1371\/journal.pone.0008025","article-title":"Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington&apos;s disease","volume":"4","author":"H Moffitt","year":"2009","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/cr.2010.32","article-title":"Polyglutamine toxicity in non-neuronal cells","volume":"20","author":"JW Bradford","year":"2010","journal-title":"Cell Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/hmg\/ddi192","article-title":"Gene expression in Huntington&apos;s disease skeletal muscle: a potential biomarker","volume":"14","author":"AD Strand","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5694\/j.1326-5377.1982.tb132224.x","article-title":"Causes of death in Huntington&apos;s disease","volume":"1","author":"E Chiu","year":"1982","journal-title":"Med J Aust"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"821","DOI":"10.4161\/auto.6502","article-title":"Protein misfolding and cardiac disease: establishing cause and effect","volume":"4","author":"JS Pattison","year":"2008","journal-title":"Autophagy"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1113\/jphysiol.2012.238113","article-title":"Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington&apos;s disease","volume":"590","author":"H Kiriazis","year":"2012","journal-title":"J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"13592","DOI":"10.1073\/pnas.0503324102","article-title":"Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy","volume":"102","author":"A Sanbe","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/(SICI)1520-6408(1998)22:3<181::AID-DVG1>3.0.CO;2-2","article-title":"Heart development in <italic>Drosophila<\/italic> and vertebrates: conservation of molecular mechanisms","volume":"22","author":"R Bodmer","year":"1998","journal-title":"Dev Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/dbio.2002.0666","article-title":"Control of cardiac development by an evolutionarily conserved transcriptional network","volume":"246","author":"RM Cripps","year":"2002","journal-title":"Dev Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ddmod.2009.02.002","article-title":"<italic>Drosophila<\/italic> melanogaster as a model system for genetics of postnatal cardiac function","volume":"5","author":"MJ Wolf","year":"2008","journal-title":"Drug Discov Today Dis Models"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1073\/pnas.0609278104","article-title":"KCNQ potassium channel mutations cause cardiac arrhythmias in <italic>Drosophila<\/italic> that mimic the effects of aging","volume":"104","author":"K Ocorr","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e22579","DOI":"10.1371\/journal.pone.0022579","article-title":"The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the <italic>Drosophila<\/italic> heart model","volume":"6","author":"GC Melkani","year":"2011","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2144\/000113078","article-title":"A new method for detection and quantification of heartbeat parameters in <italic>Drosophila<\/italic>, zebrafish, and embryonic mouse hearts","volume":"46","author":"M Fink","year":"2009","journal-title":"Biotechniques"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1471-4159.2005.03119.x","article-title":"Treatment with extracellular HSP70\/HSC70 protein can reduce polyglutamine toxicity and aggregation","volume":"94","author":"TV Novoselova","year":"2005","journal-title":"J Neurochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1161\/CIRCULATIONAHA.107.750232","article-title":"Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure","volume":"117","author":"JS Pattison","year":"2008","journal-title":"Circulation"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/ng.1103","article-title":"Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy","volume":"44","author":"J Sarparanta","year":"2012","journal-title":"Nat Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.asd.2012.02.002","article-title":"The ultrastructure of <italic>Drosophila<\/italic> heart cells","volume":"41","author":"C Lehmacher","year":"2012","journal-title":"Arthropod Struct Dev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/emmm.201000102","article-title":"Mitochondrial fission and cristae disruption increase the response of cell models of Huntington&apos;s disease to apoptotic stimuli","volume":"2","author":"V Costa","year":"2010","journal-title":"EMBO Mol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/CIRCRESAHA.110.236745","article-title":"MARF and Opa1 control mitochondrial and cardiac function in <italic>Drosophila<\/italic>","volume":"108","author":"GW Dorn 2nd","year":"2011","journal-title":"Circ Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"23354","DOI":"10.1074\/jbc.M702657200","article-title":"Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis","volume":"282","author":"T Shen","year":"2007","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1093\/hmg\/ddq398","article-title":"HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones","volume":"19","author":"MJ Vos","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1106180","article-title":"Proteotoxicity and cardiac dysfunction\u2013Alzheimer&apos;s disease of the heart?","volume":"368","author":"MS Willis","year":"2013","journal-title":"N Engl J Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1126\/science.1066648","article-title":"Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin","volume":"295","author":"JM Barral","year":"2002","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0896-6273(00)00125-2","article-title":"Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer&apos;s disease","volume":"28","author":"M Takahashi","year":"2000","journal-title":"Neuron"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1111\/j.1742-4658.2006.05318.x","article-title":"Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant","volume":"273","author":"WJ Firdaus","year":"2006","journal-title":"Febs J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbrc.2006.01.136","article-title":"Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction","volume":"342","author":"A Goswami","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington&apos;s disease: selective vulnerability of the basal ganglia","volume":"41","author":"SE Browne","year":"1997","journal-title":"Ann Neurol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1023\/A:1010911417383","article-title":"Comparative analysis of superoxide dismutase activity between acute pharmacological models and a transgenic mouse model of Huntington&apos;s disease","volume":"26","author":"A Santamaria","year":"2001","journal-title":"Neurochem Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.freeradbiomed.2008.05.014","article-title":"Proteomic and oxidative stress analysis in human brain samples of Huntington disease","volume":"45","author":"MA Sorolla","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e40329","DOI":"10.1371\/journal.pone.0040329","article-title":"Huntingtin fragments and SOD1 mutants form soluble oligomers in the cell","volume":"7","author":"YN Park","year":"2012","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"798","DOI":"10.2337\/diabetes.55.03.06.db05-1039","article-title":"Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy","volume":"55","author":"X Shen","year":"2006","journal-title":"Diabetes"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1073\/pnas.0604661103","article-title":"Antioxidants protect PINK1-dependent dopaminergic neurons in <italic>Drosophila<\/italic>","volume":"103","author":"D Wang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0891-5849(03)00062-5","article-title":"Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death","volume":"34","author":"JH Jang","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4161\/cib.15309","article-title":"Resveratrol inhibits mTOR signaling by targeting DEPTOR","volume":"4","author":"M Liu","year":"2011","journal-title":"Commun Integr Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/hmg\/ddq460","article-title":"ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington&apos;s disease","volume":"20","author":"P Maher","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref52","first-page":"111","article-title":"Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4)","volume":"60 Suppl 4","author":"G Spanier","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/cvr\/cvr022","article-title":"Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53","volume":"90","author":"C Zhang","year":"2011","journal-title":"Cardiovasc Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e32195","DOI":"10.1371\/journal.pone.0032195","article-title":"Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells","volume":"7","author":"LM Zhong","year":"2012","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.153.2.283","article-title":"Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression","volume":"153","author":"ST Suhr","year":"2001","journal-title":"J Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in <italic>Caenorhabditis elegans<\/italic>","volume":"99","author":"JF Morley","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1152\/jappl.2000.88.5.1601","article-title":"Effect of contractile activity on protein turnover in skeletal muscle mitochondrial subfractions","volume":"88","author":"MK Connor","year":"2000","journal-title":"J Appl Physiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1161\/CIRCULATIONAHA.105.572552","article-title":"Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy","volume":"112","author":"A Maloyan","year":"2005","journal-title":"Circulation"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.108.193516","article-title":"Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy","volume":"104","author":"A Maloyan","year":"2009","journal-title":"Circ Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"H1220","DOI":"10.1152\/ajpheart.00601.2011","article-title":"Desmin-related cardiomyopathy: an unfolding story","volume":"301","author":"PM McLendon","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington&apos;s disease: implications for selective neuronal damage","volume":"20","author":"U Shirendeb","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.112.268946","article-title":"Mitochondrial control of cellular life, stress, and death","volume":"111","author":"L Galluzzi","year":"2012","journal-title":"Circ Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ng0298-159","article-title":"A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase","volume":"18","author":"S Melov","year":"1998","journal-title":"Nat Genet"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"10132","DOI":"10.1073\/pnas.0401900101","article-title":"Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis","volume":"101","author":"A Sanbe","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/mds.20373","article-title":"Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington&apos;s disease","volume":"20","author":"C Saft","year":"2005","journal-title":"Mov Disord"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ydbio.2007.08.024","article-title":"The <italic>Drosophila<\/italic> Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis","volume":"311","author":"PC Lo","year":"2007","journal-title":"Dev Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1242\/dev.01899","article-title":"Hand is a direct target of Tinman and GATA factors during <italic>Drosophila<\/italic> cardiogenesis and hematopoiesis","volume":"132","author":"Z Han","year":"2005","journal-title":"Development"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.02285","article-title":"Hand, an evolutionarily conserved bHLH transcription factor required for <italic>Drosophila<\/italic> cardiogenesis and hematopoiesis","volume":"133","author":"Z Han","year":"2006","journal-title":"Development"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1242\/jcs.078964","article-title":"<italic>Drosophila<\/italic> UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability","volume":"124","author":"CF Lee","year":"2011","journal-title":"J Cell Sci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/cdd.2011.26","article-title":"Mitochondrial fusion is regulated by Reaper to modulate <italic>Drosophila<\/italic> programmed cell death","volume":"18","author":"M Thomenius","year":"2011","journal-title":"Cell Death Differ"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.neuron.2012.06.026","article-title":"Tau promotes neurodegeneration via DRP1 mislocalization in vivo","volume":"75","author":"B DuBoff","year":"2012","journal-title":"Neuron"},{"key":"ref72","first-page":"1435","article-title":"Semi-automated Optical Heartbeat Analysis of small hearts","volume":"31","author":"K Ocorr","year":"2009","journal-title":"J Vis Exp"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1474-9726.2008.00367.x","article-title":"Dystrophin deficiency in <italic>Drosophila<\/italic> reduces lifespan and causes a dilated cardiomyopathy phenotype","volume":"7","author":"O Taghli-Lamallem","year":"2008","journal-title":"Aging Cell"},{"key":"ref74","first-page":"1423","article-title":"Fluorescent labeling of <italic>Drosophila<\/italic> heart structures","volume":"32","author":"NN Alayari","year":"2009","journal-title":"J Vis Exp"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1242\/dev.044230","article-title":"<italic>Drosophila<\/italic> acinus encodes a novel regulator of endocytic and autophagic trafficking","volume":"137","author":"AS Haberman","year":"2010","journal-title":"Development"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"e18497","DOI":"10.1371\/journal.pone.0018497","article-title":"A mighty small heart: the cardiac proteome of adult <italic>Drosophila<\/italic> melanogaster","volume":"6","author":"A Cammarato","year":"2011","journal-title":"PLoS One"},{"key":"ref77","first-page":"158","article-title":"A modified method for lead staining of thin sections","volume":"17","author":"T Sato","year":"1968","journal-title":"J Electron Microsc (Tokyo)"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T12:34:53Z","timestamp":1597235693000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004024"}},"subtitle":[],"editor":[{"given":"Bingwei","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":77,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004024","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}