{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:12:15Z","timestamp":1787663535415,"version":"build-2736575974"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004089","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T16:28:15Z","timestamp":1394123295000},"page":"e1004089","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma"],"prefix":"10.1371","volume":"10","author":[{"given":"Monisha E.","family":"Nongpiur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiea Chuen","family":"Khor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda K.","family":"Cornes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Saidas","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abu-Amero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamira A.","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineo","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kurimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancy","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza-Sharmini A.","family":"Tajudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Lin","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement C. Y.","family":"Tham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T. K.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon-Tym","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balekudaru","family":"Shantha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essam A.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujie","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H. K.","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena M. L.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavan","family":"Lavanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Feng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Chee","family":"Loon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Rand","family":"Allingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaswamy","family":"Soumittra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedam L.","family":"Ramprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naushin","family":"Waseem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhany","family":"Yaakub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-Seng","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govindasamy","family":"Kumaramanickavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina T.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia C.","family":"How","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Nguyen Bich","family":"Chau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron P.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xin","family":"Bei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shomi S.","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald T.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik-Ying","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Al-Obeidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Nhu","family":"Hon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E-Shyong","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seang-Mei","family":"Saw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingam","family":"Vijaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Yin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon W. M.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Pui","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eranga N.","family":"Vithana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Aung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1136\/bjo.85.11.1277","article-title":"Glaucoma in China: how big is the problem","volume":"85","author":"PJ Foster","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/archopht.1996.01100140435011","article-title":"Glaucoma in Mongolia. A population-based survey in Hovsgol province, northern Mongolia","volume":"114","author":"PJ Foster","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/archopht.118.8.1105","article-title":"The prevalence of glaucoma in Chinese residents of Singapore: a cross-sectional population survey of the Tanjong Pagar district","volume":"118","author":"PJ Foster","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/S0161-6420(00)00274-8","article-title":"Angle-closure glaucoma in an urban population in southern India. The Andhra Pradesh eye disease study","volume":"107","author":"L Dandona","year":"2000","journal-title":"Ophthalmology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"HA Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ng.2390","article-title":"Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma","volume":"44","author":"EN Vithana","year":"2012","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"JC Cohen","year":"2006","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1056\/NEJMc0707445","article-title":"A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction","volume":"358","author":"S Kathiresan","year":"2008","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bjo.84.2.186","article-title":"Detection of gonioscopically occludable angles and primary angle closure glaucoma by estimation of limbal chamber depth in Asians: modified grading scheme","volume":"84","author":"PJ Foster","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/archopht.118.2.257","article-title":"Anterior chamber depth measurement as a screening tool for primary angle-closure glaucoma in an East Asian population","volume":"118","author":"JG Devereux","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/archopht.126.5.686","article-title":"Determinants of angle closure in older Singaporeans","volume":"126","author":"R Lavanya","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/archopht.123.4.527","article-title":"Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations","volume":"123","author":"T Aung","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.07-1052","article-title":"Heritability of anterior chamber depth as an intermediate phenotype of angle-closure in Chinese: the Guangzhou Twin Eye Study","volume":"49","author":"M He","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1136\/bjo.85.12.1470","article-title":"The importance of genes and environment for ocular refraction and its determiners: a population based study among 20\u201345 year old twins","volume":"85","author":"N Lyhne","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1167\/iovs.08-2130","article-title":"Shared genetic determinant of axial length, anterior chamber depth, and angle opening distance: the Guangzhou Twin Eye Study","volume":"49","author":"M He","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.2337\/db07-1336","article-title":"The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects","volume":"57","author":"JB McAteer","year":"2008","journal-title":"Diabetes"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1167\/iovs.06-0051","article-title":"Prevalence and clinical characteristics of glaucoma in adult Chinese: a population-based study in Liwan District, Guangzhou","volume":"47","author":"M He","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5824","DOI":"10.1167\/iovs.13-11901","article-title":"Lack of association between primary angle-closure glaucoma susceptibility Loci and the ocular biometric parameters anterior chamber depth and axial length","volume":"54","author":"ME Nongpiur","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"30069","DOI":"10.1074\/jbc.M005463200","article-title":"The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides","volume":"275","author":"G Jedlitschky","year":"2000","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1073\/pnas.120159197","article-title":"Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs","volume":"97","author":"J Wijnholds","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1158\/1535-7163.MCT-04-0291","article-title":"The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites","volume":"4","author":"S Pratt","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jop.2008.0084","article-title":"Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux","volume":"25","author":"PK Karla","year":"2009","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2199-8-42","article-title":"Three novel ABCC5 splice variants in human retina and their role as regulators of ABCC5 gene expression","volume":"8","author":"J Stojic","year":"2007","journal-title":"BMC Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cbpb.2010.09.005","article-title":"Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish","volume":"158","author":"Y Long","year":"2011","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1742-4658.2006.05591.x","article-title":"cGMP transport by vesicles from human and mouse erythrocytes","volume":"274","author":"CJ de Wolf","year":"2007","journal-title":"FEBS J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A mutation in APP protects against Alzheimer&apos;s disease and age-related cognitive decline","volume":"488","author":"T Jonsson","year":"2012","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 Associated with the Risk of Alzheimer&apos;s Disease","volume":"368","author":"T Jonsson","year":"2013","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer&apos;s disease","volume":"368","author":"R Guerreiro","year":"2013","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ophtha.2011.07.049","article-title":"Determinants of angle width in Chinese Singaporeans","volume":"119","author":"LL Foo","year":"2012","journal-title":"Ophthalmology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","year":"2007","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ng.2383","article-title":"Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes","volume":"44","author":"AP Morris","year":"2012","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/ng.960","article-title":"Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1","volume":"43","author":"CC Khor","year":"2011","journal-title":"Nat Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ng.973","article-title":"Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy","volume":"43","author":"F Zhang","year":"2011","journal-title":"Nat Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/ng.483","article-title":"Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region","volume":"41","author":"JC Barrett","year":"2009","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/ng.981","article-title":"Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease","volume":"43","author":"CC Khor","year":"2011","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/09286580600878844","article-title":"Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES)","volume":"14","author":"AW Foong","year":"2007","journal-title":"Ophthalmic Epidemiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/09286580903144738","article-title":"Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians","volume":"16","author":"R Lavanya","year":"2009","journal-title":"Ophthalmic Epidemiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00417-007-0760-9","article-title":"Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study","volume":"246","author":"H Zhang","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/hmg\/ddq511","article-title":"Collagen-related genes influence the glaucoma risk factor, central corneal thickness","volume":"20","author":"EN Vithana","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1093\/hmg\/ddr060","article-title":"Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area","volume":"20","author":"CC Khor","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/hmg\/ddr463","article-title":"Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations","volume":"21","author":"BK Cornes","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng2058","article-title":"A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21","volume":"39","author":"DA van Heel","year":"2007","journal-title":"Nat Genet"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1004352","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T00:00:00Z","timestamp":1396569600000}}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:46:06Z","timestamp":1540280766000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004089"}},"subtitle":[],"editor":[{"given":"Janey L.","family":"Wiggs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004089","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pgen.1004352","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]}}}