{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:00:35Z","timestamp":1790182835262,"version":"4.1.0"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004188","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T18:06:42Z","timestamp":1393524402000},"page":"e1004188","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":111,"title":["MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis"],"prefix":"10.1371","volume":"10","author":[{"given":"Andrew G.","family":"Hoss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay K.","family":"Kartha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne C.","family":"Latourelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Dumitriu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany C.","family":"Hadzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcy E.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Gusella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schahram","family":"Akbarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1212\/WNL.0b013e31826e9a5d","article-title":"Assessment of cortical and striatal involvement in 523 Huntington disease brains","volume":"79","author":"TC Hadzi","year":"2012","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"JP Vonsattel","year":"1985","journal-title":"Journal of neuropathology and experimental neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"A Hodges","year":"2006","journal-title":"Human molecular genetics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0166-2236(00)01609-X","article-title":"Transcriptional dysregulation in Huntington's disease","volume":"23","author":"JH Cha","year":"2000","journal-title":"Trends in neurosciences"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pneurobio.2007.03.004","article-title":"Transcriptional signatures in Huntington's disease","volume":"83","author":"JH Cha","year":"2007","journal-title":"Progress in neurobiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e1002527","DOI":"10.1371\/journal.pgen.1002527","article-title":"Sequestration of highly expressed mRNAs in cytoplasmic granules, P-bodies, and stress granules enhances cell viability","volume":"8","author":"A Lavut","year":"2012","journal-title":"PLoS genetics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pharmthera.2011.10.002","article-title":"MicroRNAs in neurodegenerative diseases and their therapeutic potential","volume":"133","author":"E Junn","year":"2012","journal-title":"Pharmacology & therapeutics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1093\/nar\/gkq575","article-title":"A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing","volume":"38","author":"E Marti","year":"2010","journal-title":"Nucleic acids research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.nbd.2007.11.001","article-title":"A microRNA-based gene dysregulation pathway in Huntington's disease","volume":"29","author":"R Johnson","year":"2008","journal-title":"Neurobiology of disease"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"14341","DOI":"10.1523\/JNEUROSCI.2390-08.2008","article-title":"The bifunctional microRNA miR-9\/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease","volume":"28","author":"AN Packer","year":"2008","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.4161\/rna.8.6.16035","article-title":"Micro RNA -214,-150,-146a and-125b target Huntingtin gene","volume":"8","author":"M Sinha","year":"2011","journal-title":"RNA biology"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ajhg.2013.05.025","article-title":"miR-196a Ameliorates Phenotypes of Huntington Disease in Cell, Transgenic Mouse, and Induced Pluripotent Stem Cell Models","volume":"93","author":"PH Cheng","year":"2013","journal-title":"American journal of human genetics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2010.10.012","article-title":"Altered microRNA regulation in Huntington's disease models","volume":"227","author":"ST Lee","year":"2011","journal-title":"Experimental neurology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1471-4159.2012.07925.x","article-title":"Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin","volume":"123","author":"J Jin","year":"2012","journal-title":"Journal of neurochemistry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1212\/WNL.43.10.2088","article-title":"Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease: a quantitative Golgi study","volume":"43","author":"A Sotrel","year":"1993","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.410270217","article-title":"Degeneration of pyramidal projection neurons in Huntington's disease cortex","volume":"27","author":"M Cudkowicz","year":"1990","journal-title":"Annals of neurology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuron.2005.03.025","article-title":"Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice","volume":"46","author":"X Gu","year":"2005","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1212\/01.wnl.0000174432.87383.87","article-title":"Regional cortical thinning in preclinical Huntington disease and its relationship to cognition","volume":"65","author":"HD Rosas","year":"2005","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1212\/WNL.58.5.695","article-title":"Regional and progressive thinning of the cortical ribbon in Huntington's disease","volume":"58","author":"HD Rosas","year":"2002","journal-title":"Neurology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"LA Greene","year":"1976","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1093\/hmg\/11.19.2279","article-title":"Modulation of polyglutamine-induced cell death by genes identified by expression profiling","volume":"11","author":"H Kita","year":"2002","journal-title":"Human molecular genetics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/hmg\/10.17.1829","article-title":"Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease","volume":"10","author":"A Wyttenbach","year":"2001","journal-title":"Human molecular genetics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/00001756-200303240-00007","article-title":"Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation","volume":"14","author":"S Igarashi","year":"2003","journal-title":"Neuroreport"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/hmg\/ddi443","article-title":"Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1\/2 protects against mutant huntingtin-associated toxicity","volume":"15","author":"BL Apostol","year":"2006","journal-title":"Human molecular genetics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1074\/jbc.M310226200","article-title":"Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis","volume":"279","author":"KL Sugars","year":"2004","journal-title":"The Journal of biological chemistry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1093\/hmg\/ddq127","article-title":"Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments","volume":"19","author":"X Li","year":"2010","journal-title":"Human molecular genetics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"S Anders","year":"2010","journal-title":"Genome biology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"DP Bartel","year":"2009","journal-title":"Cell"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"e53780","DOI":"10.1371\/journal.pone.0053780","article-title":"Parallel analysis of mRNA and microRNA microarray profiles to explore functional regulatory patterns in polycystic kidney disease: using PKD\/Mhm rat model","volume":"8. 8","author":"H Dweep","year":"2013","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/sj.hdy.6800872","article-title":"Building divergent body plans with similar genetic pathways","volume":"97","author":"BJ Swalla","year":"2006","journal-title":"Heredity (Edinb)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrg2400","article-title":"MicroRNAs in the Hox network: an apparent link to posterior prevalence","volume":"9","author":"S Yekta","year":"2008","journal-title":"Nat Rev Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"D48","DOI":"10.1093\/nar\/gks1236","article-title":"Ensembl 2013","volume":"41","author":"P Flicek","year":"2013","journal-title":"Nucleic acids research"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"JL Rinn","year":"2007","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nm.2791","article-title":"Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2","volume":"18","author":"Y Miyazaki","year":"2012","journal-title":"Nature medicine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/hmg\/ddr111","article-title":"Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease","volume":"20","author":"PM Gaughwin","year":"2011","journal-title":"Human molecular genetics"},{"key":"ref37","unstructured":"Windemuth AS, I; Pregibon, D; Marini. D. (2012) PubmiR: A Literature Search Tool for MicroRNA Research. Firefly BioWorks, Inc."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbrc.2010.05.007","article-title":"Altered microRNAs in STHdh(Q111)\/Hdh(Q111) cells: miR-146a targets TBP","volume":"396","author":"M Sinha","year":"2010","journal-title":"Biochemical and biophysical research communications"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jnc.12090","article-title":"Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease","volume":"124","author":"C Soldati","year":"2013","journal-title":"J Neurochem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1396","DOI":"10.1371\/journal.pone.0001396","article-title":"MiR-10 represses HoxB1a and HoxB3a in zebrafish","volume":"3","author":"JM Woltering","year":"2008","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"728","DOI":"10.4161\/rna.8.5.16324","article-title":"The miR-10 microRNA precursor family","volume":"8","author":"D Tehler","year":"2011","journal-title":"RNA Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/cdd.2010.172","article-title":"MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2","volume":"18","author":"NH Foley","year":"2011","journal-title":"Cell death and differentiation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1074\/jbc.M109.095612","article-title":"miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation","volume":"285","author":"H Huang","year":"2010","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1074\/jbc.M110.167817","article-title":"MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2\/ASF)","volume":"286","author":"S Meseguer","year":"2011","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e25689","DOI":"10.1371\/journal.pone.0025689","article-title":"Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4","volume":"6","author":"SL Phua","year":"2011","journal-title":"PloS one"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1053\/j.gastro.2009.08.065","article-title":"Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer","volume":"137","author":"FU Weiss","year":"2009","journal-title":"Gastroenterology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.1132040","article-title":"Genomic evolution of Hox gene clusters","volume":"313","author":"D Lemons","year":"2006","journal-title":"Science"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nrg1726","article-title":"Modulating Hox gene functions during animal body patterning","volume":"6","author":"JC Pearson","year":"2005","journal-title":"Nature reviews Genetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1126\/science.1114519","article-title":"MicroRNA expression in zebrafish embryonic development","volume":"309","author":"E Wienholds","year":"2005","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/bies.20080","article-title":"Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis","volume":"26","author":"R Diez del Corral","year":"2004","journal-title":"Bioessays"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.hdy.6800847","article-title":"Hox transcription factors and their elusive mammalian gene targets","volume":"97","author":"T Svingen","year":"2006","journal-title":"Heredity (Edinb)"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI1597","article-title":"HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium","volume":"101","author":"HS Taylor","year":"1998","journal-title":"J Clin Invest"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cell.2007.02.009","article-title":"Genome regulation by polycomb and trithorax proteins","volume":"128","author":"B Schuettengruber","year":"2007","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/hmg\/ddp524","article-title":"Huntingtin facilitates polycomb repressive complex 2","volume":"19","author":"IS Seong","year":"2010","journal-title":"Human molecular genetics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/embor.2010.182","article-title":"Is Huntington disease a developmental disorder?","volume":"11","author":"S Humbert","year":"2010","journal-title":"EMBO reports"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/jnnp.69.6.773","article-title":"Subtle changes among presymptomatic carriers of the Huntington's disease gene","volume":"69","author":"SC Kirkwood","year":"2000","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/00005072-199111000-00005","article-title":"Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus","volume":"50","author":"RH Myers","year":"1991","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/ncb1274","article-title":"MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies","volume":"7","author":"J Liu","year":"2005","journal-title":"Nature cell biology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ceb.2009.03.005","article-title":"Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs","volume":"21","author":"V Balagopal","year":"2009","journal-title":"Current opinion in cell biology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2006.04.031","article-title":"Relief of microRNA-mediated translational repression in human cells subjected to stress","volume":"125","author":"SN Bhattacharyya","year":"2006","journal-title":"Cell"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"13793","DOI":"10.1523\/JNEUROSCI.4155-08.2008","article-title":"Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation","volume":"28","author":"N Cougot","year":"2008","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1523\/JNEUROSCI.0104-08.2008","article-title":"Dynamic interaction between P-bodies and transport ribonucleoprotein particles in dendrites of mature hippocampal neurons","volume":"28","author":"M Zeitelhofer","year":"2008","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"13142","DOI":"10.1074\/jbc.M110.114561","article-title":"A role for huntington disease protein in dendritic RNA granules","volume":"285","author":"JN Savas","year":"2010","journal-title":"The Journal of biological chemistry"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"10820","DOI":"10.1073\/pnas.0800658105","article-title":"Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies","volume":"105","author":"JN Savas","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"J Sreedharan","year":"2008","journal-title":"Science"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"TJ Kwiatkowski Jr","year":"2009","journal-title":"Science"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1750-1326-7-56","article-title":"Regulated protein aggregation: stress granules and neurodegeneration","volume":"7","author":"B Wolozin","year":"2012","journal-title":"Molecular neurodegeneration"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1093\/nar\/gkr148","article-title":"Analysis of microRNA turnover in mammalian cells following Dicer1 ablation","volume":"39","author":"MP Gantier","year":"2011","journal-title":"Nucleic acids research"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"PS Mitchell","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"X Chen","year":"2008","journal-title":"Cell research"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2199-7-3","article-title":"The RIN: an RNA integrity number for assigning integrity values to RNA measurements","volume":"7","author":"A Schroeder","year":"2006","journal-title":"BMC molecular biology"},{"key":"ref72","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"B Langmead","year":"2009","journal-title":"Genome Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"AR Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"ref75","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"D Kim","year":"2013","journal-title":"Genome Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"C Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref78","unstructured":"Durinck SH, W. (2013) biomaRt: Interface to BioMart databases (e.g. Ensembl, COSMIC, Wormbase and Gramene). R. 2.10.0 ed."},{"key":"ref79","article-title":"BioMart: driving a paradigm change in biological data management","author":"A Kasprzyk","year":"2011","journal-title":"Database (Oxford) 2011"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T15:06:02Z","timestamp":1540220762000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004188"}},"subtitle":[],"editor":[{"given":"Leslie","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,27]]},"references-count":79,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004188","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,27]]}}}