{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T02:36:10Z","timestamp":1776566170692,"version":"3.51.2"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004199","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T20:33:09Z","timestamp":1395347589000},"page":"e1004199","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Sugar and Chromosome Stability: Clastogenic Effects of Sugars in Vitamin B6-Deficient Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Antonio","family":"Marzio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Merigliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiammetta","family":"Vern\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrc2091","article-title":"The impact of translocations and gene fusions on cancer causation","volume":"7","author":"F Mitelman","year":"2007","journal-title":"Nature Reviews Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrg2268","article-title":"Genome instability: a mechanistic view of its causes and consequences","volume":"9","author":"A Aguilera","year":"2008","journal-title":"Nat Rev Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrc3537","article-title":"End-joining, translocations and cancer","volume":"13","author":"SF Bunting","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2010.11.055","article-title":"Massive genomic rearrangement acquired in a single catastrophic event during cancer","volume":"144","author":"PJ Stephens","year":"2011","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"R103","DOI":"10.1186\/gb-2011-12-10-r103","article-title":"Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer","volume":"12","author":"WP Kloosterman","year":"2011","journal-title":"Genome Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/gcc.21999","article-title":"Poly-gene fusion transcripts and chromothripsis in prostate cancer","volume":"51","author":"C Wu","year":"2012","journal-title":"Genes Chromosomes cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrc3352","article-title":"Chromothripsis and cancer: causes and consequences of chromosome shattering","volume":"12","author":"JV Forment","year":"2012","journal-title":"Nature Reviews Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/gcc.21981","article-title":"Shattered and stitched chromosomes-chromothripsis and chromoanasynthesis-manifestations of a new chromosome crisis?","volume":"51","author":"C Righolt","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.4161\/cc.25266","article-title":"Chromothripsis: Breakage-fusion-bridge over and over again","volume":"12","author":"CO Sorzano","year":"2013","journal-title":"Cell cycle"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/85798","article-title":"DNA double-strand breaks: signaling, repair and the cancer connection","volume":"27","author":"KK Khanna","year":"2001","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/jncimonographs\/lgn009","article-title":"Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases","volume":"39","author":"DM Weinstock","year":"2008","journal-title":"J Natl Cancer Inst Monogr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.semcdb.2011.10.007","article-title":"DNA double-strand break repair pathways, chromosomal rearrangements and cancer","volume":"22","author":"TR Kasparek","year":"2011","journal-title":"Semin Cell Dev Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.mrfmmm.2010.12.016","article-title":"Role of oxidative stress and DNA damage in human carcinogenesis","volume":"711","author":"TB Kryston","year":"2011","journal-title":"Mutat Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrg1746","article-title":"The role of double-strand break repair- insights from human genetics","volume":"7","author":"M O'Driscoll","year":"2006","journal-title":"Nat Rev Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.genom.7.080505.115648","article-title":"DNA strand break repair and human genetic disease","volume":"8","author":"PJ McKinnon","year":"2007","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref16","first-page":"694","article-title":"Are vitamin and mineral deficiencies a major cancer risk?","volume":"2","author":"BN Ames","year":"2002","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/mutage\/geq081","article-title":"Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status","volume":"26","author":"A Lal","year":"2011","journal-title":"Mutagenesis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1371\/journal.pgen.0030134","article-title":"A screen for Suppressors of Gross Chromosomal Rearrangements Identifies a Conserved Role for PLP in Preventing DNA Lesions","volume":"3","author":"P Kanellis","year":"2007","journal-title":"Plos genetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/molecules15010442","article-title":"Vitamin B6: A Molecule for Human Health?","volume":"15","author":"H Hellmann","year":"2010","journal-title":"Molecules"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.semcdb.2011.05.003","article-title":"Pyridoxine supply in human development","volume":"22","author":"FG Bowling","year":"2011","journal-title":"Seminars in Cell & Developmental Biology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2174\/092986707780597899","article-title":"Pyridoxal 5\u2032-phosphate enzymes as targets for therapeutic agents","volume":"14","author":"A Amadasi","year":"2007","journal-title":"Curr Med Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1073\/pnas.96.16.9374","article-title":"A highly conserved sequence is a novel gene involved in de novo vitamin B6 biosynthesis","volume":"96","author":"M Ehrenshaft","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1562\/0031-8655(2000)071<0129:SIPVBP>2.0.CO;2","article-title":"Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants","volume":"71","author":"P Bilski","year":"2000","journal-title":"Photochem Photobiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pmpp.2005.09.004","article-title":"Regulation of biosynthetic genes and antioxidant properties of vitamin B6 vitamers during plant defense responses","volume":"66","author":"SA Denslow","year":"2005","journal-title":"Physiol and Mol Plant Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/bbrc.1996.0366","article-title":"Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine","volume":"220","author":"AA Booth","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1074\/jbc.272.9.5430","article-title":"In Vitro Kinetic Studies of Formation of Antigenic Advanced Glycation End Products (AGEs) Novel inhibition of post-Amadori glycation pathways","volume":"272","author":"AA Booth","year":"1997","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0065-2806(03)31004-5","article-title":"Trehalose-The insect \u201cblood sugar\u201d","volume":"31","author":"SN Thompson","year":"2003","journal-title":"Advances of Insect Physiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"9040","DOI":"10.1073\/pnas.84.24.9040","article-title":"Differential turnover of tyrosinated and detyrosinated microtubules","volume":"84","author":"DR Webster","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1083\/jcb.106.1.141","article-title":"Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level","volume":"106","author":"S Khawaja","year":"1988","journal-title":"J Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2337\/diacare.14.2.167","article-title":"von Willebrand factor and endothelial abnormalities in diabetic microangiopathy","volume":"14","author":"M Porta","year":"1991","journal-title":"Diabetes Care"},{"key":"ref31","first-page":"87","article-title":"Delayed replication of human umbilical vein endothelial cells in high glucose is corrected by L-tyrosine","volume":"19","author":"M La Selva","year":"1992","journal-title":"Diabetes Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3177\/jnsv.26.535","article-title":"Competitive inhibition between 4\u2032-substituted pyridoxine analogues and pyridoxal for pyridoxal kinase from mouse brain","volume":"26","author":"N Mizuno","year":"1980","journal-title":"J Nutr Sci Vitaminol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0006-2952(97)00252-9","article-title":"Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs","volume":"15","author":"P Lain\u00e9-Cessac","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"R236","DOI":"10.1016\/S0960-9822(02)00777-7","article-title":"The insulin signalling pathway","volume":"12","author":"JM Lizcano","year":"2002","journal-title":"Curr Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cmet.2007.09.002","article-title":"Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila","volume":"6","author":"KD Baker","year":"2007","journal-title":"Cell Metab"},{"key":"ref36","first-page":"38","article-title":"Of flies and men: insights on organismal metabolism from fruit flies","volume":"11","author":"A Rajan","year":"2013","journal-title":"BCM Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0960-9822(01)00068-9","article-title":"An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control","volume":"11","author":"W Brogiolo","year":"2001","journal-title":"Curr Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.1070058","article-title":"Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes","volume":"296","author":"EJ Rulifson","year":"2002","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e1000857","DOI":"10.1371\/journal.pgen.1000857","article-title":"Molecular evolution and functional characterization of Drosophila insulin-like peptides","volume":"6","author":"S Gr\u00f6nke","year":"2010","journal-title":"Plos Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e3721","DOI":"10.1371\/journal.pone.0003721","article-title":"Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs","volume":"3","author":"S Broughton","year":"2008","journal-title":"Plos one"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1242\/dmm.007948","article-title":"A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila","volume":"4","author":"LP Musselman","year":"2011","journal-title":"Dis Model Mech"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1096\/fj.06-5730rev","article-title":"DNA precursor metabolism and genomic stability","volume":"20","author":"CK Mathews","year":"2006","journal-title":"FASEB J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"M Brownlee","year":"2001","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.semnephrol.2009.07.013","article-title":"Identifying Advanced Glycation Ends Products as major source of oxidant in aging: implication of the management and\/or prevention of reduced renal function in elderly persons","volume":"29","author":"H Vlassara","year":"2009","journal-title":"Seminars in nephrology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.metabol.2008.05.018","article-title":"Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant \u03b1-lipoic acid on insulin resistance in the obese Zucker rat","volume":"57","author":"EA Muellenbach","year":"2008","journal-title":"Metabolism"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fphar.2011.00069","article-title":"Diabetes and alpha lipoic Acid","volume":"2","author":"S Golbidi","year":"2011","journal-title":"Front Pharmacol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cub.2009.12.048","article-title":"Drosophila timeless2 is required for chromosome stability and circadian photoreception","volume":"23","author":"C Benna","year":"2010","journal-title":"Curr Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"779S","DOI":"10.1093\/ajcn\/58.5.779S","article-title":"Protein fructosylation:fructose and the Maillard reaction","volume":"58","author":"WL Dills Jr","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycation end products: sparking the development of diabetic vascular injury","volume":"114","author":"A Goldin","year":"2006","journal-title":"Circulation"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/MOG.0b013e3282f3f4c4","article-title":"Dietary fructose and the metabolic syndrome","volume":"24","author":"A Miller","year":"2008","journal-title":"Current Opinion in Gastroenterology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1101\/gad.3.4.438","article-title":"Genes controlling essential cell-cycle functions in Drosophila melanogaster","volume":"3","author":"M Gatti","year":"1989","journal-title":"Genes Dev"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6546","DOI":"10.1073\/pnas.79.21.6546","article-title":"Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus","volume":"79","author":"SK Williams","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"11848","DOI":"10.1073\/pnas.1102664108","article-title":"Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein\/amyloid beta-peptides in human cerebrospinal fluid","volume":"108","author":"A Halim","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10545-005-0243-2","article-title":"B6-responsive disorders: a model of vitamin dependency","volume":"29","author":"PT Clayton","year":"2006","journal-title":"J Inherit Metab Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.2337\/dc09-9032","article-title":"Hyperglycemic crises in adult patients with diabetes","volume":"32","author":"AE Kitabchi","year":"2009","journal-title":"Diabetes care"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrg2841","article-title":"Advances in understanding cancer genomes through second-generation sequencing","volume":"11","author":"M Meyerson","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref57","first-page":"659","article-title":"Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction?","volume":"8","author":"CM Ulrich","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/aje\/153.7.688","article-title":"Association of the B-vitamins pyridoxal 5\u2032-phosphate (B(6)), B(12), and folate with lung cancer risk in older men","volume":"153","author":"TJ Hartman","year":"2001","journal-title":"Am J Epidemiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/aje\/kwj016","article-title":"Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women","volume":"163","author":"SM Zhang","year":"2006","journal-title":"Am J Epidemiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.celrep.2012.06.017","article-title":"Prognostic impact of vitamin B6 metabolism in lung cancer","volume":"2","author":"L Galluzzi","year":"2012","journal-title":"Cell reports"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/sj.bjc.6602619","article-title":"Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies","volume":"92","author":"R Huxley","year":"2005","journal-title":"Br J Cancer"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/jnci\/dji375","article-title":"Diabetes mellitus and risk of colorectal cancer: a meta-analysis","volume":"97","author":"SC Larsson","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cgh.2005.12.007","article-title":"The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence","volume":"4","author":"HB El-Serag","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/ijc.22717","article-title":"Diabetes mellitus and risk of breast cancer: a meta-analysis","volume":"121","author":"SC Larsson","year":"2007","journal-title":"Int J Cancer"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00125-011-2051-6","article-title":"Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies","volume":"54","author":"SC Larsson","year":"2011","journal-title":"Diabetologia"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0091-679X(08)60587-7","article-title":"Mutations affecting cell division in Drosophila","volume":"35","author":"M Gatti","year":"1991","journal-title":"Methods Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/71378","article-title":"Spindle assembly in Drosophila neuroblasts and ganglion mother cells","volume":"2","author":"S Bonaccorsi","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1039\/C1MB05358B","article-title":"A mass spectrometry-based targeted metabolomics strategy of human blastocoele fluid: a promising tool in fertility research. Mol","volume":"8","author":"A D'Alessandro","year":"2012","journal-title":"BioSyst"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1091\/mbc.01-12-0589","article-title":"Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells","volume":"13","author":"MP Somma","year":"2002","journal-title":"Mol Biol Cell"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cub.2005.12.011","article-title":"The class I PITP Giotto is required for <italic>Drosophila<\/italic> cytokinesis","volume":"16","author":"MG Giansanti","year":"2006","journal-title":"Curr Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/hmg\/ddn369","article-title":"Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA","volume":"18","author":"E Revenkova","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1093\/nar\/gkr084","article-title":"The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination","volume":"39","author":"G Cherubini","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"AH Brand","year":"1993","journal-title":"Development"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.devcel.2004.06.007","article-title":"The PDGF\/VEGF receptor controls blood cell survival in <italic>Drosophila<\/italic>","volume":"7","author":"K Br\u00fcckner","year":"2004","journal-title":"Dev Cell"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T16:47:27Z","timestamp":1648658847000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004199"}},"subtitle":[],"editor":[{"given":"R. Scott","family":"Hawley","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,20]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004199","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,20]]}}}