{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:13:50Z","timestamp":1791414830832,"version":"4.3.3"},"reference-count":92,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004229","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T16:37:00Z","timestamp":1394728620000},"page":"e1004229","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":71,"title":["Genomic View of Bipolar Disorder Revealed by Whole Genome Sequencing in a Genetic Isolate"],"prefix":"10.1371","volume":"10","author":[{"given":"Benjamin","family":"Georgi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Kember","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Lindquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice A.","family":"Egeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Bu\u0107an","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11920-004-0004-1","article-title":"The epidemiology of mood disorders","volume":"6","author":"KR Merikangas","year":"2004","journal-title":"Curr Psychiatry Rep"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/mp.2008.29","article-title":"The genetics of bipolar disorder: genome \u2018hot regions,\u2019 genes, new potential candidates and future directions","volume":"13","author":"A Serretti","year":"2008","journal-title":"Mol Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/mp.2011.89","article-title":"Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms","volume":"17","author":"JA Badner","year":"2012","journal-title":"Mol Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","year":"2007","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/sj.mp.4002151","article-title":"Whole-genome association study of bipolar disorder","volume":"13","author":"P Sklar","year":"2008","journal-title":"Mol Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/ng.209","article-title":"Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder","volume":"40","author":"MA Ferreira","year":"2008","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/ng.523","article-title":"Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1","volume":"42","author":"FJ McMahon","year":"2010","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ng.943","article-title":"Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4","volume":"43","year":"2011","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1073\/pnas.0813386106","article-title":"Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry","volume":"106","author":"LJ Scott","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tig.2008.12.002","article-title":"Genetics of bipolar disorder: successful start to a long journey","volume":"25","author":"N Craddock","year":"2009","journal-title":"Trends Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/gm102","article-title":"Genetic overlap between autism, schizophrenia and bipolar disorder","volume":"1","author":"LS Carroll","year":"2009","journal-title":"Genome Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1126\/science.2884728","article-title":"Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children","volume":"236","author":"ES Lander","year":"1987","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/35042049","article-title":"Use of population isolates for mapping complex traits","volume":"1","author":"L Peltonen","year":"2000","journal-title":"Nat Rev Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10048-008-0121-9","article-title":"Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population","volume":"9","author":"B Tuysuz","year":"2008","journal-title":"Neurogenetics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1157657","article-title":"Identifying autism loci and genes by tracing recent shared ancestry","volume":"321","author":"EM Morrow","year":"2008","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Hostetler JA (1993) Amish society. Baltimore: Johns Hopkins University Press.","DOI":"10.56021\/9780801844416"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1176\/ajp.140.1.62","article-title":"Amish Study, II: Consensus diagnoses and reliability results","volume":"140","author":"AM Hostetter","year":"1983","journal-title":"Am J Psychiatry"},{"key":"ref18","volume":"4","unstructured":"Egeland JA (1994) An epidemiologic and genetic study of affective disorders among the Old Order Amish In: Papolos DF, Lachman HM, editors. Genetic Studies in Affective Disorders. New York: J. Wiley. Chap <volume>4<\/volume>: : 70\u201390 pp."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1001\/archpsyc.1992.01820090031005","article-title":"Risks of affective illness among first-degree relatives of bipolar I Old Order Amish probands","volume":"49","author":"DL Pauls","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/325783a0","article-title":"Bipolar affective disorders linked to DNA markers on chromosome 11","volume":"325","author":"JA Egeland","year":"1987","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/342238a0","article-title":"Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish","volume":"342","author":"JR Kelsoe","year":"1989","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng0496-431","article-title":"A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish","volume":"12","author":"EI Ginns","year":"1996","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archpsyc.1978.01770300115013","article-title":"Research diagnostic criteria: rationale and reliability","volume":"35","author":"RL Spitzer","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"ref24","unstructured":"American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders 4th ed."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1101\/gr.6861907","article-title":"PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data","volume":"17","author":"K Wang","year":"2007","journal-title":"Genome Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.1181498","article-title":"Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays","volume":"327","author":"R Drmanac","year":"2010","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"L Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","article-title":"Robust relationship inference in genome-wide association studies","volume":"26","author":"A Manichaikul","year":"2010","journal-title":"Bioinformatics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"IA Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"P Kumar","year":"2009","journal-title":"Nat Protoc"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1101\/gr.3577405","article-title":"Distribution and intensity of constraint in mammalian genomic sequence","volume":"15","author":"GM Cooper","year":"2005","journal-title":"Genome Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng.548","article-title":"Variance component model to account for sample structure in genome-wide association studies","volume":"42","author":"HM Kang","year":"2010","journal-title":"Nat Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1002\/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M","article-title":"Implementing a unified approach to family-based tests of association","volume":"19 Suppl 1","author":"NM Laird","year":"2000","journal-title":"Genet Epidemiol"},{"key":"ref34","first-page":"506","article-title":"Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM)","volume":"52","author":"RS Spielman","year":"1993","journal-title":"Am J Hum Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/ajmg.b.31172","article-title":"Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder","volume":"156B","author":"P Belmonte Mahon","year":"2011","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref36","article-title":"Genome-wide association analysis identifies 13 new risk loci for schizophrenia","author":"S Ripke","year":"2013","journal-title":"Nat Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e48495","DOI":"10.1371\/journal.pone.0048495","article-title":"Rare variant analysis for family-based design","volume":"8","author":"G De","year":"2013","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1086\/381652","article-title":"Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information","volume":"74","author":"TE Fingerlin","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin\u2013rapid analysis of dense genetic maps using sparse gene flow trees","volume":"30","author":"GR Abecasis","year":"2002","journal-title":"Nat Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/gepi.1036","article-title":"Determining trait locus position from multipoint analysis: accuracy and power of three different statistics","volume":"21","author":"DA Greenberg","year":"2001","journal-title":"Genet Epidemiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1086\/338923","article-title":"HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity","volume":"70","author":"SE Hodge","year":"2002","journal-title":"Am J Hum Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.mp.4001012","article-title":"Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia","volume":"7","author":"JA Badner","year":"2002","journal-title":"Mol Psychiatry"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/sj.mp.4002039","article-title":"Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families","volume":"13","author":"T Venken","year":"2008","journal-title":"Mol Psychiatry"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.91.13.5918","article-title":"Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene","volume":"91","author":"WH Berrettini","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","first-page":"1384","article-title":"Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect","volume":"57","author":"OC Stine","year":"1995","journal-title":"Am J Hum Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1086\/491602","article-title":"Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q","volume":"77","author":"PI Lin","year":"2005","journal-title":"Am J Hum Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1073\/pnas.96.10.5604","article-title":"A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2","volume":"96","author":"SD Detera-Wadleigh","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.mp.4001916","article-title":"Dense SNP association study for bipolar I disorder on chromosome 18p11 suggests two loci with excess paternal transmission","volume":"12","author":"JG Mulle","year":"2007","journal-title":"Mol Psychiatry"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/jhg.2009.47","article-title":"Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia","volume":"54","author":"JM Meerabux","year":"2009","journal-title":"J Hum Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.mp.4001393","article-title":"Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands","volume":"9","author":"TD Als","year":"2004","journal-title":"Mol Psychiatry"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.biopsych.2006.06.029","article-title":"Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder","volume":"61","author":"S Le Hellard","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ng0496-427","article-title":"A locus for bipolar affective disorder on chromosome 4p","volume":"12","author":"DH Blackwood","year":"1996","journal-title":"Nat Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"15531","DOI":"10.1073\/pnas.95.26.15531","article-title":"A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish","volume":"95","author":"EI Ginns","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e1003649","DOI":"10.1371\/journal.pgen.1003649","article-title":"Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs","volume":"9","author":"CD Brown","year":"2013","journal-title":"PLoS Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","author":"JD Storey","year":"2002","journal-title":"Journal of the Royal Statistical Society Series B"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4161\/cam.4.4.12460","article-title":"Neuronal cell adhesion genes: Key players in risk for schizophrenia, bipolar disorder and other neurodevelopmental brain disorders","volume":"4","author":"AP Corvin","year":"2010","journal-title":"Cell Adh Migr"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/mp.2010.7","article-title":"Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility","volume":"16","author":"C O'Dushlaine","year":"2011","journal-title":"Mol Psychiatry"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng.781","article-title":"A rare variant in MYH6 is associated with high risk of sick sinus syndrome","volume":"43","author":"H Holm","year":"2011","journal-title":"Nat Genet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/ng.972","article-title":"Identification of low-frequency variants associated with gout and serum uric acid levels","volume":"43","author":"P Sulem","year":"2011","journal-title":"Nat Genet"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ng.926","article-title":"A germline variant in the TP53 polyadenylation signal confers cancer susceptibility","volume":"43","author":"SN Stacey","year":"2011","journal-title":"Nat Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ng.955","article-title":"Mutations in BRIP1 confer high risk of ovarian cancer","volume":"43","author":"T Rafnar","year":"2011","journal-title":"Nat Genet"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A mutation in APP protects against Alzheimer&apos;s disease and age-related cognitive decline","volume":"488","author":"T Jonsson","year":"2012","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ng1450","article-title":"Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice","volume":"36","author":"B Yalcin","year":"2004","journal-title":"Nat Genet"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature09821","article-title":"Catecholamine receptor polymorphisms affect decision-making in C. elegans","volume":"472","author":"A Bendesky","year":"2011","journal-title":"Nature"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1534\/genetics.109.101691","article-title":"Quantitative trait loci for aggressive behavior in Drosophila melanogaster","volume":"182","author":"AC Edwards","year":"2009","journal-title":"Genetics"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/ng0411-287","article-title":"Next-generation association studies for complex traits","volume":"43","author":"E Zeggini","year":"2011","journal-title":"Nat Genet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"R16","DOI":"10.1093\/hmg\/ddt376","article-title":"In search of low-frequency and rare variants affecting complex traits","volume":"22","author":"K Panoutsopoulou","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-genom-082908-150040","article-title":"Genetics, medicine, and the Plain people","volume":"10","author":"KA Strauss","year":"2009","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.1196554","article-title":"Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124","volume":"330","author":"F Kuhnert","year":"2010","journal-title":"Science"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1073\/pnas.1017192108","article-title":"GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier","volume":"108","author":"M Cullen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nrd2983","article-title":"Voltage-gated potassium channels as therapeutic targets","volume":"8","author":"H Wulff","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref72","article-title":"Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study","author":"PH Kuo","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref73","unstructured":"Benkert AR, Puffenberger EG, Markx S, Paul SM, Jinks RN, et al. (2013) A novel variant in the HERG3 voltage-gated potassium ion channel gene (KCHN7) is associated with bipolar spectrum disorder among the Old Order Amish. (Abstract #55) Presented at the 63rd Annual Meeting of The American Society of Human Genetics, Boston, MA."},{"key":"ref74","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fpsyt.2013.00154","article-title":"Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling Pathways","volume":"4","author":"B Kerner","year":"2013","journal-title":"Front Psychiatry"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1139\/gen-2013-0081","article-title":"Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder","volume":"56","author":"C Cruceanu","year":"2013","journal-title":"Genome"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuron.2010.10.007","article-title":"Neurocognitive phenotypes and genetic dissection of disorders of brain and behavior","volume":"68","author":"E Congdon","year":"2010","journal-title":"Neuron"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature12818","article-title":"CNVs conferring risk of autism or schizophrenia affect cognition in controls","volume":"505","author":"H Stefansson","year":"2013","journal-title":"Nature"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature12124","article-title":"Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits","volume":"497","author":"U Styrkarsdottir","year":"2013","journal-title":"Nature"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/ng.2804","article-title":"Evaluating empirical bounds on complex disease genetic architecture","volume":"45","author":"V Agarwala","year":"2013","journal-title":"Nat Genet"},{"key":"ref80","first-page":"5","article-title":"The impact of diagnoses on genetic linkage study for bipolar affective disorders among the Amish","volume":"1","author":"JA Egeland","year":"1990","journal-title":"Psychiatric Genetics"},{"key":"ref81","first-page":"1","article-title":"Schedule for Affective Disorders and Schizophrenia Lifetime Version, Third Edition","author":"J Endicott","year":"1988","journal-title":"New York State Psychiatric Institute"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","article-title":"A diagnostic interview: the schedule for affective disorders and schizophrenia","volume":"35","author":"J Endicott","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/cmb.2011.0201","article-title":"Computational techniques for human genome resequencing using mated gapped reads","volume":"19","author":"P Carnevali","year":"2012","journal-title":"J Comput Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"E2393","DOI":"10.1002\/humu.22376","article-title":"dbNSFP v2.0: a database of human non-synonymous SNVs and their functional predictions and annotations","volume":"34","author":"X Liu","year":"2013","journal-title":"Hum Mutat"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1093\/nar\/gkn556","article-title":"Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms","volume":"36","author":"SJ Diskin","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e1002134","DOI":"10.1371\/journal.pgen.1002134","article-title":"Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes","volume":"7","author":"EN Smith","year":"2011","journal-title":"PLoS Genet"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"BN Howie","year":"2009","journal-title":"PLoS Genet"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuron.2010.10.009","article-title":"Changing the landscape of autism research: the autism genetic resource exchange","volume":"68","author":"CM Lajonchere","year":"2010","journal-title":"Neuron"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ajhg.2013.02.011","article-title":"GIGI: an approach to effective imputation of dense genotypes on large pedigrees","volume":"92","author":"CY Cheung","year":"2013","journal-title":"Am J Hum Genet"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1101\/gr.7156307","article-title":"A second-generation combined linkage physical map of the human genome","volume":"17","author":"TC Matise","year":"2007","journal-title":"Genome Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/gepi.20030","article-title":"Robust estimation of critical values for genome scans to detect linkage","volume":"28","author":"SA Bacanu","year":"2005","journal-title":"Genet Epidemiol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/ng.2007.16","article-title":"A survey of genetic human cortical gene expression","volume":"39","author":"AJ Myers","year":"2007","journal-title":"Nat Genet"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T01:21:09Z","timestamp":1689038469000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004229"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Flint","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":92,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004229","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718310770.793540692","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}