{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:40:14Z","timestamp":1779396014017,"version":"3.53.1"},"reference-count":101,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004270","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T01:18:11Z","timestamp":1397783891000},"page":"e1004270","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fine Mapping of Dominant X-Linked Incompatibility Alleles in Drosophila Hybrids"],"prefix":"10.1371","volume":"10","author":[{"given":"Daniel R.","family":"Matute","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Gavin-Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"ref1","unstructured":"Coyne JA, Orr HA (2004) Speciation. Sunderland, Mass, Sinauer Associates."},{"key":"ref2","unstructured":"Price TD (2007) Speciation in Birds. Roberts &amp; Co. Publishers. Boulder, CO, USA."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0169-5347(01)02167-X","article-title":"The genetics of species differences","volume":"16","author":"HA Orr","year":"2001","journal-title":"Trends Ecol Evol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/jhered\/esl060","article-title":"Speciation in <italic>Drosophila<\/italic>: from phenotypes to molecules","volume":"98","author":"HA Orr","year":"2007","journal-title":"J Hered"},{"key":"ref5","unstructured":"Dobzhansky T (1937) Genetics and the origin of species. New York: Columbia University Press."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.ecolsys.34.011802.132412","article-title":"The role of reinforcement in speciation: theory and data","volume":"34","author":"MR Servedio","year":"2003","journal-title":"Annu Rev Ecol Evol Syst"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Nosil P (2012) Ecological speciation. Oxford University Press, Oxford.","DOI":"10.1093\/acprof:osobl\/9780199587100.001.0001"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/nph.12119","article-title":"Reinforcement in plants","volume":"197","author":"R Hopkins","year":"2013","journal-title":"New Phytol"},{"key":"ref9","first-page":"71","article-title":"Isolating mechanisms, evolution, and temperature","volume":"6","author":"HJ Muller","year":"1942","journal-title":"Biol Symp"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/genetics\/139.4.1805","article-title":"The population genetics of speciation: the evolution of hybrid incompatibilities","volume":"139","author":"HA Orr","year":"1995","journal-title":"Genetics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.1128721","article-title":"Gene transposition as a cause of hybrid sterility","volume":"313","author":"JP Masly","year":"2006","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/j.1558-5646.2010.00990.x","article-title":"The contributions of gene movement to the \u201ctwo rules of speciation\u201d","volume":"64","author":"LC Moyle","year":"2010","journal-title":"Evolution"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-genet-110410-132514","article-title":"The genetics of hybrid incompatibilities","volume":"45","author":"S Maheshwari","year":"2011","journal-title":"Annu Rev Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.tree.2011.01.001","article-title":"The genes underlying the process of speciation","volume":"26","author":"P Nosil","year":"2011","journal-title":"Trends Ecol Evol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF02983075","article-title":"Sex-ratio and unisexual sterility in hybrid animals","volume":"12","author":"JBS Haldane","year":"1922","journal-title":"J Genetics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.ecolsys.28.1.195","article-title":"Haldane&apos;s rule","volume":"28","author":"HA Orr","year":"1997","journal-title":"Annu Rev Ecol Syst"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nature01679","article-title":"Adaptive evolution drives divergence of a hybrid inviability gene in <italic>Drosophila<\/italic>","volume":"423","author":"DC Presgraves","year":"2003","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1126\/science.1169123","article-title":"Evolution of the <italic>Drosophila<\/italic> nuclear pore complex results in multiple hybrid incompatibilities","volume":"323","author":"S Tang","year":"2009","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1126\/science.1163934","article-title":"A single gene causes both male sterility and segregation distortion in <italic>Drosophila<\/italic> hybrids","volume":"323","author":"N Phadnis","year":"2009","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e243","DOI":"10.1371\/journal.pbio.0050243","article-title":"High-resolution genome-wide dissection of the two rules of speciation in <italic>Drosophila<\/italic>","volume":"5","author":"JP Masly","year":"2007","journal-title":"PLoS Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.0014-3820.2001.tb00628.x","article-title":"The evolution of postzygotic isolation: accumulating Dobzhansky-Muller incompatibilities","volume":"55","author":"HA Orr","year":"2001","journal-title":"Evolution"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1126\/science.1193440","article-title":"A test of the snowball theory for the rate of evolution of hybrid incompatibilities","volume":"329","author":"DR Matute","year":"2010","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.1193063","article-title":"Hybrid Incompatibility \u2018snowballs\u2019 between <italic>Solanum<\/italic> species","volume":"329","author":"LC Moyle","year":"2010","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/346558a0","article-title":"Microorganisms associated with chromosome destruction and reproductive isolation between two insect species","volume":"346","author":"H Breeuwer","year":"1990","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2307\/2410324","article-title":"Hybrid breakdown between two haplodiploid species: The role of nuclear and cytoplasmic genes","volume":"49","author":"JAJ Breeuwer","year":"1995","journal-title":"Evolution"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1534\/genetics.106.065979","article-title":"Asymmetric postmating isolation: Darwin&apos;s corollary to Haldane&apos;s rule","volume":"176","author":"M Turelli","year":"2007","journal-title":"Genetics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1534\/genetics.107.081364","article-title":"Accelerated mitochondrial evolution and \u2018Darwin&apos;s corollary\u2019: Asymmetric viability of reciprocal F<sub>1<\/sub> hybrids in centrarchid fishes","volume":"178","author":"DI Bolnick","year":"2008","journal-title":"Genetics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cell.2008.10.047","article-title":"Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast species","volume":"135","author":"HY Lee","year":"2008","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1000432","DOI":"10.1371\/journal.pbio.1000432","article-title":"Multiple molecular mechanisms cause reproductive isolation between three yeast species","volume":"8","author":"JY Chou","year":"2010","journal-title":"PLoS Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.2307\/2410171","article-title":"A mathematical model of Haldane&apos;s rule","volume":"47","author":"HA Orr","year":"1993","journal-title":"Evolution"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/361532a0","article-title":"Haldane&apos;s rule has multiple genetic causes","volume":"361","author":"HA Orr","year":"1993","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/genetics\/140.1.389","article-title":"The dominance theory of Haldane&apos;s rule","volume":"140","author":"M Turelli","year":"1995","journal-title":"Genetics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/genetics\/143.1.613","article-title":"Dominance and Haldane&apos;s rule","volume":"143","author":"HA Orr","year":"1995","journal-title":"Genetics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1126\/science.282.5390.952","article-title":"Haldane&apos;s rule is obeyed in taxa lacking a hemizygous sex","volume":"282","author":"DC Presgraves","year":"1998","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1086\/284701","article-title":"The relative rates of evolution of sex chromosomes and autosomes","volume":"130","author":"B Charlesworth","year":"1987","journal-title":"Am Nat"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/genetics\/147.4.1799","article-title":"Haldane&apos;s rule and <italic>X<\/italic> chromosome size in <italic>Drosophila<\/italic>","volume":"147","author":"M Turelli","year":"1997","journal-title":"Genetics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/genetics\/154.4.1663","article-title":"Dominance, epistasis and the genetics of postzygotic isolation","volume":"154","author":"M Turelli","year":"2000","journal-title":"Genetics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/genetics\/150.3.1091","article-title":"Relative paucity of genes causing inviability in hybrids between <italic>Drosophila melanogaster<\/italic> and <italic>D. simulans<\/italic>","volume":"150","author":"JA Coyne","year":"1998","journal-title":"Genetics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/genetics\/133.2.299","article-title":"Hybrid lethal systems in the <italic>Drosophila melanogaster<\/italic> species complex. I. The maternal hybrid rescue (<italic>mhr<\/italic>) gene of <italic>Drosophila simulans<\/italic>","volume":"133","author":"K Sawamura","year":"1993","journal-title":"Genetics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/BF00276943","article-title":"Cytogenetical localization of Zygotic hybrid rescue (<italic>Zhr<\/italic>), a <italic>Drosophila melanogaster<\/italic> gene that rescues interspecific hybrids from embryonic lethality","volume":"239","author":"K Sawamura","year":"1993","journal-title":"Mol Gen Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1534\/genetics.112.139683","article-title":"Incompatibility between <italic>X<\/italic> chromosome Factor and pericentric heterochromatic region causes lethality in hybrids between <italic>Drosophila melanogaster<\/italic> and its sibling species","volume":"191","author":"MV Cattani","year":"2012","journal-title":"Genetics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/genetics\/137.1.175","article-title":"Genetics of reproductive isolation in the <italic>Drosophila simulans<\/italic> clade: Complex epistasis underlying hybrid male sterility","volume":"137","author":"EL Cabot","year":"1994","journal-title":"Genetics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0169-5347(01)02177-2","article-title":"Theory and speciation","volume":"16","author":"M Turelli","year":"2001","journal-title":"Trends Ecol Evol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.0014-3820.2001.tb00628.x","article-title":"The evolution of postzygotic isolation: accumulating Dobzhansky-Muller incompatibilities","volume":"55","author":"HA Orr","year":"2001","journal-title":"Evolution"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1534\/genetics.108.095679","article-title":"Complex Epistasis for Dobzhansky-Muller Hybrid Incompatibility in <italic>Solanum<\/italic>","volume":"181","author":"LC Moyle","year":"2009","journal-title":"Genetics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/genetics\/142.3.819","article-title":"A genome-wide survey of hybrid incompatibility factors by the introgression of marked segments of <italic>Drosophila mauritiana<\/italic> chromosomes into <italic>Drosophila simulans<\/italic>","volume":"142","author":"JR True","year":"1996","journal-title":"Genetics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/genetics\/138.2.329","article-title":"Genetics of hybrid male sterility between Drosophila sibling species: a complex web of epistasis is revealed in interspecific studies","volume":"138","author":"MF Palopoli","year":"1994","journal-title":"Genetics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/genetics\/163.3.955","article-title":"A fine-scale genetic analysis of hybrid incompatibilities in <italic>Drosophila<\/italic>","volume":"163","author":"DC Presgraves","year":"2003","journal-title":"Genetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nature01679","article-title":"Adaptive evolution drives divergence of a hybrid inviability gene between two species of <italic>Drosophila<\/italic>","volume":"423","author":"DC Presgraves","year":"2003","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1126\/science.1169123","article-title":"Evolution of the <italic>Drosophila<\/italic> nuclear pore complex results in multiple hybrid incompatibilities","volume":"323","author":"S Tang","year":"2009","journal-title":"Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e1000234","DOI":"10.1371\/journal.pbio.1000234","article-title":"Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in <italic>Drosophila<\/italic>","volume":"7","author":"PM Ferree","year":"2009","journal-title":"PLoS Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1534\/genetics.110.123265","article-title":"A new resource for characterizing <italic>X<\/italic>-linked genes in <italic>Drosophila melanogaster<\/italic>: systematic coverage and subdivision of the <italic>X<\/italic> chromosome with nested, <italic>Y<\/italic>-linked duplications","volume":"186","author":"RK Cook","year":"2010","journal-title":"Genetics"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/ece3.573","article-title":"Embryonic lethality leads to hybrid male inviability in hybrids between <italic>Drosophila melanogaster<\/italic> and <italic>D. santomea<\/italic>","volume":"3","author":"J Gavin-Smyth","year":"2013","journal-title":"Ecology and Evolution"},{"key":"ref54","first-page":"1","article-title":"The genetics of <italic>Drosophila simulans<\/italic>","volume":"399","author":"AH Sturtevant","year":"1929","journal-title":"Carnegie Inst Wash Publ"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/genetics\/145.4.1031","article-title":"The developmental genetics of hybrid inviability: a mitotic defect in <italic>Drosophila<\/italic> hybrids","volume":"145","author":"HA Orr","year":"1997","journal-title":"Genetics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1534\/genetics.107.079939","article-title":"Developmental and cell cycle progression defects in <italic>Drosophila<\/italic> hybrid males","volume":"177","author":"BJ Bolkan","year":"2007","journal-title":"Genetics"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.104.3.483","article-title":"Requirements for <italic>X<\/italic>-linked zygotic gene activity during cellularization of early <italic>Drosophila<\/italic> embryos","volume":"104","author":"E Wieschaus","year":"1988","journal-title":"Development"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/genetics\/122.4.869","article-title":"Gene expression in adult metafemales of <italic>Drosophila melanogaster<\/italic>","volume":"122","author":"JA Birchler","year":"1989","journal-title":"Genetics"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1073\/pnas.46.1.47","article-title":"The occurrence of partially fertile metafemales in <italic>Drosophila melanogaster<\/italic>","volume":"46","author":"JN Frost","year":"1960","journal-title":"Proc Natl Acad Sci U S"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1266\/jjg.55.405","article-title":"Further studies on the Lethal hybrid rescue (<italic>Lhr<\/italic>) gene of <italic>Drosophila simulans<\/italic>","volume":"55","author":"T Takamura","year":"1980","journal-title":"Jap J Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1534\/genetics.106.060541","article-title":"Misregulation of sex-lethal and disruption of male-specific lethal complex localization in <italic>Drosophila<\/italic> species hybrids","volume":"174","author":"M Pal Bhadra","year":"2006","journal-title":"Genetics"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12041-007-0028-5","article-title":"<italic>Drosophila simulans<\/italic> Lethal hybrid rescue mutation (<italic>Lhr<\/italic>) rescues inviable hybrids by restoring <italic>X<\/italic> chromosomal dosage compensation and causes fluctuating asymmetry of development","volume":"86","author":"RN Chatterjee","year":"2007","journal-title":"J Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/genetics\/156.4.1913","article-title":"The population genetics of the origin and divergence of the <italic>Drosophila simulans<\/italic> complex species","volume":"156","author":"RM Kliman","year":"2000","journal-title":"Genetics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1073\/pnas.0610385104","article-title":"Adaptive genic evolution in the <italic>Drosophila<\/italic> genomes","volume":"104","author":"JA Shapiro","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e1001388","DOI":"10.1371\/journal.pbio.1001388","article-title":"Revisiting an old riddle: what determines genetic diversity levels within species?","volume":"10","author":"EM Leffler","year":"2012","journal-title":"PLoS Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/genetics\/147.1.231","article-title":"Reproductive isolation and morphogenetic evolution in <italic>Drosophila<\/italic> analyzed by breakage of ethological barriers","volume":"147","author":"L Sanchez","year":"1997","journal-title":"Genetics"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1098\/rspb.2000.1169","article-title":"Evolutionary Novelties in Islands: <italic>Drosophila santomea<\/italic>, a new <italic>melanogaster<\/italic> Sister Species from S\u00e3o Tom\u00e9","volume":"267","author":"D Lachaise","year":"2000","journal-title":"Proc R Soc Lond B"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1534\/genetics.104.033597","article-title":"Multilocus analysis of introgression between two sympatric sister species of <italic>Drosophila: Drosophila yakuba<\/italic> and <italic>D. santomea<\/italic>","volume":"171","author":"A Llopart","year":"2005","journal-title":"Genetics"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/genetics\/96.1.165","article-title":"Male-specific lethal mutations of <italic>Drosophila melanogaster<\/italic>","volume":"96","author":"JM Belote","year":"1980","journal-title":"Genetics"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/genetics\/107.2.231","article-title":"Autoregulatory functioning of a <italic>Drosophila<\/italic> gene product that establishes and maintains the sexually determined state","volume":"107","author":"TW Cline","year":"1984","journal-title":"Genetics"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrg3124","article-title":"Dosage compensation in <italic>Drosophila melanogaster<\/italic>: epigenetic fine-tuning of chromosome-wide transcription","volume":"13","author":"T Conrad","year":"2012","journal-title":"Nature Reviews Genetics"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"E808","DOI":"10.1073\/pnas.1222542110","article-title":"Male-specific lethal complex in <italic>Drosophila<\/italic> counteracts histone acetylation and does not mediate dosage compensation","volume":"110","author":"L Sun","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(91)90157-T","article-title":"Positive autoregulation of <italic>Sex-lethal<\/italic> by alternative splicing maintains the female determined state in <italic>Drosophila<\/italic>","volume":"65","author":"LR Bell","year":"1991","journal-title":"Cell"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0092-8674(88)90248-6","article-title":"<italic>Sex-lethal<\/italic>, a <italic>Drosophila<\/italic> sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins","volume":"55","author":"LR Bell","year":"1988","journal-title":"Cell"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/genetics\/90.4.683","article-title":"Two closely linked mutations in <italic>Drosophila melanogaster<\/italic> that are lethal to opposite sexes and interact with <italic>daughterless<\/italic>","volume":"90","author":"TW Cline","year":"1978","journal-title":"Genetics"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1534\/genetics.109.108100","article-title":"Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation","volume":"184","author":"DA Barbash","year":"2010","journal-title":"Genetics"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1202876","article-title":"Comment on \u201cA test of the snowball theory for the rate of evolution of hybrid incompatibilities\u201d","volume":"333","author":"DA Barbash","year":"2011","journal-title":"Science"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1203149","article-title":"Response to Comment on \u201cA test of the snowball theory for the rate of evolution of hybrid incompatibilities\u201d","volume":"333","author":"DR Matute","year":"2011","journal-title":"Science"},{"key":"ref79","first-page":"84","article-title":"The synthesis of an attached <italic>XY<\/italic> chromosome","volume":"24","author":"DL Lindsley","year":"1950","journal-title":"Drosophila Information System"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/genetics\/44.2.187","article-title":"Compound chromosomes involving the <italic>X<\/italic> and <italic>Y<\/italic> chromosomes of <italic>Drosophila melanogaster<\/italic>","volume":"44","author":"DL Lindsley","year":"1959","journal-title":"Genetics"},{"key":"ref81","first-page":"151","article-title":"Inviability of hybrids between <italic>D. melanogaster<\/italic> and <italic>D. simulans<\/italic> results from the absence of <italic>simulans X<\/italic> not the presence of <italic>simulans Y<\/italic> chromosome","volume":"87","author":"MT Yamamoto","year":"1992","journal-title":"Genetica"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/genetics\/163.1.217","article-title":"A novel system of fertility rescue in <italic>Drosophila<\/italic> hybrids reveals a link between hybrid lethality and female sterility","volume":"163","author":"DA Barbash","year":"2003","journal-title":"Genetics"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/327331a0","article-title":"Genetic rescue of inviable hybrids between <italic>Drosophila melanogaster<\/italic> and its sibling species","volume":"327","author":"P Hutter","year":"1987","journal-title":"Nature"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/genetics\/154.4.1747","article-title":"The <italic>Drosophila melanogaster hybrid male rescue<\/italic> gene causes inviability in male and female species hybrids","volume":"154","author":"DA Barbash","year":"2000","journal-title":"Genetics"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2307\/1536473","article-title":"Non-criss-cross inheritance in <italic>Drosophila melanogaster<\/italic>","volume":"42","author":"LV Morgan","year":"1922","journal-title":"Biol Bull Wood's Hole"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/genetics\/10.5.403","article-title":"Crossing over in a case of attached <italic>X<\/italic> chromosomes in <italic>Drosophila melanogaster<\/italic>","volume":"10","author":"EG Anderson","year":"1925","journal-title":"Genetics"},{"key":"ref87","unstructured":"Lindsey DL, Zimm GG (1992) The Genome of <italic>Drosophila melanogaster<\/italic>. Academic Press, New York."},{"key":"ref88","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0168-9525(93)90138-8","article-title":"The <italic>Drosophila<\/italic> sex determination signal: how do flies count to two?","volume":"9","author":"TW Cline","year":"1993","journal-title":"Trends Genet"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/genetics\/20.2.192","article-title":"Further studies of crossing over in attached-X chromosomes of <italic>Drosophila melanogaster<\/italic>","volume":"20","author":"GW Beadle","year":"1935","journal-title":"Genetics"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/genetics\/23.5.423","article-title":"Effects of a compound duplication of the <italic>X<\/italic> chromosome of <italic>Drosophila melanogaster<\/italic>","volume":"23","author":"LV Morgan","year":"1938","journal-title":"Genetics"},{"key":"ref91","first-page":"61","article-title":"A stable double <italic>X<\/italic> chromosome","volume":"17","author":"HJ Muller","year":"1943","journal-title":"Drosophila Information Service"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1558-5646.2008.00588.x","article-title":"Thermal adaptation and extrinsic reproductive isolation in two species of <italic>Drosophila<\/italic>","volume":"63","author":"DR Matute","year":"2009","journal-title":"Evolution"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1558-5646.2009.00879.x","article-title":"Intrinsic reproductive isolation between two sister species of <italic>Drosophila<\/italic>","volume":"64","author":"DR Matute","year":"2010","journal-title":"Evolution"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/genetics\/117.4.727","article-title":"Heritability of two morphological characters within and among natural populations of <italic>Drosophila melanogaster<\/italic>","volume":"117","author":"JA Coyne","year":"1987","journal-title":"Genetics"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0016672300027245","article-title":"Dubious maternal inheritance of mitochondrial DNA in <italic>Drosophila simulans<\/italic> and evolution of <italic>Drosophila mauritiana<\/italic>","volume":"52","author":"Y Satta","year":"1988","journal-title":"Genet Res"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1017\/S0016672300030639","article-title":"Genetics of sexual isolation in females of the <italic>Drosophila simulans<\/italic> species complex","volume":"60","author":"JA Coyne","year":"1992","journal-title":"Genet Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1534\/genetics.112.142018","article-title":"Genomic variation in natural populations of <italic>Drosophila melanogaster<\/italic>","volume":"192","author":"CH Langley","year":"2012","journal-title":"Genetics"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"ee1003080","DOI":"10.1371\/journal.pgen.1003080","article-title":"Population genomics of sub-Saharan <italic>Drosophila melanogaster<\/italic>: African diversity and non-African admixture","volume":"8","author":"JE Pool","year":"2012","journal-title":"PLoS Genet"},{"key":"ref99","unstructured":"Thompson JGP, Schedl P, Pulak R (2004) Sex-specific GFP-expression in <italic>Drosophila<\/italic> embryos and sorting by Copas flow cytometry technique. Presented at the 45<sup>th<\/sup> Annual <italic>Drosophila<\/italic> Research Conference, Washington, DC, 24\u201328 March 2004."},{"key":"ref100","unstructured":"R Development Core Team (2005) R: A language and environment for statistical computing, reference index version 2.2.1. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.R-project.org\" xlink:type=\"simple\">http:\/\/www.R-project.org<\/ext-link>."},{"key":"ref101","first-page":"626","article-title":"Rectangular confidence regions for the means of multivariate normal distributions","volume":"62","author":"Z Sidak","year":"1967","journal-title":"Journal of the American Statistical Association"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1005558","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000}}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T21:28:26Z","timestamp":1648848506000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004270"}},"subtitle":[],"editor":[{"given":"David J.","family":"Begun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,17]]},"references-count":101,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004270","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,17]]}}}