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Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/icb\/43.1.55","article-title":"Epithelium\u2014The Primary Building Block for Metazoan Complexity","volume":"43","author":"S Tyler","year":"2003","journal-title":"Integr Comp Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/jez.b.21442","article-title":"Epithelia, an evolutionary novelty of metazoans","volume":"318","author":"SP Leys","year":"2012","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Raff R (1996) The Shape of Life: Genes, Development, and the Evolution of Animal Form. 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