{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:33:49Z","timestamp":1791923629126,"version":"4.3.4"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004606","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T01:55:47Z","timestamp":1409882147000},"page":"e1004606","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":318,"title":["Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias"],"prefix":"10.1371","volume":"10","author":[{"given":"Gary W.","family":"Beecham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Naj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eden R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Huentelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Corneveaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Vonsattel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Younkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"De Jager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Crane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ilyas","family":"Kamboh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Kofler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah C.","family":"Mash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Duque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Gwirtsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Buxbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Kukull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Mayeux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Pericak-Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Reiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Genetics Consortium (ADGC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard D.","family":"Schellenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Montine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/ana.21208","article-title":"Pathological correlates of dementia in a longitudinal, population-based sample of aging","volume":"62","author":"JA Sonnen","year":"2007","journal-title":"Ann Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/archneurol.2011.157","article-title":"Ecology of the aging human brain","volume":"68","author":"JA Sonnen","year":"2011","journal-title":"Arch Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer&apos;s pathological cascade","volume":"9","author":"CR Jack Jr","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJMsa1204629","article-title":"Monetary costs of dementia in the United States","volume":"368","author":"MD Hurd","year":"2013","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1001\/archneurol.2010.201","article-title":"Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes","volume":"67","author":"G Jun","year":"2010","journal-title":"Arch Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1001130","DOI":"10.1371\/journal.pgen.1001130","article-title":"Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities","volume":"6","author":"AC Naj","year":"2010","journal-title":"PLoS Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer&apos;s disease","volume":"43","author":"P Hollingworth","year":"2011","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer&apos;s disease","volume":"43","author":"AC Naj","year":"2011","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1001\/archneurol.2012.2052","article-title":"Comprehensive search for Alzheimer disease susceptibility loci in the APOE region","volume":"69","author":"G Jun","year":"2012","journal-title":"Arch Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e58618","DOI":"10.1371\/journal.pone.0058618","article-title":"SORL1 is genetically associated with late-onset Alzheimer&apos;s disease in Japanese, Koreans and Caucasians","volume":"8","author":"A Miyashita","year":"2013","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer&apos;s disease","volume":"45","author":"JC Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer&apos;s disease in late onset families","volume":"261","author":"EH Corder","year":"1993","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1510.e1519","DOI":"10.1016\/j.neurobiolaging.2013.12.010","article-title":"Missense variant in TREML2 protects against Alzheimer&apos;s disease","volume":"35","author":"BA Benitez","year":"2014","journal-title":"Neurobiol Aging"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature12825","article-title":"Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer&apos;s disease","volume":"505","author":"C Cruchaga","year":"2014","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/jamaneurol.2013.2815","article-title":"Genetic susceptibility for Alzheimer disease neuritic plaque pathology","volume":"70","author":"JM Shulman","year":"2013","journal-title":"JAMA Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1001\/jamaneurol.2013.600","article-title":"APOE epsilon4 increases risk for dementia in pure synucleinopathies","volume":"70","author":"D Tsuang","year":"2013","journal-title":"JAMA Neurol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10048-007-0087-z","article-title":"Association study of cholesterol-related genes in Alzheimer&apos;s disease","volume":"8","author":"MA Wollmer","year":"2007","journal-title":"Neurogenetics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/jnen\/62.1.34","article-title":"Characterization of an O-glycosylated plaque-associated protein from Alzheimer disease brain","volume":"62","author":"B Espinosa","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/abbi.2001.2304","article-title":"Characterization of high-affinity binding between gangliosides and amyloid beta-protein","volume":"388","author":"T Ariga","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"ref20","first-page":"39","article-title":"Regulated O-glycosylation of the Alzheimer beta-A4 amyloid precursor protein in thyrocytes","volume":"66","author":"KS Graebert","year":"1995","journal-title":"Eur J Cell Biol"},{"key":"ref21","first-page":"132","article-title":"Making the diagnosis of Alzheimer&apos;s disease. A primer for practicing pathologists","volume":"117","author":"SS Mirra","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"H Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease","volume":"56","author":"BT Hyman","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng2088","article-title":"A new multipoint method for genome-wide association studies by imputation of genotypes","volume":"39","author":"J Marchini","year":"2007","journal-title":"Nat Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"GR Abecasis","year":"2012","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Venables W, Ripley D (2003) Modern Applied Statistics with S. New York: Springer. 497 p.","DOI":"10.1007\/978-0-387-21706-2"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"CJ Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"ref30","unstructured":"Hastie T, Pregibon D (1992) Generalized linear models. In: Chambers J, Hastie T, editors. Statistical Models in S. Pacific Grove, CA: Wadsworth &amp; Brooks\/Cole. pp. 195\u2013246."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1198\/000313002533","article-title":"Corrgrams: Exploratory displays for correlation matrices","volume":"56","author":"M Friendly","year":"2002","journal-title":"American Statistician"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1004867","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000}}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:35:06Z","timestamp":1588991706000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004606"}},"subtitle":[],"editor":[{"given":"Greg","family":"Gibson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,9,4]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004606","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pgen.1004867","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,4]]}}}