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Liangos","year":"2010","journal-title":"Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1086\/505331","article-title":"Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression","volume":"79","author":"WS Modi","year":"2006","journal-title":"American journal of human genetics"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1523\/JNEUROSCI.2830-13.2014","article-title":"Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain","volume":"34","author":"IL Campbell","year":"2014","journal-title":"J Neurosci"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"e1003444","DOI":"10.1371\/journal.pgen.1003444","article-title":"Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases","volume":"9","author":"RC Ferreira","year":"2013","journal-title":"PLoS Genet"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.2337\/db07-0505","article-title":"Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women","volume":"56","author":"L Qi","year":"2007","journal-title":"Diabetes"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbamcr.2009.12.001","article-title":"ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase","volume":"1803","author":"A Chalaris","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.02.067","article-title":"Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han","volume":"1327","author":"M Wang","year":"2010","journal-title":"Brain research"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0006-8993(97)01355-3","article-title":"Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease","volume":"780","author":"H Hampel","year":"1998","journal-title":"Brain research"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0304-3940(95)11384-9","article-title":"Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures","volume":"188","author":"R Del Bo","year":"1995","journal-title":"Neuroscience letters"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0167-5699(91)90032-O","article-title":"Is amyloidogenesis during Alzheimer's disease due to an IL-1-\/IL-6-mediated \u2018acute phase response\u2019 in the brain?","volume":"12","author":"P Vandenabeele","year":"1991","journal-title":"Immunology today"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0169-328X(97)00356-2","article-title":"Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor\/interleukin-6 complex","volume":"55","author":"GE Ringheim","year":"1998","journal-title":"Brain research Molecular brain research"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/CIRCULATIONAHA.113.002251","article-title":"Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease","volume":"128","author":"M Sabater-Lleal","year":"2013","journal-title":"Circulation"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e1000072","DOI":"10.1371\/journal.pgen.1000072","article-title":"A genome-wide association study identifies protein quantitative trait loci (pQTLs)","volume":"4","author":"D Melzer","year":"2008","journal-title":"PLoS Genet"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1471-2350-8-S1-S8","article-title":"Framingham Heart Study genome-wide association: results for pulmonary function measures","volume":"8","author":"JB Wilk","year":"2007","journal-title":"BMC Med Genet"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1182\/blood.V87.3.1104.bloodjournal8731104","article-title":"Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B","volume":"87","author":"D Chauhan","year":"1996","journal-title":"Blood"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1359-6101(02)00027-8","article-title":"IL-6 in autoimmune disease and chronic inflammatory proliferative disease","volume":"13","author":"K Ishihara","year":"2002","journal-title":"Cytokine & growth factor reviews"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/01.ju.0000168723.42824.40","article-title":"Interleukin-6 polymorphism is associated with more aggressive prostate cancer","volume":"174","author":"D Tan","year":"2005","journal-title":"The Journal of urology"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jalz.2010.03.008","article-title":"Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects","volume":"6","author":"JQ Trojanowski","year":"2010","journal-title":"Alzheimers Dement"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/ana.20730","article-title":"Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans","volume":"59","author":"AM Fagan","year":"2006","journal-title":"Ann Neurol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00439-008-0568-7","article-title":"Missing data imputation and haplotype phase inference for genome-wide association studies","volume":"124","author":"SR Browning","year":"2008","journal-title":"Hum Genet"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref99","article-title":"Metal\u2014Meta Analysis Helper","author":"G Abecasis","year":"2007","journal-title":"Center for Statistical Genetics"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/bioinformatics\/btm108","article-title":"GenABEL: an R library for genome-wide association analysis","volume":"23","author":"YS Aulchenko","year":"2007","journal-title":"Bioinformatics"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1212\/WNL.0b013e3181bc010c","article-title":"Relationships between biomarkers in aging and dementia","volume":"73","author":"WJ Jagust","year":"2009","journal-title":"Neurology"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"K Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using 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