{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:38:31Z","timestamp":1790030311797,"version":"4.0.1"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004785","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T14:14:45Z","timestamp":1415888085000},"page":"e1004785","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":169,"title":["Evolution of DNA Methylation Patterns in the Brassicaceae is Driven by Differences in Genome Organization"],"prefix":"10.1371","volume":"10","author":[{"given":"Danelle K.","family":"Seymour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hagmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Weigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"8689","DOI":"10.1073\/pnas.1002720107","article-title":"Conservation and divergence of methylation patterning in plants and animals","volume":"107","author":"S Feng","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1186366","article-title":"Genome-wide evolutionary analysis of eukaryotic DNA methylation","volume":"328","author":"A Zemach","year":"2010","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrg2341","article-title":"DNA methylation landscapes: provocative insights from epigenomics","volume":"9","author":"MM Suzuki","year":"2008","journal-title":"Nat Rev Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.cell.2014.01.029","article-title":"Dnmt1-independent CG methylation contributes to nucleosome positioning in diverse eukaryotes","volume":"156","author":"JT Huff","year":"2014","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/292860a0","article-title":"Sequence specificity of methylation in higher-plant DNA","volume":"292","author":"Y Gruenbaum","year":"1981","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cell.2006.08.003","article-title":"Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis","volume":"126","author":"X Zhang","year":"2006","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/ng1929","article-title":"Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription","volume":"39","author":"D Zilberman","year":"2007","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/15479","article-title":"Differential methylation of genes and retrotransposons facilitates shotgun sequencing of the maize genome","volume":"23","author":"PD Rabinowicz","year":"1999","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1101\/gr.153510.112","article-title":"The maize methylome influences mRNA splice sites and reveals widespread paramutation-like switches guided by small RNA","volume":"23","author":"M Regulski","year":"2013","journal-title":"Genome Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1471-2164-13-300","article-title":"Single-base resolution maps of cultivated and wild rice methylomes and regulatory roles of DNA methylation in plant gene expression","volume":"13","author":"X Li","year":"2012","journal-title":"BMC Genomics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1073\/pnas.1215380110","article-title":"Gene body methylation is conserved between plant orthologs and is of evolutionary consequence","volume":"110","author":"S Takuno","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg2072","article-title":"Transposable elements and the epigenetic regulation of the genome","volume":"8","author":"RK Slotkin","year":"2007","journal-title":"Nat Rev Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrg3374","article-title":"How important are transposons for plant evolution?","volume":"14","author":"D Lisch","year":"2013","journal-title":"Nat Rev Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature06745","article-title":"Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning","volume":"452","author":"SJ Cokus","year":"2008","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2008.03.029","article-title":"Highly integrated single-base resolution maps of the epigenome in Arabidopsis","volume":"133","author":"R Lister","year":"2008","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature08514","article-title":"Human DNA methylomes at base resolution show widespread epigenomic differences","volume":"462","author":"R Lister","year":"2009","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1002988","DOI":"10.1371\/journal.pgen.1002988","article-title":"Deposition of histone variant H2A.Z within gene bodies regulates responsive genes","volume":"8","author":"D Coleman-Derr","year":"2012","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature11968","article-title":"Patterns of population epigenomic diversity","volume":"495","author":"RJ Schmitz","year":"2013","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4161\/epi.26869","article-title":"Epigenetic differences between shoots and roots in Arabidopsis reveals tissue-specific regulation","volume":"9","author":"N Widman","year":"2014","journal-title":"Epigenetics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"E2183","DOI":"10.1073\/pnas.1209329109","article-title":"Widespread dynamic DNA methylation in response to biotic stress","volume":"109","author":"RH Dowen","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/15490","article-title":"Epigenetic inheritance at the agouti locus in the mouse","volume":"23","author":"HD Morgan","year":"1999","journal-title":"Nat Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/43657","article-title":"An epigenetic mutation responsible for natural variation in floral symmetry","volume":"401","author":"P Cubas","year":"1999","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/ng1841","article-title":"A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening","volume":"38","author":"K Manning","year":"2006","journal-title":"Nat Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/nature08498","article-title":"A transposon-induced epigenetic change leads to sex determination in melon","volume":"461","author":"A Martin","year":"2009","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/genetics\/136.3.1121","article-title":"Variegated phenotype and developmental methylation changes of a maize allele originating from epimutation","volume":"136","author":"OP Das","year":"1994","journal-title":"Genetics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1101\/gad.1217304","article-title":"siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidopsis","volume":"18","author":"J Liu","year":"2004","journal-title":"Genes Dev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11218","DOI":"10.1073\/pnas.0901942106","article-title":"A metastable DWARF1 epigenetic mutant affecting plant stature in rice","volume":"106","author":"K Miura","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cell.2014.02.045","article-title":"Transgenerational epigenetic inheritance: myths and mechanisms","volume":"157","author":"E Heard","year":"2014","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1126\/science.1059745","article-title":"Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation","volume":"292","author":"AM Lindroth","year":"2001","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0022-2836(88)90122-2","article-title":"Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases","volume":"203","author":"T Bestor","year":"1988","journal-title":"J Mol Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/nar\/21.10.2383","article-title":"Isolation and identification by sequence homology of a putative cytosine methyltransferase from Arabidopsis thaliana","volume":"21","author":"EJ Finnegan","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0092-8674(92)90561-P","article-title":"A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei","volume":"71","author":"H Leonhardt","year":"1992","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1126\/science.277.5334.1996","article-title":"Human DNA (cytosine-5) methyltransferase PCNA complex as a target for p21(WAF1)","volume":"277","author":"LSH Chuang","year":"1997","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/nar\/27.7.1625","article-title":"Heavy de novo methylation at symmetrical and non-symmetrical sites is a hallmark of RNA-directed DNA methylation","volume":"27","author":"T Pelissier","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"16491","DOI":"10.1073\/pnas.162371599","article-title":"Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes","volume":"99","author":"X Cao","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrg2719","article-title":"Establishing, maintaining and modifying DNA methylation patterns in plants and animals","volume":"11","author":"JA Law","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.1095989","article-title":"RNA silencing genes control de novo DNA methylation","volume":"303","author":"SW Chan","year":"2004","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cell.2013.02.033","article-title":"The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin","volume":"153","author":"A Zemach","year":"2013","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature10555","article-title":"Spontaneous epigenetic variation in the Arabidopsis thaliana methylome","volume":"480","author":"C Becker","year":"2011","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1126\/science.1212959","article-title":"Transgenerational epigenetic instability is a source of novel methylation variants","volume":"334","author":"RJ Schmitz","year":"2011","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cell.2012.09.001","article-title":"Reprogramming of DNA methylation in pollen guides epigenetic inheritance via small RNA","volume":"151","author":"JP Calarco","year":"2012","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/molbev\/msr188","article-title":"Body-methylated genes in Arabidopsis thaliana are functionally important and evolve slowly","volume":"29","author":"S Takuno","year":"2012","journal-title":"Mol Biol Evol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e00348","DOI":"10.7554\/eLife.00348","article-title":"Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates","volume":"2","author":"HK Long","year":"2013","journal-title":"eLife"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"18724","DOI":"10.1073\/pnas.0909766107","article-title":"Dated molecular phylogenies indicate a Miocene origin for Arabidopsis thaliana","volume":"107","author":"MA Beilstein","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/aob\/mci016","article-title":"Evolution of genome size in Brassicaceae","volume":"95","author":"JS Johnston","year":"2005","journal-title":"Ann Bot"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ng.807","article-title":"The Arabidopsis lyrata genome sequence and the basis of rapid genome size change","volume":"43","author":"TT Hu","year":"2011","journal-title":"Nat Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ng.2669","article-title":"The Capsella rubella genome and the genomic consequences of rapid mating system evolution","volume":"45","author":"T Slotte","year":"2013","journal-title":"Nat Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1101\/gr.3436305","article-title":"Comparative genome analyses of Arabidopsis spp.: inferring chromosomal rearrangement events in the evolutionary history of A. thaliana","volume":"15","author":"K Yogeeswaran","year":"2005","journal-title":"Genome Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1073\/pnas.0510791103","article-title":"Mechanisms of chromosome number reduction in Arabidopsis thaliana and related Brassicaceae species","volume":"103","author":"MA Lysak","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/35048692","article-title":"Analysis of the genome sequence of the flowering plant Arabidopsis thaliana","volume":"408","year":"2000","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"D1009","DOI":"10.1093\/nar\/gkm965","article-title":"The Arabidopsis Information Resource (TAIR): gene structure and function annotation","volume":"36","author":"D Swarbreck","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/molbev\/msn223","article-title":"The dynamic ups and downs of genome size evolution in Brassicaceae","volume":"26","author":"MA Lysak","year":"2009","journal-title":"Mol Biol Evol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/aob\/mcg057","article-title":"Comparisons with Caenorhabditis (similar to 100 Mb) and Drosophila (similar to 175 Mb) using flow cytometry show genome size in Arabidopsis to be similar to 157 Mb and thus similar to 25% larger than the Arabidopsis genome initiative estimate of similar to 125 Mb","volume":"91","author":"MD Bennett","year":"2003","journal-title":"Ann Bot"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/aob\/mcq258","article-title":"Nuclear DNA amounts in angiosperms: targets, trends and tomorrow","volume":"107","author":"MD Bennett","year":"2011","journal-title":"Ann Bot"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1101\/gr.152538.112","article-title":"Epigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population","volume":"23","author":"RJ Schmitz","year":"2013","journal-title":"Genome Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1128\/MCB.20.10.3434-3441.2000","article-title":"SINE retroposons can be used in vivo as nucleation centers for de novo methylation","volume":"20","author":"P Arnaud","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.1128\/MCB.24.18.8210-8220.2004","article-title":"cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four","volume":"24","author":"FL Sun","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1038\/sj.emboj.7601788","article-title":"Heritable epigenetic mutation of a transposon-flanked Arabidopsis gene due to lack of the chromatin-remodeling factor DDM1","volume":"26","author":"H Saze","year":"2007","journal-title":"EMBO J"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nature09147","article-title":"Relationship between nucleosome positioning and DNA methylation","volume":"466","author":"RK Chodavarapu","year":"2010","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/embr.201337915","article-title":"Meristem-specific expression of epigenetic regulators safeguards transposon silencing in Arabidopsis","volume":"15","author":"T Baubec","year":"2014","journal-title":"EMBO Rep"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cell.2008.12.038","article-title":"Epigenetic reprogramming and small RNA silencing of transposable elements in pollen","volume":"136","author":"RK Slotkin","year":"2009","journal-title":"Cell"},{"key":"ref62","unstructured":"Lynch M (2007) The Origins of Genome Architecture. Sunderland, MA: Sinauer Associates. 389 p."},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"F Krueger","year":"2011","journal-title":"Bioinformatics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2011.08.016","article-title":"Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates","volume":"146","author":"A Molaro","year":"2011","journal-title":"Cell"},{"key":"ref65","article-title":"Century-scale methylome stability in a recently diverged Arabidopsis thaliana lineage","author":"J Hagmann","year":"2014","journal-title":"bioRxiv"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"JD Storey","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1006\/jmbi.2000.5197","article-title":"Automatic clustering of orthologs and in-paralogs from pairwise species comparisons","volume":"314","author":"M Remm","year":"2001","journal-title":"J Mol Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1101\/gr.080200.108","article-title":"Sequencing of natural strains of Arabidopsis thaliana with short reads","volume":"18","author":"S Ossowski","year":"2008","journal-title":"Genome Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"MD Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"E2655","DOI":"10.1073\/pnas.1309606110","article-title":"Comparative transcriptomics reveals patterns of selection in domesticated and wild tomato","volume":"110","author":"D Koenig","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e94101","DOI":"10.1371\/journal.pone.0094101","article-title":"Deep investigation of Arabidopsis thaliana junk DNA reveals a continuum between repetitive elements and genomic dark matter","volume":"9","author":"F Maumus","year":"2014","journal-title":"PLoS ONE"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1038\/ncomms5104","article-title":"Ancestral repeats have shaped epigenome and genome composition for millions of years in Arabidopsis thaliana","volume":"5","author":"F Maumus","year":"2014","journal-title":"Nat Commun"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"M Krzywinski","year":"2009","journal-title":"Genome Res"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:33:15Z","timestamp":1650587595000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004785"}},"subtitle":[],"editor":[{"given":"Brandon S.","family":"Gaut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,13]]},"references-count":74,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004785","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,13]]}}}