{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:46:02Z","timestamp":1790243162564,"version":"4.1.0"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004923","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T19:19:56Z","timestamp":1420744796000},"page":"e1004923","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["ASAR15, A cis-Acting Locus that Controls Chromosome-Wide Replication Timing and Stability of Human Chromosome 15"],"prefix":"10.1371","volume":"11","author":[{"given":"Nathan","family":"Donley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Thayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/bies.201200035","article-title":"Mammalian chromosomes contain cis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes","volume":"34","author":"MJ Thayer","year":"2012","journal-title":"Bioessays"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1601-5223.1964.tb01943.x","article-title":"Extreme chromosome breakage induced by measles virus in different in vitro systems","volume":"51","author":"WW Nichols","year":"1964","journal-title":"Hereditas"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1601-5223.1965.tb02008.x","article-title":"Chromosome damage associated with measles virus in vitro","volume":"54","author":"WW Nichols","year":"1965","journal-title":"Hereditas"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/226717a0","article-title":"Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei","volume":"226","author":"RT Johnson","year":"1970","journal-title":"Nature"},{"key":"ref5","first-page":"235","article-title":"The phenomenon of premature chromosome condensation: its relevance to basic and applied research","volume":"23","author":"K Sperling","year":"1974","journal-title":"Humangenetik"},{"key":"ref6","first-page":"1117","article-title":"Chromosome pulverization in chinese hamster cells induced by Sendai virus","volume":"41","author":"H Kato","year":"1968","journal-title":"J Natl Cancer Inst"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"13300","DOI":"10.1073\/pnas.241355098","article-title":"Delayed Replication Timing Leads to Delayed Mitotic Chromosome Condensation and Chromosomal Instability of Chromosome Translocations","volume":"98","author":"L Smith","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","first-page":"683","article-title":"Chromosomal changes of similar nature in seven established cell lines derived from the peripheral blood of patients with leukemia","volume":"38","author":"H zur Hausen","year":"1967","journal-title":"J Natl Cancer Inst"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Stubblefield E (1964) DNA Synthesis and Chromosomal Morphology of Chinese Hamster Cells Cultured in Media Containing N-deacetyl-N-methylcolchicine (Colcemid). In: Harris RJC, editor. Cytogenetics of Cells in Culture. New York, New York: Academic Press. pp.223\u2013248.","DOI":"10.1016\/B978-1-4832-3075-7.50021-9"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.34.1.35","article-title":"Chromosome pulverization in human binucleate cells following colcemid treatment","volume":"34","author":"H Kato","year":"1967","journal-title":"J Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature10802","article-title":"DNA breaks and chromosome pulverization from errors in mitosis","volume":"482","author":"K Crasta","year":"2012","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1083\/jcb.52.1.97","article-title":"Chromosome pulverization in micronuclei induced by tritiated thymidine","volume":"52","author":"T Ikeuchi","year":"1972","journal-title":"J Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/BF00284471","article-title":"Do individual allocyclic chromosomes in metaphase reflect their interphase domains?","volume":"77","author":"EM Kuhn","year":"1987","journal-title":"Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF00286023","article-title":"The behavior of allocyclic chromosomes in Bloom&apos;s syndrome","volume":"84","author":"PG Otto","year":"1981","journal-title":"Chromosoma"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1158\/0008-5472.CAN-04-0879","article-title":"Ionizing radiation induces frequent translocations with delayed replication and condensation","volume":"64","author":"KS Breger","year":"2004","journal-title":"Cancer Research"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/sj.onc.1209995","article-title":"Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability","volume":"26","author":"BH Chang","year":"2007","journal-title":"Oncogene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/hmg\/ddi314","article-title":"Engineering translocations with delayed replication: evidence for cis control of chromosome replication timing","volume":"14","author":"KS Breger","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1003423","DOI":"10.1371\/journal.pgen.1003423","article-title":"Asynchronous Replication, Mono-Allelic Expression, and Long Range Cis-Effects of ASAR6","volume":"9","author":"N Donley","year":"2013","journal-title":"PLoS Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1093\/hmg\/ddr138","article-title":"An autosomal locus that controls chromosome-wide replication timing and mono-allelic expression","volume":"20","author":"EP Stoffregen","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1534-5807(03)00399-X","article-title":"Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice","volume":"6","author":"CS Branda","year":"2004","journal-title":"Dev Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0168-9525(01)02321-6","article-title":"From mouse to man: generating megabase chromosome rearrangements","volume":"17","author":"AA Mills","year":"2001","journal-title":"Trends Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/scd.2007.0015","article-title":"Multiarm high-throughput integration site detection: limitations of LAM-PCR technology and optimization for clonal analysis","volume":"16","author":"MA Harkey","year":"2007","journal-title":"Stem Cells Dev"},{"key":"ref23","first-page":"e4400","article-title":"Chromosome replicating timing combined with fluorescent in situ hybridization","volume":"10","author":"L Smith","year":"2012","journal-title":"J Vis Exp"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1534\/genetics.105.051375","article-title":"A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes","volume":"174","author":"SV Diaz-Perez","year":"2006","journal-title":"Genetics"},{"key":"ref25","first-page":"258","article-title":"Amanitin binding to calf thymus RNA polymerase B. FEBS Lett","volume":"9","author":"M Meihlac","year":"1970"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.0105-2896.2004.00158.x","article-title":"Monoallelic gene expression: a repertoire of recurrent themes","volume":"200","author":"M Goldmit","year":"2004","journal-title":"Immunol Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/j.1460-2075.1992.tb05162.x","article-title":"Delineation of DNA replication time zones by fluorescence in situ hybridization","volume":"11","author":"S Selig","year":"1992","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ncb1006","article-title":"Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication","volume":"5","author":"V Azuara","year":"2003","journal-title":"Nat Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/35102606","article-title":"Asynchronous replication and allelic exclusion in the immune system","volume":"414","author":"R Mostoslavsky","year":"2001","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/hmg\/ddh062","article-title":"Coordinated replication timing of monoallelically expressed genes along human autosomes","volume":"13","author":"AW Ensminger","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng1102","article-title":"Coordination of the random asynchronous replication of autosomal loci","volume":"33","author":"N Singh","year":"2003","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1101\/gr.6584707","article-title":"Computational and experimental identification of novel human imprinted genes","volume":"17","author":"PP Luedi","year":"2007","journal-title":"Genome Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1126\/science.1148910","article-title":"Widespread monoallelic expression on human autosomes","volume":"318","author":"A Gimelbrant","year":"2007","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1101\/gad.544509","article-title":"Allelic inactivation of rDNA loci","volume":"23","author":"S Schlesinger","year":"2009","journal-title":"Genes Dev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000133516","article-title":"Strand-specific FISH reveals orientation of chromosome 18 alphoid DNA","volume":"63","author":"E Goodwin","year":"1993","journal-title":"Cytogenet Cell Genet"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Rhind N, Gilbert DM (2013) DNA replication timing. Cold Spring Harb Perspect Biol 5.","DOI":"10.1101\/cshperspect.a010132"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1101\/gr.099655.109","article-title":"Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types","volume":"20","author":"T Ryba","year":"2010","journal-title":"Genome Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1001011","DOI":"10.1371\/journal.pgen.1001011","article-title":"Comparative analysis of DNA replication timing reveals conserved large-scale chromosomal architecture","volume":"6","author":"E Yaffe","year":"2010","journal-title":"PLoS Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nbt.2030","article-title":"DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes","volume":"29","author":"S De","year":"2011","journal-title":"Nat Biotechnol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1101\/sqb.2010.75.011","article-title":"Space and time in the nucleus: developmental control of replication timing and chromosome architecture","volume":"75","author":"DM Gilbert","year":"2011","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1101\/gad.209999.112","article-title":"Location, location, location: it&apos;s all in the timing for replication origins","volume":"27","author":"OM Aparicio","year":"2013","journal-title":"Genes Dev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10577-009-9100-8","article-title":"Domain-wide regulation of DNA replication timing during mammalian development","volume":"18","author":"BD Pope","year":"2010","journal-title":"Chromosome Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1101\/gad.1841409","article-title":"Genomic imprinting: employing and avoiding epigenetic processes","volume":"23","author":"MS Bartolomei","year":"2009","journal-title":"Genes Dev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrg3239","article-title":"Mechanisms and consequences of widespread random monoallelic expression","volume":"13","author":"A Chess","year":"2012","journal-title":"Nat Rev Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrg2987","article-title":"Regulation of X-chromosome inactivation by the X-inactivation centre","volume":"12","author":"S Augui","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tig.2008.03.005","article-title":"Random monoallelic expression: making a choice","volume":"24","author":"C Krueger","year":"2008","journal-title":"Trends Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00412-009-0206-8","article-title":"Monoallelic gene expression in mammals","volume":"118","author":"IS Zakharova","year":"2009","journal-title":"Chromosoma"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1186\/gb-2012-13-2-r10","article-title":"Autosomal monoallelic expression in the mouse","volume":"13","author":"LM Zwemer","year":"2012","journal-title":"Genome Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e31751","DOI":"10.1371\/journal.pone.0031751","article-title":"Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families","volume":"7","author":"SM Li","year":"2012","journal-title":"PLoS One"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.200706053","article-title":"Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed","volume":"179","author":"MK Alexander","year":"2007","journal-title":"J Cell Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.semcdb.2003.09.015","article-title":"The Lyon and the LINE hypothesis","volume":"14","author":"MF Lyon","year":"2003","journal-title":"Semin Cell Dev Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00239-008-9195-0","article-title":"Exceptional LINE density at V1R loci: the Lyon repeat hypothesis revisited on autosomes","volume":"68","author":"MB Kambere","year":"2009","journal-title":"J Mol Evol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"9940","DOI":"10.1073\/pnas.1737401100","article-title":"High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes","volume":"100","author":"E Allen","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.cell.2014.01.042","article-title":"Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes","volume":"156","author":"LL Hall","year":"2014","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000014969","article-title":"X-chromosome inactivation: a repeat hypothesis","volume":"80","author":"MF Lyon","year":"1998","journal-title":"Cytogenet Cell Genet"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1093\/hmg\/ddg268","article-title":"X inactivation-specific methylation of LINE-1 elements by DNMT3B: implications for the Lyon repeat hypothesis","volume":"12","author":"RS Hansen","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.cell.2010.04.042","article-title":"LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation","volume":"141","author":"JC Chow","year":"2010","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1534\/genetics.105.043026","article-title":"The element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in the mouse","volume":"171","author":"S Diaz-Perez","year":"2005","journal-title":"Genetics"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-1218(94)90122-8","article-title":"Single-base deletion induced by benzo[a]pyrene diol epoxide at the adenine phosphoribosyltransferase locus in human fibrosarcoma cell lines","volume":"321","author":"Y Zhu","year":"1994","journal-title":"Mutat Res"},{"key":"ref60","unstructured":"Helm S (1995) Cancer Cytogenetics. New York: Wiley-Liss."},{"key":"ref61","unstructured":"Trask B, Pinkel D (1990) Flow cytometry; Crissman HA, Darzynkiewica Z, editors. New York: Academic Press."}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:36:49Z","timestamp":1588966609000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004923"}},"subtitle":[],"editor":[{"given":"Marisa S.","family":"Bartolomei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004923","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]}}}