{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:19:21Z","timestamp":1791433161991,"version":"4.3.3"},"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1004977","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T14:22:47Z","timestamp":1426515767000},"page":"e1004977","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":139,"title":["The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese"],"prefix":"10.1371","volume":"11","author":[{"given":"Julia E.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren S.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Storz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Imlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.1163100","article-title":"Elements and evolution","volume":"322","author":"AD Anbar","year":"2008","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0168-6445(03)00055-X","article-title":"Bacterial iron homeostasis","volume":"27","author":"SC Andrews","year":"2003","journal-title":"FEMS Microbiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1073\/pnas.032066599","article-title":"A small RNA regulates the expression of genes involved in iron metabolism in <italic>Escherichia coli<\/italic>","volume":"99","author":"E Masse","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1128\/JB.187.3.912-922.2005","article-title":"Transcriptional regulation of <italic>sitABCD<\/italic> of <italic>Salmonella enterica<\/italic> serovar Typhimurium by MntR and Fur","volume":"187","author":"J Ikeda","year":"2005","journal-title":"J Bacteriol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1128\/JB.184.12.3151-3158.2002","article-title":"Regulation of <italic>Salmonella enterica<\/italic> serovar Typhimurium <italic>mntH<\/italic> transcription by H<sub>2<\/sub>O<sub>2<\/sub>, Fe<sup>2+<\/sup>, and Mn<sup>2+<\/sup>","volume":"184","author":"DG Kehres","year":"2002","journal-title":"J Bacteriol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1128\/jb.175.6.1687-1696.1993","article-title":"Interaction of six global transcription regulators in expression of manganese superoxide dismutase in <italic>Escherichia coli<\/italic> K-12","volume":"175","author":"I Compan","year":"1993","journal-title":"J Bacteriol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/bi101881d","article-title":"<italic>Escherichia coli<\/italic> class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo","volume":"50","author":"JA Cotruvo","year":"2011","journal-title":"Biochemistry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2958.2011.07593.x","article-title":"The alternative aerobic ribonucleotide reductase of <italic>Escherichia coli<\/italic>, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation","volume":"80","author":"JE Martin","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"15544","DOI":"10.1074\/jbc.M111.330365","article-title":"Mononuclear iron enzymes are primary targets of hydrogen peroxide stress","volume":"287","author":"A Anjem","year":"2012","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1073\/pnas.1100410108","article-title":"Iron enzyme ribulose-5-phosphate 3-epimerase in <italic>Escherichia coli<\/italic> is rapidly damaged by hydrogen peroxide but can be protected by manganese","volume":"108","author":"JM Sobota","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1365-2958.2009.06699.x","article-title":"Manganese import is a key element of the OxyR response to hydrogen peroxide in <italic>Escherichia coli<\/italic>","volume":"72","author":"A Anjem","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1046\/j.1365-2958.2000.01922.x","article-title":"The NRAMP proteins of <italic>Salmonella typhimurium<\/italic> and <italic>Escherichia coli<\/italic> are selective manganese transporters involved in the response to reactive oxygen","volume":"36","author":"DG Kehres","year":"2000","journal-title":"Mol Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1128\/JB.184.3.864-866.2002","article-title":"ZupT is a Zn(II) uptake system in <italic>Escherichia coli<\/italic>","volume":"184","author":"G Grass","year":"2002","journal-title":"J Bacteriol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1128\/JB.110.1.186-195.1972","article-title":"Manganese-resistant mutants of <italic>Escherichia coli<\/italic>: physiological and genetic studies","volume":"110","author":"S Silver","year":"1972","journal-title":"J Bacteriol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00337769","article-title":"Selection procedure for deregulated iron transport mutants (<italic>fur<\/italic>) in <italic>Escherichia coli<\/italic> K 12: <italic>fur<\/italic> not only affects iron metabolism","volume":"0","author":"K Hantke","year":"1987","journal-title":"Mol Gen Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nsb951","article-title":"Structure of the manganese-bound manganese transport regulator of <italic>Bacillus subtilis<\/italic>","volume":"10","author":"A Glasfeld","year":"2003","journal-title":"Nat Struct Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1128\/JB.183.16.4806-4813.2001","article-title":"Dual repression by Fe<sup>2+<\/sup>-Fur and Mn<sup>2+<\/sup>-MntR of the <italic>mntH<\/italic> gene, encoding an NRAMP-like Mn<sup>2+<\/sup> transporter in <italic>Escherichia coli<\/italic>","volume":"183","author":"SI Patzer","year":"2001","journal-title":"J Bacteriol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2958.2009.06638.x","article-title":"Role of the manganese efflux system <italic>mntE<\/italic> for signalling and pathogenesis in <italic>Streptococcus pneumoniae<\/italic>","volume":"72","author":"JW Rosch","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e1002261","DOI":"10.1371\/journal.ppat.1002261","article-title":"A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and <italic>Neisseria meningitidis<\/italic> virulence","volume":"7","author":"FJ Veyrier","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1128\/JB.05872-11","article-title":"The <italic>Escherichia coli<\/italic> MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis","volume":"193","author":"LS Waters","year":"2011","journal-title":"J Bacteriol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1128\/JB.183.24.7173-7181.2001","article-title":"Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in <italic>Escherichia coli<\/italic>","volume":"183","author":"LC Seaver","year":"2001","journal-title":"J Bacteriol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1016\/S0021-9258(18)62675-4","article-title":"Superoxide dismutase from <italic>Escherichia coli<\/italic> B. A new manganese-containing enzyme","volume":"245","author":"BB Keele Jr.","year":"1970","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"8923","DOI":"10.1021\/bi9704212","article-title":"Mutagenesis of a proton linkage pathway in <italic>Escherichia coli<\/italic> manganese superoxide dismutase","volume":"36","author":"MM Whittaker","year":"1997","journal-title":"Biochemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1128\/JB.187.3.912-922.2005","article-title":"Transcriptional regulation of <italic>citABCD<\/italic> of <italic>Salmonella enterica<\/italic> serovar Typhimurium by MntR and Fur","volume":"187","author":"J Ikeda","year":"2005","journal-title":"J Bacteriol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10534-010-9319-z","article-title":"Point mutations change specificity and kinetics of metal uptake by ZupT from <italic>Escherichia coli<\/italic>","volume":"23","author":"N Taudte","year":"2010","journal-title":"Biometals"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1021\/bi00173a020","article-title":"Translocation of metal phosphate via the phosphate inorganic transport system of <italic>Escherichia coli<\/italic>","volume":"33","author":"HW van Veen","year":"1994","journal-title":"Biochemistry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0162-0134(93)80025-5","article-title":"Binding of the ferric uptake regulation repressor protein (Fur) to Mn(II), Fe(II), Co(II), and Cu(II) ions as co-repressors: electronic absorption, equilibrium, and <sup>57<\/sup>Fe Mossbauer studies","volume":"50","author":"MY Hamed","year":"1993","journal-title":"J Inorg Biochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nrmicro2356","article-title":"Building Fe-S proteins: bacterial strategies","volume":"8","author":"B Py","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/j.1365-2958.2010.07418.x","article-title":"Hydrogen peroxide inactivates the <italic>Escherichia coli<\/italic> Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate","volume":"78","author":"S Jang","year":"2010","journal-title":"Mol Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"9009","DOI":"10.1073\/pnas.160261497","article-title":"The cysteine desulfurase, IscS, has a major role in <italic>in vivo<\/italic> Fe-S cluster formation in <italic>Escherichia coli<\/italic>","volume":"97","author":"CJ Schwartz","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jmb.2009.01.055","article-title":"Sequence-specific binding to a subset of IscR-regulated promoters does not require IscR Fe-S cluster ligation","volume":"387","author":"AD Nesbit","year":"2009","journal-title":"J Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2006.0008","DOI":"10.1038\/msb4100050","article-title":"Construction of <italic>Escherichia coli<\/italic> K-12 in-frame, single-gene knockout mutants: the Keio collection","volume":"2","author":"T Baba","year":"2006","journal-title":"Mol Syst Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1101\/gad.901001","article-title":"Identification of novel small RNAs using comparative genomics and microarrays","volume":"15","author":"KM Wassarman","year":"2001","journal-title":"Genes Dev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"458","DOI":"10.4161\/rna.19065","article-title":"The small RNA RybA regulates key genes in the biosynthesis of aromatic amino acids under peroxide stress in <italic>E<\/italic>. <italic>coli<\/italic>","volume":"9","author":"K Gerstle","year":"2012","journal-title":"RNA Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1074\/jbc.R112.441386","article-title":"Bacterial small RNA-based negative regulation: Hfq and its accomplices","volume":"288","author":"N De Lay","year":"2013","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.2834821","article-title":"Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro","volume":"240","author":"JA Imlay","year":"1988","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1128\/jb.177.9.2305-2314.1995","article-title":"Lethal oxidative damage and mutagenesis are generated by iron in delta <italic>fur<\/italic> mutants of <italic>Escherichia coli<\/italic>: protective role of superoxide dismutase","volume":"177","author":"D Touati","year":"1995","journal-title":"J Bacteriol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"8344","DOI":"10.1073\/pnas.0812808106","article-title":"The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity","volume":"106","author":"L Macomber","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/mmi.12188","article-title":"Coproporphyrin III excretion identifies the anaerobic coproporphyrinogen III oxidase HemN as a copper target in the Cu<sup>+<\/sup>-ATPase mutant <italic>copA<sup>-<\/sup><\/italic> of <italic>Rubrivivax gelatinosus<\/italic>","volume":"88","author":"A Azzouzi","year":"2013","journal-title":"Mol Microbiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/mmi.12263","article-title":"Superoxide poisons mononuclear iron enzymes by causing mismetallation","volume":"89","author":"M Gu","year":"2013","journal-title":"Mol Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1039\/c1mt00099c","article-title":"Cobalt stress in <italic>Escherichia coli<\/italic> and <italic>Salmonella enterica<\/italic>: molecular bases for toxicity and resistance","volume":"3","author":"F Barras","year":"2011","journal-title":"Metallomics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1111\/j.1365-2958.2011.07891.x","article-title":"Fructose-1,6-bisphosphate aldolase (class II) is the primary site of nickel toxicity in <italic>Escherichia coli<\/italic>","volume":"82","author":"L Macomber","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1039\/c1mt00063b","article-title":"Mechanisms of nickel toxicity in microorganisms","volume":"3","author":"L Macomber","year":"2011","journal-title":"Metallomics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1749-6632.1987.tb48763.x","article-title":"Metal inhibition of ferrochelatase","volume":"514","author":"HA Dailey","year":"1987","journal-title":"Ann N Y Acad Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jmb.2009.08.042","article-title":"Product release rather than chelation determines metal specificity for ferrochelatase","volume":"393","author":"AE Medlock","year":"2009","journal-title":"J Mol Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/162746a0","article-title":"Order of stability of metal complexes","volume":"162","author":"H Irving","year":"1948","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1073\/pnas.032066599","article-title":"A small RNA regulates the expression of genes involved in iron metabolism in <italic>Escherichia coli<\/italic>","volume":"99","author":"E Masse","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"15223","DOI":"10.1073\/pnas.1007805107","article-title":"A small RNA promotes siderophore production through transcriptional and metabolic remodeling","volume":"107","author":"H Salvail","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1365-2958.2012.08057.x","article-title":"Manganese is required for oxidative metabolism in unstressed <italic>Bradyrhizobium japonicum<\/italic> cells","volume":"84","author":"TH Hohle","year":"2012","journal-title":"Mol Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2958.2006.05101.x","article-title":"<italic>Bradyrhizobium japonicum<\/italic> senses iron through the status of haem to regulate iron homeostasis and metabolism","volume":"60","author":"J Yang","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"10691","DOI":"10.1073\/pnas.1002342107","article-title":"Control of bacterial iron homeostasis by manganese","volume":"107","author":"S Puri","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/10408418609108735","article-title":"Manganese: its acquisition by and function in the lactic acid bacteria","volume":"13","author":"F Archibald","year":"1986","journal-title":"Crit Rev Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.1103185","article-title":"Accumulation of Mn(II) in <italic>Deinococcus radiodurans<\/italic> facilitates gamma-radiation resistance","volume":"306","author":"MJ Daly","year":"2004","journal-title":"Science"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-410515-7.00001-9","article-title":"Heme proteins in lactic acid bacteria","volume":"62","author":"M Baureder","year":"2013","journal-title":"Adv Microb Physiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"14326","DOI":"10.1073\/pnas.94.26.14326","article-title":"The <italic>zntA<\/italic> gene of <italic>Escherichia coli<\/italic> encodes a Zn(II)-translocating P-type ATPase","volume":"94","author":"C Rensing","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1128\/JB.183.15.4664-4667.2001","article-title":"ZitB (YbgR), a member of the cation diffusion facilitator family, is an additional zinc transporter in <italic>Escherichia coli<\/italic>","volume":"183","author":"G Grass","year":"2001","journal-title":"J Bacteriol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jinorgbio.2012.02.008","article-title":"ZntR-mediated transcription of <italic>zntA<\/italic> responds to nanomolar intracellular free zinc","volume":"111","author":"D Wang","year":"2012","journal-title":"J Inorg Biochem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"12054","DOI":"10.1073\/pnas.1218274110","article-title":"Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in <italic>Salmonella<\/italic> typhimurium","volume":"110","author":"ER Frawley","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00203-004-0739-4","article-title":"FieF (YiiP) from <italic>Escherichia coli<\/italic> mediates decreased cellular accumulation of iron and relieves iron stress","volume":"183","author":"G Grass","year":"2005","journal-title":"Arch Microbiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1128\/JB.187.8.2912-2916.2005","article-title":"Identification of <italic>rcnA<\/italic> (<italic>yohM<\/italic>), a nickel and cobalt resistance gene in <italic>Escherichia coli<\/italic>","volume":"187","author":"A Rorigue","year":"2005","journal-title":"J Bacteriol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1073\/pnas.97.2.652","article-title":"CopA: an <italic>Escherichia coli<\/italic> Cu(I)-translocating P-type ATPase","volume":"97","author":"C Rensing","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.biochi.2011.07.016","article-title":"Dual-function RNA regulators in bacteria","volume":"93","author":"CK Vanderpool","year":"2011","journal-title":"Biochemie"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nature06093","article-title":"Crystal structure of the MgtE Mg<sup>2+<\/sup> transporter","volume":"448","author":"M Hattori","year":"2007","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1038\/emboj.2009.288","article-title":"Mg<sup>2+<\/sup>-dependent gating of bacterial MgtE channel underlies Mg<sup>2+<\/sup> homeostasis","volume":"28","author":"M Hattori","year":"2009","journal-title":"EMBO J"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1021\/cr900077w","article-title":"Coordination chemistry of bacterial metal transport and sensing","volume":"109","author":"Z Ma","year":"2009","journal-title":"Chem Rev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in <italic>Escherichia coli<\/italic> K-12 using PCR products","volume":"97","author":"KA Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref67","article-title":"Experiments in Molecular Genetics","author":"JH Miller","year":"1972"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1128\/JB.183.21.6384-6393.2001","article-title":"Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies of bacteria","volume":"183","author":"A Haldimann","year":"2001","journal-title":"J Bacteriol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1128\/JB.119.3.736-747.1974","article-title":"Culture medium for enterobacteria","volume":"119","author":"FC Neidhardt","year":"1974","journal-title":"J Bacteriol"},{"key":"ref70","first-page":"6049","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"JM McCord","year":"1969","journal-title":"J Biol Chem"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0003-9861(80)90544-5","article-title":"Distinguishing between Mn-containing and Fe-containing superoxide dismutases in crude extracts of cells","volume":"201","author":"T Kirby","year":"1980","journal-title":"Arch Biochem Biophys"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1128\/JB.01357-06","article-title":"Intracellular copper does not catalyze the formation of oxidative DNA damage in <italic>Escherichia coli<\/italic>","volume":"189","author":"L Macomber","year":"2007","journal-title":"J Bacteriol"},{"key":"ref73","first-page":"3013","article-title":"Demonstration of separate genetic loci encoding distinct membrane-bound respiratory NADH dehydrogenases in <italic>Escherichia coli<\/italic>","volume":"175","author":"MW Calhoun","year":"1993","journal-title":"JBact"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1021\/bi00398a029","article-title":"NADH-ubiquinone oxidoreductases of the <italic>Escherichia coli<\/italic> aerobic respiratory chain","volume":"26","author":"K Matsushita","year":"1987","journal-title":"Biochemistry"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1365-2958.2007.05701.x","article-title":"Submicromolar hydrogen peroxide disrupts the ability of Fur protein to control free-iron levels in <italic>Escherichia coli<\/italic>","volume":"64","author":"S Varghese","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1016\/S0021-9258(20)89596-9","article-title":"Assay of metabolic superoxide production in <italic>Escherichia coli<\/italic>","volume":"266","author":"JA Imlay","year":"1991","journal-title":"J Biol Chem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1021\/bi0018943","article-title":"Outer sphere mutations perturb metal reactivity in manganese superoxide dismutase","volume":"40","author":"RA Edwards","year":"2001","journal-title":"Biochemistry"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1128\/JB.06195-11","article-title":"Cellular iron distribution in <italic>Bacillus anthracis<\/italic>","volume":"194","author":"WY Tu","year":"2012","journal-title":"J Bacteriol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(02)49316-0","article-title":"Quantitation of intracellular free iron by electron paramagnetic resonance spectroscopy","volume":"349","author":"AL Woodmansee","year":"2002","journal-title":"Meth Enzymol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s004380050509","article-title":"Effects of starvation for heme on the synthesis of porphyrins in <italic>Escherichia coli<\/italic>","volume":"255","author":"T Nakayashiki","year":"1997","journal-title":"Mol Gen Genet"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1005322","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1004977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T22:00:38Z","timestamp":1651528838000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1004977"}},"subtitle":[],"editor":[{"given":"William F.","family":"Burkholder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,16]]},"references-count":80,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1004977","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,16]]}}}