{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:21:16Z","timestamp":1790749276269,"version":"4.1.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1005021","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T13:59:00Z","timestamp":1425650340000},"page":"e1005021","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["HDAC4-Myogenin Axis As an Important Marker of HD-Related Skeletal Muscle Atrophy"],"prefix":"10.1371","volume":"11","author":[{"given":"Michal","family":"Mielcarek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Toczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleo J. L. M.","family":"Smeets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie K.","family":"Bondulich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Jolinon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhoriam","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R. T.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Piotrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Greensmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard T.","family":"Smolenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian P.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"ref1","author":"GP Bates","year":"2014"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ng1193-259","article-title":"Widespread expression of the human and rat Huntington&apos;s disease gene in brain and nonneural tissues","volume":"5","author":"TV Strong","year":"1993","journal-title":"Nat Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0896-6273(93)90127-D","article-title":"Huntington&apos;s disease gene (IT15) is widely expressed in human and rat tissues","volume":"11","author":"SH Li","year":"1993","journal-title":"Neuron"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin-protein interactions and the pathogenesis of Huntington&apos;s disease","volume":"20","author":"SH Li","year":"2004","journal-title":"Trends Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15916","DOI":"10.1074\/jbc.M511007200","article-title":"Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein","volume":"281","author":"W Li","year":"2006","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0968-0004(03)00168-3","article-title":"The hunt for huntingtin function: interaction partners tell many different stories","volume":"28","author":"P Harjes","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ng1095-155","article-title":"Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington&apos;s disease gene homologue","volume":"11","author":"S Zeitlin","year":"1995","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999","article-title":"Nuclear and neuropil aggregates in Huntington&apos;s disease: relationship to neuropathology","volume":"19","author":"CA Gutekunst","year":"1999","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/hmg\/ddp467","article-title":"Identical oligomeric and fibrillar structures captured from the brains of R6\/2 and knock-in mouse models of Huntington&apos;s disease","volume":"19","author":"K Sathasivam","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e8025","DOI":"10.1371\/journal.pone.0008025","article-title":"Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington&apos;s disease","volume":"4","author":"H Moffitt","year":"2009","journal-title":"PLoS One"},{"key":"ref11","first-page":"2547","article-title":"Cardiac dysfunction in Huntington\u2019s Disease","volume":"20","author":"D Zielonka","year":"2014","journal-title":"Exp Clin Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1161\/CIRCULATIONAHA.107.750232","article-title":"Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure","volume":"117","author":"JS Pattison","year":"2008","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1004550","DOI":"10.1371\/journal.pgen.1004550","article-title":"Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington&apos;s Disease","volume":"10","author":"M Mielcarek","year":"2014","journal-title":"PLoS Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e108961","DOI":"10.1371\/journal.pone.0108961","article-title":"The Huntington&apos;s Disease-Related Cardiomyopathy Prevents a Hypertrophic Response in the R6\/2 Mouse Model","volume":"9","author":"M Mielcarek","year":"2014","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the brain: widespread pathology in Huntington&apos;s disease","volume":"8","author":"JM van der Burg","year":"2009","journal-title":"Lancet Neurol"},{"issue":"380","key":"ref16","first-page":"1","article-title":"Skeletal muscle pathology in Huntington&apos;s disease","volume":"5","author":"D Zielonka","year":"2014","journal-title":"Front Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/mds.21550","article-title":"Myopathy as a first symptom of Huntington&apos;s disease in a Marathon runner","volume":"22","author":"CM Kosinski","year":"2007","journal-title":"Mov Disord"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain","volume":"11","author":"R Luthi-Carter","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/hmg\/ddi192","article-title":"Gene expression in Huntington&apos;s disease skeletal muscle: a potential biomarker","volume":"14","author":"AD Strand","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/1531-8249(200007)48:1<72::AID-ANA11>3.0.CO;2-I","article-title":"Abnormal in vivo skeletal muscle energy metabolism in Huntington&apos;s disease and dentatorubropallidoluysian atrophy","volume":"48","author":"R Lodi","year":"2000","journal-title":"Ann Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/mds.20373","article-title":"Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington&apos;s disease","volume":"20","author":"C Saft","year":"2005","journal-title":"Mov Disord"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/mds.23258","article-title":"Low anaerobic threshold and increased skeletal muscle lactate production in subjects with Huntington&apos;s disease","volume":"26","author":"A Ciammola","year":"2011","journal-title":"Mov Disord"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.brainresbull.2009.07.010","article-title":"Role of mitochondrial dysfunction in the pathogenesis of Huntington&apos;s disease","volume":"80","author":"RA Quintanilla","year":"2009","journal-title":"Brain Res Bull"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"J Lin","year":"2005","journal-title":"Cell Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/hmg\/ddr541","article-title":"Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington&apos;s disease","volume":"21","author":"A Johri","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"34908","DOI":"10.1074\/jbc.M506288200","article-title":"Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models","volume":"280","author":"M Fujimoto","year":"2005","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"L Mangiarini","year":"1996","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington&apos;s disease","volume":"10","author":"CH Lin","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainresbull.2006.11.004","article-title":"The Hdh(Q150\/Q150) knock-in mouse model of HD and the R6\/2 exon 1 model develop comparable and widespread molecular phenotypes","volume":"72","author":"B Woodman","year":"2007","journal-title":"Brain Res Bull"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1073\/pnas.1221891110","article-title":"Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease","volume":"110","author":"K Sathasivam","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/8.5.813","article-title":"Formation of polyglutamine inclusions in non-CNS tissue","volume":"8","author":"K Sathasivam","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00401-012-1043-z","article-title":"Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion","volume":"125","author":"JC Mitchell","year":"2013","journal-title":"Acta Neuropathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"36154","DOI":"10.1074\/jbc.M807461200","article-title":"Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype","volume":"283","author":"RW Tsika","year":"2008","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/ATVBAHA.107.155788","article-title":"MCAT elements and the TEF-1 family of transcription factors in muscle development and disease","volume":"28","author":"T Yoshida","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1128\/MCB.23.15.5143-5164.2003","article-title":"Transcription enhancer factor 1 binds multiple muscle MEF2 and A\/T-rich elements during fast-to-slow skeletal muscle fiber type transitions","volume":"23","author":"N Karasseva","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1074\/jbc.M507440200","article-title":"Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway","volume":"281","author":"P Zhao","year":"2006","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"ref37","doi-asserted-by":"crossref","first-page":"S269","DOI":"10.1016\/S0925-4773(03)00127-8","article-title":"VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage","volume":"119","author":"M Mielcarek","year":"2002","journal-title":"Mech Dev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.gep.2008.12.002","article-title":"VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development","volume":"9","author":"M Mielcarek","year":"2009","journal-title":"Gene Expr Patterns"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/nar\/gkh248","article-title":"VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation","volume":"32","author":"S Gunther","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/hmg\/ddt458","article-title":"p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin","volume":"23","author":"DE Ehrnhoefer","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1096\/fj.08-115931","article-title":"The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity","volume":"23","author":"TJ Cohen","year":"2009","journal-title":"FASEB J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"33752","DOI":"10.1074\/jbc.M706268200","article-title":"The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming","volume":"282","author":"TJ Cohen","year":"2007","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e73589","DOI":"10.1371\/journal.pone.0073589","article-title":"miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4","volume":"8","author":"CE Winbanks","year":"2013","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1172\/JCI62656","article-title":"microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice","volume":"122","author":"N Liu","year":"2012","journal-title":"J Clin Invest"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1126\/science.1181046","article-title":"MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice","volume":"326","author":"AH Williams","year":"2009","journal-title":"Science"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1093\/brain\/awt164","article-title":"Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression","volume":"136","author":"G Bruneteau","year":"2013","journal-title":"Brain"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1093\/hmg\/dds286","article-title":"Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice","volume":"21","author":"KV Bricceno","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/10409238.2013.857291","article-title":"Signaling pathways controlling skeletal muscle mass","volume":"49","author":"MA Egerman","year":"2014","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.biochem.75.103004.142622","article-title":"Signaling pathways in skeletal muscle remodeling","volume":"75","author":"R Bassel-Duby","year":"2006","journal-title":"Annu Rev Biochem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fphys.2014.00099","article-title":"Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways","volume":"5","author":"NE Brooks","year":"2014","journal-title":"Front Physiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1111\/j.1460-9568.2004.03783.x","article-title":"Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington&apos;s disease mutation","volume":"20","author":"RR Ribchester","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.biocel.2013.05.016","article-title":"Muscle type and fiber type specificity in muscle wasting","volume":"45","author":"S Ciciliot","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"S Schiaffino","year":"2011","journal-title":"Physiol Rev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"9160","DOI":"10.1073\/pnas.1220068110","article-title":"Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction","volume":"110","author":"CW Waters","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2007.06.059","article-title":"Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington&apos;s disease mutation","volume":"1188","author":"A Wade","year":"2008","journal-title":"Brain Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1523\/JNEUROSCI.2011-10.2011","article-title":"Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease","volume":"31","author":"JL Rozas","year":"2011","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000339528","article-title":"Consistent neurodegeneration and its association with clinical progression in Huntington&apos;s disease: a coordinate-based meta-analysis","volume":"12","author":"I Dogan","year":"2013","journal-title":"Neurodegener Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fphys.2014.00032","article-title":"A metabolic link to skeletal muscle wasting and regeneration","volume":"5","author":"R Koopman","year":"2014","journal-title":"Front Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/sj.cdd.4401967","article-title":"Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington&apos;s disease subjects","volume":"13","author":"A Ciammola","year":"2006","journal-title":"Cell Death Differ"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ydbio.2014.04.005","article-title":"Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells","volume":"391","author":"I Ismailoglu","year":"2014","journal-title":"Dev Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/cvr\/cvr144","article-title":"FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model","volume":"91","author":"TG Schips","year":"2011","journal-title":"Cardiovasc Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0361-9230(03)00185-0","article-title":"Standardization and statistical approaches to therapeutic trials in the R6\/2 mouse","volume":"61","author":"E Hockly","year":"2003","journal-title":"Brain Res Bull"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e27746","DOI":"10.1371\/journal.pone.0027746","article-title":"SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6\/2 mouse model of Huntington&apos;s disease","volume":"6","author":"M Mielcarek","year":"2011","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e1001717","DOI":"10.1371\/journal.pbio.1001717","article-title":"HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration","volume":"11","author":"M Mielcarek","year":"2013","journal-title":"PLoS Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e80849","DOI":"10.1371\/journal.pone.0080849","article-title":"HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo","volume":"8","author":"M Mielcarek","year":"2013","journal-title":"PLoS One"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0378-4347(00)82125-8","article-title":"Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation","volume":"527","author":"RT Smolenski","year":"1990","journal-title":"J Chromatogr"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"H1468","DOI":"10.1152\/ajpheart.00624.2004","article-title":"Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle","volume":"288","author":"GK Soppa","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1242\/dmm.007237","article-title":"A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis","volume":"4","author":"A Acevedo-Arozena","year":"2011","journal-title":"Dis Model Mech"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e40998","DOI":"10.1371\/journal.pone.0040998","article-title":"Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS","volume":"7","author":"CH Lu","year":"2012","journal-title":"PLoS One"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1005021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T14:50:59Z","timestamp":1566399059000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1005021"}},"subtitle":[],"editor":[{"given":"Harry T.","family":"Orr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1005021","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}