{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:42:35Z","timestamp":1792651355580,"version":"4.5.0"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1005067","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T14:28:09Z","timestamp":1426516089000},"page":"e1005067","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites"],"prefix":"10.1371","volume":"11","author":[{"given":"Jacob A.","family":"Tennessen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Th\u00e9ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Marine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Ying","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rognon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Blouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)66457-4","article-title":"Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis","volume":"365","author":"CH King","year":"2005","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"P Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.actatropica.2009.11.012","article-title":"Parasites and poverty: The case of schistosomiasis","volume":"113","author":"CH King","year":"2010","journal-title":"Acta Tropica"},{"key":"ref4","article-title":"The Causes and Impacts of Neglected Tropical and Zoonotic Diseases: Opportunities for Integrated Intervention Strategies","author":"CH King","year":"2011"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1017\/S0031182009000493","article-title":"Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs","volume":"136","author":"MJ Doenhoff","year":"2009","journal-title":"Parasitology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","article-title":"Drug resistant schistosomiasis: Resistance to praziquantel and oxaminquine induced in <italic>Schistosoma mansoni<\/italic> in mice is drug specific","volume":"51","author":"PG Fallon","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e504","DOI":"10.1371\/journal.pntd.0000504","article-title":"Reduced susceptibility of Kenyan <italic>Schistosoma mansoni<\/italic> to praziquantel following repeated exposures: origin, measurement, and likelihood of persistence","volume":"3","author":"SD Melman","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1017\/S0031182009990400","article-title":"The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002\u20132008","volume":"136","author":"A Fenwick","year":"2009","journal-title":"Parasitology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e03401","DOI":"10.7554\/eLife.03401","article-title":"Concerning RNA-guided gene drives for the alteration of wild populations","volume":"3","author":"KM Esvelt","year":"2014","journal-title":"eLife"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke <italic>Schistosoma mansoni<\/italic>","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1186\/1471-2164-9-634","article-title":"<italic>Biomphalaria glabrata<\/italic> transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to <italic>Schistosoma mansoni<\/italic>","volume":"9","author":"A Lockyer","year":"2008","journal-title":"BMC Genomics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molimm.2009.10.019","article-title":"Differential transcriptomic responses of <italic>Biomphalaria glabrata<\/italic> (Gastropoda, Mollusca) to bacteria and metazoan parasites, <italic>Schistosoma mansoni<\/italic> and <italic>Echinostoma paraensei<\/italic> (Digenea, Platyhelminthes)","volume":"47","author":"CM Adema","year":"2010","journal-title":"Mol Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.2307\/3282295","article-title":"The genetic variation of compatibility in <italic>Biomphalaria glabrata<\/italic> and <italic>Schistosoma mansoni<\/italic>","volume":"73","author":"CS Richards","year":"1987","journal-title":"J Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0169-4758(92)90015-T","article-title":"Genetics of <italic>Biomphalaria glabrata<\/italic> and its effect on the outcome of <italic>Schistosoma mansoni<\/italic> infection","volume":"8","author":"CS Richards","year":"1992","journal-title":"Parasitol Today"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/j.1558-5646.1998.tb02243.x","article-title":"Selection and strain specificity of compatibility between snail intermediate hosts and their parasitic schistosomes","volume":"52","author":"JP Webster","year":"1998","journal-title":"Evolution"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1073\/pnas.96.4.1510","article-title":"The identification of markers segregating with resistance to <italic>Schistosoma mansoni<\/italic> infection in the snail <italic>Biomphalaria glabrata<\/italic>","volume":"96","author":"M Knight","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1086\/424607","article-title":"Do hosts and parasites coevolve? Empirical support from the <italic>Schistosoma<\/italic> system","volume":"164","author":"JP Webster","year":"2004","journal-title":"Am Nat"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2009.01.005","article-title":"Successful parasitism of vector snail <italic>Biomphalaria glabrata<\/italic> by the human blood fluke (trematode) <italic>Schistosoma mansoni<\/italic>: A 2009 assessment","volume":"165","author":"CJ Bayne","year":"2009","journal-title":"Mol Biochem Parasitol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4419-8059-5_2","article-title":"Gastropod immunobiology","volume":"708","author":"ES Loker","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dci.2011.09.002","article-title":"Compatibility polymorphism in snail\/schistosome interactions: From field to theory to molecular mechanisms","volume":"37","author":"G Mitta","year":"2012","journal-title":"Dev Comp Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1126\/science.1139862","article-title":"Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes","volume":"316","author":"RM Waterhouse","year":"2007","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-ento-120710-100651","article-title":"Mosquito genomics: progress and challenges","volume":"57","author":"DW Severson","year":"2012","journal-title":"Annu Rev Entomol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"21087","DOI":"10.1073\/pnas.1011242107","article-title":"Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection","volume":"107","author":"PC Hanington","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1591","DOI":"10.1371\/journal.pntd.0001591","article-title":"A somatically diversified defense factor, FREP3, is a determinant of snail resistance to schistosome infection","volume":"6","author":"PC Hanington","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1002677","DOI":"10.1371\/journal.ppat.1002677","article-title":"Reversing the resistance phenotype of the <italic>Biomphalaria glabrata<\/italic> snail host <italic>Schistosoma mansoni<\/italic> infection by temperature modulation","volume":"8","author":"W Ittiprasert","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molbiopara.2006.02.009","article-title":"<italic>Biomphalaria glabrata<\/italic> cytosolic copper\/zinc superoxide dismutase (SOD1) gene: Association of SOD1 alleles with resistance\/susceptibility to <italic>Schistosoma mansoni<\/italic>","volume":"147","author":"CP Goodall","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1701","DOI":"10.1371\/journal.pntd.0001701","article-title":"Effects of Cu\/Zn superoxide dismutase (sod1) genotype and genetic background on growth, reproduction and defense in <italic>Biomphalaria glabrata<\/italic>","volume":"6","author":"KM Bonner","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0020-7519(75)90012-0","article-title":"An interpretation of snail-trematode infection rates: specificity based on concordance of compatible phenotypes","volume":"5","author":"PF Basch","year":"1975","journal-title":"Int J Parasitol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0014-4894(76)90022-9","article-title":"Intermediate host specificity in <italic>Schistosoma mansoni<\/italic>","volume":"39","author":"PF Basch","year":"1976","journal-title":"Exp Parasitol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1017\/S0031182000049696","article-title":"Genetic factors in susceptibility of <italic>Biomphalaria glabrata<\/italic> for different strains of <italic>Schistosoma mansoni<\/italic>","volume":"70","author":"CS Richards","year":"1975","journal-title":"Parasitology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2307\/2411336","article-title":"Selection and strain specificity of compatibility between snail intermediate hosts and their parasitic schistosomes","volume":"52","author":"JP Webster","year":"1998","journal-title":"Evolution"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.meegid.2014.04.025","article-title":"Multi-host parasite infectivity and multi-parasite host susceptibility: a new approach of the <italic>Biomphalaria glabrata\/Schistosoma mansoni<\/italic> compatibility polymorphism","volume":"26","author":"A Th\u00e9ron","year":"2014","journal-title":"Infect Genet Evol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1017\/S0031182008004745","article-title":"Effects of laboratory culture on compatibility between snails and schistosomes","volume":"135","author":"A Th\u00e9ron","year":"2008","journal-title":"Parasitology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11036","DOI":"10.1073\/pnas.0403151101","article-title":"Host-parasite interactions and the evolution of ploidy","volume":"101","author":"SL Nuismer","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1111\/mec.12354","article-title":"<italic>Stacks<\/italic>: <italic>an analysis tool set for population genomics<\/italic>","volume":"22","author":"J Catchen","year":"2013","journal-title":"Mol Ecol"},{"key":"ref36","article-title":"eLS","author":"MC Pahl","year":"2013"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1590\/S0074-02762006000900027","article-title":"A bacterial artificial chromosome library for <italic>Biomphalaria glabrata<\/italic>, intermediate snail host of <italic>Schistosoma mansoni<\/italic>","volume":"101","author":"CM Adema","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2443.2010.01468.x","article-title":"How are exons encoding transmembrane sequences distributed in the exon-intron structure of genes?","volume":"16","author":"R Sawada","year":"2011","journal-title":"Genes Cells"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1099-1352(200007\/08)13:4<167::AID-JMR502>3.0.CO;2-9","article-title":"Engineered protein scaffolds for molecular recognition","volume":"13","author":"A Skerra","year":"2000","journal-title":"J Mol Recognit"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1371\/journal.pntd.0000330","article-title":"Controlled chaos of polymorphic mucins in a metazoan parasite (<italic>Schistosoma mansoni<\/italic>) interacting with its invertebrate host (<italic>Biomphalaria glabrata<\/italic>)","volume":"2","author":"E Roger","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1073\/pnas.94.16.8691","article-title":"A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection","volume":"94","author":"CM Adema","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e813","DOI":"10.1371\/journal.pntd.0000813","article-title":"A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host\/parasite model","volume":"4","author":"Y Mon\u00e9","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1371\/journal.pgen.0020064","article-title":"Balancing selection and its effects on sequences in nearby genome regions","volume":"2","author":"D Charlesworth","year":"2006","journal-title":"PLoS Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1002680","DOI":"10.1371\/journal.pgen.1002680","article-title":"Recombination drives vertebrate genome contraction","volume":"8","author":"K Nam","year":"2012","journal-title":"PLoS Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2307\/3285775","article-title":"Genetic diversity and recruitment pattern of <italic>Schistosoma mansoni<\/italic> in a <italic>Biomphalaria glabrata<\/italic> snail population: a field study using random-amplified polymorphic DNA markers","volume":"85","author":"C Sire","year":"1999","journal-title":"J Parasitol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1371\/journal.pbio.0050310","article-title":"Population genomics: whole-genome analysis of polymorphism and divergence in <italic>Drosophila simulans<\/italic>","volume":"5","author":"DJ Begun","year":"2007","journal-title":"PLoS Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1601-5223.1997.00075.x","article-title":"A microsatellite-based MHC genotyping system for house mice (<italic>Mus domesticus<\/italic>)","volume":"127","author":"S Meagher","year":"1997","journal-title":"Hereditas"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/molbev\/mss246","article-title":"Recent and ancient signature of balancing selection around the S-locus in <italic>Arabidopsis halleri<\/italic> and <italic>A<\/italic>. <italic>lyrata<\/italic>","volume":"30","author":"C Roux","year":"2013","journal-title":"Mol Biol Evol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/j.0014-3820.2002.tb00116.x","article-title":"Pathogen resistance and genetic variation at MHC loci","volume":"56","author":"PW Hedrick","year":"2002","journal-title":"Evolution"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0166-6851(93)90133-I","article-title":"Molecular characterisation of mitochondrial DNA provides evidence for the recent introduction of <italic>Schistosoma mansoni<\/italic> into America","volume":"60","author":"L Despr\u00e8s","year":"1993","journal-title":"Mol Biochem Parasitol"},{"issue":"Suppl","key":"ref51","first-page":"S229","article-title":"Evolutionary relationships between trematodes and snails emphasizing schistosomes and paragonimids","volume":"123","author":"D Blair","year":"2001"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/genetics\/130.4.925","article-title":"Polymorphism and balancing selection at major histocompatibility complex loci","volume":"130","author":"N Takahata","year":"1992","journal-title":"Genetics"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1093\/molbev\/msn208","article-title":"Balancing selection at a frog antimicrobial peptide locus: fluctuating immune effector alleles?","volume":"25","author":"JA Tennessen","year":"2008","journal-title":"Mol Biol Evol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1093\/molbev\/msp190","article-title":"Targets of balancing selection in the human genome","volume":"26","author":"AM Andr\u00e9s","year":"2009","journal-title":"Mol Biol Evol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1126\/science.1124153","article-title":"Natural malaria infection in <italic>Anopheles gambiae<\/italic> is regulated by a single genomic control region","volume":"312","author":"MM Riehle","year":"2006","journal-title":"Science"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/1471-2148-8-274","article-title":"The evolution of TEP1, an exceptionally polymorphic immunity gene in <italic>Anopheles gambiae<\/italic>","volume":"8","author":"DJ Obbard","year":"2008","journal-title":"BMC Evol Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e1000600","DOI":"10.1371\/journal.pbio.1000600","article-title":"Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of <italic>Anopheles gambiae<\/italic>","volume":"9","author":"SM Rottschaefer","year":"2011","journal-title":"PLoS Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev.phyto.39.1.285","article-title":"Resistance gene complexes: evolution and utilization","volume":"39","author":"SH Hulbert","year":"2001","journal-title":"Annu Rev Phytopathol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0959-437X(05)80163-7","article-title":"The MHC: relationship between linkage and function","volume":"2","author":"J Trowsdale","year":"1992","journal-title":"Curr Opin Genet Dev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1073\/pnas.0609809104","article-title":"Transgenic malaria-resistant mosquitoes have a fitness advantage when feeding on Plasmodium-infected blood","volume":"104","author":"MT Marrelli","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1073\/pnas.1019295108","article-title":"Genetic elimination of dengue vector mosquitoes","volume":"108","author":"MR Wise de Valdez","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e1001115","DOI":"10.1371\/journal.ppat.1001115","article-title":"Involvement of the cytokine MIF in the snail host immune response to the parasite <italic>Schistosoma mansoni<\/italic>","volume":"6","author":"A Baeza Garcia","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e1212","DOI":"10.1371\/journal.pntd.0001212","article-title":"Polyethyleneimine (PEI) mediated siRNA gene silencing in the <italic>Schistosoma mansoni<\/italic> snail host, <italic>Biomphalaria glabrata<\/italic>","volume":"5","author":"M Knight","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e3376","DOI":"10.1371\/journal.pone.0003376","article-title":"Rapid SNP discovery and genetic mapping using sequenced RAD markers","volume":"3","author":"NA Baird","year":"2008","journal-title":"PLoS ONE"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler Transform","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1046\/j.1365-294x.1999.00620.x","article-title":"Estimating population structure in diploids with multilocus dominant DNA markers","volume":"8","author":"LA Zhivotovsky","year":"1999","journal-title":"Mol Ecol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/bioinformatics\/btr011","article-title":"A fast, lock-free approach for efficient parallel counting of occurrences of k-mers","volume":"27","author":"G Mar\u00e7ais","year":"2001","journal-title":"Bioinformatics"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1101\/gr.089532.108","article-title":"ABySS: a parallel assembler for short read sequence data","volume":"19","author":"JT Simpson","year":"2009","journal-title":"Genome Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1745-6150-7-12","article-title":"Domain enhanced lookup time accelerated BLAST","volume":"7","author":"GM Boratyn","year":"2012","journal-title":"Biol Direct"},{"key":"ref70","first-page":"45","article-title":"A convention for naming molluscan genes","volume":"5","author":"CJ Bayne","year":"2012","journal-title":"Curr Top in Genet"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"W197","DOI":"10.1093\/nar\/gkn238","article-title":"The Jpred 3 secondary structure prediction server","volume":"36","author":"C Cole","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/bioinformatics\/btp187","article-title":"DnaSP v5: a software for comprehensive analysis of DNA polymorphism data","volume":"25","author":"P Librado","year":"2009","journal-title":"Bioinformatics"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/genetics\/123.3.585","article-title":"Statistical method for testing the neutral mutation hypothesis by DNA polymorphism","volume":"123","author":"F Tajima","year":"1989","journal-title":"Genetics"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1005067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T22:01:31Z","timestamp":1651528891000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1005067"}},"subtitle":[],"editor":[{"given":"Brian P.","family":"Lazzaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,16]]},"references-count":73,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1005067","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,16]]}}}