{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:13:01Z","timestamp":1782421981380,"version":"3.54.5"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1005255","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T14:28:52Z","timestamp":1432909732000},"page":"e1005255","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Genetic Mechanism of Human Neutrophil Antigen 2 Deficiency and Expression Variations"],"prefix":"10.1371","volume":"11","author":[{"given":"Yunfang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Mair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy M.","family":"Schuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tmrv.2009.06.001","article-title":"The role of neutrophils in the pathogenesis of transfusion-related acute lung injury","volume":"23","author":"YL Fung","year":"2009","journal-title":"Transfus Med Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1111\/j.1537-2995.2008.01810.x","article-title":"The role of donor antibodies in the pathogenesis of transfusion-related acute lung injury: a systematic review","volume":"48","author":"RA Middelburg","year":"2008","journal-title":"Transfusion"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1046\/j.1365-2141.1996.d01-1703.x","article-title":"Transfusion-related acute lung injury due to HLA-A2-specific antibodies in recipient and NB1-specific antibodies in donor blood","volume":"93","author":"J Bux","year":"1996","journal-title":"Br J Haematol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1537-2995.2006.01148.x","article-title":"The transfusion of neutrophil-specific antibodies causes leukopenia and a broad spectrum of pulmonary reactions","volume":"47","author":"EA Fadeyi","year":"2007","journal-title":"Transfusion"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1097\/00000542-199911000-00048","article-title":"Transfusion-related lung injury with leukopenic reaction caused by fresh frozen plasma containing anti-NB1","volume":"91","author":"R Leger","year":"1999","journal-title":"Anesthesiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/MOH.0b013e3282efed9e","article-title":"Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177","volume":"14","author":"DF Stroncek","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1182\/blood-2014-05-538181","article-title":"Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies","volume":"124","author":"EK Storch","year":"2014","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1182\/blood-2005-04-1744","article-title":"Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model","volume":"107","author":"UJ Sachs","year":"2006","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1423-0410.2012.01613.x","article-title":"Comparative analysis of the pathological events involved in immune and non-immune TRALI models","volume":"103","author":"MB Tamarozzi","year":"2012","journal-title":"Vox Sang"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1172\/JCI106582","article-title":"NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia","volume":"50","author":"P Lalezari","year":"1971","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1046\/j.1537-2995.1994.341195065037.x","article-title":"Characterization of the neutrophil molecules identified by quinine-dependent antibodies from two patients","volume":"34","author":"DF Stroncek","year":"1994","journal-title":"Transfusion"},{"key":"ref12","first-page":"247","article-title":"Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions","volume":"123","author":"DF Stroncek","year":"1994","journal-title":"J Lab Clin Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1537-2995.1993.33293158050.x","article-title":"Prolonged neutropenia resulting from antibodies to neutrophil-specific antigen NB1 following marrow transplantation","volume":"33","author":"DF Stroncek","year":"1993","journal-title":"Transfusion"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1479-5876-2-8","article-title":"CD177: A member of the Ly-6 gene superfamily involved with neutrophil proliferation and polycythemia vera","volume":"2","author":"DF Stroncek","year":"2004","journal-title":"J Transl Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J","article-title":"Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions","volume":"31","author":"K Kissel","year":"2001","journal-title":"Eur J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/clim.2001.5154","article-title":"The use of bioinformatics to identify the genomic structure of the gene that encodes neutrophil antigen NB1, CD177","volume":"102","author":"MP Bettinotti","year":"2002","journal-title":"Clin Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1537-2995.2006.00741.x","article-title":"The gene overexpressed in polycythemia rubra vera, PRV-1, and the gene encoding a neutrophil alloantigen, NB1, are alleles of a single gene, CD177, in chromosome band 19q13.31","volume":"46","author":"L Caruccio","year":"2006","journal-title":"Transfusion"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.0041-1132.2004.00606.x","article-title":"CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression","volume":"44","author":"L Caruccio","year":"2004","journal-title":"Transfusion"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.21307\/immunohematology-2019-492","article-title":"Assessment of the relative number of copies of the gene encoding human neutrophil antigen-2a(HNA-2a), CD177, and a homologous pseudogene by quantitative real-time PCR","volume":"19","author":"K Dittmar","year":"2003","journal-title":"Immunohematology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1182\/blood.V95.8.2569","article-title":"Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera","volume":"95","author":"S Temerinac","year":"2000","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jlb.49.2.163","article-title":"Neutrophil-specific antigen NB1 is anchored via a glycosyl-phosphatidylinositol linkage","volume":"49","author":"KM Skubitz","year":"1991","journal-title":"J Leukoc Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.4049\/jimmunol.0903136","article-title":"Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1","volume":"184","author":"B Bayat","year":"2010","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"23603","DOI":"10.1074\/jbc.M701120200","article-title":"The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)","volume":"282","author":"UJ Sachs","year":"2007","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1182\/blood-2006-10-055327","article-title":"NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils","volume":"109","author":"S von Vietinghoff","year":"2007","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2249.2010.04154.x","article-title":"Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression","volume":"161","author":"M Abdgawad","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1189\/jlb.0806514","article-title":"Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils","volume":"81","author":"S Bauer","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/art.24442","article-title":"Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils","volume":"60","author":"N Hu","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1074\/jbc.M110.171256","article-title":"Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation","volume":"286","author":"U Jerke","year":"2011","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2141.2004.05027.x","article-title":"Neutrophil CD177 (NB1 gp, HNA-2a) expression is increased in severe bacterial infections and polycythaemia vera","volume":"126","author":"K Gohring","year":"2004","journal-title":"Br J Haematol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1471-230X-13-122","article-title":"Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer","volume":"13","author":"T Toyoda","year":"2013","journal-title":"BMC Gastroenterol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1423-0410.2009.01233.x","article-title":"Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2","volume":"98","author":"E Moritz","year":"2010","journal-title":"Vox Sang"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1182\/blood-2002-09-2831","article-title":"Lack of NB1 GP (CD177\/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms","volume":"102","author":"J Wolff","year":"2003","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1182\/blood.V99.11.4231","article-title":"Molecular basis of NB1 (HNA-2a, CD177) deficiency","volume":"99","author":"K Kissel","year":"2002","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1046\/j.1537-2995.2000.40060654.x","article-title":"Variations in the expression of granulocyte antigen NB1","volume":"40","author":"K Matsuo","year":"2000","journal-title":"Transfusion"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1182\/blood.V86.6.2403.bloodjournal8662403","article-title":"Neutrophil Fc gamma RIIIb deficiency, nature, and clinical consequences: a study of 21 individuals from 14 families","volume":"86","author":"M de Haas","year":"1995","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1182\/blood.V79.8.2131.2131","article-title":"Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia","volume":"79","author":"P Fromont","year":"1992","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1182\/blood.V76.10.1927.1927","article-title":"Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia","volume":"76","author":"TW Huizinga","year":"1990","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1084\/jem.20072413","article-title":"Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake","volume":"205","author":"LC Willcocks","year":"2008","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.exphem.2007.09.008","article-title":"Epigenetic control of PRV-1 expression on neutrophils","volume":"35","author":"J Jelinek","year":"2007","journal-title":"Exp Hematol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1126\/science.1090100","article-title":"Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays","volume":"302","author":"JM Johnson","year":"2003","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/ng0102-13","article-title":"A genomic view of alternative splicing","volume":"30","author":"B Modrek","year":"2002","journal-title":"Nat Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1093\/nar\/gkf492","article-title":"Genome-wide detection of tissue-specific alternative splicing in the human transcriptome","volume":"30","author":"Q Xu","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-genet-111212-133424","article-title":"Organizing principles of mammalian nonsense-mediated mRNA decay","volume":"47","author":"MW Popp","year":"2013","journal-title":"Annu Rev Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1537-2995.1996.36296181931.x","article-title":"Analysis of the expression of NB1 antigen using two monoclonal antibodies","volume":"36","author":"DF Stroncek","year":"1996","journal-title":"Transfusion"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1600-0463.2011.02755.x","article-title":"Analysis of CD177 neutrophil expression in beta-thalassemia patients","volume":"119","author":"LM Montaser","year":"2011","journal-title":"APMIS"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.leukres.2007.09.018","article-title":"Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines","volume":"32","author":"M Dillon","year":"2008","journal-title":"Leuk Res"},{"key":"ref47","first-page":"405","article-title":"Expression of polycythemia rubra vera-1 decreases the dependency of cells on growth factors for proliferation","volume":"90","author":"Z Mnjoyan","year":"2005","journal-title":"Haematologica"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1309\/AJCPDFBEBQZW1OI7","article-title":"CD177 expression on neutrophils: in search of a clonal assay for myeloid neoplasia by flow cytometry","volume":"140","author":"HJ Meyerson","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1365-3148.1998.00136.x","article-title":"The expression of the NB1 antigen on myeloid precursors and neutrophils from children and umbilical cords","volume":"8","author":"DF Stroncek","year":"1998","journal-title":"Transfus Med"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1005360","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1005255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T22:35:37Z","timestamp":1652135737000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1005255"}},"subtitle":[],"editor":[{"given":"Marshall S.","family":"Horwitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,29]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1005255","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725524291.793508501","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,29]]}}}