{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:39:53Z","timestamp":1792096793158,"version":"4.4.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1005347","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T18:45:12Z","timestamp":1435689912000},"page":"e1005347","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy"],"prefix":"10.1371","volume":"11","author":[{"given":"Samuel K.","family":"Asinof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Sukoff Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra R.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verity A.","family":"Letts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne N.","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Boumil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ajhg.2014.08.013","article-title":"De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies","volume":"95","year":"2014","journal-title":"Am J Hum Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature14135","article-title":"Large-scale discovery of novel genetic causes of developmental disorders","volume":"519","year":"2015","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature12439","article-title":"De novo mutations in epileptic encephalopathies","volume":"501","author":"AS Allen","year":"2013","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1212\/01.NXG.0000464295.65736.da","article-title":"Epileptic encephalopathy causing <italic>DNM1<\/italic> mutations impair synaptic vesicle endocytosis","volume":"1","author":"RS Dhindsa","year":"2015","journal-title":"Neurol Genet"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001046","article-title":"A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice","volume":"6","author":"RM Boumil","year":"2010","journal-title":"PLoS Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.1140621","article-title":"A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis","volume":"316","author":"SM Ferguson","year":"2007","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.devcel.2009.11.005","article-title":"Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits","volume":"17","author":"SM Ferguson","year":"2009","journal-title":"Dev Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.seizure.2006.02.019","article-title":"Cognitive problems related to epilepsy syndromes, especially malignant epilepsies","volume":"15","author":"K van Rijckevorsel","year":"2006","journal-title":"Seizure"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrg2949","article-title":"The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms","volume":"12","author":"GP Wagner","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"L Madisen","year":"2010","journal-title":"Nature Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuron.2011.07.026","article-title":"A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex","volume":"71","author":"H Taniguchi","year":"2011","journal-title":"Neuron"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1523\/JNEUROSCI.22-15-06309.2002","article-title":"Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage","volume":"22","author":"JA Gorski","year":"2002","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1371\/journal.pbio.0030159","article-title":"A developmental switch in the response of DRG neurons to ETS transcription factor signaling","volume":"3","author":"S Hippenmeyer","year":"2005","journal-title":"PLoS Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mcn.2008.10.003","article-title":"Generation of Cre-transgenic mice using Dlx1\/Dlx2 enhancers and their characterization in GABAergic interneurons","volume":"40","author":"GB Potter","year":"2009","journal-title":"Mol Cell Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"M Bartos","year":"2007","journal-title":"Nature Rev Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nrn1519","article-title":"Interneurons of the neocortical inhibitory system","volume":"5","author":"H Markram","year":"2004","journal-title":"Nature Rev Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35049047","article-title":"Interneurons unbound","volume":"2","author":"CJ McBain","year":"2001","journal-title":"Nature Rev Neurosci"},{"key":"ref18","first-page":"211","article-title":"Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility","volume":"49C","author":"SB Dutton","year":"2012","journal-title":"Neurobiol Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/dneu.20853","article-title":"Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons","volume":"71","author":"B Rudy","year":"2010","journal-title":"Dev Neurobiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.yebeh.2012.09.017","article-title":"Potential mechanisms of sudden unexpected death in epilepsy","volume":"26","author":"GP Tolstykh","year":"2013","journal-title":"Epilepsy Behav"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuron.2006.07.006","article-title":"The endocannabinoid system controls key epileptogenic circuits in the hippocampus","volume":"51","author":"K Monory","year":"2006","journal-title":"Neuron"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1073\/pnas.0712171105","article-title":"Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons","volume":"105","author":"M Hayashi","year":"2008","journal-title":"PNAS"},{"issue":"Suppl 1","key":"ref23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1528-1167.2010.02906.x","article-title":"Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children","volume":"52","author":"A Brooks-Kayal","year":"2011","journal-title":"Epilepsia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s13311-014-0301-2","article-title":"Epileptic encephalopathies: new genes and new pathways","volume":"11","author":"SE Nieh","year":"2014","journal-title":"Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0006-3223(00)01008-8","article-title":"Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism","volume":"49","author":"K Pierce","year":"2001","journal-title":"Biol Psychiatry"},{"key":"ref26","unstructured":"World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders. Geneva, Switzerland."},{"key":"ref27","unstructured":"American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders. Washington D.C."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1093\/hmg\/ddt331","article-title":"Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome","volume":"22","author":"I Ogiwara","year":"2013","journal-title":"Hum Mol Gen"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nrg906","article-title":"Mechanisms and consequences of somatic mosaicism in humans","volume":"3","author":"H Youssoufian","year":"2002","journal-title":"Nat Rev Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s002130100687","article-title":"Limitations on the use of the C57BL\/6 mouse in the tail suspension test","volume":"155","author":"AJ Mayorga","year":"2001","journal-title":"Psychopharmacol (Berl)"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1005347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T21:22:52Z","timestamp":1566940972000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1005347"}},"subtitle":[],"editor":[{"given":"Gregory S.","family":"Barsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1005347","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]}}}