{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:27:24Z","timestamp":1791149244382,"version":"4.1.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1005426","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T18:17:03Z","timestamp":1438712223000},"page":"e1005426","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":89,"title":["mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway"],"prefix":"10.1371","volume":"11","author":[{"given":"Bin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinglin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daozhang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(95)90487-5","article-title":"Derynck R Toward a molecular understanding of skeletal development","volume":"80","author":"A Erlebacher","year":"1995","journal-title":"Cell"},{"key":"ref2","first-page":"115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"SC Manolagas","year":"2000","journal-title":"Endocr Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1136\/jcp.2010.077842","article-title":"The pathogenesis, diagnosis, investigation and management of osteoporosis","volume":"64","author":"SK Sandhu","year":"2011","journal-title":"J Clin Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.289.5484.1501","article-title":"The osteoblast: a sophisticated fibroblast under central surveillance","volume":"289","author":"P Ducy","year":"2000","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrm3254","article-title":"Building strong bones: molecular regulation of the osteoblast lineage","volume":"13","author":"F Long","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1242\/jcs.051011","article-title":"mTOR signaling at a glance","volume":"122","author":"M Laplante","year":"2009","journal-title":"Journal of Cell Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/cr.2007.64","article-title":"Expanding mTOR signaling","volume":"17","author":"Q Yang","year":"2007","journal-title":"Cell Research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molcel.2012.06.009","article-title":"TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1","volume":"47","author":"CC Dibble","year":"2012","journal-title":"Mol Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"N Hay","year":"2004","journal-title":"Genes & Development"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1054\/jcms.2002.0322","article-title":"Tuberous sclerosis: clinicopathologic features and review of the literature","volume":"30","author":"RP Barron","year":"2002","journal-title":"J Craniomaxillofac Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1067\/mjd.2001.111626","article-title":"Tuberous sclerosis. Part II. Musculoskeletal and visceral findings","volume":"45","author":"TA Bernauer","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1440-1673.1996.tb00352.x","article-title":"Choo HF Bone changes in tuberous sclerosis mimicking metastases","volume":"40","author":"MH Pui","year":"1996","journal-title":"Australas Radiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1001\/archneurpsyc.1955.02330110041004","article-title":"Nature of certain osseous lesions in tuberous sclerosis","volume":"73","author":"WW DICKERSON","year":"1955","journal-title":"AMA Arch Neurol Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1148\/58.1.1","article-title":"The osseous lesions of tuberous sclerosis","volume":"58","author":"JF HOLT","year":"1952","journal-title":"Radiology"},{"key":"ref15","first-page":"46","article-title":"Defining the role of common variation in the genomic and biological architecture of adult human height","author":"AR Wood","year":"2014","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/bbrc.1998.9118","article-title":"Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17\/2.8) cells","volume":"249","author":"T Ogawa","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-5793(01)03236-7","article-title":"Inhibition of PI3K\/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2","volume":"510","author":"F Vinals","year":"2002","journal-title":"FEBS Lett"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/jbmr.114","article-title":"NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells","volume":"25","author":"SK Martin","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jcb.10474","article-title":"Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells","volume":"88","author":"LN Shoba","year":"2003","journal-title":"J Cell Biochem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00776-006-1079-9","article-title":"Rapamycin as an inhibitor of osteogenic differentiation in bone marrow-derived mesenchymal stem cells","volume":"12","author":"S Isomoto","year":"2007","journal-title":"J Orthop Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/jcb.21411","article-title":"Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells","volume":"103","author":"UK Singha","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/jcb.24519","article-title":"Rapamycin inhibits BMP-7-induced osteogenic and lipogenic marker expressions in fetal rat calvarial cells","volume":"114","author":"LC Yeh","year":"2013","journal-title":"J Cell Biochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF01352014","article-title":"Lack of change of cancellous bone volume with short-term use of the new immunosuppressant rapamycin in rats","volume":"53","author":"I Joffe","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/jbmr.5650100513","article-title":"Rapamycin: a bone sparing immunosuppressant?","volume":"10","author":"DF Romero","year":"1995","journal-title":"J Bone Miner Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nm.2793","article-title":"Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells","volume":"18","author":"L Xian","year":"2012","journal-title":"Nat Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development","volume":"284","author":"S Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1634\/stemcells.2005-0661","article-title":"Notch signaling in stem cell systems","volume":"24","author":"S Chiba","year":"2006","journal-title":"Stem Cells"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1172\/JCI37964","article-title":"Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3\/p63\/Jagged\/Notch cascade","volume":"120","author":"J Ma","year":"2010","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI40221","article-title":"The evolutionarily conserved TSC\/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development","volume":"120","author":"M Karbowniczek","year":"2010","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/jcp.24670","article-title":"mTORC1 Is Involved in Hypoxia-Induced Pulmonary Hypertension Through the Activation of Notch3","volume":"229","author":"W Wang","year":"2014","journal-title":"J Cell Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1359\/jbmr.1999.14.6.893","article-title":"Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation\/mineralization potential","volume":"14","author":"D Wang","year":"1999","journal-title":"J Bone Miner Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nm1712","article-title":"Dimorphic effects of Notch signaling in bone homeostasis","volume":"14","author":"F Engin","year":"2008","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1074\/jbc.M508370200","article-title":"Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt\/beta-catenin but not bone morphogenetic protein signaling","volume":"281","author":"V Deregowski","year":"2006","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm1716","article-title":"Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation","volume":"14","author":"MJ Hilton","year":"2008","journal-title":"Nat Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1210\/en.2008-0140","article-title":"Notch inhibits osteoblast differentiation and causes osteopenia","volume":"149","author":"S Zanotti","year":"2008","journal-title":"Endocrinology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1074\/jbc.M800183200","article-title":"Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3","volume":"283","author":"WK Chu","year":"2008","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0960-9822(99)00268-7","article-title":"Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR","volume":"10","author":"K Yokogami","year":"2000","journal-title":"Curr Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1074\/jbc.M108080200","article-title":"The p53 family member genes are involved in the Notch signal pathway","volume":"277","author":"Y Sasaki","year":"2002","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/dev.02325","article-title":"p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation","volume":"133","author":"J Laurikkala","year":"2006","journal-title":"Development"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.yexmp.2007.03.006","article-title":"p63\u2014Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis","volume":"83","author":"K Murata","year":"2007","journal-title":"Exp Mol Pathol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"51408","DOI":"10.1074\/jbc.M309943200","article-title":"p63 alpha expression is regulated by the phosphoinositide 3-kinase pathway","volume":"278","author":"CE Barbieri","year":"2003","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"24731","DOI":"10.1074\/jbc.274.35.24731","article-title":"Osmotic stress inhibits p70\/85 S6 kinase through activation of a protein phosphatase","volume":"274","author":"LA Parrott","year":"1999","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/scd.2009.0147","article-title":"Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP\/Smad Pathway","volume":"19","author":"K Lee","year":"2010","journal-title":"Stem Cells and Development"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7164\/antibiotics.28.721","article-title":"Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle","volume":"28","author":"C Vezina","year":"1975","journal-title":"J Antibiot (Tokyo)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejim.2006.07.017","article-title":"Dramatic effect of sirolimus on renal angiomyolipomas in a patient with tuberous sclerosis complex","volume":"18","author":"I Herry","year":"2007","journal-title":"Eur J Intern Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3109\/0886022X.2010.517345","article-title":"Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient","volume":"32","author":"H Micozkadioglu","year":"2010","journal-title":"Ren Fail"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00381-013-2185-6","article-title":"Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86","volume":"30","author":"M Canpolat","year":"2014","journal-title":"Childs Nerv Syst"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejpn.2013.03.002","article-title":"Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex","volume":"17","author":"K Kotulska","year":"2013","journal-title":"Eur J Paediatr Neurol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1073\/pnas.0604153104","article-title":"Lifelong accumulation of bone in mice lacking Pten in osteoblasts","volume":"104","author":"X Liu","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1128\/MCB.00075-14","article-title":"Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis","volume":"34","author":"RC Riddle","year":"2014","journal-title":"Mol Cell Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1242\/jcs.042770","article-title":"Akt promotes BMP2-mediated osteoblast differentiation and bone development","volume":"122","author":"A Mukherjee","year":"2009","journal-title":"J Cell Sci"},{"key":"ref52","article-title":"Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity","author":"LP Lai","year":"2014","journal-title":"Bone"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/en.2012-1732","article-title":"Osteoblast lineage-specific effects of notch activation in the skeleton","volume":"154","author":"E Canalis","year":"2013","journal-title":"Endocrinology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI40221","article-title":"The evolutionarily conserved TSC\/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development","volume":"120","author":"M Karbowniczek","year":"2010","journal-title":"J Clin Invest"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3757","article-title":"Making new contacts: the mTOR network in metabolism and signalling crosstalk","volume":"15","author":"M Shimobayashi","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1210\/endo-100-5-1233","article-title":"Parathyroid hormone- and prostaglandin E1-response in a selected population of bone cells after repeated subculture and storage at -80C","volume":"100","author":"LG Rao","year":"1977","journal-title":"Endocrinology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/8756-3282(88)90005-1","article-title":"Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells","volume":"9","author":"U Bhargava","year":"1988","journal-title":"Bone"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0012-1606(89)90291-1","article-title":"Determination of numbers of osteoprogenitors present in isolated fetal rat calvaria cells in vitro","volume":"133","author":"CG Bellows","year":"1989","journal-title":"Dev Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/11.5.525","article-title":"A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells","volume":"11","author":"DJ Kwiatkowski","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1242\/dev.02480","article-title":"Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors","volume":"133","author":"SJ Rodda","year":"2006","journal-title":"Development"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1074\/jbc.M412911200","article-title":"Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype","volume":"280","author":"L Ye","year":"2005","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/labinvest.2011.153","article-title":"Microvascular density as an independent predictor of clinical outcome in renal cell carcinoma: an automated image analysis study","volume":"92","author":"VV Iakovlev","year":"2012","journal-title":"Lab Invest"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"T Hildebrand","year":"1999","journal-title":"J Bone Miner Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1177\/0022034510397839","article-title":"DMP1 processing is essential to dentin and jaw formation","volume":"90","author":"Y Sun","year":"2011","journal-title":"J Dent Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"12919","DOI":"10.1073\/pnas.0912855107","article-title":"Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice","volume":"107","author":"X Zhou","year":"2010","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1005426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:20:56Z","timestamp":1588965656000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1005426"}},"subtitle":[],"editor":[{"given":"Gregory S.","family":"Barsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,4]]},"references-count":65,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1005426","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,4]]}}}