{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:53:02Z","timestamp":1790067182148,"version":"4.0.1"},"reference-count":104,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1005905","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T13:32:03Z","timestamp":1456752723000},"page":"e1005905","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":74,"title":["SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane"],"prefix":"10.1371","volume":"12","author":[{"given":"Meghan A.","family":"Morrissey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjay","family":"Jayadev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger R.","family":"Miley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Blebea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyi","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Sherwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.tcb.2008.08.007","article-title":"Breaching the basement membrane: who, when and how?","volume":"18","author":"RG Rowe","year":"2008","journal-title":"Trends in Cell Biology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"D Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1083\/jcb.201311112","article-title":"Traversing the basement membrane in vivo: A diversity of strategies","volume":"204","author":"LC Kelley","year":"2014","journal-title":"The Journal of cell biology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"KR Levental","year":"2009","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.201102147","article-title":"The extracellular matrix: a dynamic niche in cancer progression","volume":"196","author":"P Lu","year":"2012","journal-title":"J Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004911","article-title":"Basement membranes: cell scaffoldings and signaling platforms","volume":"3","author":"PD Yurchenco","year":"2011","journal-title":"Cold Spring Harbor perspectives in biology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/science.1176811","article-title":"A sulfilimine bond identified in collagen IV","volume":"325","author":"R Vanacore","year":"2009","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1073\/pnas.1318499111","article-title":"A unique covalent bond in basement membrane is a primordial innovation for tissue evolution","volume":"111","author":"AL Fidler","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1242\/dev.01037","article-title":"Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development","volume":"131","author":"E Poschl","year":"2004","journal-title":"Development"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1534\/genetics.111.133173","article-title":"Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease","volume":"190","author":"Y Kubota","year":"2012","journal-title":"Genetics"},{"key":"ref11","article-title":"An active role for basement membrane assembly and modification in tissue sculpting","author":"MA Morrissey","year":"2015","journal-title":"J Cell Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.devcel.2011.06.026","article-title":"Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan","volume":"21","author":"JC Pastor-Pareja","year":"2011","journal-title":"Dev Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1126\/science.1199424","article-title":"Global tissue revolutions in a morphogenetic movement controlling elongation","volume":"331","author":"SL Haigo","year":"2011","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1432-1033.1981.tb05690.x","article-title":"A network model for the organization of type IV collagen molecules in basement membranes","volume":"120","author":"R Timpl","year":"1981","journal-title":"Eur J Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jcb.21688","article-title":"A prototypic matricellular protein in the tumor","volume":"104","author":"CJ Clark","year":"2008","journal-title":"Journal of Cellular Biochemistry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0960-9822(07)00540-4","article-title":"Importance of the basement membrane protein SPARC for viability and fertility in Caenorhabditis elegans","volume":"8","author":"MC Fitzgerald","year":"1998","journal-title":"Current Biology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10555-008-9135-x","article-title":"The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host","volume":"27","author":"OL Podhajcer","year":"2008","journal-title":"Cancer Metastasis Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12079-009-0072-4","article-title":"SPARC: a matricellular regulator of tumorigenesis","volume":"3","author":"SA Arnold","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/carcin\/bgu072","article-title":"Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis","volume":"35","author":"GP Nagaraju","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.celrep.2014.08.029","article-title":"Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells","volume":"8","author":"DT Ting","year":"2014","journal-title":"Cell Rep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature03799","article-title":"Genes that mediate breast cancer metastasis to lung","volume":"436","author":"AJ Minn","year":"2005","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0736-5748(99)00009-X","article-title":"Increased SPARC expression promotes U87 glioblastoma invasion in vitro","volume":"17","author":"WA Golembieski","year":"1999","journal-title":"Int J Dev Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1038\/sj.onc.1205857","article-title":"Transcriptional upregulation of SPARC, in response to c-Jun overexpression, contributes to increased motility and invasion of MCF7 breast cancer cells","volume":"21","author":"J Briggs","year":"2002","journal-title":"Oncogene"},{"key":"ref24","first-page":"4453","article-title":"Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone","volume":"59","author":"K Jacob","year":"1999","journal-title":"Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/01.sla.0000171866.45848.68","article-title":"Osteonectin influences growth and invasion of pancreatic cancer cells","volume":"242","author":"A Guweidhi","year":"2005","journal-title":"Ann Surg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000024503","article-title":"Stimulation of motility of human renal cell carcinoma by SPARC\/Osteonectin\/BM-40 associated with type IV collagen","volume":"18","author":"Y Kato","year":"1998","journal-title":"Invasion Metastasis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nm0297-171","article-title":"Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells","volume":"3","author":"MF Ledda","year":"1997","journal-title":"Nat Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neulet.2007.04.037","article-title":"SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells","volume":"419","author":"HM McClung","year":"2007","journal-title":"Neurosci Lett"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1083\/jcb.121.6.1433","article-title":"SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway","volume":"121","author":"PM Tremble","year":"1993","journal-title":"J Cell Biol"},{"key":"ref30","first-page":"5529","article-title":"SPARC\/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines","volume":"58","author":"C Gilles","year":"1998","journal-title":"Cancer Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"15951","DOI":"10.1074\/jbc.M211498200","article-title":"Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model","volume":"278","author":"JN Rich","year":"2003","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"H841","DOI":"10.1152\/ajpheart.01247.2010","article-title":"SPARC regulates collagen interaction with cardiac fibroblast cell surfaces","volume":"301","author":"BS Harris","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.109.1.341","article-title":"SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix","volume":"109","author":"H Sage","year":"1989","journal-title":"J Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"36483","DOI":"10.1074\/jbc.M504663200","article-title":"SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity","volume":"280","author":"TH Barker","year":"2005","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1074\/jbc.M808285200","article-title":"SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling","volume":"284","author":"J Nie","year":"2009","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1038\/sj.onc.1210181","article-title":"Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases","volume":"26","author":"Q Shi","year":"2007","journal-title":"Oncogene"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00427-009-0313-9","article-title":"Molecular evolution of SPARC: absence of the acidic module and expression in the endoderm of the starlet sea anemone, Nematostella vectensis","volume":"219","author":"A Koehler","year":"2009","journal-title":"Dev Genes Evol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/154405910708600402","article-title":"Is SPARC an evolutionarily conserved collagen chaperone?","volume":"86","author":"N Martinek","year":"2007","journal-title":"J Dent Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12079-009-0062-6","article-title":"The role of SPARC in extracellular matrix assembly","volume":"3","author":"AD Bradshaw","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/jcs.021931","article-title":"Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in Drosophila embryos","volume":"121","author":"N Martinek","year":"2008","journal-title":"Journal of Cell Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/dvdy.24243","article-title":"Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster","volume":"244","author":"J Shahab","year":"2015","journal-title":"Dev Dyn"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"22062","DOI":"10.1074\/jbc.M700167200","article-title":"SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts","volume":"282","author":"TJ Rentz","year":"2007","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/emboj\/17.6.1625","article-title":"Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40\/SPARC\/osteonectin","volume":"17","author":"T Sasaki","year":"1998","journal-title":"The EMBO journal"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"19551","DOI":"10.1074\/jbc.M710001200","article-title":"Mapping of SPARC\/BM-40\/osteonectin-binding sites on fibrillar collagens","volume":"283","author":"C Giudici","year":"2008","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"18273","DOI":"10.1073\/pnas.0808452105","article-title":"Structural basis of sequence-specific collagen recognition by SPARC","volume":"105","author":"E Hohenester","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e23880","DOI":"10.1371\/journal.pone.0023880","article-title":"Secreted protein acidic and rich in cysteine is a matrix scavenger chaperone","volume":"6","author":"A Chlenski","year":"2011","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ceb.2011.05.002","article-title":"Cell invasion through basement membrane: the anchor cell breaches the barrier","volume":"23","author":"EJ Hagedorn","year":"2011","journal-title":"Current opinion in cell biology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.devcel.2014.08.024","article-title":"B-LINK: A Hemicentin, Plakin, and Integrin-Dependent Adhesion System that Links Tissues by Connecting Adjacent Basement Membranes","volume":"31","author":"MA Morrissey","year":"2014","journal-title":"Developmental cell"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1083\/jcb.201301091","article-title":"The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo","volume":"201","author":"EJ Hagedorn","year":"2013","journal-title":"The Journal of cell biology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.cell.2005.03.031","article-title":"FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans","volume":"121","author":"DR Sherwood","year":"2005","journal-title":"Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.devcel.2009.06.006","article-title":"Integrin acts upstream of netrin signaling to regulate formation of the anchor cell&apos;s invasive membrane in C. elegans","volume":"17","author":"EJ Hagedorn","year":"2009","journal-title":"Dev Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/ncb1825","article-title":"UNC-6 (netrin) orients the invasive membrane of the anchor cell in C-elegans","volume":"11","author":"JW Ziel","year":"2009","journal-title":"Nature Cell Biology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1534-5807(03)00168-0","article-title":"Anchor cell invasion into the vulval epithelium in C. elegans","volume":"5","author":"DR Sherwood","year":"2003","journal-title":"Developmental cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1242\/dev.115048","article-title":"Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins","volume":"141","author":"ST Armenti","year":"2014","journal-title":"Development"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e1005786","DOI":"10.1371\/journal.pgen.1005786","article-title":"A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation","volume":"12","author":"LL Lohmer","year":"2016","journal-title":"PLoS Genet"},{"key":"ref56","article-title":"ADF\/cofilin promotes invadopodial membrane recycling during cell invasion in vivo","author":"EJ Hagedorn","year":"2014","journal-title":"The Journal of cell biology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tcb.2014.12.006","article-title":"Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance","volume":"25","author":"L Seguin","year":"2015","journal-title":"Trends Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nrc3005","article-title":"Novel roles for Slits and netrins: axon guidance cues as anticancer targets?","volume":"11","author":"P Mehlen","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/j.ejca.2005.08.008","article-title":"The Fos family of transcription factors and their role in tumourigenesis","volume":"41","author":"K Milde-Langosch","year":"2005","journal-title":"Eur J Cancer"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10555-013-9459-z","article-title":"Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer","volume":"33","author":"SY Ko","year":"2014","journal-title":"Cancer Metastasis Rev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1073\/pnas.0709810105","article-title":"Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer","volume":"105","author":"J Fitamant","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cellsig.2011.04.001","article-title":"Cdc42 in oncogenic transformation, invasion, and tumorigenesis","volume":"23","author":"K Stengel","year":"2011","journal-title":"Cell Signal"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"ra35","DOI":"10.1126\/scisignal.2000654","article-title":"In vivo identification of regulators of cell invasion across basement membranes","volume":"3","author":"DQ Matus","year":"2010","journal-title":"Sci Signal"},{"key":"ref64","first-page":"6270","article-title":"Secreted protein acidic and rich in cysteine promotes glioma invasion and delays tumor growth in vivo","volume":"62","author":"C Schultz","year":"2002","journal-title":"Cancer Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.devcel.2015.10.002","article-title":"Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression","volume":"35","author":"DQ Matus","year":"2015","journal-title":"Dev Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1091\/mbc.4.9.941","article-title":"The Caenorhabditis-Elegans Homolog of the Extracellular Calcium-Binding Protein Sparc\/Osteonectin Affects Nematode Body Morphology and Mobility","volume":"4","author":"JE Schwarzbauer","year":"1993","journal-title":"Molecular Biology of the Cell"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1083\/jcb.137.5.1171","article-title":"Type IV collagen is detectable in most, but not all, basement membranes of Caenorhabditis elegans and assembles on tissues that do not express it","volume":"137","author":"PL Graham","year":"1997","journal-title":"Journal of Cell Biology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/jmbi.1995.0557","article-title":"The C-terminal portion of BM-40 (SPARC\/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV","volume":"253","author":"P Maurer","year":"1995","journal-title":"J Mol Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1432-1033.1997.t01-1-00209.x","article-title":"Structural and functional characterization of the extracellular calcium-binding protein BM-40\/secreted protein, acidic, rich in cysteine\/osteonectin from the nematode Caenorhabditis elegans","volume":"248","author":"P Maurer","year":"1997","journal-title":"Eur J Biochem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"22826","DOI":"10.1074\/jbc.M706563200","article-title":"The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase","volume":"283","author":"MS Weaver","year":"2008","journal-title":"J Biol Chem"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/349707a0","article-title":"Embryonic Lethality Caused by Mutations in Basement-Membrane Collagen of C-Elegans","volume":"349","author":"XD Guo","year":"1991","journal-title":"Nature"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1083\/jcb.123.1.255","article-title":"Genetic identification, sequence, and alternative splicing of the Caenorhabditis elegans alpha 2(IV) collagen gene","volume":"123","author":"MH Sibley","year":"1993","journal-title":"J Cell Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/ncb2233","article-title":"Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans","volume":"13","author":"S Ihara","year":"2011","journal-title":"Nat Cell Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1091\/mbc.01-10-0514","article-title":"Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons","volume":"13","author":"MM Rolls","year":"2002","journal-title":"Mol Biol Cell"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1083\/jcb.152.6.1219","article-title":"The NC1\/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance","volume":"152","author":"BD Ackley","year":"2001","journal-title":"J Cell Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1523\/JNEUROSCI.17-21-08061.1997","article-title":"Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles","volume":"17","author":"ML Nonet","year":"1997","journal-title":"J Neurosci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1242\/jeb.00433","article-title":"Food transport in the C. elegans pharynx","volume":"206","author":"L Avery","year":"2003","journal-title":"J Exp Biol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1098\/rstb.1976.0085","article-title":"The pharynx of Caenorhabditis elegans","volume":"275","author":"DG Albertson","year":"1976","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.biocel.2011.12.021","article-title":"Diverse biological functions of the SPARC family of proteins","volume":"44","author":"AD Bradshaw","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.20051210","article-title":"Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils","volume":"203","author":"S Wang","year":"2006","journal-title":"J Exp Med"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2353\/ajpath.2010.090510","article-title":"Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation","volume":"176","author":"MB Voisin","year":"2010","journal-title":"The American journal of pathology"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2353\/ajpath.2006.051321","article-title":"The role of type IV collagen and basement membranes in cancer progression and metastasis","volume":"168","author":"H Tanjore","year":"2006","journal-title":"The American journal of pathology"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1091\/mbc.E10-03-0251","article-title":"The evolution of extracellular matrix","volume":"21","author":"S Ozbek","year":"2010","journal-title":"Molecular Biology of the Cell"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/genetics\/159.1.133","article-title":"Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants","volume":"159","author":"H Fares","year":"2001","journal-title":"Genetics"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1167\/iovs.05-0460","article-title":"Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule","volume":"46","author":"Q Yan","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref86","article-title":"Dynamic regulation of basement membrane protein levels promotes egg chamber elongation in Drosophila","author":"AJ Isabella","year":"2015","journal-title":"Dev Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/jcb.20091","article-title":"SPARC and tumor growth: Where the seed meets the soil?","volume":"92","author":"PE Framson","year":"2004","journal-title":"Journal of Cellular Biochemistry"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/sj.bjc.6602376","article-title":"Aberrant methylation of SPARC in human lung cancers","volume":"92","author":"M Suzuki","year":"2005","journal-title":"Br J Cancer"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0002-9440(10)61732-4","article-title":"SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells","volume":"159","author":"GK Yiu","year":"2001","journal-title":"Am J Pathol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/sj.leu.2404102","article-title":"Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein","volume":"20","author":"JF DiMartino","year":"2006","journal-title":"Leukemia"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1593\/neo.81146","article-title":"Aberrant promoter methylation of SPARC in ovarian cancer","volume":"11","author":"MJ Socha","year":"2009","journal-title":"Neoplasia"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1038\/sj.onc.1206807","article-title":"SPARC\/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions","volume":"22","author":"N Sato","year":"2003","journal-title":"Oncogene"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1172\/JCI16804","article-title":"Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM","volume":"111","author":"RA Brekken","year":"2003","journal-title":"J Clin Invest"},{"key":"ref94","first-page":"1895","article-title":"SPARC, an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells","volume":"12","author":"SC Mok","year":"1996","journal-title":"Oncogene"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s00428-005-1256-9","article-title":"Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breast","volume":"446","author":"PJ Barth","year":"2005","journal-title":"Virchows Arch"},{"key":"ref96","first-page":"5351","article-title":"The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types","volume":"62","author":"CA Iacobuzio-Donahue","year":"2002","journal-title":"Cancer Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/gyno.2000.5894","article-title":"Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer","volume":"78","author":"PJ Paley","year":"2000","journal-title":"Gynecol Oncol"},{"key":"ref98","first-page":"1301","article-title":"Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma","volume":"17","author":"FJ Rodriguez-Jimenez","year":"2007","journal-title":"Oncol Rep"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ijc.22706","article-title":"Frequent inactivation of SPARC by promoter hypermethylation in colon cancers","volume":"121","author":"E Yang","year":"2007","journal-title":"Int J Cancer"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref101","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb1420s92","article-title":"Computer control of microscopes using microManager","author":"A Edelstein","year":"2010","journal-title":"Current protocols in molecular biology"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","article-title":"Genome-wide RNAi screening in Caenorhabditis elegans","volume":"30","author":"RS Kamath","year":"2003","journal-title":"Methods"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1242\/dev.00481","article-title":"Laminin alpha subunits and their role in C. elegans development","volume":"130","author":"CC Huang","year":"2003","journal-title":"Development"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1534\/g3.112.003830","article-title":"large-scale screening for targeted knockouts in the Caenorhabditis elegans genome","volume":"2","year":"2012","journal-title":"G3 (Bethesda)"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1005905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T15:57:30Z","timestamp":1654444650000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1005905"}},"subtitle":[],"editor":[{"given":"Andrew D.","family":"Chisholm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,29]]},"references-count":104,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1005905","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/037218","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,29]]}}}