{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:16:46Z","timestamp":1790378206385,"version":"4.1.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS041449"],"award-info":[{"award-number":["NS041449"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS095279"],"award-info":[{"award-number":["NS095279"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG019206"],"award-info":[{"award-number":["AG019206"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Basic Research Program of China","award":["2012CBA01304"],"award-info":[{"award-number":["2012CBA01304"]}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB13000000"],"award-info":[{"award-number":["XDB13000000"]}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006083","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T23:17:01Z","timestamp":1463872621000},"page":"e1006083","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy"],"prefix":"10.1371","volume":"12","author":[{"given":"Xudong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-En","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta A.","family":"Gaertig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,20]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington disease: natural history, biomarkers and prospects for therapeutics","volume":"10","author":"CA Ross","year":"2014","journal-title":"Nature reviews Neurology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"CA Ross","year":"2011","journal-title":"Lancet neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/978-3-642-45106-5_14","article-title":"Huntington's disease","volume":"220","author":"C Zuccato","year":"2014","journal-title":"Handbook of experimental pharmacology"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0092-8674(95)90542-1","article-title":"Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes","volume":"81","author":"J Nasir","year":"1995","journal-title":"Cell"},{"issue":"5222","key":"ref5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.7618107","article-title":"Inactivation of the mouse Huntington's disease gene homolog Hdh","volume":"269","author":"MP Duyao","year":"1995","journal-title":"Science"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ng1095-155","article-title":"Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue","volume":"11","author":"S Zeitlin","year":"1995","journal-title":"Nat Genet"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","article-title":"A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration","volume":"23","author":"JG Hodgson","year":"1999","journal-title":"Neuron"},{"issue":"24","key":"ref8","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"M Gray","year":"2008","journal-title":"Journal of Neuroscience"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The Biology of Huntingtin","volume":"89","author":"F Saudou","year":"2016","journal-title":"Neuron"},{"issue":"36","key":"ref10","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1073\/pnas.0603772103","article-title":"Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant","volume":"103","author":"Z Ignatova","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"e1000838","DOI":"10.1371\/journal.pgen.1000838","article-title":"Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice","volume":"6","author":"S Zheng","year":"2010","journal-title":"PLoS genetics"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3233\/JHD-2012-120016","article-title":"Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice","volume":"1","author":"M Neveklovska","year":"2012","journal-title":"Journal of Huntington's disease"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1073\/pnas.1221891110","article-title":"Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease","volume":"110","author":"K Sathasivam","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/hmg\/9.4.503","article-title":"Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice","volume":"9","author":"VC Wheeler","year":"2000","journal-title":"Hum Mol Genet"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington's disease","volume":"10","author":"CH Lin","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.10776","article-title":"Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats","volume":"465","author":"LB Menalled","year":"2003","journal-title":"The Journal of comparative neurology"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/78054","article-title":"Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity","volume":"25","author":"H Li","year":"2000","journal-title":"Nat Genet"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/molbev\/msm258","article-title":"Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin","volume":"25","author":"M Tartari","year":"2008","journal-title":"Molecular biology and evolution"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.neuron.2009.11.020","article-title":"Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice","volume":"64","author":"X Gu","year":"2009","journal-title":"Neuron"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.neuron.2015.01.008","article-title":"N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice","volume":"85","author":"X Gu","year":"2015","journal-title":"Neuron"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/hmg\/dds554","article-title":"The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal","volume":"22","author":"T Maiuri","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200909067","article-title":"IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome","volume":"187","author":"LM Thompson","year":"2009","journal-title":"The Journal of cell biology"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nchembio.279","article-title":"Protein folding: sticky N17 speeds huntingtin pile-up","volume":"6","author":"SW Liebman","year":"2010","journal-title":"Nature chemical biology"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/exnr.1998.6778","article-title":"Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases","volume":"150","author":"SK Singhrao","year":"1998","journal-title":"Experimental neurology"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1523\/JNEUROSCI.23-06-02193.2003","article-title":"Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease","volume":"23","author":"ZX Yu","year":"2003","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/sj.mt.6300185","article-title":"Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates","volume":"15","author":"S Palfi","year":"2007","journal-title":"Mol Ther"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1523\/JNEUROSCI.3516-14.2015","article-title":"The JAK\/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases","volume":"35","author":"L Ben Haim","year":"2015","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"21","key":"ref28","doi-asserted-by":"crossref","first-page":"8345","DOI":"10.1523\/JNEUROSCI.0772-15.2015","article-title":"Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain","volume":"35","author":"W Yang","year":"2015","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1152\/jn.01056.2014","article-title":"Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease","volume":"113","author":"T Indersmitten","year":"2015","journal-title":"J Neurophysiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1093\/hmg\/ddq285","article-title":"Early autophagic response in a novel knock-in model of Huntington disease","volume":"19","author":"MY Heng","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1385\/MN:28:3:259","article-title":"Wild-type huntingtin plays a role in brain development and neuronal survival","volume":"28","author":"A Reiner","year":"2003","journal-title":"Molecular neurobiology"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.neuron.2010.06.027","article-title":"Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis","volume":"67","author":"JD Godin","year":"2010","journal-title":"Neuron"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ydbio.2015.07.013","article-title":"Huntingtin is required for ciliogenesis and neurogenesis during early Xenopus development","volume":"408","author":"T Haremaki","year":"2015","journal-title":"Developmental biology"},{"issue":"41","key":"ref34","doi-asserted-by":"crossref","first-page":"14794","DOI":"10.1523\/JNEUROSCI.2774-11.2011","article-title":"Spatial and temporal requirements for huntingtin (Htt) in neuronal migration and survival during brain development","volume":"31","author":"Y Tong","year":"2011","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng1297-404","article-title":"Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion","volume":"17","author":"JK White","year":"1997","journal-title":"Nat Genet"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1089\/hyb.2005.24.231","article-title":"Epitope mapping of monoclonal antibody 4C8 recognizing the protein huntingtin","volume":"24","author":"SY Cong","year":"2005","journal-title":"Hybridoma"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.neuro.29.051605.113042","article-title":"Trinucleotide repeat disorders","volume":"30","author":"HT Orr","year":"2007","journal-title":"Annual review of neuroscience"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ana.21569","article-title":"Sustained effects of nonallele-specific Huntingtin silencing","volume":"65","author":"V Drouet","year":"2009","journal-title":"Annals of neurology"},{"issue":"24","key":"ref39","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1073\/pnas.0610628104","article-title":"Huntingtin facilitates dynein\/dynactin-mediated vesicle transport","volume":"104","author":"JP Caviston","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1091\/mbc.E10-03-0233","article-title":"Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes","volume":"22","author":"JP Caviston","year":"2011","journal-title":"Molecular biology of the cell"},{"issue":"15","key":"ref41","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1523\/JNEUROSCI.2033-12.2013","article-title":"Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites","volume":"33","author":"G Liot","year":"2013","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.stemcr.2014.02.011","article-title":"Huntingtin regulates mammary stem cell division and differentiation","volume":"2","author":"S Elias","year":"2014","journal-title":"Stem cell reports"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/81593","article-title":"Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice","volume":"26","author":"I Dragatsis","year":"2000","journal-title":"Nat Genet"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","article-title":"A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration","volume":"23","author":"JG Hodgson","year":"1999","journal-title":"Neuron"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/1073858404266777","article-title":"Huntingtin and its role in neuronal degeneration","volume":"10","author":"SH Li","year":"2004","journal-title":"The Neuroscientist: a review journal bringing neurobiology, neurology and psychiatry"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuron.2012.05.024","article-title":"Network organization of the huntingtin proteomic interactome in mammalian brain","volume":"75","author":"DI Shirasaki","year":"2012","journal-title":"Neuron"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"SW Davies","year":"1997","journal-title":"Cell"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/ncb3101","article-title":"Huntingtin functions as a scaffold for selective macroautophagy","volume":"17","author":"YN Rui","year":"2015","journal-title":"Nature cell biology"},{"issue":"47","key":"ref49","doi-asserted-by":"crossref","first-page":"16889","DOI":"10.1073\/pnas.1420103111","article-title":"Potential function for the Huntingtin protein as a scaffold for selective autophagy","volume":"111","author":"J Ochaba","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/mds.26020","article-title":"Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing","volume":"29","author":"N Aronin","year":"2014","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/1073858410386236","article-title":"Gene therapy in mouse models of huntington disease","volume":"17","author":"AL Southwell","year":"2011","journal-title":"The Neuroscientist: a review journal bringing neurobiology, neurology and psychiatry"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/gt.2011.170","article-title":"Using non-coding small RNAs to develop therapies for Huntington's disease","volume":"18","author":"Y Zhang","year":"2011","journal-title":"Gene therapy"},{"key":"ref53","article-title":"Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis","author":"G Wang","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.neuron.2014.07.043","article-title":"Efficient, complete deletion of synaptic proteins using CRISPR","volume":"83","author":"S Incontro","year":"2014","journal-title":"Neuron"},{"issue":"8","key":"ref55","doi-asserted-by":"crossref","first-page":"e105584","DOI":"10.1371\/journal.pone.0105584","article-title":"CRISPR\/Cas9-mediated gene knock-down in post-mitotic neurons","volume":"9","author":"C Straub","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"RJ Platt","year":"2014","journal-title":"Cell"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nbt.3055","article-title":"In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9","volume":"33","author":"L Swiech","year":"2015","journal-title":"Nature biotechnology"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1083\/jcb.200306038","article-title":"Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity","volume":"163","author":"H Zhou","year":"2003","journal-title":"The Journal of cell biology"},{"issue":"7","key":"ref59","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/hmg\/ddr023","article-title":"Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation","volume":"20","author":"LS Havel","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1083\/jcb.200710158","article-title":"Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin","volume":"181","author":"CE Wang","year":"2008","journal-title":"The Journal of cell biology"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2008.08.041","article-title":"Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice","volume":"157","author":"MA Hickey","year":"2008","journal-title":"Neuroscience"},{"issue":"17","key":"ref62","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1093\/hmg\/ddn175","article-title":"Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease","volume":"17","author":"CE Wang","year":"2008","journal-title":"Hum Mol Genet"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T15:15:32Z","timestamp":1600614932000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006083"}},"subtitle":[],"editor":[{"given":"Diane","family":"Merry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,20]]},"references-count":62,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006083","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,20]]}}}