{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:56:43Z","timestamp":1788897403950,"version":"build-2803163510"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD043403"],"award-info":[{"award-number":["R01 HD043403"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21 AI099642"],"award-info":[{"award-number":["R21 AI099642"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006109","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T19:27:11Z","timestamp":1466018831000},"page":"e1006109","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterranea"],"prefix":"10.1371","volume":"12","author":[{"given":"Harini","family":"Iyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip A.","family":"Newmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1126\/science.287.5457.1489","article-title":"Regulation of cell fate decision of undifferentiated spermatogonia by GDNF","volume":"287","author":"X Meng","year":"2000","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.stem.2009.04.020","article-title":"Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation","volume":"5","author":"J Lee","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1242\/dev.076539","article-title":"FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation","volume":"139","author":"K Ishii","year":"2012","journal-title":"Development"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2164\/jandrol.109.008227","article-title":"The power of mouse genetics to study spermatogenesis","volume":"31","author":"AN Yatsenko","year":"2010","journal-title":"J Androl"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0035-9203(84)90129-9","article-title":"A review of schistosomiasis in immigrants in Western Australia, demonstrating the unusual longevity of <italic>Schistosoma mansoni<\/italic>","volume":"78","author":"AR Harris","year":"1984","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0140-6736(88)90334-0","article-title":"Longstanding infection with <italic>Schistosoma mansoni<\/italic>","volume":"1","author":"GC Cook","year":"1988","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0092-8674(87)90513-7","article-title":"A multiplicity of CCAAT box-binding proteins","volume":"50","author":"A Dorn","year":"1987","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1126\/science.3399893","article-title":"Selective activation of transcription by a novel CCAAT binding factor","volume":"241","author":"SN Maity","year":"1988","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/10409238.2011.628970","article-title":"NF-Y and the transcriptional activation of CCAAT promoters","volume":"47","author":"D Dolfini","year":"2012","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0092-8674(02)01087-5","article-title":"Whole-genome analysis of dorsal-ventral patterning in the <italic>Drosophila<\/italic> embryo","volume":"111","author":"A Stathopoulos","year":"2002","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nature07419","article-title":"Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons","volume":"456","author":"M Morey","year":"2008","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2443.2007.01155.x","article-title":"Transcription factor NF-Y is involved in regulation of the JNK pathway during <italic>Drosophila<\/italic> thorax development","volume":"13","author":"Y Yoshioka","year":"2008","journal-title":"Genes Cells"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ydbio.2007.05.021","article-title":"Transcription factor NFY globally represses the expression of the <italic>C<\/italic>. <italic>elegans<\/italic> Hox gene <italic>Abdominal-B<\/italic> homolog <italic>egl-5<\/italic>","volume":"308","author":"H Deng","year":"2007","journal-title":"Dev Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.bone.2009.01.374","article-title":"Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development","volume":"44","author":"Y-H Chen","year":"2009","journal-title":"Bone"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1101\/gad.1951010","article-title":"A functional genomic screen in planarians identifies novel regulators of germ cell development","volume":"24","author":"Y Wang","year":"2010","journal-title":"Genes Dev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s12864-015-1533-1","article-title":"Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in <italic>Schmidtea mediterranea<\/italic>","volume":"16","author":"G Rodr\u00edguez-Esteban","year":"2015","journal-title":"BMC Genomics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ng1366","article-title":"Plzf is required in adult male germ cells for stem cell self-renewal","volume":"36","author":"FW Buaas","year":"2004","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ng1367","article-title":"Essential role of Plzf in maintenance of spermatogonial stem cells","volume":"36","author":"JA Costoya","year":"2004","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1101\/gad.1290105","article-title":"Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID","volume":"19","author":"AE Falender","year":"2005","journal-title":"Genes Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"18491","DOI":"10.1073\/pnas.0509507102","article-title":"The planarian <italic>Schmidtea mediterranea<\/italic> as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain","volume":"102","author":"RM Zayas","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1073\/pnas.0609708104","article-title":"<italic>nanos<\/italic> function is essential for development and regeneration of planarian germ cells","volume":"104","author":"Y Wang","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-213X-11-69","article-title":"Molecular markers to characterize the hermaphroditic reproductive system of the planarian <italic>Schmidtea mediterranea<\/italic>","volume":"11","author":"T Chong","year":"2011","journal-title":"BMC Dev Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1002\/j.1460-2075.1993.tb06153.x","article-title":"Mutations in yeast HAP2\/HAP3 define a hybrid CCAAT box binding domain","volume":"12","author":"Y Xing","year":"1993","journal-title":"EMBO J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1073\/pnas.91.8.3009","article-title":"Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short alpha-helix in HAP2","volume":"91","author":"Y Xing","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1128\/MCB.16.8.4003","article-title":"Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule","volume":"16","author":"IS Kim","year":"1996","journal-title":"Mol Cell Biol"},{"key":"ref26","first-page":"179","article-title":"Growth and regeneration in <italic>Planaria lugubris<\/italic>","volume":"13","author":"TH Morgan","year":"1901","journal-title":"Arch Entwm Org"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1038\/ncomms2811","article-title":"A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite","volume":"4","author":"T Chong","year":"2013","journal-title":"Nat Commun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1002\/j.1460-2075.1995.tb00130.x","article-title":"Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression","volume":"14","author":"J Zwicker","year":"1995","journal-title":"EMBO J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/sj.onc.1202494","article-title":"The cyclin B2 promoter depends on NF-Y, a trimer whose CCAAT-binding activity is cell-cycle regulated","volume":"18","author":"F Bolognese","year":"1999","journal-title":"Oncogene"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1074\/jbc.M006052200","article-title":"NF-Y mediates the transcriptional inhibition of the <italic>cyclin B1<\/italic>, <italic>cyclin B2<\/italic>, and <italic>cdc25C<\/italic> promoters upon induced G2 arrest","volume":"276","author":"I Manni","year":"2001","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1093\/nar\/gkl801","article-title":"Inhibition of CBF\/NF-Y mediated transcription activation arrests cells at G2\/M phase and suppresses expression of genes activated at G2\/M phase of the cell cycle","volume":"34","author":"Q Hu","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.5483\/BMBRep.2011.44.8.553","article-title":"NF-Y binds to both G1-and G2-specific cyclin promoters; a possible role in linking CDK2\/Cyclin A to CDK1\/Cyclin B","volume":"44","author":"HD Chae","year":"2011","journal-title":"BMB Reports"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1038\/sj.onc.1202472","article-title":"Down-regulation of cyclin B1 gene transcription in terminally differentiated skeletal muscle cells is associated with loss of functional CCAAT-binding NF-Y complex","volume":"18","author":"A Farina","year":"1999","journal-title":"Oncogene"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11728","DOI":"10.1073\/pnas.0503405102","article-title":"NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal","volume":"102","author":"J Zhu","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1371\/journal.pgen.0030145","article-title":"Systematic identification of cis-regulatory sequences active in mouse and human embryonic stem cells","volume":"3","author":"M Grskovic","year":"2007","journal-title":"PLoS Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1182\/blood-2011-06-359406","article-title":"NF-Y is necessary for hematopoietic stem cell proliferation and survival","volume":"119","author":"G Bungartz","year":"2012","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.molcel.2014.07.005","article-title":"Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors","volume":"55","author":"AJ Oldfield","year":"2014","journal-title":"Mol Cell"},{"key":"ref38","first-page":"4","article-title":"Etude ultrastructurale des testicules de <italic>Polycelis tenuis<\/italic> et <italic>Polycelis nigra<\/italic> (Planaires). Evolution des cellules germinales males avant la spermiogenese","volume":"87","author":"R Franquinet","year":"1973","journal-title":"Z Mikrosk Anat Forsch"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s004120050256","article-title":"Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation","volume":"106","author":"MJ Hendzel","year":"1997","journal-title":"Chromosoma"},{"key":"ref40","first-page":"8167","article-title":"The B subunit of the CCAAT box binding transcription factor complex (CBF\/NF-Y) is essential for early mouse development and cell proliferation","volume":"63","author":"A Bhattacharya","year":"2003","journal-title":"Cancer Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature11924","article-title":"Adult somatic stem cells in the human parasite <italic>Schistosoma mansoni<\/italic>","volume":"494","author":"JJ Collins","year":"2013","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e1003396","DOI":"10.1371\/journal.ppat.1003396","article-title":"It&apos;s no fluke: the planarian as a model for understanding schistosomes","volume":"9","author":"JJ Collins","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e00768","DOI":"10.7554\/eLife.00768","article-title":"Functional genomic characterization of neoblast-like stem cells in larval <italic>Schistosoma mansoni<\/italic>","volume":"2","author":"B Wang","year":"2013","journal-title":"eLife"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2006.11.016","article-title":"Pathway to Totipotency: Lessons from Germ Cells","volume":"127","author":"G Seydoux","year":"2006","journal-title":"Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.cellbio.23.090506.123326","article-title":"Controls of germline stem cells, entry into meiosis, and the sperm\/oocyte decision in <italic>Caenorhabditis elegans<\/italic>","volume":"23","author":"J Kimble","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cell.2008.02.003","article-title":"Germ Cells Are Forever","volume":"132","author":"RM Cinalli","year":"2008","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"45586","DOI":"10.1074\/jbc.M302884200","article-title":"Expression of the germ cell-specific transcription factor ALF in <italic>Xenopus<\/italic> oocytes compensates for translational inactivation of the somatic factor TFIIA","volume":"278","author":"S Han","year":"2003","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1095\/biolreprod.104.030247","article-title":"A short core promoter drives expression of the ALF transcription factor in reproductive tissues of male and female mice","volume":"71","author":"S Han","year":"2004","journal-title":"Biol Reprod"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"13720","DOI":"10.1073\/pnas.96.24.13720","article-title":"Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells","volume":"96","author":"M Teichmann","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1126\/science.1059188","article-title":"Spermiogenesis Deficiency in Mice Lacking the <italic>Trf2<\/italic> Gene","volume":"292","author":"Di Zhang","year":"2001","journal-title":"Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1242\/dev.129.4.945","article-title":"Distinct functions of TBP and TLF\/TRF2 during spermatogenesis: Requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids","volume":"129","author":"I Martianov","year":"2002","journal-title":"Development"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ydbio.2005.09.038","article-title":"TAF4b, a TBP associated factor, is required for oocyte development and function","volume":"288","author":"AE Falender","year":"2005","journal-title":"Dev Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1101\/gad.869101","article-title":"Developmental regulation of transcription by a tissue-specific TAF homolog","volume":"15","author":"MA Hiller","year":"2001","journal-title":"Genes Dev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1182\/blood-2003-01-0251","article-title":"NF-Y cooperates with USF1\/2 to induce the hematopoietic expression of HOXB4","volume":"102","author":"J Zhu","year":"2003","journal-title":"Blood"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1017\/S003118200008152X","article-title":"Expression of NF-Y nuclear factor in <italic>Schistosoma mansoni<\/italic>","volume":"113","author":"E Serra","year":"1996","journal-title":"Parasitology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1091\/mbc.E11-03-0212","article-title":"The RNA-binding protein ELAVL1\/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages","volume":"22","author":"MN Chi","year":"2011","journal-title":"Mol Biol Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/dbio.2000.9658","article-title":"A Sequence-Specific RNA Binding Complex Expressed in Murine Germ Cells Contains MSY2 and MSY4","volume":"221","author":"HG Davies","year":"2000","journal-title":"Dev Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1242\/dev.129.15.3669","article-title":"Translational repression by MSY4 inhibits spermatid differentiation in mice","volume":"129","author":"F Giorgini","year":"2002","journal-title":"Development"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1411.010","article-title":"Toward understanding the core meiotic transcriptome in mammals and its implications for somatic cancer","volume":"1120","author":"F Chalmel","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.0609923104","article-title":"Mouse oocytes within germ cell cysts and primordial follicles contain a Balbiani body","volume":"104","author":"ME Pepling","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1242\/dev.01941","article-title":"Planarian homologs of <italic>netrin<\/italic> and <italic>netrin receptor<\/italic> are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture","volume":"132","author":"F Cebri\u00e0","year":"2005","journal-title":"Development"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1242\/dev.00167","article-title":"The <italic>Schmidtea mediterranea<\/italic> database as a molecular resource for studying platyhelminthes, stem cells and regeneration","volume":"129","author":"Alvarado A S\u00e1nchez","year":"2002","journal-title":"Development"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/dvg.22872","article-title":"SmedGD 2.0: The <italic>Schmidtea mediterranea<\/italic> genome database","volume":"53","author":"SMC Robb","year":"2015","journal-title":"Genesis"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1387\/ijdb.113443cm","article-title":"An insulin-like peptide regulates size and adult stem cells in planarians","volume":"56","author":"CM Miller","year":"2012","journal-title":"Int J Dev Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e1000509","DOI":"10.1371\/journal.pbio.1000509","article-title":"Genome-wide analyses reveal a role for peptide hormones in planarian germline development","volume":"8","author":"JJ Collins","year":"2010","journal-title":"PLoS Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/dvdy.21849","article-title":"Formaldehyde-based whole-mount in situ hybridization method for planarians","volume":"238","author":"BJ Pearson","year":"2009","journal-title":"Dev Dyn"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-213X-13-8","article-title":"In situ hybridization protocol for enhanced detection of gene expression in the planarian <italic>Schmidtea mediterranea<\/italic>","volume":"13","author":"RS King","year":"2013","journal-title":"BMC Dev Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ydbio.2011.05.669","article-title":"Stem cell-based growth, regeneration, and remodeling of the planarian intestine","volume":"356","author":"DJ Forsthoefel","year":"2011","journal-title":"Dev Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ydbio.2009.09.015","article-title":"Cell death and tissue remodeling in planarian regeneration","volume":"338","author":"J Pellettieri","year":"2010","journal-title":"Dev Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2307\/3280632","article-title":"Cultivation of <italic>Schistosoma mansoni<\/italic> in vitro. I. Establishment of cultures from cercariae and development until pairing","volume":"67","author":"PF Basch","year":"1981","journal-title":"J Parasitol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2307\/3280633","article-title":"Cultivation of <italic>Schistosoma mansoni<\/italic> in vitro. II. production of infertile eggs by worm pairs cultured from cercariae","volume":"67","author":"PF Basch","year":"1981","journal-title":"J Parasitol"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T19:47:07Z","timestamp":1656704827000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006109"}},"subtitle":[],"editor":[{"given":"A. Aziz","family":"Aboobaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,15]]},"references-count":71,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006109","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,15]]}}}